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Biomedical Perspectives About Women with Chronic Pelvic Pain:A Qualitative Analysis

International Journal of Clinical Medicine 2012年第5期3卷 411-418页

作者： Paula P.Souza Adriana P.M.S.Romao Ana Marcia S.Nakano Julio C.Rosa-e-Silva Francisco J.Candido-dos-Reis antonio a.nogueira Omero B.Poli-Neto Department of Gynaecology and Obstetrics School of Medicine University HospitalUniversity of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil Department of Public Health School of NursingUniversity of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil School of Medicine University Hospital University of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil

Because the aetiology of chronic pelvic pain is complex, studies of the condition involve extensive investigation but provide few conclusions. Numerous studies have addressed the experiences of women with chronic pelvic pain, as well as the interaction between those women and their health care providers. Our objective was to investigate how physicians at a specialised clinic perceive the medical care provided to such women. This was a qualitative study employing semi-structured interviews and content analysis. We interviewed seven physicians at the Chronic Pelvic Pain Outpatient Clinic of the University Hospital, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Brazil. Medical training and practice constituted the central theme of the study, which was subdivided into categories addressing the influence that the current medical training has on the type of medical care provided to women with chronic pelvic pain. Medical practice has been characterised by a reductionist approach to health and illness, as well as by the fragmentation of health care. These characteristics are, to a certain extent, the result of the biomedical model of education, which has been predominant, ignoring social, cultural, psychological and emotional aspects. There is a need to shift the medical paradigms toward a humanistic model of health care. We hope that we have provided a critical view of current medical training and practice, as well as of their effects in various health care settings, particularly in the provision of care to women with chronic pelvic pain.

关键词： Chronic Pelvic Pain Biomedical Model Qualitative Research

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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

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Effectiveness of Acupuncture on Pain, Physical Function and Health-Related Quality of Life in Patients with Rheumatoid Arthritis: A Systematic Review of Quantitative Evidence

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Chinese Journal of Integrative Medicine 2019年第9期25卷 704-709页

作者： Susana Seca Diana Miranda Daniela Cardoso Bernice nogueira Henry J.Greten antonio Cabrita Manuel Alves Rodrigues Faculty of Medicine University of CoimbraInstitute of Science Biomedicine Abel Salazar University of Porto Porto PortugalHeidelberg School of Chinese Medicine Heidelberg Germany Institute of Science Biomedicine Abel Salazar University of Porto Porto Portugal Health Sciences Research Unit:Nursing (UICISA: E) Nursing School of Coimbra (ESEnfC) Portugal Centre for Evidenee Based Practice: A Joanna Briggs Institute Centre of Excellence Coimbra Portugal School of Health Sciences Macao Polytechnic Institute Macao SAR China Institute of Science Biomedicine Abel Salazar University of PortoHeidelberg School of Chinese Medicine Heidelberg Germany Faculty of Medicine University of Coimbra Portugal Health Sciences Research Unit: Nursing (UICISA:E) Nursing School of Coimbra (ESEnfC)Portugal Centre for Evidence Based Practice: A Joanna Briggs Institute Centre of Excellence Portugal

Objective: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life(HRQoL) in patients with rheumatoid arthritis(RA). Methods: A comprehensive search of 12 Western and Chinese databases was undertaken from their inception up to end of 2016. Randomized controlled trials(RCTs), concerning patients with RA treated with needle acupuncture, written in English, Portuguese, German or Chinese were included. Primary outcomes included pain, physical function and HRQoL. Secondary outcomes included morning stiffness, functional impairment, number of tender and swollen joints and serum concentrations of inflamatory markers. Methodological quality was assessed by three independent reviewers using the standardized critical appraisal instrument from the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument. Results: Twenty-two studies met the inclusion criteria. Of those, 9 studies were excluded after assessment of their methodological quality. The remaining 13 original RCTs included 974 patients. Ten of these studies published in China, showed favorable statistical significant effects of acupuncture in relieving symptoms of RA compared with controls. Conclusions: Evidence suggests that acupuncture interventions may have a positive effect in pain relief, physical function and HRQo L in RA patients. However, due to the heterogeneity and methodologic limitations of the studies included in this systematic review, evidence is not strong enough to produce a best practice guideline.

关键词： acupuncture rheumatoid arthritis quality of life pain physical function randomized clinical trial

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Optimal and synchronized germination of Robinia pseudoacacia,Acacia dealbata and other woody Fabaceae using a handheld rotary tool:concomitant reduction of physical and physiological seed dormancy

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Journal of Forestry Research 2018年第2期29卷 283-290页

作者： Nuria Pedrol Carolina G.Puig antonio Lo′pez-nogueira Maria Pardo-Muras Luis Gonzalez Pablo Souza-Alonso Department of Plant Biology and Soil Science Faculty of BiologyUniversity of VigoUniversity Campus36310 VigoSpain

The Fabaceae(legume family) is one of the largest families of plants with a worldwide distribution and a major role in agriculture and in agroforestry.A hard seed coat impermeable to water is a typical feature of several *** dormancy delays and reduces germination so that mechanical,physical and chemical scarification methods have been classically used to break seed dormancy of many *** evaluate the effectiveness of a methodology to scarify seeds of several woody Fabaceae of ecological and economical importance,including Robinia pseudoacacia and Acacia dealbata and the shrubs Cytisus scoparius,*** and Ulex *** describe the optimized use of a handheld rotary tool(HRT),and compare its effectiveness with other scarification methods reported to break dormancy such as boiling or dry *** germination and/or speed of germination were enhanced after the application of the HRT,with germination percentages significantly higher than those achieved by other methods of *** on a thorough literature review,a mode of action for the HRT is suggested which could operate by breaking the physical and physiological dormancy of treated seeds through thecombined action of coat abrasion and moderate *** these results,we recommend the application of this rapid,effective,low-cost and highly reproducible HRT method to break seed dormancy and enhance germination of these species and others with similar dormancy constraints.

关键词： Combinational dormancy Hardcoat Rotary tool Scarification Temperature

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Quasi-freestanding graphene on Ni（110）： A graphene/ metal contact with suppressed interface states

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Nano Research 2016年第6期9卷 1795-1800页

作者： antonio Politano Department of Physics University of Calabria via Ponte Bucci 3 I/C 1-87036 Rende (CS) Italy

Graphene/Ni（110） has been studied by time-resolved X-ray photoelectron spectroscopy and near-edge X-ray absorption fine structure. The C ls core level shows a splitting typical of periodically rippled interfaces. The analysis of the C K-edge reveals that the interface states previously observed for graphene/Ni（111） are suppressed in graphene/Ni（110）. This suppression is due to the reduced hybridization of the Dirac-cone electrons in graphene with the d-bands of the （110）-oriented nickel contacts. Our results show that, contrary to commensurate growth of graphene on Ni（111）, epitaxially grown graphene on Ni（110） behaves as a quasi-freestanding sheet, as the lattice mismatch gives rise to a moir6 reconstruction.

关键词： graphene electronic properties synchrotron radiation X-ray photoelectronspectroscopy near-edge X-rayphotoelectron spectroscopy

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Gas Exchanges and Biological Nitrogen Fixation in Soybean under Water Restriction

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American Journal of Plant Sciences 2014年第26期5卷 4011-4017页

作者： Paula Cerezini antonio Eduardo Pípolo Mariangela Hungria Marco antonio nogueira Department of Agronomy Universidade Estadual de Londrina Londrina Brazil Embrapa Soybean Londrina Brazil

Biological nitrogen fixation (BNF) in soybean is vulnerable to drought;however, there are genotypic variations among soybean cultivars regarding the ability to keep BNF under moderate water restriction. The aim of this study was to evaluate parameters related to gas exchanges and regulation of BNF in soybean genotypes BNF drought-tolerant (R01-581F and R01-416F), or drought-susceptible (CD 215 and BRS 317), submitted to adequate water supply or restriction between 45 and 55 days after emergence. We searched for traits associated with tolerance/susceptibility to drought, which might be useful in the selection of drought-tolerant soybean genotypes. Plant biomass was not affected under water restriction, but the number and dry weight of nodules reduced by 33% and 12%, respectively, in the average of genotypes. Drought-tolerant genotypes were more effective in maintaining gas exchanges under water restriction. Under water restriction, all genotypes increased the concentration of ureides in nodules, but only the susceptible genotypes showed that in leaves. The maintenance of gas exchanges and N metabolism regulation under water restriction in genotype R01-581F suggests that these parameters may be used to characterize soybean genotypes that can be sources of drought tolerance in genetic breeding programs.

关键词： Bradyrhizobium Drought Glycine max Photosynthesis Ureides

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Interplay between the glass and the gel transition

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Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 45-50页

作者： Annalisa Fierro antonio de Candia antonio Coniglio CNR-SPIN c/o Complesso di Monte S.AngeloNapoli 80126Italy Dipartimento di Fisica"Pancini" Universita di Napoli"FedericoⅡ"Complesso di Monte S.AngeloNapoli 80126Italy

By changing the control parameters, many physical systems reach a slow dynamics regime followed by an arrested or a quasiarrested state. Examples, among others, are gels and glasses. In this paper, we discuss some experimental and theoretical results in polymer and colloidal systems, where gel and glass transitions interfere, and use models from Mode Coupling Theory（MCT）to illustrate the rich phenomenology observed. The continuous and the discontinuous transition lines, found in the MCT models,are considered suitable to describe respectively the gel and the glass transitions, so we suggest that the interplay between gel and glass may be interpreted in terms of the F13 MCT model, clarifying also the origin of logarithmic decays often observed in such systems. In particular, the theoretical predictions of the MCT in the F13 model are compared with Molecular Dynamics simulations in model systems for chemical gels and charged colloids.

关键词： glass gel and sol colloid

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Soybean Seed Co-Inoculation with <i>Bradyrhizobium</i>spp. and <i>Azospirillum brasilense</i>: A New Biotechnological Tool to Improve Yield and Sustainability

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American Journal of Plant Sciences 2015年第6期6卷 811-817页

作者： Mariangela Hungria Marco antonio nogueira Ricardo Silva Araujo Embrapa Soja Londrina Brazil Total Biotecnologia Indústria e Comércio Ltda Curitiba Brazil

Legume nodulation by rhizobia can supply crops with nitrogen and reduce environmental impacts caused by chemical fertilization. The soybean crop in Brazil is an impressive example of how biological N2 fixation can be employed with a plant species of high economic value. However, the development of more productive cultivars, along with the increasing global climatic changes demand agricultural practices to become more productive and yet more environmentally friendly. Plant growth-promoting rhizobacteria (PGPR) are highly beneficial to agriculture worldwide, acting in plant nutrition, protection, and growth stimulation. Azospirillum is, certainly, the most employed PGPR in the world, but little is known about its interaction with rhizobia, when both are applied to legume seeds. We have evaluated the co-inoculation of bradyrhizobia and azospirilla on soybean seeds under different soil and climate conditions in Brazil. Our results demonstrated that co-inoculation is efficient and beneficial to the crop, and promotes yield increases without adding any chemical N fertilizers even in soils where established populations of soybean bradyrhizobia exist. The strategy of co-inoculation thus represents a new biotechnological tool to improve soybean yield without adding any chemical N fertilizers, thus contributing to current practices of sustainability in agriculture.

关键词： Soybean Azospirillum Bradyrhizobium Inoculation Yield

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Cost-effective synthesis of giant molecule acceptors(GMAs)for stable polymer solar cells

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Science China Chemistry 2024年第4期67卷 1041-1043页

作者： antonio Facchetti Department of Chemistry and the Materials Research Center Northwestern University2145 Sheridan Road60208 EvanstonIllinoisUSA School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive30332 AtlantaGeorgiaUSA

Polymer solar cells(PSCs)have emerged as a disruptive energy technology due to simple device architecture,earthabundant elemental composition,lightweight nature,and inherent mechanical flexibility[1,2].Via a strategic acceptordonor-acceptor(A-D-A)design of small-molecule acceptors(SMAs),device power conversion efficiency(PCE)has now increased>19%.

关键词： acceptor synthesis donor

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Impact of radiative cooling on the energy performance of courtyards in Mediterranean climate

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Building Simulation 2024年第9期17卷 1491-1513页

作者： Carlos-antonio Domínguez-Torres antonio Domínguez-Delgado Escuela Técnica Superior de Arquitectura Universidad de SevillaAv.de Reina Mercedes241012 SevillaSpain Department of Applied Mathematics 1 Escuela Técnica Superior de ArquitecturaUniversidad de SevillaAv.de Reina Mercedes241012 SevillaSpain

Radiative cooling has proven to be a useful tool to address the problems of lack of comfort and excessive energy consumption in situations of high temperatures,overheating and heat ***,incorporating courtyards in warm climate zones has been found to be highly beneficial in addressing similar ***,there is interest in analyzing the combined effects of both:radiative cooling and *** paper presents an analysis of the impact of the application of radiative cooling on a courtyard using a comprehensive simulation approach that includes a CFD model for the thermodynamic airflow in the adjacent roofs and inside the courtyard,equations for the transient heat conduction through roofs,walls and courtyard slabs,and a hybrid raytracing-radiosity model for the evaluation of the solar radiation reaching the building surfaces and its reflections,both of specular and diffuse origin,and for the calculation of the thermal radiation exchange,especially with the *** results show that in the hot season,the courtyard with radiative cooling always provides lower temperatures than the initial courtyard does,with a temperature range of 18.33℃to 33.78℃,compared to a range of 19.32℃to 38.00℃in the initial courtyard,and producing a greater difference with outdoor temperatures that can reach 12℃versus 8℃for the reference *** addition,it was found that the courtyard with radiative cooling is able to significantly reduce the observed nighttime overheating by providing lower temperatures than the outdoor temperatures in the 50%of the nights *** was also found that the thermal loads to achieve indoor thermal comfort in the spaces adjacent to the courtyard were reduced by 63.46%to 69.85%.

关键词： radiative cooling passive cooling CFD three-dimensional modeling energy saving thermal comfort

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