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PBX/Knotted 1 homeobox-2(PKNOX2)is a novel regulator of myocardial fibrosis

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signal Transduction and Targeted Therapy 2024年第5期9卷 2231-2249页

作者： Liang Chen Haotong Li Xiaorui Liu Ningning Zhang Kui Wang Anteng shi Hang Gao deniz Akdis Ardan Msaguner Xinjie Xu Elena Osto Willem Van de Veen Guangyu Li antoni bayés-Genís Firat Duru Jiangping song Xiangjie Li shengshou Hu state Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China school of statistics and Data science Nankai UniversityTianjinChina department of Cardiology University Heart CenterUniversity Hospital Zurich and University of ZurichZurichSwitzerland Institute for Clinical Chemistry University Hospital Zurich and University of ZürichZurichSwitzerland swiss Institute of Allergy and Asthma Research(sIAF) University of ZurichDavosSwitzerland Heart Institute Hospital Universitari Germans Trias i PujolBadalonaCIBERCVSpain

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA ***,the cardiac transcriptional regulation networks have not been systematically described because of the limitations in detecting transcription *** this study,we optimized a pipeline for isolating nuclei and conducting single-nucleus RNA sequencing targeted to detect a higher number of cell signal genes and an optimal number of transcription *** this unbiased protocol,we characterized the cellular composition of healthy human hearts and investigated the transcriptional regulation networks involved in determining the cellular identities and functions of the main cardiac cell *** in fibroblasts,a novel regulator,PKNOX2,was identified as being associated with physiological fibroblast activation in healthy *** validate the roles of these transcription factors in maintaining homeostasis,we used single-nucleus RNA-sequencing analysis of transplanted failing hearts focusing on fibroblast *** trajectory analysis suggested that PKNOX2 was abnormally decreased from fibroblast activation to pathological myofibroblast *** gain-and loss-of-function in vitro experiments demonstrated the inhibitory role of PKNOX2 in pathological fibrosis ***,fibroblast-specific overexpression and knockout of PKNOX2 in a heart failure mouse model induced by transverse aortic constriction surgery significantly improved and aggravated myocardial fibrosis,*** summary,this study established a high-quality pipeline for single-nucleus RNA-sequencing analysis of heart *** this optimized protocol,we described the transcriptional regulation networks of the main cardiac cell subtypes and identified PKNOX2 as a novel regulator in suppressing fibrosis and a potential therapeutic target for future translational studies.

关键词： NOX2 homeostasis fibrosis

In-port-plug transmission line design of the ITER plasma position reflectometer

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Plasma science and Technology 2020年第6期22卷 15-20页

作者： J MARTÍNEZ-FERNÁNdeZ ÁCAPPA A sIMONETTO T EsTRADA E de LA luna E J BLANCO Laboratorio Nacional de Fusión.CIEMAT Avda Complutense 40.Madrid 28040Spain CNR-IsTP via Cozzi 5320125 MilanoItaly

This work describes the microwave design of the transmission line housed in the in-port-plug region of the ITER plasma position reflectometer(PPR).The design of the components of the inport-plug reflectometers(located in equatorial port-plug 10(EPP10) and in upper-port-plug 01(UPP01)) is *** a 3 D ray tracing code, the spatial position and optimum orientation angles of each set of emission and detection antennas were determined.A feasible path was then created from the obtained antenna positions and orientations to the primary vacuum *** tall waveguides were chosen to reduce ohmic *** to space constraints in the ITER crowded environment, bends in oversized waveguides were unavoidable, and thus mode conversion was *** keep mode conversion losses at bay, hyperbolic secant curvature bends had to be used whenever ***, E-plane bends in tall waveguides proved to be especially critical, making it necessary to employ other approaches when higher bending angles were *** conversion results were obtained by evaluating the mode coupling *** losses have also been computed and their results compared with commercial simulators, obtaining a perfect agreement.

关键词： reflectometry microwave technology ITER diagnostic

主动心律与被动心律有相似P波的二联律之辨识

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临床心电学杂志 1992年第1期 39-40页

作者： bayés de luna A 任在镐

如果把一对QRs波后面有一长间歇的节律称为二联律,则有许多机理可以形成二联律,包括1.房性二联律;2.3∶2外出的窦房阻滞;3.隐匿性房性三联律;4.逸搏—早搏序列;5.心房扑动2∶1与4∶1交替下传心室;6.3∶2下传的房室阻滞;7.交接区心律呈3... 详细信息

如果把一对QRs波后面有一长间歇的节律称为二联律,则有许多机理可以形成二联律,包括1.房性二联律;2.3∶2外出的窦房阻滞;3.隐匿性房性三联律;4.逸搏—早搏序列;5.心房扑动2∶1与4∶1交替下传心室;6.3∶2下传的房室阻滞;7.交接区心律呈3∶2外出的文克白周期;8.逸搏-夺获二联律;9.心房颤动的巧合。这些二联律的鉴别诊断并不容易,其中最难鉴别的是3∶2外出的窦房阻滞与早搏起源于窦房结或其周围区域的房性二联律,这些早搏的P波与窦性P波相似。窦房阻滞是被动性心律失常,房性二联律是主动性心律失常,两者

关键词：二联律间期鉴别诊断房性静止期(细胞学) 心律窦房阻滞

心血管磁共振成像检出的已愈合心肌梗死部位和心电图模式之间的一致性

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 31-32页

作者： bayés de luna A. Cino J.M. Pujadas s. 姜朝晖 Institute of Cardiology Institut Catal de Ciencias Cardiovasculares Service of Cardiology Hospital Sant Pau Barcelona Spain Dr.

Q- wave myocardial infarction(MI) location is generally based on a pathologic correlation first proposed >50 years ago. despite the proved reliability of contrast- enhanced cardiovascular magnetic resonance(CE- CMR) imaging to detect and locate infarcted areas, no global study has been conducted with the aim of correlating the electrocardiographic(ECG) patterns of Q- wave MI with infarct location. We studied this correlation in 51 patients with sT- elevation acute coronary syndrome who presented with Q waves or equivalents during MI. seven preestablished ECG patterns that matched with high specificity to 7 different MI locations as detected by CE- CMR imaging were used to assess its value in clinical practice to locate an infarcted area. There were 4 ECG patterns in the anteroseptal zone(23 patients; septal, apical, and/or anteroseptal, extensive anterior, and limited anterolateral) and 3 ECG patterns in the inferolateral zone(28 patients; lateral, inferior, and inferolateral). In conclusion,(1) the predefined ECG patterns we used matched well(86% global concordance) with their corresponding infarction areas as detected by CE- CMR imaging and have real value in clinical practice, and(2) the Rs morphology in lead V1 is due to lateral MI and the Qs morphology in lead aVL is due to mid- anterior and mid- lateral MI. Therefore, the terms posterior and high lateral infarction are incorrect and should be changed to lateral wall and limited anterolateral wall MI.

关键词：心血管磁共振成像 Q波心肌梗死梗死部位心电图一致性急性冠状动脉综合征愈合检出 sT段抬高型梗死区域

Ecological distribution and population structure of Litsea glaucescens(Lauraceae)in the ravines of sierra Fría and sierra Laurel,Central Mexico

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Journal of Mountain science 2022年第7期19卷 1945-1960页

作者： Mara Irais FLOREs-GALLEGOs Edmundo GARCIA-MOYA Angelica ROMERO-MANZANAREs Mario luna-CAVAZOs Martin Alfonso MENDOZA-BRIsENO Heike VIBRANs Posgrado en Botánica Colegio de PostgraduadosCampus Montecillo.Km 36.5carretera México-TexcocoMontecilloTexcocoEdo.de México56230México Colegio de Postgraduados Campus Veracruz.Carretera Jalapa Veracruz Km 88.5Altamirano91690VeracruzMéxico

Litsea glaucescens Kunth(Mexican bay leaf,laurel)has a wide distribution in Mexico,growing at both riparian and rupicolous environments in the mountainous region of the Central Highlands of the *** Fría-sierra Laurel is a protected natural area covered by a dry *** Mexican bay leaf is associated with the oak forest,especially on *** species has been considered at risk in recent *** research is focused on analyzing the elements of the environment of the ravines,which are influencing the distribution and establishment of laurel populations in the *** mountainous regions of Aguascalientes were selected,sierra Fría and sierra *** ravines of the basin were selected to obtain environmental *** registered were topographic,edaphic,and *** component analysis was used to identify ecological factors associated with the presence of *** bay leaf populations were registered in 10 *** the structural level in the community,29 woody species were registered,Mexican bay leaf had an Importance Value Index of 15.8,ranking 10th among all *** of laurel were classified by size classes(s,individuals with heights ranging from 0 to 20 cm;s,heights ranging from 0.2 to 1.0 m;s,heights between 1 and 2 m with light trace of flowering;s,heights greater than 2 m with flowering greater than 30% of the canopy;and s,individuals with heights greater than 5 m,curved trunk and basal regrowth)to obtain the population *** importance index value for all the species in the riparian community was calculated to the community *** factors that characterized the presence of Mexican bay leaf were a high percentage of rock coverage(90%),less mulch depth,and sandy loam shallow *** that showed higher cation exchange capacity had a higher presence of individuals of the s,s,and ssize *** sindividuals were found in shady places with 97% of intercepted *** o

关键词： Dry Forest Ephemeral stream Importance Value Index Mexican bay leaf Population structure Principal Component Analysis

Potential Ecosystem Level Effects of a shrimp Trawling Fishery in La Paz bay, Mexico

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Open Journal of Marine science 2012年第3期2卷 85-89页

作者： Luís antonio salcido-Guevara Pablo del Monte-luna Francisco Arreguín-sánchez Víctor Hugo Cruz-Escalona Centro Interdisciplinario de Ciencias Marinas del IPN Apartado Postal La Paz México

The shrimp trawling fishery is the most important one in Mexico in value terms and given its putative environmental, societal and economical implications, it is also the most difficult to manage. Although this fishery was restricted from national bays and estuaries since the 1970’s, local fisheries cooperatives recently claimed access to shrimp stocks within La Paz bay by using an artisanal fleet and a low impact trawling net. This study is aiming at simulating some ecosystem level effects of such a potential fishing effort release. We explored the response of three ecosystem indicators under two different exploitation scenarios: 30% and 80% of shrimp biomass removal. The indicators were: relative ecosystem biomass distribution as function of trophic level, trophic replacement and interaction strength, all computed from the outputs of a mass balance dynamic model (Ecopath with Ecosim) of this ecosystem. Our results suggest that moderate fishing scenario (30%) would not cause major changes in either indicator whilst the scenario of strong fishing pressure (80%) seems to increase not only the fish resources variability at the population level but also the variability of the overall biomass, hence potentially reducing ecosystem stability.

关键词： Gulf of California shrimp Trawling Ecosystem Impact

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绵羊在澳大利亚的引进和传播

农业考古 2021年第1期 204-211页

作者：肖璐娜张箭西南石油大学马克思主义学院四川大学历史文化学院

在欧洲白人到达之前,澳大利亚并没有畜牧业,土著人也没有饲养牲畜。1788年,英国“第一舰队”抵达植物湾,不仅带来了大量农作物,随船还带有羊、牛、猪等若干家畜,这些家畜成为澳大利亚早期畜牧业的基础。后经麦克阿瑟、佩平等优秀养羊者... 详细信息

在欧洲白人到达之前,澳大利亚并没有畜牧业,土著人也没有饲养牲畜。1788年,英国“第一舰队”抵达植物湾,不仅带来了大量农作物,随船还带有羊、牛、猪等若干家畜,这些家畜成为澳大利亚早期畜牧业的基础。后经麦克阿瑟、佩平等优秀养羊者的改良培育,外加优越的放牧条件和科研配种技术的投入,羊毛业有了飞速发展,大量羊毛出口成为促进澳大利亚19世纪经济增长的重要原因,其副业羊肉生产也得益于冷冻技术的应用而有所发展。迄今澳大利亚已发展为现代农牧业最为发达的国家之一,羊群总数及羊毛产量稳居世界第一,特别是澳洲美利奴羊毛,更是享誉世界。故旧大陆绵羊的传入,不仅是家畜的传播,更是新旧大陆农业文明交流的重要结晶,对澳大利亚畜牧业产生了不可估量的重大影响。

关键词：绵羊澳大利亚畜牧业农业文明

Potential Ecosystem Level Effects of a shrimp Trawling Fishery in La Paz bay, Mexico

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