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End points of clinical trials in metastatic castration-resistant prostate cancer:A systematic review

World Journal of Methodology 2014年第2期4卷 123-132页

作者： Giuseppe Colloca antonella venturino Division of Medical Oncology ＂Giovanni Borea＂ HospitalI-18038 SanremoItalyIlaria GovernatoDivision of Medical OncologySanto Spirito Hospital00186 RomaItaly

AIM： To review the defnition and performance of the commonly used end points in trials of systemic thera-pies in metastatic castration-resistant prostate cancer patients. METHODS： A literature search was undertaken on PubMed database to identify studies meeting estab-lished criteria, with the aim of selecting randomized clinical trials and study definition and performance of their end points. The end points were grouped into three categories： overall survival （OS）, time-to-event end points, and response end points. A special analysis was performed for secondary end points of the studies which documented a beneft in OS in the experimental arm. Finally, publishes analyses for surrogacy of the in-cluded end points were also reported. RESULTS： OS, time-to-event and response end points in 31 selected trials were analyzed. OS was the pri-mary end point in 14 trials, and the secondary end point in 17. A time-to-event end point was the primaryend point in 8 studies, and the secondary end point in 22; the most reported time-to-event end points were composite end points, and the events changed among trials. A response end point was the primary end point in 9 studies, in 3 it was prostate-specifc antigen （PSA）-related, in 3 pain-related and in 3 mixed. A response end point was the secondary end point in 19 studies： PSA response and radiologic response were the most frequently used secondary end points in 19 and 11 tri-als, respectively, while pain response was used in 5 ***： A homogeneous defnition of progres-sion in future trials is mandatory. Among response end points, pain-response and PSA-response appear to be the most reliable.

关键词： Metastatic castration-resistant prostate cancer End points Progression-free survival Prostate-specifc antigen Chemotherapy Palliative response

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Experimental and Numerical Analysis of Cavity/Mean-Flow Interaction in Low Pressure Axial Flow Turbines

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Journal of Thermal Science 2021年第6期30卷 2178-2185页

作者： BARSI Dario COSTA Carlo LENGANI Davide SIMONI Daniele venturino Giulio ZUNINO Pietro DIME-Universita di Genova Via Montallegro 11-16145 Genova

The increasing performance of modern aeroengines led the research towards the optimization of machine components not deeply analyzed in the *** this context,the mechanisms driving the interaction process between the secondary flows evolving at the hub of low-pressure turbines with the rotor-stator cavity systems have been poorly investigated in the *** this work,an experimental and numerical analysis of the interaction between the endwall near wall flow and the leakage flow of a real cavity system is *** experimental results were carried out in the annular low-pressure axial flow turbine of the University of *** blade loading and pressure distributions into the cavity,as well as the measured total pressure loss coefficient,have been used for a proper validation of CFD *** steady and unsteady calculations were carried out through the commercial solver ***,several numerical approaches have been tested into this work:RANS,Non Linear Harmonic(NLH),and *** most promising CFD techniques have been firstly identified by comparison with experimental results and then systematically employed to extend the analysis of secondary flow-cavity flow interaction to positions and quantities not available from the *** characterizing the mean flow-cavity flow interaction process will be shown to cover a great amount of the overall stage losses and should be properly accounted for the design of future optimized cavity configurations.

关键词： axial flow turbine cavity mean-flow interaction experimental analysis CFD

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从废气洗涤回收的氟硅酸溶液返回到普钙生产中去的方法

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肥料与健康 1978年第6期 55-60页

作者： R.Monaldi ,G.venturino ,毕克侣南化公司设计院

一、氟循环的工艺1.氟的利用从化成室逸出的气体中,一般含有磷矿中20～30%的氟,这些气体在空塔中用水洗涤,获得了含有悬浮二氧化硅的氟硅酸溶液,一般浓度为20～28%H2SiF6,相当于16～22%F。许多小厂直接将此溶液排放,另外一些较负责的生... 详细信息

一、氟循环的工艺1.氟的利用从化成室逸出的气体中,一般含有磷矿中20～30%的氟,这些气体在空塔中用水洗涤,获得了含有悬浮二氧化硅的氟硅酸溶液,一般浓度为20～28%H2SiF6,相当于16～22%F。许多小厂直接将此溶液排放,另外一些较负责的生产厂家则在排放前先加以中和。较大的生产厂家如Montedison,为回收氟,设置了中心工厂,从分散各处的过磷酸钙

关键词：过磷酸钙循环法计量单位磷矿氟硅酸溶液操作条件格栅氟硅酸循环逸出

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复合手术室中不可触及的肺结节的同步定位和胸腔镜切除

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中华医学杂志 2021年第33期101卷 2581-2581页

作者：施琴朗(编译) Mazza F venturino M Peano E 深圳市第三人民医院南方科技大学第二附属医院胸外科不详

随着肺结节检出率的提高,胸腔镜肺楔形切除术是部分小结节可靠的检出方式,如果小结节无法定位,胸腔镜手术则可能中转开胸手术。本研究纳入2016年4月到2019年11月共39例图像引导的胸腔镜手术(iVATS)。研究报告了对不可触及的未确诊肺结... 详细信息

随着肺结节检出率的提高,胸腔镜肺楔形切除术是部分小结节可靠的检出方式,如果小结节无法定位,胸腔镜手术则可能中转开胸手术。本研究纳入2016年4月到2019年11月共39例图像引导的胸腔镜手术(iVATS)。研究报告了对不可触及的未确诊肺结节进行同步定位和胸腔镜切除的经验。纳入标准为:病变小(1 cm)、亚实性或位于营养不良区域内。使用锥形束CT进行扫描并用定位钩及线圈进行术中标记,定位结节大小为(12±6)mm,从病变深缘到胸膜表面的距离为(24±9)mm,共使用20根定位钩19个线圈进行定位。

关键词：锥形束CT 胸腔镜小结节图像引导肺楔形切除术肺结节纳入标准中转开胸

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