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Feasibility of cabazitaxel in octogenarian prostate cancer patients

Current Urology 2023年第3期17卷 153-158页

作者： Paolo tralongo Sebastiano Bordonaro Giuseppe Di Lorenzo Ugo De Giorgi NicolòBorsellino Gaetano Facchini Sabrina Rossetti Giuseppe Fornarini Vito Longo antonino carmelo tralongo Francesca Caspani Massimiliano Spada Nicola Calvani Paolo Carlini Medical Oncology Unit RAO-Umberto I HospitalSiracusa96100Italy Department of Medicine and Health Sciences‘Vincenzo Tiberio' University of MoliseCampobassoItaly Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori(IRST)IRCCS Meldola(FC)Italy Medical Oncology Unit Ospedale Buccheri La FerlaFatebenefratelliPalermoItaly Medical Oncology Unit Santa Maria delle Grazie di PozzuoliNapoliItaly Departmental Unit of Clinical and Experimental Uro-Andrologic Oncology Istituto Nazionale TumoriIRCCSFondazione G.PascaleNapoliItaly Medical Oncology 1 IRCCSOspedale Policlinico San MartinoGenovaItaly Istituto Tumori Giovanni PaoloⅡI.R.C.C.S. BaOspedale di CircoloVareseItaly Medical Oncology Unit ASSTSETTE LAGHIOspedale di CircoloVareseItaly Medical Oncology Unit Fondazione Istituto G.Giglio di CefalùPalermoItaly Medical Oncology Division&Breast Unit Sen.A.Perrino HospitalBrindisiItaly Medical Oncology 1 Istituto Nazionale Tumori Regina ElenaRomaItaly

Background:To evaluate the effectiveness and safety of cabazitaxel in castration-resistant prostate cancer patients aged>80 years,we performed a retrospective study on a sample of patients from 11 Italian cancer *** and methods:Fifty-seven patients aged>80 years were treated with cabazitaxel after previous failure with docetaxel;39 completed a comprehensive geriatric assessment questionnaire(34 fit and 5 vulnerable)and 8 patients(14%)had an Eastern Cooperative Oncology Group performance status(PS)>2,while most had a PS of 0-1(86%).Cabazitaxel was administered at a dose of 25 mg/m^(2)in 30(52%)patients and 20 mg/m^(2)or adapted schedules in 27(48%)*** schedules were adopted mainly in patients>85 years(75%),with a PS>2(87.5%),and those classified as vulnerable(100%).Results:The duration of treatment was 4.8 months and was comparable in all subgroups;disease control rate was reported in 36 patients(63%);prostate-specific antigen response was recorded in 18 patients(31.5%).Median overall survival was 13.1 months regardless of age(85 years),but overall survival was reduced in vulnerable(7.2 months)and PS>2 patients(6.8 months).The most frequently documented grade 3-4 toxicities were neutropenia(14%)and diarrhea(10.5%).Six patients(10.5%)dropped out due to severe ***:Octogenarian patients can be treated with cabazitaxel with reduced doses or alternative schedules that are associated with less toxicity and fewer treatment *** geriatric assessment could facilitate more appropriate patient selection.

关键词： Cabazitaxel Cancer Octogenarian Prostate

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Gastric metastasis by lung small cell carcinoma

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World Journal of Gastroenterology 2006年第25期12卷 4096-4097页

作者： Giovanni Casella Camillo Di Bella antonino Roberto Cambareri carmelo Antonio Buda Gianluigi Corti Filippo Magri Stefano Crippa Vittorio Baldini Department of Medicine Desio Hospital DesioMilanItaly Pathology Department Desio Hospital DesioMilanItaly Surgery Department Desio Hospital DesioMilanItaly Oncology Department Università di Messina MessinaItaly

Metastatic tumors of the gastrointestinal tract are rare. We describe a case of gastric metastasis due to primary lung cancer, revealed by an upper gastrointestinal endoscopy （UGIE）. Haematogenous metastases to the stomach are a rare event. To our knowledge, only 55 cases have been described in the international literature. In these patients, the prognosis is very poor. We report herein a case of gastric metastasis by lung small cell carcinoma, with a review of the literature about this rare entity.

关键词： Gastric metastasis Lung cancer

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Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits

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World Journal of Gastroenterology 2005年第13期11卷 1987-1990页

作者： Aldo Spadaro antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni Dipartimento Clinico Sperimentale di Medicina e Farmacologia Dipartimento di Statistica Dipartimento di Scienze Radiologiche Unità Operativa di Gastroenterologia

AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable. High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC). METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD) as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, non-parametric combination test and confidence interval analysis were used for statistical analysis. RESULTS: Serum CgA above normal values (100 ng/mL) were found in 83% of HCC patients, in 48% of LC patients, in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1046), in LC (249±369), in CH (87±94), in CRF (1390±1401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18). HCC patients had higher CgA values (P200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between a-FP and CgA in patients with HCC and in patients with cirrhosis. CONCLUSION: When HCC is suspected and a-FP

关键词： Chromogranin-A Hepatocellular carcinoma Liver cirrhosis Chronic hepatitis Diagnosis

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High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

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World Journal of Gastroenterology 2008年第10期14卷 1549-1552页

作者： Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi carmelo Luigiano Giuseppe De Caro antonino Ajello Oscar Ferraù Maria Antonietta Freni Department of Medicine and Pharmacology University Hospital Messina 98125 Italy Department of Statistics University oMessina Messina 98125 Italy

AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity.

关键词： D-dimers Liver cirrhosis Ascites Hepatocellular carcinoma Hyperfibrinolysis

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Low utility of plasma Nociceptin/orphanin FQ in the diagnosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第29期12卷 4716-4720页

作者： Aldo Spadaro antonino Ajello carmelo Luigiano Carmela Morace Maria Letizia Resta Grazia Berlinghieri Salvatore Campo Claudio Scisca Angela Alibrandi Graziella D'arrigo Nunziata Alessi Oscar Ferraù Maria Antonietta Freni Dipartimento Clinico Sperimentale di Medicina e Farmacologia Clinica Medica Pad.CAOUVia Consolare Valeria No.1Messina 98125Italy

AIM： The utility of serum alpha-fetoprotein （α-FP） in the detection of hepatocellular carcinoma （HCC） is questionable. Very high circulating levels of nociceptin/ orphanin FQ （N/OFQ）, a ligand for a novel opioid receptor, have recently been reported in HCC. The aim of this study was to assess the role of plasma N/OFQ in the diagnosis of HCC arising in patients with liver cirrhosis. METHODS： Plasma N/OFQ levels were measured by ELISA in 58 patients （28 HCC and 30 liver cirrhosis） and in 25 healthy controls. The values were correlated with clinical and laboratory features including α-FP. Spearman index, biserial correlation coefficient, non parametric combination （NPC） test and discriminant stepwise analysis were used for statistical evaluation of data.RESULTS： The upper normal limit of nociceptin was 122 pg/mL. Plasma levels above this cut-off were found in 21.4% of patients with HCC, in 23.3% of those with cirrhosis and in 8% of healthy subjects. α-FP serum levels〉200 ng/mL were found in 46.4% of the patients with HCC and in none of those with cirrhosis. No correlation was found between N/OFQ levels and any of the clinical and laboratory features, including α-FP. By NPC test, HCC and cirrhotic patients were different with regard to α-FP （P = 0.000） but not in terms of nociceptin （P = 0.595）. By point biserial correlation, HCC presence was positively correlated with α-FP （rpb = 0.52, P = 0.000） but not with N/OFQ （rpb = 0.16, P = 0.157）. In a discriminant analysis, α-FP was significant in the Wilks test （Y = -0.709 ＋ 0.03 α-FP） and properly classified 81% of all patients and 61% of HCC. N/OFQ had lower sensitivity, specificity and predictive values than α-FP. CONCLUSION： Nociceptin is increased in patients with chronic liver disease, independently of the presence of HCC, although the underlying mechanism has yet to be clarified. We conclude it is not a useful marker for HCC.

关键词： Hepatocellular carcinoma Nociceptin/orphanin FQ Liver cirrhosis Alpha-fetoprotein

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Immune response to hepatitis B virus vaccine in celiac subjects at diagnosis

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World Journal of Hepatology 2016年第26期8卷 1105-1109页

作者： Martina Filippelli Maria Teresa Garozzo antonino Capizzi Massimo Spina Sara Manti Lucia Tardino carmelo Salpietro Salvatore Leonardi Depart-ment of Medical and Pediatric Sciences University of Catania Department of Pediatric Sciences University of Messina

AIM To evaluate hepatitis B virus(HBV) vaccine response and correlation with human leukocyte antigens(HLA) and/or gluten intake in celiac patients at *** Fifty-one patients affected by celiac disease, diagnosed at the Department of Pediatrics of the University of Catania(Italy), were recruited. All patients were tested at admission for immunization against HBV, according to findings from analysis of quantitative HBV surface antibody(anti-HBs). The anti-HBs titer was measured by enzyme-linked immunosorbent assay. Following the international standards, subjects with antibody titer 0.05). With regard to the HLA haplotype, comparison of the distribution of vaccination response showed no statistically significant difference between the different genotypes(homozygosity for the HLADQ2 haplotype compared with HLADQ2/DQ8 heterozygosity or other haplotypes; P > 0.05). Moreover, distribution of the responders according to clinical features of celiac disease showed no statistically significant differences(P > 0.05).CONCLUSION This prospective study confirmed the lower percentage of response to HBV vaccine in celiac subjects. However, the underlying mechanism remains unclear and further studies are needed.

关键词： Celiac disease Hepatitis B virus vaccination Human leukocyte antigens Gluten Poor response

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The enhanced X-ray Timing and Polarimetry mission—eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 3-27页

作者： ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für Astronomie und Astrophysik Eberhard Karls Universität INAF-Istituto di Astrofisica e Planetologia Spaziali INFN-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Physics and Center for Astrophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Space Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espacials de Catalunya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of Astronomy University of Genevachemin d’Ecogia 16 Osservatorio di Astrofisica e Scienza Dello Spazio di Bologna Istituto Nazionale di Astofisica Astronomical Institute Czech Academy of Sciences Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1 CEA Paris-Saclay/IRFU Beijing Institute of Spacecraft System Engineering CAST Osservatorio Astronomico di Brera Istituto Nazionale di Astofisica Space Research Center Polish Academy of Sciences Key Laboratory of Advanced Material Microstructure of Education Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Physics and Center for Astrophysics Tsinghua University Universita’degli Studi di Udine Via delle Scienze 206 Mullard Space Science Laboratory University College London Department of Nuclear and Particle Physics University of Geneva SRON Netherlands Institute for Space Research Politecnico di Milano Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fisica e Chimica Fondazione Bruno Kessler Dr.Karl Remeis-Observatory and Erlangen Centre for Astroparticle Physics Universität Erlangen-Nürnberg University of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Physics and Astronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave *** paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.

关键词： X-ray instrumentation X-ray polarimetry X-ray timing space mission:eXTP

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