检索结果-南通市图书馆

International Journal of Clinical Medicine 2018年第9期9卷 737-749页

作者： Omero Benedicto Poli-Neto Raquel Verceze Bortolieiro Júlio Cesar Rosa-e-Silva Francisco Jose Candido-dos-Reis antonio Alberto nogueira Department of Gynecology and Obstetrics Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSPBrazil

Objective: To assess the satisfaction and occupational performance of women with chronic pelvic pain and to discuss unassisted intervention strategies by the occupational therapist for the care of these patients. Methods: A case-control study was conducted on 75 women with chronic pelvic pain and 75 apparently healthy women. The study was approved by the Research Ethics Committee of the institution and all subjects gave written informed consent to participate. Pain intensity was determined using a visual analogue scale and each patient was submitted to psycho-metric assessment using the Patient Health Questionnaire, the Self-Reporting Questionnaire of Psychiatric Screening and the Tampa Scale of Kinesiophofobia in their Brazilian version. The main outcomes regarding occupational performance and satisfaction were evaluated using the Canadian Measure of Occupational Performance. Results: The performance and satisfaction scores of women with chronic pelvic pain were significantly lower than those of healthy women. The presence of pain and kinesophobia was directly and independently correlated with low performance and satisfaction scores regardless of ethnicity, marital status, schooling, or psychometric scores. Conclusion: women with chronic pelvic pain present significant impairment of satisfaction and occupational performance. Coping is a potential unassisted intervention strategy to be applied to this population by occupational therapists.

关键词： Coping Occupational Therapy Performance Resilience Satisfaction

Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2019年第2期10卷 28-37页

作者： antonio Braga Paulo Mora Andréia Cristina de Melo Angélica nogueira-Rodrigues Joffre Amim-Junior Jorge Rezende-Filho Michael J Seckl Postgraduate Program of Medical Sciences Fluminense Federal University Department of Gynecology and Obstetrics Faculty of Medicine Rio de Janeiro Federal University Postgraduate Program of Perinatal Health Maternity School Brazilian National Cancer Hospital do Cancer 2 Department of Internal Medicine Faculty of Medicine Minas Gerais Federal University Department of Medical Oncology Charing Cross Gestational Trophoblastic Disease Centre Charing Cross Hospital Imperial College London

Gestational trophoblastic neoplasia(GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma(CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor(PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic *** diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics(FIGO)2000 criteria: four or more plateaued human chorionic gonadotropin(hCG)concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. However,the latter reason for treatment is no longer used by many centers. In addition,GTN is diagnosed with a pathological diagnosis of CCA or PSTT/ETT. For staging after a molar pregnancy, FIGO recommends pelvic-transvaginal Doppler ultrasound and chest X-ray. In cases of pulmonary metastases with more than 1cm, the screening should be complemented with chest computed tomography and brain magnetic resonance image. Single agent chemotherapy, usually Methotrexate(MTX) or Actinomycin-D(Act-D), can cure about 70% of patients with FIGO/World Health Organization(WHO) prognosis risk score ≤ 6(low risk), reserving multiple agent chemotherapy, such as EMA/CO(Etoposide,MTX, Act-D, Cyclophosphamide and Oncovin) for cases with FIGO/WHO prognosis risk score ≥ 7(high risk) that is often metastatic. Best overall cure rates for low and high risk disease is close to 100% and > 95%, respectively. The management of PSTT/ETT differs and cure rates tend to be a bit lower. The early diagnosis of this disease and the appropriate treatment avoid maternal death,allow the healing and maintenance of the reproductive potential of these women.

关键词： Gestational trophoblastic neoplasia Chemotherapy Chorionic gonadotropin Invasive mole Choriocarcinoma Placental site trophoblastic tumor Epithelioid trophoblastic tumor

Cytokine profiles in sickle cell anemia:Pathways to be unraveled

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2013年第7期4卷 6-12页

作者： Thassila nogueira Pitanga Wendell Vilas-Boas Bruno antonio Veloso Cerqueira Magda Oliveira Seixas Cynara Gomes Barbosa Elisangela Vitoria Adorno Marilda Souza Goncalves Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo CruzSalvadorBrasil Instituto de Ciencia e Tecnologia do Sangue CampinasBrasil Universidade Estadual de Santa Cruz IlheusBrasil Faculdade de Farmacia da Universidade Federal da Bahia SalvadorBrasil

Sickle cell anemia (SCA) is a genetically inherited hemolytic disorder characterized by chronic inflammation. Cytokine expression affects the pivotal pathways that contribute to disease pathogenesis, but the mechanisms involved are not well understood. SCA is associated with a proinflammatory state, and an enhanced inflammatory response occurs during vasoocclusive crisis. The immune system thus plays an important role in this inflammatory condition, with several cell types secreting pro-inflammatory cytokines that contribute to the occurrence of common cyclical events in SCA patients, such as hemolysis, vascular occlusion and inflammation. Studies of these cytokines and chemokines in SCA patients have clarified the mechanisms that underlie this disease and highlighted the need for a better understanding of cytokine participation in SCA pathophysiology.

关键词： Sickle Cell Anemia Cytokines Chemokine Inflammation Inflammasome

Recognizing Brazilian Cerrado Enclaves by Modeling Geoenvironmental Parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geographic Information System 2020年第2期12卷 125-140页

作者： Marcus Vinicius de Melo Oliveira antonio Manoel dos Santos Oliveira Augusto Francener nogueira Gonzaga Paulo Eduardo de Oliveira Anderson Targino da Silva Ferreira Master Program in Geoenvironmental Analysis of the Guarulhos University (MAG-UNG) Guarulhos São Paulo Brazil Faculdade de Goiana (FAG) Goiana Pernambuco Brazil Geosciences Institute of the University of São Paulo (IGc-USP) Cidade Universitária São Paulo Brazil

This work focused on the prediction modeling of Cerrado occurrences in the Atlantic Rainforest predominance in the São Paulo Metropolitan Region (SPMR), the fourth largest urban area, in the city of Guarulhos, southeastern Brazil. The methodology was based on the selection of records of occurrence of Cerrado in georeferenced databases, thematic maps of geoenvironmental layers, and modeling of the distribution of species through the MaxEnt tool. Besides that, field research confirmed the presence or not of the species in the areas with a high probability of occurrence of Cerrado (≥0.7). As a result, the model observed a great capacity for the prediction of the occurrence of Cerrado in Ecotonal and anthropic regions (AUC = 0.82), revealing important hotspots such as relics from the past or Cerrado enclaves of high biodiversity. The work also points priority areas for the conservation and preservation of this increasingly endangered biome.

关键词： Cerrado Enclave Hotspots Remaining Geoenvironmental Parameters Prediction of Adequacy MaxEnt

Relevant Aspects of Expert Interest in the Perception of the Facial Aesthetic Damage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forensic Medicine and Anatomy Research 2020年第1期8卷 1-10页

作者： Luiz Eugênio Nigro Mazzilli Nelson Massanobu Sakaguti Mário Marques Fernandes Juan antonio Cobo Plana Fernanda Capurucho Horta Bouchardet Rogério nogueira de Oliveira Forensic Dentistry Department of Social Dentistry University of São Paulo São Paulo Brazil Institute of Legal Medicine Zaragoza Spain

Forensic aesthetic facial damage—AFD expert’s valuation is a concerning matter in court as expressively vary in between experts. In fact, differences can be quite significant suggesting examiners age, sex and professional qualification may influence this valuation. Aiming to offer a systematic and more objective evaluation, some methods for assessing AFD had been proposed lately. Known as Aesthetic Impairment Impact Perception (AIPE), Cobo-Plana’s revised methodology (2010) was idealized to minimize the examiner’s subjectivity by means of answering an ordered sequence of questions related to the specific damage perception. This research aims to access AFD perception differences (simulated cases) in between Lawyers, Heath professionals (Physicians and Dental surgeons) and general professionals (laypeople) under AIPE methodology in order to allow a better comprehension of AFD when dealing with forensic expertise cases. Within Groups perceptions varied (p < 0.05) when evaluating lesions below “important” severity grade. Raters over 35 Years age scored higher AFD lesions, and rater’s sex (as an independent variable) did not express any significant difference in AFD scoring. The tendency of under-rating AFD lesions below very important severity grade was observed being a matter of major concern considered their prevalence and the effective consequences involved to the victim. These results recommend extra caution when performing AFD evaluation and consequently expertise reports, claiming a more judicious analysis based on consolidated standards and suggest, examiners to be more perceptive to physical damage evaluation in order to include social perceptions and reactions, mainly, victims feelings and constrains over their aesthetic loss.

关键词： Aesthetic Facial Damage Aesthetic Facial Damage Society

Sickle cell disease:Only one road,but different pathways for inflammation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2012年第4期3卷 538-550页

作者： Wendell Vilas-Boas Bruno antonio Veloso Cerqueira Thassila nogueira Pitanga Magda Oliveira Seixas Joelma Menezes Cyntia Cajado de Souza Elisangela Vitoria Adorno Marilda Souza Goncalves Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz(FIOCRUZ)SalvadorBahiaBrasil Instituto Nacional de Ciencia e Tecnologia do Sangue Sao PauloBrasil Universidade Estadual de Santa Cruz(UESC) IlheusBahiaBrasil Faculdade de Farmacia da Universidade Federal da Bahia(UFBA) SalvadorBahiaBrasil

Sickle cell disease (SCD) is a genetic disorder characterized by a chronic inflammatory process, and new biomarkers have been studied as promising molecules for understanding the inflammation in its pathophysiology. The hemolysis and the release of molecules associated to the hemoglobin (Hb) catabolism, such as free Hb, iron, and heme, generating a oxidant environment with production of reactive oxygen and nitrogen species. The immune system plays a very important role in the inflammation, with cells secreting pro-inflammatory cytokines and chemokines. There is also a nitric oxide (NO) resistance state, with an impaired NO bioactivity, leading to a vascular dys-function;activation of platelet, leukocytes, erythrocytes, and endothelial cells, with expression of adhesion molecules and its ligands, and several receptors, that altogether participate at inflammatory process. During inflammation, there is an increase of dendritic cells (DCs) expresse toll like receptors (TLR), but the role of DCs and TLR in SCD pathogenesis is unclear. Also, there are molecules contributing for enhance the endothelium dysfunction, such as homocysteine that has been associated with vascular complications in the pathology of other diseases and it may contribute to the vascular complications presented by SCD patients. Circulating microparticules (MPs) levels are augmented in several diseases and have been described in SCD, where cells membrane compounds are associated to cell’s thrombotic and coagulation state, such as tissue factor and phosphatidylserine (PS), which may contribute to endothelial dysfunction. The knowledge of all these biomarkers may contribute to new therapeutic approach discover, improveing SCD patient life quality.

关键词： Sickle Cell Disease Inflammation Oxidative Stress Cells Activation

Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2018年第1期6卷 52-60页

作者： Marina Silva de Lucca Eveline Tortes Pereira Thamires Righi Camilo Amaro de Carvalho Clayton Israel nogueira Daise Nunes Queiroz da Cunha antonio Jose Natali Luciana Moreira Lima Department of Medicine and Nursing Federal University of Vigosa MG CEP 36. 570-900 Brazil Postgraduate Program in Physical Education Federal University of Vigosa MG CEP 36. 5 70-900 Brazil Department of Biochemistry and Molecular Biology Federal University of Vicosa MG CEP 36. 570-900 Brazil Department of Veterinary Medicine Federal University of Vigosa MG CEP 36.570-900 Brazil

Objectives： To investigate the effects of physical training on the liver morphology and morphometry after chronic use of alcohol in rats. Methods： Twenty-four Wistar rats were housed in cages with controlled environment and randomly divided into four groups according to treatment received. In the initial treatment, alcohol was administered to SA （sedentary alcohol） and EA （exercise alcohol） groups. After four weeks, physical training program was held on a treadmill with EA and EC （exercise control） groups. Area, perimeter, maximum and minimum diameter and form factor of nucleus and cytoplasm of hepatocytes were analyzed. Key findings： Micro-vesicular fatty degeneration, predominantly pericentrolobular, of mild to moderate intensity, was found especially in animals treated with alcohol. EC group showed nucleus area greater than the nucleus area of EA and SA groups. The form factor was lower in the EC group than in the EA group. EA group showed maximum cytoplasm diameter is smaller than in SC （sedentary control） group. Conclusions： Physical training for two weeks was not enough to suppress histopathologic changes in the liver caused by chronic use of alcohol in rats. Chronic use of alcohol seems to have minimized the beneficial effect of physical training in the nucleus area of hepatocytes.

关键词： Alcohol exercise steatosis alcoholic liver disease animal model.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

费尔南多·佩索阿诗选

Conditional Cash Transfer Program Effects on Anthropometric Index from Children in Latin America: A Systematic Review

丛书名： 20世纪世界诗歌译丛

2004年

作者：（葡）费尔南多·佩索阿（Fernando antonio nogueira Pessoa）杨子译

本书是这位葡萄牙籍的“二十世纪最佳英语诗人”之一的诗歌作品选，针对这位诗人“神仙一样俯瞰着”俗世的创作，进行翻译的作品有《葡萄牙海》、《突然，一只手》等，以及其他葡籍诗人的作品。

ISBN: (纸本)7543452340

关键词：文学欧洲文学

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Health 2016年第7期8卷 664-671页

作者： Larissa Grace nogueira Serafim de Melo Severina Alice da Costa Uchoa Ricardo Ney Oliveira Cobucci José Vilton Costa antonio José do Nascimento Gouveia Costa Isabella Tarciana Pinheiro de Gois Mirella Cristina Silveira Gomes Faculdade de Ciências da Saúde do Trairi Universidade Federal do Rio Grande do Norte Santa Cruz Brasil Departamento de Saúde Coletiva Universidade Federal do Rio Grande do Norte Natal Brasil Maternidade Escola Januário Cicco Universidade Federal do Rio Grande do Norte Natal Brasil Programa de Pós-Graduacao em Demografia Universidade Federal do Rio Grande do Norte Natal Brasil Curso de Graduacao em Medicina Universidade Federal do Rio Grande do Norte Natal Brasil

Introduction: To compare the Brazilian conditional cash transfer program, the “Bolsa Família” with the similar programs found in Latin America regarding its effects in the children’s growth and development. Methods: The systematic review contemplated the Scopus, Embase, Pubmed, Scielo and Lilacs data bases. The inclusion criteria were epidemiological quantitative, observational, descriptive and analytical studies that had as target public children contemplated by the income transfer program with health conditionalities in Latin America. Narrative reviews related to the research theme were excluded as well as systematic reviews with or without meta-analysis related to the research theme. Results: The titles and abridgements review from 1007 articles resulted in the selection of 17 complete studies. After the quality analysis of these, as well as the application of the inclusion criteria, 10 articles were included in this review. Among the types of epidemiologic studies selected to compose this systematic review, 3 are cohort analytical studies. Conclusion: Studies carried out in Brazil, Mexico, Ecuador and Nicaragua were selected and indicated the positive effects that the conditional income transfer brought to the anthropometric index from beneficiary children in the researched countries.

关键词： Cash Transfer Program Child Development Income Distribution Primary Health Care

Multicentric Cervical Paraganglioma. Rare Case of Five Locations in One Patient. Case Report and Literature Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Otolaryngology and Head & Neck Surgery 2014年第2期3卷 82-88页

作者： José Francisco de Sales Chagas Maria Beatriz nogueira Pascoal José Luis Braga de Aquino Luis antonio Brandi Filho Fernanda Fruet Douglas Alexandre Rizzanti Pereira Amilcar de Castro Matos Thalita Ruba Fernanda Callegari Department of Pathology School of Medicine Catholic Uni-versity of Campinas Campinas Brazil Head and Neck Service School of Medicine Catholic University of Campinas Campinas Brazil School of Medicine Catholic University of Campinas Cam-pinas Brazil

Objective: To report a case of a multiple paraganglioma with 5 concurrent locations and also describe a complication not found in the literature, spontaneous tumor bleeding. Introduction: The paragangliomas are mostly benign and more frequent in women. Can be multiple, and these are considered as the most likely source of familial origin (30%-35%). The multicentric lesions can occur at different life stages not being necessarily simultaneous, a fact that prevents image exam research to be conclusive for tumor presence or absence. In this way the examination of the family members of patients, specially young ones, diagnosed with multicentric tumors may lead to negative results which doesn’t meant that the disease can be developed at a later time period. Therefore routine examination is not justifiable when symptoms relative to tumor presence are not present. Case report: A female patient of 32 years old complaining of tinnitus and diagnosed with five paragangliomas (jugulo-timpanic, bilateral carotid body and bilateral brachiocephalic trunk) through imaging studies. She reported suffering relatives of paragangliomas. Conclusion: The paper reports a rare case and perhaps unique in the literature, multiple paraganglioma with five locations and discusses difficult choice of treatment and complications.

关键词： Glomus Tumor Paraganglioma Glomus Jugulare Carotid Body Tumor Postoperative Complications