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International Journal of Otolaryngology and Head & Neck Surgery 2014年第2期3卷 71-74页

作者： Jose Francisco de Salles Chagas Jose Luis Braga de Aquino Maria Beatriz nogueira Paschoal Luis antonio Brandi Filho Fernanda Fruet Douglas Alexandre Rizzanti Pereira Fernanda Garcia Callegari Thalita dos Reis Ruba Service of Head and Neck Surgery Beneficiencia Portuguesa de Sao PauloMedical SchoolCatholic University of CampinasCampinasBrazil

Introduction: One of the most common causes of hyperthyroidism is Graves’ disease. The malignant exophthalmos is a rare condition characterized by the loss of visual function that doesn’t adequately respond to various forms of treatment, requiring, in most cases, surgical correction. Objective: We report a case of conjunctival edema and protrusion of the eyeball in patients secondary to Graves’ disease, characterizing malignant ophthalmopathy and discuss their surgical treatment. Case Report: A 73-year-old male patient presenting bilateral conjunctive hyperaemia, decreased visual acuity, exophtalmos with progressive deterioration. Pulse therapy was performed without improvement and then underwent bilateral ethmoidectomy. Discussion: Late diagnosis is harmful due to the fact that malignant disease is extremely aggressive and fast, as reported in this case. Most often, the ophthalmopathy follows a relatively mild and self-limiting course, making a proper diagnosis difficult if the disease progresses. In extreme cases acute orbital decompression is indicated complementing appropriate medical treatment, which will allow herniation of orbital contents. Many orbital decompression techniques have been used in the treatment of Graves’ ophthalmopathy. The most common of these is the endoscopic sinus surgery which potentiated act in decompression of the medial wall safely and minimally invasive. In our case, open bilateral ethmoidectomy was used, due to the fact that surgeons are most experienced in this technique. Although the post-operative has been successfully submitted, no signs of recurrence were observed after fifteen days due to the evolution of Graves’ disease. Even with outpatient treatment, he walked to the total visual loss. Conclusion: We observed that the malignant ophthalmopathy is rare and aggressive;however, in spite of therapeutic resources used, it can progress to total visual loss.

关键词： Malignant Exophthalmos Ethmoidectomy Hyperthyroidism

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Biomedical Perspectives About Women with Chronic Pelvic Pain:A Qualitative Analysis

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International Journal of Clinical Medicine 2012年第5期3卷 411-418页

作者： Paula P.Souza Adriana P.M.S.Romao Ana Marcia S.Nakano Julio C.Rosa-e-Silva Francisco J.Candido-dos-Reis antonio A.nogueira Omero B.Poli-Neto Department of Gynaecology and Obstetrics School of Medicine University HospitalUniversity of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil Department of Public Health School of NursingUniversity of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil School of Medicine University Hospital University of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil

Because the aetiology of chronic pelvic pain is complex, studies of the condition involve extensive investigation but provide few conclusions. Numerous studies have addressed the experiences of women with chronic pelvic pain, as well as the interaction between those women and their health care providers. Our objective was to investigate how physicians at a specialised clinic perceive the medical care provided to such women. This was a qualitative study employing semi-structured interviews and content analysis. We interviewed seven physicians at the Chronic Pelvic Pain Outpatient Clinic of the University Hospital, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Brazil. Medical training and practice constituted the central theme of the study, which was subdivided into categories addressing the influence that the current medical training has on the type of medical care provided to women with chronic pelvic pain. Medical practice has been characterised by a reductionist approach to health and illness, as well as by the fragmentation of health care. These characteristics are, to a certain extent, the result of the biomedical model of education, which has been predominant, ignoring social, cultural, psychological and emotional aspects. There is a need to shift the medical paradigms toward a humanistic model of health care. We hope that we have provided a critical view of current medical training and practice, as well as of their effects in various health care settings, particularly in the provision of care to women with chronic pelvic pain.

关键词： Chronic Pelvic Pain Biomedical Model Qualitative Research

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“In Vitro”Antibacterial Activity of the Hidroalcoholic Extract of the Schinus terebinthifolius Raddi Barks

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Advances in Microbiology 2014年第12期4卷 761-765页

作者： Erica Renata nogueira Sá Cássio Ilan Soares Medeiros Juliana Raquel de Morais Santos Oliveira antonio José de Jesus Evangelista Maria Iranilda Silva Magalhaes Geraldo Goncalves de Almeida Filho Andréa Maria Rolim da Paz Hilzeth de Luna Freire Pessoa Department of Microbiology Research Integrated College of PatosPatosBrazil Department of Medical Sciences Federal University of CearáCearáBrazil Department of Health Sciences Cruzeiro of Sul UniversitySao PauloBrazil Department of Pharmaceutical Technology Federal University of ParaíbaJoao PessoaBrazil Department of Cell and Molecular Biology Federal University of ParaíbaJoao PessoaBrazil

The Schinus terebinthifolius Raddi is a native plant of South America popularly known in Brazil as aroeira. It is a medium-sized plant, which demonstrates a high adaptive potential in various environments, besides having various medicinal properties such as anti-inflammatory and antidiarrheal. Bacterial susceptibility tests were carried out and the minimal inhibitory concentration (MIC) was obtained. The results were interpreted based on the conventionally microbiological protocols and data from the CLSI. For the microbiological tests, microorganisms obtained from the American Type Culture Collection (ATCC), specifically, (Pseudomonas aeruginosa, Staphylococcus aureus and Encherichia coli) were used. Of the tested bacterial strains, only the Staphylococcus aureus 6538 presented susceptibility to the aroeira’s hydroalcoholic extract, forming zones of inhibition of 8.0 mm of diameter up to the MIC of 35.3 mg/mL, while the other tested strains showed to be resistant in all the concentrations of hydroalcoholic extract of the Schinus terebinthifolius Raddi bark. Our aim is to analyze the “in vitro” antibacterial potential of the 70% hydroalcoholic extract of the Schinus terebinthifolius Raddi.

关键词： Aroeira Antibacterial Activity Schinus terebinthifolius Raddi Hydroalcoholic Extract

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Public Use and Landscape Analysis in the Serra da Canastra National Park, Brazil: A Geospatial Approach

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Natural Resources 2016年第2期7卷 93-101页

作者： Marcos Cicarini Hott Luiz Otávio Moras Filho Marco Aurélio Leite Fontes Aline Aparecida Silva Pereira Cláudia de Oliveira Gonçalves nogueira Luis Marcelo Tavares de Carvalho Luís Antônio Coimbra Borges João Cesar de Resende Mauro antonio Homem Antunes Department of Forest Sciences Federal University of Lavras Lavras Brazil Brazilian Agricultural Research Corporation—Embrapa Juiz de Fora Brazil Department of Engineering Federal Rural University of Rio de Janeiro Seropédica Brazil

The Conservation Units (CU) were created to protect natural environments from growing degradation and to impede the expansion of urbanization and agricultural crops. The Serra da Canastra National Park, established to protect the headwaters of the S?o Francisco River and other places of scenic and ecological interest, is extensively visited due to its many tourist attractions, such as waterfalls, fauna and flora. An analysis of the park’s geography is needed to assess the risk involved in and its suitability for public use due to its territorial extension and environmental complexities. Thus, this study aimed to investigate the background of issues of interest to CU management. Additionally, we used high-resolution RapidEye imagery, altimetry and database of park infrastructure to build geospatial database and estimate classes of suitability for and risk in public use through GIS tools. The resulting cartographic data can support the planning of policies concerning the landscape and park’s territorial management.

关键词： Conservation Units Environment GIS RapidEye Imagery

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The Use of Mathematical Morphology in the Detection of Impact Craters on Digital Images of the Martian Surface

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通讯和计算机（中英文版） 2012年第12期9卷 1351-1357页

作者： Miriam Maria PedrosaI Erivaldo antonio da Silva Maurfcio Dias Jose Roberto nogueira Univ. Estadual Paulista Sao Paulo 19060 900 Brazil

Planet Mars"s exploration has been more and more intense with the relevant number of probes sent for acquiring images and information about this planet. So, there is already a large file of orbital images of the Martian surface, and the identification and counting of craters on these images has a crucial importance about studying this planet. Due this prominence we developed in this paper an approach for impact crater detection from digital images of Martian surface by using morphology mathematic tools. The used images as study areas were obtained by THEMIS (thermal emission imaging system) camera, on board at Mars Odyssey probe, launched on 2001 and orbiting the planet until nowadays. The morphologic routine developed for impact craters detection has encompassed transformations to pre-processing, filtering, binarization and segmentation by watershed. The results have proved the feasibility of using mathematic morphology related to impact craters detection on Martian surface by orbital images. These obtained results can support projects on several knowledge areas which have interest on Martian surface exploration, such as cartography, geology, physics, astronomy among others.

关键词：数学形态学火星表面数字图像撞击坑 “奥德赛”探测器检测辐射成像系统信息发送

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Adaptability and Stability Analysis of Soybean Genotypes Using Toler and Centroid Methods

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American Journal of Plant Sciences 2015年第9期6卷 1509-1518页

作者： Raphael Lemes Hamawaki Osvaldo Toshiyuki Hamawaki Ana Paula Oliveira nogueira Cristiane Divina Lemes Hamawaki Larissa Barbosa Sousa David A. Lightfoot Stella K. Kantartzi Ministry of Education of Brazil CAPES Foundation Brasilia Brazil Crop Science Institute Federal University of Uberlandia Uberlandia Brazil Informatics Department President Antonio Carlos University Araguari Brazil Department of Plant Soil and Agricultural Systems Southern Illinois University Carbondale Carbondale Illinois USA

Soybean (Glycine max L. Merr.) adaptation to new environments has been hard to predict based on maturity group. The aim of this study was to evaluate the performance of 14 soybean genotypes, from the Soybean Breeding Program of the Federal University of Uberlandia, in their adaptive capacity and seed yield stability at 3 locations and 2 growing seasons. For the adaptability and stability analysis the Toler and Centroid methods were used;5 genotypic groups were identified in the first whereas 4 groups were identified in the latter. By the Toler method group A was composed by 4 genotypes, UFU-001, UFU-003, UFU-0010, and UFU-001. They showed a convex pattern of adaptability and stability. In contrast, the genotypes UFU-008 and UFU-0013 were classified in Group E with a concave pattern of adaptability and stability. Regarding results from the Centroid method, the Genotype UFU-002, with higher seed yield than average, was the only genotype in Ideotype VI with moderate adaptability to favorable environments. In contrast, 10 genotypes were included in the Ideotype V, of medium general adaptability. The genotypes UFU-001, UFU-002, UFU-006, UFU-0010, and UFU-0011 were recommended for use in the Brazilian Cerrado growing region. These genotypes had high seed yield potential in high quality environments.

关键词： Glycine max Adaptability Analysis Non-Linear Regression Multivariate Analysis

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International consensus on natural orifice specimen extraction surgery(NOSES)for colorectal cancer

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Gastroenterology Report 2019年第1期7卷 24-31,I0001页

作者： Xu Guan Zheng Liu antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-Kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee Petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejingChina Department of Coloproctology and Pelvic Diseases Humanitas GavazzeniBergamoItaly Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenChina Department of Surgery China Medical University HospitalTaichungTaiwanChina Department of Abdominal Surgery Fujian Medical University Cancer HospitalFuzhouChina Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Surgery Hospital de BragaBragaPortugal Colorectal Surgery Department Sechenov First Moscow State Medical UniversityMoscowRussia Universidad Central de Venezuela Centro Medico LoiraCaracasVenezuela Department of General Surgery Shandong University Qilu HospitalJinanChina Department of General Surgery Huaihe Hospital of Henan UniversityKaifengChina Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Korea University Anam HospitalKorea University College of MedicineSeoulSouth Korea Department of Colorectal Surgery Portsmouth Hospitals NHS TrustQueen Alexandra HospitalPortsmouthUK Division of Colorectal Surgery Taipei Medical University HospitalTaipeiTaiwanChina Department of Surgery Nagaka Chuo General HospitalNagaoka CityJapan Innovation Unit/Colorectal Cancer Osaka Medical College Hospital Cancer CenterOsakaJapan Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhouChina Department of Gastric and Colorectal Surgery Jilin University First HospitalChangchunChina Division of Surgical Oncology Nagoya University Graduate School of MedicineNagoyaJapan Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical

In recent years,natural orifice specimen extraction surgery(NOSES)in the treatment of colorectal cancer has attracted widespread *** potential benefits of NOSES including reduction in postoperative pain and wound complications,less use of postoperative analgesic,faster recovery of bowel function,shorter length of hospital stay,better cosmetic and psychological effect have been described in colorectal *** significant decrease in surgical trauma of NOSES have been observed,the potential pitfalls of this technique have been ***,several issues including bacteriological concerns,oncological outcomes and patient selection are raised with this new ***,it is urgent and necessary to reach a consensus as an industry guideline to standardize the implementation of NOSES in colorectal *** three rounds of discussion by all members of the International Alliance of NOSES,the consensus is finally completed,which is also of great significance to the long-term progress of NOSES worldwide.

关键词： colorectal cancer natural orifice specimen extraction surgery(NOSES) laparoscopy natural orifice transluminal endoscopic surgery(NOTES) transanal total mesorectal excision(TaTME)

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Activity of Secondary Bacterial Metabolites in the Control of Citrus Canker

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Agricultural Sciences 2015年第3期6卷 295-303页

作者： Leticia Sayuri Murate Admilton Goncalves de Oliveira Allan Yukio Higashi Andre Riedi Barazetti Ane Stefano Simionato Caroline Santos da Silva Glenda Cavalari Simoes Igor Matheus Oliveira dos Santos Marlon Renan Ferreira Martha Viviana Torres Cely Miguel Octavio Pérez Navarro Vanessa Fogaca de Freitas Marco antonio nogueira Joao Carlos Palazzo de Mello Rui Pereira Leite Jr. Galdino Andrade Department of Microbiology Londrina State UniversityLondrinaBrazil Embrapa Soja LondrinaBrazil Department of Pharmacy and Pharmacology Maringa State UniversityMaringáBrazil Plant Protection Agronomic Institute of ParanáIAPARLondrinaBrazil

This study investigated the protective effects of secondary bacterial metabolites, produced by Pseudomonas sp. (bacterium strain LN), on citrus canker disease caused by Xanthomonas axonopodis pv. citri (Xac 306). The LN bacteria strain was cultured in liquid medium and the supernatant free-cells was treated with methanol (AMF) and ethyl acetate (AEF), respectively, and then the extract was concentrated, filtrated, lyophilized and fractionated by vacuum liquid chromatography (VLC). After VLC, eight fractions were obtained. All fractions’ activity against Xac 306 by agar well diffusion assay and minimum inhibitory concentration but in different concentrationswere tested. Cytotoxicity effects were observed in all fractions in 50 μg·mL-1 concentration. The comet assay demonstrated that the fractions EAF, VLC2 and VLC3 presented no genotoxic effects at tested concentrations. In plants only VLC3 showed significant results (p<0.05), reducing the incidence of citrus canker lesions.

关键词： X.axonopodis pv.citri Citrus sinensis Antibiosis Biological Control Natural Antibiotic

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Interleukin 28B-related polymorphisms: A pathway for understanding hepatitis C virus infection?

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World Journal of Gastroenterology 2013年第42期19卷 7399-7404页

作者： Raquel Francine Liermann Garcia Simone Moreira Ana Lucia de Araújo Ramos Leslie Ecker Ferreira Angelo Alves de Mattos Cristiane Valle Tovo Lysandro Alsina Nader Juliene antonio Ramos Edson Rondinelli Arnaldo de Jesus Dominici Christian Evangelista Garcia Mauro de Souza Leite Pinho Carlos Eduardo Brando-Mello Cristiane Alves Villela-nogueira Paulo Henrique Condeixa de Frana Departamento de Medicina Universidade da Regio de Joinville/UnivilleJoinville89219-719 Santa CatarinaBrazil Departamento de Clinica Médica e Cirurgia Geral Hospital Municipal So José Joinville89202-000 Santa CatarinaBrazil Departamento de Clínica Médica Servio de HepatologiaFaculdade de Medicina/Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro21941-913 Rio de JaneiroBrazil Servio de Gastroenterologia e Hepatologia Irmandade da Santa Casa de Misericórdia/ISCMPAPorto Alegre90020-090 Rio Grande do SulBrazil Servio de Endoscopia Universidade Federal de Pelotas/UFPelPelotas96010-610 Rio Grande do SulBrazil Instituto de Biofísica Carlos Chagas Filho/UFRJ 21941-902 Rio de JaneiroBrazil Departamento de Gastroenterologia Hospital Universitário da Universidade Federal do Maranh o/UFMASo Luis65020-560 MaranhoBrazil Servio de Gastroenterologia Hospital Universitário Gaffrée Guinle/HUGG/UNIRIO20270-004 Rio de JaneiroBrazil

AIM:To analyze the role of rs12979860 and rs8099917polymorphisms in hepatitis C virus(HCV)genotype 1infection of ***:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C(CHC)who had completed a 48-wk regimen of pegylated-interferonα-2a or-2b plus ribavirin combination therapy were recruited from six large urban healthcare centers and199 healthy blood donors(controls)from a single site between January 2010 and January *** on the patients’response to treatment was *** chain reaction-restriction fragment length polymorphism genotyping of the interleukin(IL)28B gene fragment encompassing the single nucleotide polymorphisms(SNPs)rs12979860(C/T)and rs8099917(T/G)was carried out for 79 of the CHC patients and 199 of the ***-directional amplicon sequencing of the two SNPs was carried out for the remaining 66 CHC ***:SNP rs12979860 genotyping was successful in 99.5%of the controls and 97.2%of the CHC patients,whereas the SNP rs8099917 genotyping was successful in 95.5%of the controls and 100%of the CHC *** genotype and allele distributions for both rs12979860 and rs8099917 were significantly different between the control and CHC patient groups,with significantly higher genotype frequencies of CC and TT in the controls(P=0.037 and 0.046,respectively)and of TT and GG in the CHC patients(P=0.0009and 0.0001,respectively).Analysis of the CHC patients who achieved sustained virological response(SVR)to treatment(n=55)indicated that the rs12979860 C allele and CC genotype were predictors of SVR(P=0.02).No significant correlation was found between rs8099917 genotypes and treatment response,but carriers of the T allele showed significantly higher rates of SVR(P=0.02).Linkage disequilibrium analysis of the group that achieved SVR showed a significant association between rs12979860 and rs8099917(P=0.07).CONCLUSION:The higher allele frequency of rs12979860 C and rs8099917 T observed in non-HCVinfec

关键词： Hepatitis C Interleukin 28B Single nucleotide polymorphisms Sustained virological response Brazil

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International consensus on natural orifice specimen extraction surgery(NOSES)for gastric cancer(2019)

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Gastroenterology Report 2020年第1期8卷 5-10,I0001页

作者： Xu Guan Zheng Liu Amjad Parvaiz antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda nogueira Feng Gao Fang-Hai Han Qing-Si He Ho-Kyung Chun Chang-Ming Huang Hai-Yang Huang Rui Huang Zhi-Wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack Son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong Liu Juan Liu Dan Ma Ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan Petr Tsarkov Xin-Yu Qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao Tian Gui-Yu Wang Guo-Jun Wang Guo-Rong Wang Xiao-Qiang Wang William Tzu-Liang Chen Woo Yong Lee Su Yan Zu-Li Yang Gang Yu Pei-Wu Yu Dan Zhao Yun-Shi Zhong Jian-Ping Wang Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Poole Hospital NHS Trust PooleUK European Center of Coloproctology and Pelvic Diseases-Multimedica Hospital MilanItaly Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenFujianP.R.China Section of Colon and Rectal Surgery Creighton University School of MedicineOmahaNEUSA Department of General Surgery Chinese People’s Liberation Army General HospitalBeijingP.R.China Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Hospital de BragaBragaPortugal Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Gastroenterological Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery Shandong University Qilu HospitalJinanShandongP.R.China Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Gastric Surgery Fujian Medical University Union HospitalFuzhouFujianP.R.China Department of General Surgery Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsuP.R.China Department of Colorectal Surgery PortsmouthHospitals NHSTrustQueen Alexandra HospitalPortsmouthUK King’s College Hospital LondonUK Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Surgical Oncology Department of SurgeryNagoya University School of MedicineNagoyaJapan Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongP.R.China Department of Gastric Cancer

At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological ***,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical ***,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative ***,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide.

关键词： gastric cancer natural orifice specimen extraction surgery transanal specimen extraction transvaginal specimen extraction transoral specimen extraction consensus

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