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What does irritable bowel syndrome share with non-alcoholic fatty liver disease?

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World Journal of Gastroenterology 2013年第33期19卷 5402-5420页

作者： antonella Scalera Matteo Nicola Dario Di Minno Giovanni Tarantino Department of Clinical Medicine and Surgery Federico Ⅱ University Medical School of Naples INT "Fondazione Pascale" - Cancer Research Center of Mercogliano

Non-alcoholic fatty liver disease(NAFLD)and irritable bowel syndrome(IBS)are two very common diseases in the general *** date,there are no studies that highlight a direct link between NAFLD and IBS,but some recent reports have found an interesting correlation between obesity and IBS.A systematic PubMed database search was conducted highlighting that common mechanisms are involved in many of the local and systemic manifestations of NAFLD,leading to an increased cardiovascular risk,and IBS,leading to microbial dysbiosis,impaired intestinal barrier and altered intestinal *** is not known when considering local and systemic inflammation/immune system activation,which one has greater importance in NAFLD and IBS ***,the nervous system is *** fact,inflammation participates in the development of mood disorders,such as anxiety and depression,characteristics of obesity and consequently of NAFLD and,on the other hand,in intestinal hypersensitivity and dysmotility.

关键词： Non-alcoholic fatty liver disease Irritable bowel syndrome Low grade chronic inflammation Cytokines

Effect of thinning on above-ground biomass accumulation in a Douglas-fir plantation in southern Italy

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Journal of Forestry Research 2016年第6期27卷 1313-1320页

作者： Vittoria Coletta Giuliano Menguzzato Gaetano Pellicone antonella Veltri Pasquale Antonio Marziliano Institute for Agricultural and Forest Systems in the Mediterranean (ISAFoM) National Research Council (CNR) Agraria Department University ‘‘Mediterranea’’ of Reggio Calabria

We investigated the effects of a long-term thinning experiment on the distribution of above-ground biomass of Douglas-fir （Pseudotsuga menziesii [Mirb.] Franco var. menziesii） in a plantation in southern Italy. Allometric equations were used to estimate biomass and partitioning to stem and crown compartments. Variation in biomass stock estimated with allometric equations were evaluated according to seven thinning treatments： geo- metric-systematic （1 row every 3）, selective （light-moderate-heavy）, mixed systematic-selective （1 row every 4, 1 row every 5）, unthinned （control）. Over the experimental period of 13 years, current annual increments of carbon were lower （3.4 Mg ha^-1 year^-1） in control plots than in treated plots. At age 30, plots subjected to light selective thinning showed higher values of above-ground biomass （249.7 Mg ha^-1）. The biomass harvested with this treatment was 29.3 Mg ha^-1, and the mean annual increment of carbon over 13 years was 4.8 Mg ha^-1. Our results showed that light thinning stimulated increase in carbon stock, with a minimal loss of carbon during the treatment and a current annual increment of carbon higher than in control sub-plots and sub-plots thinned using systematic methods. This treatment yielded least carbon emissions and we affirm it has discrete global warming mitigation potential.

关键词： Allometric equation Biomass Carbon Douglas-fir Thinning

Human bocavirus: Current knowledge and future challenges

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World Journal of Gastroenterology 2016年第39期22卷 8684-8697页

作者： Marcello Guido Maria Rosaria Tumolo Tiziano Verri Alessandro Romano Francesca Serio Mattia De Giorgi antonella De Donno Francesco Bagordo antonella Zizza Laboratory of Hygiene Department of Biological and Environmental Sciences and Technologies Faculty of Sciences University of Salento Institute of Clinical Physiology National Research Council Laboratory of Physiology Department of Biological and Environmental Sciences and Technologies University of Salento Neuropathology Unit Institute of Experimental Neurology and Division of Neuroscience IRCCS San Raffaele Scientific Institute

Human bocavirus(HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate(HBoV 1), namely HBoV 2, HBoV 3 and HBoV 4, have been detected principally in human faeces. HBo Vs are small nonenveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1(NS1) and nuclear phosphoprotein(NP1) and the third the viral capsid proteins 1 and 2(VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBo V infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzymelinked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoV s as true pathogen or innocent bystander is also emphasized.

关键词： Human bocavirus Respiratory virus Molecular tests Gastrointestinal virus Pathogenesis Epidemiology Immunoassay methods

Carpobrotus edulis(L.) ***. extract as a skin preserving agent: From traditional medicine to scientific validation

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Journal of Integrative Medicine 2021年第6期19卷 526-536页

作者： Miriam Bazzicalupo Laura Cornara Bruno Burlando Alberta Cascini Marcella Denaro antonella Smeriglio Domenico Trombetta3 Department for the Earth Environment and Life Sciences(DiSTAV)University of GenovaGenova 16132Italy Department of Pharmacy University of GenovaGenova 16132Italy Department of Chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaMessina 98166Italy

Objective:Carpobrotus edulis(L.)*** a succulent perennial plant native to South Africa and grows invasively in the Mediterranean *** is commonly used for the treatment of various diseases,including skin wound healing and regeneration,for which experimental validation is *** therefore evaluated the skin healing properties by testing a *** aqueous leaf extract(CAE)on cell cultures and in enzymatic ***:Micro-morphological analysis of leaves was carried out using scanning electron microscopy and light *** features and antioxidant activity of CAE were evaluated by reversed-phase liquid chromatography coupled with diode array detection and electrospray ion trap mass spectrometry(RP-LC-DAD-ESI-MS),and in vitro cell-free *** activities were evaluated using keratinocytes and fibroblasts,as well as elastase,collagenase,and ***:CAE showed high carbohydrates(28.59%±0.68%),total phenols([101.9±6.0]g gallic acid equivalents/kg dry extract[DE]),and flavonoids([545.9±26.0]g rutin equivalents/kg DE).RP-LC-DAD-ESI-MS revealed the predominant presence of hydroxycinnamic acids(51.96%),followed by tannins(14.82%)and flavonols(11.32%).The extract was not cytotoxic,had a strong and dose-dependent antioxidant activity,and inhibited collagenase(>90%at 500 mg/m L)and hyaluronidase(100%at 1000 mg/m L).In cell culture experiments,CAE increased wound closure and collagen production,which was consistent with its high polyphenol ***:Our data support the use of the *** for skin care and the treatment of skin ***,use of *** for skin care purposes could be an eco-friendly solution to reduce its invasiveness in the environment.

关键词： Traditional medicine Carbohydrates Polyphenols Antioxidant Wound healing

Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate

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World Journal of Gastroenterology 2016年第32期22卷 7186-7202页

作者： antonella Gallo Giovanna Passaro Antonio Gasbarrini Raffaele Landolfi Massimo Montalto Institute of Internal Medicine Fondazione Policlinico "Agostino Gemelli" Catholic University of Sacred Heart Institute of Internal Medicine Gastroenterology and Hepatology Department of Medical Science Catholic University

Alterations of intestinal microflora may significantly contribute to the pathogenesis of different inflammatory and autoimmune disorders. There is emerging interest on the role of selective modulation of microflora in inducing benefits in inflammatory intestinal disorders, by as probiotics, prebiotics, synbiotics, antibiotics, and fecal microbiota transplantation(FMT). To summarize recent evidences on microflora modulation in main intestinal inflammatory disorders, Pub Med was searched using terms microbiota, intestinal flora, probiotics, prebiotics, fecal transplantation. More than three hundred articles published up to 2015 were selected and reviewed. Randomized placebo-controlled trials and meta-analysis were firstly included, mainly for probiotics. A meta-analysis was not performed because of the heterogeneity of these studies. Most of relevant data derived from studies on probiotics, reporting some efficacy in ulcerative colitis and in pouchitis, while disappointing results are available for Crohn's disease. Probiotic supplementation may significantly reduce rates of rotavirus diarrhea. Efficacy of probiotics in NSAID enteropathy and irritable bowel syndrome is still controversial. Finally, FMT has been recently recognized as an efficacious treatment for recurrent Clostridium difficile infection. Modulation of intestinal flora represents a very interesting therapeutic target, although it still deserves some doubts and limitations. Future studies should be encouraged to provide new understanding about its therapeutical role.

关键词： Microbiota Inflammation Gut Probiotic Prebiotic

Immune reaction and colorectal cancer:Friends or foes?

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World Journal of Gastroenterology 2014年第35期20卷 12407-12419页

作者： Vincenzo Formica Vittore Cereda antonella Nardecchia Manfredi Tesauro Mario Roselli Medical Oncology Unit ‘Tor Vergata’ University Hospital Internal Medicine Department ‘Tor Vergata’ University Hospital

The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid *** cancer is one of the most studied neoplasms for the tumor-host immunity *** immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified,still no approved therapies based on host immunity intensification have so far been introduced in clinical ***,a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has limited the emphasis of this *** aim of the present review is to discuss immune components involved in the host immune reaction against colorectal cancer and analyze the fine balance between pro-tumoral and anti-tumoral effect of immunity in this model of disease.

关键词： Colitis-associated colorectal cancer Antitumor immunity Innate immunity Adaptive immunity

Role of omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes on intestinal barrier integrity and immunity in animals

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1240-1261页

作者： Tamil Selvi Sundaram Carlotta Giromini Raffaella Rebucci Juraj Pistl Mangesh Bhide antonella Baldi Department of Veterinary Science for Health Animal Production and Food SafetyUniversity of MilanVia Trentacoste 220134 MilanItaly University of Veterinary Medicine and Pharmacy in Kosice Komenskeho 68/7304181 KosiceSlovakia

The gastrointestinal tract of livestock and poultry is prone to challenge by feedborne antigens,pathogens,and other stress factors in the farm *** physiological inflammation and oxidative stress that arises firstly disrupts the intestinal epithelial barrier followed by other components of the gastrointestinal *** the present review,the interrelationship between intestinal barrier inflammation and oxidative stress that contributes to the pathogenesis of inflammatory bowel disease was ***,the role of naturally existing immunomodulatory nutrients such as the omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes in preventing intestinal barrier inflammation was *** on the existing evidence,the possible molecular mechanism of these bioactive nutrients in the intestinal barrier was outlined for application in animal diets.

关键词： Citrus pectin Immunomodulatory nutrients Inflammation Intestinal epithelial barrier Milk-derived exosomes Omega-3 polyunsaturated fatty acids Oxidative stress

An analytical method for Fe(Ⅱ) and Fe(Ⅲ) determination in pharmaceutical grade iron sucrose complex and sodium ferric gluconate complex

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Journal of Pharmaceutical Analysis 2012年第6期2卷 450-453页

作者： Daniele Merli antonella Profumo Carlo Dossi Dipartimento di Chimica Università degli Studi di Pavia Via Taramelli 12/14/16 27100 Pavia Italy Dipartimento di Scienze Teoriche ed Applicate (DSTA) Università dell'Insubria Via Dunant 7 21100 Varese Italy

A robust voltammetric method has been developed and validated for the determination of Fe（Ⅱ） and Fe（Ⅲ） in pharmaceutical iron polysaccharidic complexes. Undesirable low molecular weight iron complexes, at concentration about 3% in the pharmaceutical formulation, can be easily determined with good accuracy and precision. This methodology can be proposed as a viable, environmentally sustainable substitute for the conventional Normal Pulse Polarographic method in US Pharmacopeia, with better analytical figures of merit, and reduced Hg consumption. A deeper insight in Fe（Ⅱ） and Fe（Ⅲ） composition can be gained by the combined use of a new potentiometric technique after chemical decomposition of the complex.

关键词： Sodium ferric gluconatecomplex Iron sucrose complex Iron polysaccharides Voltammetry

Statins decrease the risk of acute pancreatitis after endoscopic ultrasound fine-needle aspiration of pancreatic cysts

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 74-79页

作者： Antonio Facciorusso Vincenzo Rosario Buccino Valentina Del Prete Matteo Antonino antonella Contaldo Nicola Muscatiello Gastroenterology Unit Department of Medical Sciences University of Foggia AOU Ospedali Riuniti

Background: Basic and clinical studies suggest that statins may prevent and even ameliorate acute pan- creatitis. The present study was to evaluate whether statin decreases the risk of acute pancreatitis in patients undergoing endoscopic ultrasound-guided ne-needle aspiration of pancreatic cysts. Methods: Out of 456 patients with pancreatic cysts referred to our center between 2006 and 2018, 365 were nally included in analyses: 86 were treated with statins and 279 were not at the time of endo- scopic ultrasound ne-needle aspiration. We compared the acute pancreatitis incidence between the two groups, and we also compared other complications such as bleeding and infections. Results: Median age was 64 years [interquartile range (IQR) 62 69] and median cyst size was 24mm (IQR, 21 29). The most frequent histology was intraductal papillary mucinous neoplasm (45.3% and 42.3% in the two groups, respectively;P =0.98). All 13 patients experiencing post-endoscopic ultrasound acute pancreatitis were from the control group (4.7%), of which 3 were classi ed as severe pancreatitis. None of statin users developed post-procedural acute pancreatitis (odds ratio: 0.15;95% con dence interval: 0.03 0.98;P=0.03). No difference was registered with regard to severe pancreatitis and other complications. Conclusions: Statins exert a bene cial role in preventing acute pancreatitis in patients with pancreatic cysts undergoing endoscopic ultrasound-guided ne-needle aspiration. If con rmed in prospective trials, our ndings may pave the way to an extensive use of statins as prophylactic agents in pancreatic inter- ventional endoscopy.

关键词： Endoscopic ultrasound Fine-needle aspiration Pancreas Lesion