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Probiotics against neoplastic transformation of gastric mucosa:Effects on cell proliferation and polyamine metabolism

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World Journal of Gastroenterology 2014年第37期20卷 13258-13272页

作者： Francesco Russo Michele Linsalata antonella orlando Laboratory of Nutritional Pathophysiology National Institute for Digestive DiseasesI.R.C.C.S. "S.de Bellis"70013 Castellana Grotte (Ba)Italy

Gastric cancer is still the second leading cause of cancer death worldwide, accounting for about 10% of newly diagnosed neoplasms. In the last decades, an emerging role has been attributed to the relations between the intestinal microbiota and the onset of both gastrointestinal and non-gastrointestinal neoplasms. Thus, exogenous microbial administration of peculiar bacterial strains(probiotics) has been suggested as having a profound influence on multiple processes associated with a change in cancer risk. The internationally accepted definition of probiotics is live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. The possible effects on the gastrointestinal tract following probiotic administration have been investigated in vitro and in animal models, as well as in healthy volunteers and in patients suffering from different human gastrointestinal diseases. Although several evidences are available on the use of probiotics against the carcinogen Helicobacter pylori,little is still known about the potential cross-interactions among probiotics, the composition and quality of intestinal flora and the neoplastic transformation of gastric mucosa. In this connection, a significant role in cell proliferation is played by polyamines(putrescine, spermidine, and spermine). These small amines are required in both pre-neoplastic and neoplastic tissue to sustain the cell growth and the evidences here provided suggest that probiotics may act as antineoplastic agents in the stomach by affecting also the polyamine content and functions. This review will summarize data on the most widely recognized effects of probiotics against neoplastic transformation of gastric mucosa and in particular on their ability in modulating cell proliferation, paying attention to the polyamine metabolism.

关键词： Cell proliferation Gastric cancer Microbiota Polyamines Probiotics

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100 years of high GEM concentration in the Central Italian Herbarium and Tropical Herbarium Studies Centre(Florence,Italy)

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Journal of Environmental Sciences 2020年第1期32卷 377-388页

作者： Jacopo Cabassi Valentina Rimondi Zhang Yeqing antonella Vacca orlando Vaselli antonella Buccianti Pilario Costagliola Department of Earth Sciences University of FlorenceVia G.La Pira4-50121 FlorenceItaly CNR-Institute of Geosciences and Earth Resources Via G.La Pira4-50121 FlorenceItaly

Up to 1980 s,the most used preservative for herbaria specimens was HgCl2,sublimating at ambient air conditions;ionic Hg then reduces to Hg0(gaseous elemental mercury,GEM)and diffuses throughout poor ventilated *** GEM levels may indeed persist for decades,representing a health *** this study,we present new GEM data from the Central Italian Herbarium and Tropical Herbarium Studies Centre of the University of Florence(Italy).These herbaria host one of the largest collection of plants in the ***,HgCl2 was documented as plant preservative up to the 1920 *** surveys were conducted in July 2013 and July and December 2017,to account for temporal and seasonal *** show GEM concentrations well above those of external locations,with peak levels within specimen storage cabinets,exceeding 50,000 ng/*** concentrations up to^7800 ng/m3 were observed where the most ancient collections are stored and no ventilation systems were *** the contrary,lower GEM concentrations were observed at the first ***,lower and more homogeneously distributed GEM concentrations were measured in 2017 than in 2013 since the air-conditioning system was updated in *** concentrations were similar to other herbaria worldwide and lower than Italian permissible exposure limit of 20,000 ng/m3(8-hr working day).Our results indicate that after a century from the latest HgCl2 treatment GEM concentrations are still high,i.e.,the treatment itself is almost *** conditioning and renewing is probably the less expensive and more effective method for GEM lowering.

关键词： Gaseous elemental mercury(GEM) Mercuric chloride Herbaria Florence Health safety

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Complex Systems in Economics and Where to Find Them

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Journal of Systems Science & Complexity 2021年第1期34卷 314-338页

作者： GOMES orlando GUBAREVA Mariya ISCAL-Lisbon Accounting and Business School Instituto Politécnico de Lisboaand CEFAGE-ISCAL/IPL Research CenterISCALAv.Miguel Bornbarda 201069-035 LisbonPortugal Accounting and Business School Instituto Politécnico de Lisboa SOCIUS-Research Centre in Economic and Organizational Sociology CSG-Research in Social Sciences and Management

The economy as a whole and most of its constituent parts, like markets, government institutions, firms, or households, are inherently complex conceptual constructions. Micro-level diversity,decentralized interaction, self-organization, adaptation and learning, emergence, and evolution, are some of the fundamental features that the above entities share and that allow to classify them as being complex entities. In a complex economic system, existing structures of interaction are in constant mutation as individual agents contact and influence one another and, by doing so, reshape the macro environment in which socio-economic relations unfold. Notwithstanding the observed pervasiveness of complexity in economics, there are a few areas of economic thought where the discussion on the theme has gained an exceptional relevance. In this article, six of such areas are identified and their complex nature is highlighted and scrutinized. These pertain to:(i) Knowledge interactions and technological innovation;(ii) Corporate design and organizational learning;(iii) Public policies directed at market regulation;(iv) Banking and financial markets;(v) Environmental economics, sustainability,and climate change;and(vi) income inequality.

关键词： Agent-based models complex networks complex systems emergent phenomena evolutionary nature market regulation public policies

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Robust Control of a Bevel-Tip Needle for Medical Interventional Procedures

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 244-256页

作者： Surender Hans Felix orlando Maria Joseph Department of Electrical Engineering Indian Institute of Technology RoorkeeRoorkeeUttarakhand 247667India

In minimally invasive surgery, one of the main objectives is to ensure safety and target reaching accuracy during needle steering inside the target organ. In this research work, the needle steering approach is determined using a robust control algorithm namely the integral sliding mode control(ISMC) strategy to eliminate the chattering problem associated with the general clinical scenario. In general, the discontinuity component of feedback control input is not appropriate for the needle steering methodology due to the practical limitations of the driving actuators. Thus in ISMC, we have incorporated the replacement of the discontinuous component using a super twisting control(STC)input due to its unique features of chattering elimination and disturbance observation characteristics. In our study, the kinematic model of an asymmetric flexible bevel-tip needle in a soft-tissue phantom is used to evaluate stability analysis. A comparative study based on the analysis of chattering elimination is executed to determine the performance of the proposed control strategy in real-time needle steering with conventional sliding mode control using vision feedback through simulation and experimental results. This validates the efficacy of the proposed control strategy for clinical needle steering.

关键词： Minimal invasive surgery needle steering nonholonomic system robust control sliding mode control

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Probabilistic Quantitative Temporal Constraints:Representing,Reasoning,and Query Answering

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Journal of Electronic Science and Technology 2018年第1期16卷 1-10页

作者： Paolo Terenziani antonella Andolina Dipartimento di Scienze e Innovazione Tecnologica University of Eastern PiedmontAlessandria 15121 Istituto Tecnico Commerciale Sommeiller Torino 10129

In many applications and domains,temporal constraints between actions, and their probabilities play an important role. We propose the first approach in the literature coping with probabilistic quantitative constraints. To achieve such a challenging goal, we extend the widely used simple temporal problem(STP) framework to consider ***,we propose i) a formal representation of probabilistic quantitative constraints, ii) an algorithm,based on the operations of intersection and composition,for the propagation of such temporal constraints, and iii) facilities to support query answering on a set of such constraints. As a result, we provide users with the first homogeneous method supporting the treatment(representing,reasoning,and querying) of probabilistic quantitative constraints, as required by many applications and domains.

关键词： Artificial intelligence(AI) probabilities query answering quantitative temporal constraints temporal reasoning

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The intricate debate on neurodegeneration and neuroinflammation in Parkinson’s disease:which came first?

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Neural Regeneration Research 2023年第1期18卷 125-126页

作者： antonella Cardinale Valeria Calabrese Experimental Neurophysiology Laboratory IRCCS San Raffaele RomaRomeItaly Department of Medicine Universitàdegli Studi di PerugiaPerugiaItaly

Parkinson’s disease(PD)is a heterogeneous multifactorial disorder and,during the last years,new scientific evidence has supported this *** principal hallmarks of PD are the loss of dopaminergic neurons in the substan... 详细信息

关键词： inflammation aggregation debate

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Continuous dynamic monitoring of a centenary iron bridge for structural modification assessment

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 26-41页

作者： Carmelo GENTILE antonella SAISI Department of Architecture Built environment and Construction engineering (ABC) Piazza Leonardo da Vinci 32 Milan 20133Italy

A multi-channel continuous dynamic monitoring system has been installed in a centenary iron arch bridge on late November 2011. The historic infrastructure, completed in 1889 and crossing the Adda river about 50 km far from Milan, is the most important monument of XIX century iron architecture in Italy and is still used as roadway and railway bridge. The monitoring project follows a series of preliminary ambient vibration tests carried out on the bridge since June 2009. The paper describes the bridge structure and its dynamic characteristics identified from the experimental studies developed since 2009, the installed monitoring system and the software developed in LabVIEW for automatically processing the collected data. Subsequently, the tracking of automatically identified natural frequencies over a period of about 18 months is presented and discussed, highlighting the effects of environmental and operational conditions on the bridge dynamic characteristics as well as the detection of structural changes, mainly based on natural frequencies shifts.

关键词： automated modal identification continuous dynamic monitoring environmental/operational effects iron arch bridge structural health monitoring

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Intravascular contrast agents in diagnostic applications： Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents

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Nano Research 2017年第3期10卷 731-766页

作者： antonella Antonelli Carla Sfara Mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biology Section University of Urbino 'Carlo Bo' Via Saffi 2 61029Urbino (PU) Italy

In medicine, discrimination between pathologies and normal areas is of great importance, and in most cases, such discrimination is made possible by novel imaging technologies. Numerous modalities have been developed to visualize tissue vascularization in cardiovascular diseases or during angiogenic and vasculogenic processes. Here, we report the recent advances in vasculature imaging, providing an overview of the current non-invasive approaches in biomedical diagnostics and potential future strategies for prognostic assessment of vessel diseases, such as aneurysms and coronary artery occlusion leading to myocardial infarction. There are several contrast agents （CAs） available to improve the visibility of specific tissues at the early stage of diseases, allowing for rapid treatment. However, CAs are also hampered by numerous limitations, including rapid diffusion from blood vessels into the interstitial space, toxicity, and low sensitivity. Extravasation from blood vessels leads to a rapid loss of the image. If the contrast medium can fully be confined to the vascular space, high-resolution structural and functional vascular imaging could be obtained. Many scientists have contributed new materials and/or new carrier systems. For example, the use of red blood cells （RBCs） as CA-delivery systems appears to provide a scalable alternative to current procedures that allows adequate vascular imaging. Recognition and removal of CAs from the circulation can be prevented and/or delayed by using RBCs as biomimetic CA-carriers, and this technology should be clinically validated.

关键词： diagnostic applications magnetic resonanceimaging (MRI) vascular contrast agents red blood cells medical imaging new tomography

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Regenerative medicine technology applied to gastroenterology:Current status and future perspectives

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World Journal of Gastroenterology 2012年第47期18卷 6874-6875页

作者： Giuseppe orlando Marie Curie Fellow Department of General SurgerySection of TransplantationWake Forest University School of MedicineWinston SalemNC 27157-1095United States

This special issue of World Journal of Gastroenterology has been conceived to illustrate to gastroenterology operators the role that regenerative medicine(RM) will have in the progress of gastrointestinal(GI) *** is a multidisciplinary field aiming to replace,regenerate or repair diseased tissues or *** past decade has been marked by numerous ground-breaking achievements that led experts in the field to manufacture functional substitutes of relatively simple *** progress is paving the ground for investigations that aims to the bioengineering and regeneration of more complex organs like livers,pancreas and *** this special issue,the reader will be introduced,hand-in-hand,to explore the field of RM and will be educated on the progress,pitfalls and promise of RM technologies as applied to GI medicine.

关键词： Regenerative medicine Gastroenterology

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HOMOCLINIC SOLUTIONS OF NONLINEAR LAPLACIAN DIFFERENCE EQUATIONS WITHOUT AMBROSETTI-RABINOWITZ CONDITION

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Acta Mathematica Scientia 2021年第3期41卷 712-718页

作者： antonella NASTASI Stepan TERSIAN Calogero VETRO University of Palermo Department of Mathematics and Computer ScienceVia Archirafi 3490123PalermoItaly Institute of Mathematics and Informatics Bulgarian Academy of Sciences1113 SofiaBulgaria

The aim of this paper is to establish the existence of at least two non-zero homoclinic solutions for a nonlinear Laplacian difference equation without using AmbrosettiRabinowitz type-conditions. The main tools are mo... 详细信息

关键词： Difference equations homoclinic solutions non-zero solutions (p,q)-Laplacian operator

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