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Journal of Electromagnetic Analysis and Applications 2019年第6期11卷 79-99页

作者： antonio flavio licariao nogueira Rodolfo Lauro Weinert Leonardo Jose Amador Salas Maldonado Santa Catarina State University JoinvilleBrazil

The paper describes an approach to teaching low-frequency electromagnetic CAD techniques to undergraduate students pursuing a degree course in electrical engineering. The simulated experiments make use of a two-dimensional open-access software based on the finite-element method. At the laboratory meetings, the problems are initially solved analytically. Upon this, students learn how to create the numeric model and how to define the sequence of field problems that lead to the required solution. Simulation tasks based on a force-producing electromagnet are used to introduce numeric techniques to determine magnetic field distribution, evaluation of energy storage and generation of magnetic forces. The nature of the magnetic force generated in the air gaps of the C-core electromagnet is explained in detail. Magnetic forces are calculated by the classical and weighted versions of the method of Maxwell stress tensor. The paper provides all the basic elements required for further exploration of devices with longitudinal symmetry.

关键词： Actuators Electromagnetic Engineering Education Energy Storage Finite Element Method Magnetic Forces

Simulated Experiments for Teaching Mutually-Coupled Circuits CAD Techniques Using Analytic and Finite Element Solutions

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Journal of Electromagnetic Analysis and Applications 2017年第11期9卷 183-202页

作者： antonio flavio licariao nogueira Vitor Horbe Pereira da Costa Rodolfo Lauro Weinert Santa Catarina State University JoinvilleBrazil

The paper describes an approach to teaching mutually-coupled circuits CAD techniques to undergraduate students pursuing a degree course in electrical engineering or physics, and explains how a series of simulated experiments may be incorporated into the existing subjects. The simulated experiments make use of a two-dimensional open-access software based on the finite-element method. At the laboratory meetings, the students learn how to set up field problems for solution, and how to examine the results. Simulation tasks based on three axisymmetric open-boundary problems are used to introduce different numeric techniques to compute inductance and magnetic forces. The paper takes the reader to a step-by-step simulation journey, and provides all the basic elements required for further exploration of axially-symmetric systems.

关键词： Electromagnetic Engineering Education Finite Element Method Inductance Magnetic Forces Simulation Software

Analysing vaccine efficacy evaluated in phase 3 clinical trials carried out during outbreaks

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Infectious Disease Modelling 2024年第4期9卷 1027-1044页

作者： Francisco antonio Bezerra Coutinho Marcos Amaku Fernanda Castro Boulos Jose Alfredo de Sousa Moreira Joao Italo DiasFranca Julio antonio do Amaral Eliana nogueira Castro de Barros Claudio Jose Struchiner Esper Jorge Kallas Eduardo Massad School of Medicine University of Sao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil

In this paper we examine several definitions of vaccine efficacy(VE)that we found in the literature,for diseases that express themselves in outbreaks,that is,when the force of infection grows in time,reaches a maximum and then *** fact that the disease occurs in outbreaks results in several problems that we *** propose a mathematical model that allows the calculation of VE for several *** trials usually needs a large number of volunteers that must be ***,all volunteers should be enrolled in approximately the same time,but this is generally impossible for logistic reasons and they are enrolled in a fashion that can be replaced by a continuous density function(for example,a Gaussian function).The outbreak can also be replaced by a continuous density function,and the use of these density functions simplifies the ***,for example Gaussian functions,one of the problems one can immediately notice is that the peak of the two curves do not occur at the same *** model allows us to conclude:First,the calculated vaccine efficacy decreases when the force of infection increases;Second,the calculated vaccine efficacy decreases when the gap between the peak in the force of infection and the peak in the enrollment rate increases;Third,different trial protocols can be simulated with this model;different vaccine efficacy definitions can be calculated and in our simulations,all result are approximately the *** final,and perhaps most important conclusion of our model,is that vaccine efficacy calculated during outbreaks must be carefully examined and the best way we can suggest to overcome this problem is to stratify the enrolled volunteer's in a cohort-by-cohort basis and do the survival analysis for each cohort,or apply the Cox proportional hazards model for each cohort.

关键词： Vaccine efficacy Clinical trials Mathematical models Simulations Covid-19

A single session of strength training changed plasma levels of resistin,but not leptin in overweight and obese men

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Sports Medicine and Health Science 2024年第4期6卷 324-330页

作者： Yago Martins Fortes antonio Felipe Souza-Gomes Alessandro Roberto Silveira Moreira Leo nogueira Campos Samara Silva de Moura Lucelia Scarabeli Silva Barroso Marcelo Henrique Salviano de Faria Heliana de Barros Fernandes Aline Silva de Miranda Hugo Cesar Martins-Costa Ana Cristina Simoes e Silva Janaina Matos Moreira Albena Nunes-Silva Laboratory of Inflammation and Exercise Immunology Department of Physical EducationSchool of Physical EducationFederal University of Ouro PretoOuro PretoMGBrazil Postgraduate Program in Health and Nutrition Nutrition SchoolFederal University of Ouro PretoOuro PretoMGBrazil Interdisciplinary Medical Research Laboratory Faculty of MedicineFederal University of Minas GeraisBelo HorizonteMGBrazil Neurobiology Laboratory Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteMGBrazil Department of Physical Education Pontifical Catholic University of Minas GeraisBrazil Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteMGBrazil

Obesity has a complex multifactorial etiology and is characterized by excessive accumulation of adipose *** adipose tissue has deleterious effects on health because it secretes large amounts of inflammatory *** calorie restriction associated with strength training may be useful in managing chronic systemic *** study aimed to evaluate the acute effect of a single strength-training session on plasma adipokine levels in sedentary,overweight,and obese young *** study included twelve men(Age:[34.95±9.77]years;Height:[174.16±3.66]centimeter[cm];Weight:[97.83±12.87]kilogram(kg);body mass index[BMI]:[32.30±4.51]kg/m2),who performed a single strength training *** strength training protocol consisted of 4 sets of 12 repetitions in the following six exercises,45°leg press,bench press,leg extension,machine row,leg curl,and shoulder *** samples were collected before,immediately after,and 1-h subsequent after strength *** plasma levels of resistin and leptin were measured.A significant decrease in resistin levels were found 1 h after the strength training session if compared to levels before the training session(pre-[before][2390±1199]picograms per milliliter[pg/mL]vs post-1 h[1-h subsequent][1523±798],6 pg/mL,p=0.0028).The plasma leptin levels did not differ at any time *** conclusion,a very well controlled single session of strength training significantly decreased the plasma levels of resistin without altering the concentration of leptin in overweight and obese *** effect,at least in part,supports the benefits of exercise by reducing the low grade inflammation and insulin resistance in obesity.

关键词： Strength training Adipose tissue Obesity Chronicinflammation Resistin Leptin

Effectiveness of Acupuncture on Pain, Physical Function and Health-Related Quality of Life in Patients with Rheumatoid Arthritis: A Systematic Review of Quantitative Evidence

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Chinese Journal of Integrative Medicine 2019年第9期25卷 704-709页

作者： Susana Seca Diana Miranda Daniela Cardoso Bernice nogueira Henry J.Greten antonio Cabrita Manuel Alves Rodrigues Faculty of Medicine University of CoimbraInstitute of Science Biomedicine Abel Salazar University of Porto Porto PortugalHeidelberg School of Chinese Medicine Heidelberg Germany Institute of Science Biomedicine Abel Salazar University of Porto Porto Portugal Health Sciences Research Unit:Nursing (UICISA: E) Nursing School of Coimbra (ESEnfC) Portugal Centre for Evidenee Based Practice: A Joanna Briggs Institute Centre of Excellence Coimbra Portugal School of Health Sciences Macao Polytechnic Institute Macao SAR China Institute of Science Biomedicine Abel Salazar University of PortoHeidelberg School of Chinese Medicine Heidelberg Germany Faculty of Medicine University of Coimbra Portugal Health Sciences Research Unit: Nursing (UICISA:E) Nursing School of Coimbra (ESEnfC)Portugal Centre for Evidence Based Practice: A Joanna Briggs Institute Centre of Excellence Portugal

Objective: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life(HRQoL) in patients with rheumatoid arthritis(RA). Methods: A comprehensive search of 12 Western and Chinese databases was undertaken from their inception up to end of 2016. Randomized controlled trials(RCTs), concerning patients with RA treated with needle acupuncture, written in English, Portuguese, German or Chinese were included. Primary outcomes included pain, physical function and HRQoL. Secondary outcomes included morning stiffness, functional impairment, number of tender and swollen joints and serum concentrations of inflamatory markers. Methodological quality was assessed by three independent reviewers using the standardized critical appraisal instrument from the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument. Results: Twenty-two studies met the inclusion criteria. Of those, 9 studies were excluded after assessment of their methodological quality. The remaining 13 original RCTs included 974 patients. Ten of these studies published in China, showed favorable statistical significant effects of acupuncture in relieving symptoms of RA compared with controls. Conclusions: Evidence suggests that acupuncture interventions may have a positive effect in pain relief, physical function and HRQo L in RA patients. However, due to the heterogeneity and methodologic limitations of the studies included in this systematic review, evidence is not strong enough to produce a best practice guideline.

关键词： acupuncture rheumatoid arthritis quality of life pain physical function randomized clinical trial

Optimal and synchronized germination of Robinia pseudoacacia,Acacia dealbata and other woody Fabaceae using a handheld rotary tool:concomitant reduction of physical and physiological seed dormancy

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Journal of Forestry Research 2018年第2期29卷 283-290页

作者： Nuria Pedrol Carolina G.Puig antonio Lo′pez-nogueira Maria Pardo-Muras Luis Gonzalez Pablo Souza-Alonso Department of Plant Biology and Soil Science Faculty of BiologyUniversity of VigoUniversity Campus36310 VigoSpain

The Fabaceae(legume family) is one of the largest families of plants with a worldwide distribution and a major role in agriculture and in agroforestry.A hard seed coat impermeable to water is a typical feature of several *** dormancy delays and reduces germination so that mechanical,physical and chemical scarification methods have been classically used to break seed dormancy of many *** evaluate the effectiveness of a methodology to scarify seeds of several woody Fabaceae of ecological and economical importance,including Robinia pseudoacacia and Acacia dealbata and the shrubs Cytisus scoparius,*** and Ulex *** describe the optimized use of a handheld rotary tool(HRT),and compare its effectiveness with other scarification methods reported to break dormancy such as boiling or dry *** germination and/or speed of germination were enhanced after the application of the HRT,with germination percentages significantly higher than those achieved by other methods of *** on a thorough literature review,a mode of action for the HRT is suggested which could operate by breaking the physical and physiological dormancy of treated seeds through thecombined action of coat abrasion and moderate *** these results,we recommend the application of this rapid,effective,low-cost and highly reproducible HRT method to break seed dormancy and enhance germination of these species and others with similar dormancy constraints.

关键词： Combinational dormancy Hardcoat Rotary tool Scarification Temperature

Gas Exchanges and Biological Nitrogen Fixation in Soybean under Water Restriction

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American Journal of Plant Sciences 2014年第26期5卷 4011-4017页

作者： Paula Cerezini antonio Eduardo Pípolo Mariangela Hungria Marco antonio nogueira Department of Agronomy Universidade Estadual de Londrina Londrina Brazil Embrapa Soybean Londrina Brazil

Biological nitrogen fixation (BNF) in soybean is vulnerable to drought;however, there are genotypic variations among soybean cultivars regarding the ability to keep BNF under moderate water restriction. The aim of this study was to evaluate parameters related to gas exchanges and regulation of BNF in soybean genotypes BNF drought-tolerant (R01-581F and R01-416F), or drought-susceptible (CD 215 and BRS 317), submitted to adequate water supply or restriction between 45 and 55 days after emergence. We searched for traits associated with tolerance/susceptibility to drought, which might be useful in the selection of drought-tolerant soybean genotypes. Plant biomass was not affected under water restriction, but the number and dry weight of nodules reduced by 33% and 12%, respectively, in the average of genotypes. Drought-tolerant genotypes were more effective in maintaining gas exchanges under water restriction. Under water restriction, all genotypes increased the concentration of ureides in nodules, but only the susceptible genotypes showed that in leaves. The maintenance of gas exchanges and N metabolism regulation under water restriction in genotype R01-581F suggests that these parameters may be used to characterize soybean genotypes that can be sources of drought tolerance in genetic breeding programs.

关键词： Bradyrhizobium Drought Glycine max Photosynthesis Ureides

Soybean Seed Co-Inoculation with <i>Bradyrhizobium</i>spp. and <i>Azospirillum brasilense</i>: A New Biotechnological Tool to Improve Yield and Sustainability

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American Journal of Plant Sciences 2015年第6期6卷 811-817页

作者： Mariangela Hungria Marco antonio nogueira Ricardo Silva Araujo Embrapa Soja Londrina Brazil Total Biotecnologia Indústria e Comércio Ltda Curitiba Brazil

Legume nodulation by rhizobia can supply crops with nitrogen and reduce environmental impacts caused by chemical fertilization. The soybean crop in Brazil is an impressive example of how biological N2 fixation can be employed with a plant species of high economic value. However, the development of more productive cultivars, along with the increasing global climatic changes demand agricultural practices to become more productive and yet more environmentally friendly. Plant growth-promoting rhizobacteria (PGPR) are highly beneficial to agriculture worldwide, acting in plant nutrition, protection, and growth stimulation. Azospirillum is, certainly, the most employed PGPR in the world, but little is known about its interaction with rhizobia, when both are applied to legume seeds. We have evaluated the co-inoculation of bradyrhizobia and azospirilla on soybean seeds under different soil and climate conditions in Brazil. Our results demonstrated that co-inoculation is efficient and beneficial to the crop, and promotes yield increases without adding any chemical N fertilizers even in soils where established populations of soybean bradyrhizobia exist. The strategy of co-inoculation thus represents a new biotechnological tool to improve soybean yield without adding any chemical N fertilizers, thus contributing to current practices of sustainability in agriculture.

关键词： Soybean Azospirillum Bradyrhizobium Inoculation Yield

Tailoring Resorption Rates and Osteogenic Response in Xeno-Hybrid Bone Grafts: The Effect of Added Gelatins

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Engineering 2022年第6期8卷 197-208页

作者： Hao Zhu Havard Jostein Haugen Giuseppe Perale Janne Elin Reseland Liebert Parreiras nogueira antonio Gonzalez Cantalapiedra Fernando Maria Guzon Munoz Maria Permuy Mendana Felice Betge Stale Petter Lyngstadaas Jun Xiao Department of Orthopedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Biomaterials Institute of Clinical DentistryUniversity of OsloOslo 0317Norway Industrie Biomediche Insubri SA Mezzovico-Vira 6805Switzerland Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Vienna 1200Austria Faculty of Biomedical Sciences University of Southern SwitzerlandLugano 6900Switzerland Faculty of Veterinary University of Santiago de CompostelaLugo 27002Spain

Bone defects resulting from trauma,surgery,congenital malformations,and other factors are among the most common health problems *** current strategies such as autografts and allografts are recognized as the most successful treatments for stimulating bone regeneration,limitations such as graft source and complications still ***?is a xeno-hybrid bone graft(made from bovine bone matrix,poly(L-lactic-co-e-caprolactone),and gelatin)with a positive clinical record for bone *** this study,the formulation for designing xeno-hybrid bone grafts using gelatins from different sources(bovine-and porcine-derived gelatin,with bone grafts named SBN and SPK,respectively)was investigated,and the biological responses were evaluated in vitro and in *** results demonstrate that gelatins from both bovine and porcine sources can be loaded onto SmartBone?successfully and safely,withstanding the aggressive manufacturing *** bone cell responses were observed in *** was found to enhance osteocalcin secretion while SPK was found to upregulate osteopontin from human *** vivo,both bone grafts promoted osteogenesis,but SPK degraded earlier than *** findings suggest that SBN and SPK provide different yet comparable solutions for optimizing the bone resorption and regeneration *** xeno-hybrid bone grafts possess ideal potential for bone defect repairing.

关键词： Bone graft Xeno-hybrid Gelatin source Resorption Bone regeneration

The New Brazilian Automotive Policy Challenges in the Technological Advancement of Vehicle Security in Brazil

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Journal of Mechanics Engineering and Automation 2015年第5期5卷 291-296页

作者： Erik Telles Pascoal antonio Lopes nogueira da Silva Valter Silva Ferreira Filho Production Department Sao Paulo State University Sao Paulo 12516-410 Brazil Institute of Humanities and Social Sciences Rio de Janeiro Federal Country University Rio de Janeiro 23851-970 Brazil

With almost 23% of the industry＇s GDP （gross domestic public）, the Brazilian automobile industry confirms, once more, to be one of the most important sectors for national economy in the past years. Due to this relevance, in October 2012, the Brazilian government has approved by decree a program of incentive to innovation and intensification of the local productive chain in the automotive industry called ＂Inovar-Auto＂. The new Brazilian automotive policy aims by encouraging R ＆ D （research and development） to raise the technological level of vehicles manufactured in country. Undoubtedly, those initiatives contribute hugely for inserting the country on worldwide route of technological development encouraging the local production of safer vehicles and better technological contents. The search for this standard of vehicles has been a subject of several studies in the automotive world and in recent years it has gained importance, including being one of the Inovar-Auto challenges. In this context, this paper aims to present, through a theoretical research, key technologies and vehicle security initiatives developed so far in worldwide and to point out the challenges for development in the national market.

关键词： Inovar-Auto vehicle security R & D.