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Thera.eutic ta.geting of cellula. prion protein: towa.d the development of dua. mecha.ism a.ti-prion compounds

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1009-1014页

作者： antonio Ma.one Chia.a.Zucchelli Enrico Ca.uso Giova.na.Musco Roberto Chiesa La.ora.ory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecula. NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Depa.tment of Biotechnology a.d Life Sciences University of InsubriaVareseItaly

PrPSc,a.misfolded,a.grega.ion-prone isoform of the cellula. prion protein(PrPC),is the infectious prion a.ent responsible for fa.a. neurodegenera.ive disea.es of huma.s a.d other *** a.opt different pa.hogenic conforma.ions(prion stra.ns),which ca. be resista.t to potentia. drugs,or a.quire drug resista.ce,posing cha.lenges for the development of effective *** PrPCis the obliga.e precursor of a.y prion stra.n a.d serves a. the media.or of prion neurotoxicity,it represents a. a.tra.tive thera.eutic ta.get fo r prion *** this minireview,we briefly outline the a.proa.hes to ta.get PrPCa.d discuss our recent identifica.ion of Zn(Ⅱ)-Bn PyP,a.PrPC-ta.geting porphyrin with a. unprecedented bimoda. mecha.ism of *** a.gue tha. in-depth understa.ding of the molecula. mecha.ism by which Zn(Ⅱ)-Bn PyP ta.gets PrPCma. lea. towa.d the development of a.new cla.s of dua. mecha.ism a.ti-prion compounds.

关键词： a.ti-prion drug a.ti-PrPC a.tibody a.tisense oligonucleotide neurodegenera.ion pha.ma.ologica. cha.erone porphyrin prion disea.e PrPC degra.er PrPC shedding zinc finger repressor

Tra.ectedin thera.y a. a. emerging trea.ment stra.egy for recurrent pla.inum-sensitive ova.ia. ca.cer

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Chinese Journa. of Ca.cer 2015年第1期34卷 41-49页

作者： José antonio López-Guerrero Igna.io romero a.drés Poveda La.ora.ory of Molecula. Biology Fundación Instituto Valenciano de Oncología Clinica. a.ea.of Gynecologica. Ca.cer Fundación Instituto Valenciano de Oncología

Epithelia. ova.ia. ca.cer(OC) is a.common gynecologic ma.igna.cy in women. The sta.da.d trea.ment for OC is ma.ima. cytoreductive surgica. debulking followed by pla.inum-ba.ed chemothera.y. Despite the high response ra.e to prima.y thera.y, a.proxima.ely 85% of pa.ients will develop recurrent ova.ia. ca.cer(ROC). This review identifies the clinica. use of tra.ectedin in the trea.ment a.gorithm for ROC, with specific empha.is on pla.inum-sensitive ROC, for which tra.ectedin in combina.ion with pegyla.ed liposoma. doxorubicin ha. been a.proved a. a.trea.ment protocol. The ma.n mecha.isms of a.tion of tra.ectedin a. the cellula. level a.d in the tumor microenvironment is a.so discussed a. ba.es for identifying bioma.kers for selecting pa.ients who ma. la.gely benefit from tra.ectedin-ba.ed thera.ies.

关键词：治疗方案卵巢癌敏感复发铂疗法恶性肿瘤聚乙二醇化

a.cha.ged sta. with geometric Ka.ma.ka. condition

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Communica.ions in Theoretica. Physics 2023年第8期75卷 139-149页

作者： Ga.ino Estevez-Delga.o Joa.uin Estevez-Delga.o Ra.a.l Soto-Espitia.antonio Rendón romero Jorge Ma.ricio Pa.lin-Fuentes Fa.ulta. de Químico Fa.ma.obiología.de la.Universida. Michoa.a.a.de Sa. Nicolás de Hida.go Fa.ulta. de Ciencia. Físico Ma.emática. de la.Universida. Michoa.a.a.de Sa. Nicolás de Hida.go Edificio BCiudad Universitaria Fa.ulta. de Ingeniería.Civil de la.Universida. Michoa.a.a.de Sa. Nicolás de Hida.go Edificio A Ciudad Universitaria Fa.ulta. de Ingeniería.Mecánica.de la.Universida. Michoa.a.a.de Sa. Nicolás de Hida.go Edificio W Ciudad Universitaria División a.a.émica.de Ciencia. Básica. de la.Universida. Juárez a.tónoma.de Ta.a.co

In this pa.er,we a.a.yse a. a.a.ytica. solution of the Einstein–Ma.well field equa.ions tha. considers ma.ter with a.isotropic pressures in a.sta.ic a.d spherica.ly symmetric *** report the ma.ner in which we obta.ned the solution,which is by mea.s of the Ka.ma.ka. *** the model,we a.sume a.sta.e equa.ion tha. describes the intera.tion of ma.ter from qua.ks P=(c^(2)ρ-4B_(g))/3 a.d we consider the presence of electric cha.ge,which ca. genera.e tha. the ra.ia. a.d ta.gentia. pressures a.e not *** a.gra.hic ma.ner,we a.a.yse the physica. properties of the model,ta.ing a. the observa.iona. da.a.those of ma.s 1M⊙a.d ra.ius7.69 km which were reported for the sta. Her *** cha.ge va.ues a.e found between 5.57×10^(18)C≤Q≤1.31×10^(20)C a.d the interva. of the Ba. consta.t Bg∈[118.7,122.13]MeV/fm^(3).a.so,we show the sta.ility of the configura.ion by mea.s of the sta.ic sta.ility criteria.of Ha.rison–Zeldovich–Novikov((?M)/?ρc>0),a. well a. in rega.ds to infinitesima. ra.ia. a.ia.a.ic perturba.ion,since the a.ia.a.ic indexγ>3.3 which gua.a.tees the sta.ility of the solution.

关键词： genera. rela.ivity exa.t solutions a.isotropic fluid Ka.ma.ka. condition

a.socia.ion between vita.in D a.d hepa.itis C virus infection: a.meta.a.a.ysis

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World Journa. of Ga.troenterology 2013年第35期19卷 5917-5924页

作者： Livia.Melo Villa. José antonio Del Ca.po Isidora.Ra.cha. Elisa.eth La.pe Ma.uel romero-Gomez La.ora.ory of Vira. Hepa.itis Oswaldo Cruz Institute Fiocruz Rio de Janeiro RJ 210360-040 Brazil Unit for the Clinica. Ma.a.ement of Digestive Disea.es a.d CIBERehd Hospital Universitario de Valme41014 SevillaSpain

a.M:To eva.ua.e the a.socia.ion between 25-hydroxyvita.in D[25(OH)D]a.d susta.ned virologica. response(SVR)in hepa.itis C virus(HCV)infected ***:Releva.t studies were identified by systema.ica.ly sea.ching MEDLINE da.a.a.es up to Ma.ch2012 a.d a.stra.ts of the Europea. a.d a.erica. Congress of Hepa.ology conducted in *** must provide informa.ion on SVR a.d the levels of 25(OH)D3a.d/or 25(OH)D2[henceforth referred to a. 25(OH)D]in sera.sa.ples from HCV infected *** inclusion criteria.were:clinica. studies tha. included HCV infected pa.ients a.ed older tha. 18 yea.s rega.dless of HCV genotype or ethnic group;provided informa.ion on SVR ra.es;a.d were reported in the English la.gua.ea. full *** to the heterogeneity of studies in ca.egorizing serum vita.in D levels,a.cut-off va.ue of30 ng/mL of serum 25(OH)D wa. *** wa. a.sessed using *** summa.y odds ra.ios with their corresponding 95%CI were ca.cula.ed ba.ed on a.ra.dom-effects ***:Overa.l,11 studies(8 observa.iona. a.d 3interventiona.)involving 1575 individua.s were included a.d 1117 HCV infected individua.s(71%)showed low vita.in D *** of the studies included monoinfected HCV individua.s with the mea. a.e ra.ging from 38 to 56 *** studies were conducted in huma. immunodeficiency virus/HCV infected *** vita.in D mea.urement,most of the studies employed ra.ioimmunoa.sa.s(n=5)followed by chemiluminescence(n=4)a.d just one study employed high performa.ce/pressure liquid chroma.ogra.hy(HPLC).Ba.a. vita.in D levels va.ied from 17 to43 ng/mL in the studies selected,a.d most of the HCV infected individua.s ha. genotype 1(1068/1575)with mea. vira. loa. va.ying from log 4.5-5.9 UI/*** rega.d to HCV trea.ment,most of the studies(n=8)included HCV individua.s without previous trea.ment,where the pooled SVR ra.e wa. 46.4%.High ra.es of SVR were observed in HCV individua.s with vita.in D levels a.ove 30 ng/mL(OR=1

关键词： Vita.in D Hepa.itis C Thera.y Meta.na.ysis Susta.ned virologica. response

Modelling potentia. distribution of a.pine ba.k beetle in Mexica. tempera.e forests using foreca.t da.a.a.d spa.ia. a.a.ysis tools

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Journa. of Forestry Resea.ch 2020年第2期31卷 649-659页

作者： antonio Gonza.ez-Herna.dez Rene Mora.es-Villa.a.a.Ma.tin Enrique romero-Sa.chez Brenda.Isla.-Trejo Ra.iro Perez-Mira.da Conserva.ion a.d Enha.cement of Forest Ecosystems National Institute of ForestryAgriculture and Livestock ResearchProgreso 504010 Coyoacan Mexico CityMexico Geogra.hy Depa.tment The National Autonomous University of MexicoUniversidad 300004010 Coyoacan Mexico CityMexico

a.cura.e a.d relia.le predictions of pest species distributions in forest ecosystems a.e urgently needed by forest ma.a.ers to develop ma.a.ement pla.s a.d monitor new a.ea. of potentia. ***-only species distribution models a.e commonly used in these *** ma.imum entropy a.gorithm(Ma.Ent)ha. ga.ned popula.ity for modelling species ***,Ma.Ent wa. used to model the spa.ia. distribution of the Mexica. pine ba.k beetle(Dendroctonus mexica.us)in a.da.ly fa.hion by using foreca.t da.a.from the Wea.her Resea.ch a.d Foreca.ting *** study a.med to exploit freely a.a.la.le geogra.hic a.d environmenta. da.a.a.d softwa.e a.d thus provide a.pa.hwa. to overcome the la.k of costly da.a.a.d technica. guida.ce tha. a.e a.cha.lenge to implementing na.iona. monitoring a.d ma.a.ement stra.egies in developing *** results showed overa.l a.reement va.ues between 60 a.d 87%.The results of this resea.ch ca. be used for *** monitoring a.d ma.a.ement a.d ma. a.d a. a.model to monitor simila. species.

关键词： Spa.ia. a.a.ysis Dendroctonus mexica.us Geoda.a.a.es Ma.Ent Forest modelling

Gluta.inolysis-a.monia.urea.Cycle a.is,Non-a.coholic Fa.ty Liver Disea.e Progression a.d Development of Novel Thera.ies

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Journa. of Clinica. a.d Tra.sla.iona. Hepa.ology 2022年第2期10卷 356-362页

作者： Ángela.Roja. Ma.ía.Rosa.io Ga.cía.Loza.o antonio Gil-Gómez Ma.uel romero-Gómez Ja.ier a.puero Depa.tment of Unit of Digestive Disea.es Virgen del Rocío University HospitalSevilleSpain SeLiver group a. the Insti-tute of Biomedicine of Seville(IBIS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Center for the Study of Liver a.d Ga.trointestina. Disea.es(CIBERehd) Carlos III National Institute of HealthMadridSpain De-pa.tment of Orga.ic a.d Medicina. Chemistry Faculty of PharmacyUniversity of SevilleE-41071SevilleSpain

The preva.ence of non-a.coholic fa.ty liver disea.e(Na.LD)is increa.ing worldwide,reflecting the current epidemics of obesity,insulin resista.ce,type 2 dia.etes mellitus,a.d meta.olic *** is cha.a.terized by the a.cumula.ion of fa. in the liver,a.d is known to be a.ca.se of *** ma.y pa.hwa.s ha.e been proposed,the ca.se of Na.LD-linked fibrosis progression is still unclea.,which posed cha.lenges for the development of new thera.ies to prevent Na.H-rela.ed cirrhosis a.d hepa.ocellula. *** is a.socia.ed with a.tiva.ion of hepa.ic stella.e cells(HSC)a.d a.cumula.ion of excess extra.ellula. ma.rix proteins,a.d inhibiting the a.tiva.ion of HSCs would be expected to slow the progression of *** molecula. signa.s a.d pa.hwa.s such a. oxida.ive stress a.d gluta.inolysis ha.e been reported to promote HSC *** mecha.isms a.e pla.sible a.tifibrotic ta.gets in Na.H,a. the a.tiva.ion of HSCs the prolifera.ion of myofibrobla.ts depend on those *** review summa.izes the role of the gluta.inolysis-a.monia.urea.cycle a.is in the context of Na.LD progression,a.d shows how the a.is could be a.novel thera.eutic ta.get.

关键词： Non-a.coholic fa.ty liver disea.e Cirrhosis Fibrosis Gluta.inoly-sis a.monia Urea

Hepa.itis B a.d D viruses replica.ion interference: Influence of hepa.itis B genotype

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World Journa. of Ga.troenterology 2016年第11期22卷 3165-3174页

作者： antonio Ma.ejón Míria. romero ángela.Hernández a.a.eli Ga.cía.Sánchez Ma.ta.Sánchez-Ca.rillo antonio Olveira.Ja.ier Ga.cía.Sa.a.iego Hepa.ology Section Gastroenterology Department Hospital Universitario La Paz 28046 Madrid Spain Centro de Investiga.ión Biomédica.en Red de Enfermeda.es Hepática.y Digestiva. (CIBERehd) 28046 Madrid Spain Instituto de Investiga.ión del Hospita. Universita.io La.Pa. (IdiPa.) 28046 Madrid Spain

a.M: To study the hepa.itis B virus(HBV) a.d hepa.itis D virus(HDV) replica.ion interferences in pa.ients with chronic hepa.itis delta.infected with different HBV ***: We conducted a.tra.sversa. study including 68 chronic hepa.itis delta.CHD)(37 HIVpositive) pa.ients a.d a.control group of 49 chronic hepa.itis B(CHB)(22 HIV-positive) pa.ients. In a.dition, a.dyna.ic follow-up wa. performed in 16 CHD pa.ients. In a.l the sa.ples, the surfa.e a.tigen of hepa.itis B(HBs a.) serum titers were a.a.yzed with the Monolisa.HBs a. Ultra.system(Bio-Ra.), using a. qua.tifica.ion sta.da.d a.seria. dilution curve of a. interna.iona. HBs a. sta.da.d. Serum HBV-DNa.titers were a.a.yzed using the Roche Coba. Ta. Ma.(Roche, Ba.celona. Spa.n), a.d the serum HDV-RNa.using a. in-house rea.-time q RT-PCR method, with Ta. Ma. probes. HBV genotype wa. determined with the line immunoa.sa. Li Pa.HBV genotyping system(Innogenetics, Ghent, Belgium). In those pa.ients nega.ive for Li Pa.a.sa., a.nested PCR method of complete HBs a. coding region, followed by sequence a.a.ysis wa. ***: No differences in the HBV-DNa.levels were found in CHB pa.ients infected with different HBV genotypes. However, in CHD pa.ients the HBV-DNa.levels were lower in those infected with HBV-a.tha. in those with HBV-D, both in HIV nega.ive [media.(IQR): 1.25(1.00-1.35) vs 2.95(2.07-3.93) log10(copies/m L), P = 0.013] a.d HIV positive pa.ients [2.63(1.24-2.69) vs 7.25(4.61-7.55) log10(copies/m L), P a. confirmed in the dyna.ic study of the HBV/HDV pa.ients. These differences induce a. under-estima.ion of HBV-a.incidence in pa.ients with CHD a.a.yzed with Li Pa.a.sa.. Fina.ly, the HBs a. titers reflected no significa.t differences in CHD pa.ients infected with HBV-a.or ***: Vira. replica.ion interference between HBV a.d HDV is HBV-genotype dependent, a.d more evident in pa.ients infected with HBV-genotype a. tha. with HBV-D or E.

关键词： Hepa.itis D virus Hepa.itis B virus Delta hepa.itis Replica.ion interference Vira. replica.ion

Rela.ivistic cha.ged stella. modeling with a.perfect fluid sphere

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Communica.ions in Theoretica. Physics 2023年第9期75卷 113-121页

作者： Joa.uin Estevez-Delga.o Joel a.turo Rodríguez Ceba.los Jorge Ma.ricio Pa.lin-Fuentes JoséVega.Ca.rera.antonio Rendón romero Fa.ulta. de Ciencia. Físico Ma.emática. de la.Universida. Michoa.a.a.de Sa. Nicolás de Hida.go Edificio BCiudad UniversitariaMorelia MichoacánCP 58040Mexico Fa.ulta. de Químico Fa.ma.obiología.de la.Universida. Michoa.a.a.de Sa. Nicolás de Hida.go Tzintzuntzan No.173Col.MatamorosMorelia MichoacánC.P.58240Mexico División a.a.émica.de Ciencia. Básica. de la.Universida. Juárez a.tónoma.de Ta.a.co Carretera Cunduacán-Jalpa Km.1Col.La Esmeralda86690CunduacánTabascoMexico Fa.ulta. de Ingenieria.Meca.ica.de la.Universida. Michoa.a.a.de Sa. Nicolás de Hida.go Edificio W Ciudad UniversitariaCP 58030Morelia MichoacánMexico

In this report we present the genera.iza.ion of a.solution to Einstein's equa.ions with perfect fluid for the ca.e of Einstein–Ma.well with perfect *** effect of the cha.ge is reflected by a.pa.a.eter,ν,a.d its interva. is determined by the positivity condition from the pressure in the interior of the *** is shown tha. the solution is sta.le a.cording to the Zeldovich criteria.a. well a. in rela.ion to the criteria.of the a.ia.a.ic *** compa.tness,u=GM/c^(2)R,of this cha.ged model is grea.er tha. it is for the cha.geless ca.e a. a.result of the effect of the presence of the *** a.lows it to represent sta.s with a.high compa.tness,in pa.ticula. a.gra.hic a.a.ysis is presented for the sta. Sa. J1808.4-3658 with ma.s M=1.435M_(⊙)a.d ra.ius R=7.07 *** these da.a.a.d employing the solution,we obta.n tha. the tota. ma.imum cha.ge for the sta. is Q=2.4085×10^(20)C.

关键词： genera. rela.ivity exa.t solutions cha.ged fluid sta.s models

Va.P2 is implica.ed in the secretion of a.tibodies by huma. pla.ma.cells a.d ca. be repla.ed by other syna.tobrevins

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Cellula. & Molecula. Immunology 2018年第4期15卷 353-366页

作者： La.ra.Gómez-Ja.a.illo Ra.uel romero-Ga.cía.Gema.Jiménez-Gómez Lisa.Riegle a.a.Belén Ra.os-a.a.a.Joséantonio Brieva.Ma.ie Kelly-Worden antonio Ca.pos-Ca.o Unida. de Investiga.ión Hospital Universitario Puerta del MarCádizSpain Depa.tment of Biology Ball State UniversityMuncieINUSA

The production a.d secretion of a.tibodies by huma. pla.ma.cells(PCs)a.e two essentia. processes of humora. *** secretion process relies on a.group of proteins known a. soluble N-ethylma.eimide-sensitive fa.tor a.ta.hment protein receptors(SNa.Es),which a.e loca.ed in the pla.ma.membra.e(t-SNa.Es)a.d in the a.tibody-ca.rying vesicle membra.e(v-SNa.E),a.d media.e the fusion of both *** ha.e previously shown tha. SNa.23 a.d STX4 a.e the t-SNa.Es responsible for a.tibody ***,using huma. PCs a.d a.tibody-secreting cell lines,we studied a.d cha.a.terized the expression a.d subcellula. distribution of vesicle a.socia.ed membra.e protein(Va.P)isoforms,demonstra.ing tha. a.l isoforms(with the exception of Va.P1)a.e expressed by the referenced ***,the functiona. role in a.tibody secretion of ea.h expressed Va.P isoform wa. tested using *** results show tha. Va.P2 ma. be the v-SNa.E involved in vesicula. a.tibody *** further support this conclusion,we used teta.us toxin light cha.n to clea.e Va.P2,conducted experiments to verify co-loca.iza.ion of Va.P2 in a.tibody-ca.rying vesicles,a.d demonstra.ed the coimmunoprecipita.ion of Va.P2 with STX4 a.d SNa.23 a.d the in situ intera.tion of Va.P2 with *** together,these findings implica.e Va.P2 a. the ma.n Va.P isoform functiona.ly involved in a.tibody secretion.

关键词： exocytosis huma. immunoglobulin pla.ma.cells Va.P proteins