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Role of Arabidopsis UV RESISTANCE LOCUS 8 in Plant Growth Reduction under Osmotic Stress and Low Levels of UV-B

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Molecular Plant 2014年第5期7卷 773-791页

作者： Rossella Fasano Nathalie Gonzalez Alessandra Tosco Fabrizio Dal Piaz Teresa Docimo Ramon Serrano Stefania Grillo antonella leone Dirk Inze Department of Pharmacy University of Salerno Fisciano Italy Department of Plant Systems Biology VIB 9052 Ghent Belgium Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Gent Belgium Max Planck Institute for Chemical Ecology Jena Germany Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia CSIC Valencia Spain National Research Council of Italy Institute of Plant Genetics Res. Div. Portici Portici Italy

In high-light environments, plants are exposed to different types of stresses, such as an excess of UV-B, but also drought stress which triggers a common morphogenic adaptive response resulting in a general reduction of plant growth. Here, we report that the Arabidopsis thaliana UVRESISTANCE LOCUS 8 （UVR8） gene, a known regulator of the UV-B morphogenic response, was able to complement a Saccharomyces cerevisiae osmo-sensitive mutant and its expression was induced after osmotic or salt stress in Arabidopsis plants. Under low levels of UV-B, plants overexpressing UVR8 are dwarfed with a reduced root development and accumulate more flavonoids compared to control plants. The growth defects are mainly due to the inhibition of cell expansion. The growth inhibition triggered by UVR8 overexpression in plants under low levels of UV-B was exacerbated by mannitol-induced osmotic stress, but it was not significantly affected by ionic stress. In contrast, uvr8-6 mutant plants do not differ from wild-type plants under standard conditions, but they show an increased shoot growth under high-salt stress. Our data suggest that UVR8-mediated accumulation of flavonoid and possibly changes in auxin homeostasis are the underlying mechanism of the observed growth phenotypes and that UVR8 might have an important role for integrating plant growth and stress signals.

关键词： osmotic stress growth reduction cell expansion flavonoid auxin.

Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine

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World Journal of Orthopedics 2024年第3期15卷 204-214页

作者： Dayane Maria Braz Nogueira Marcelie Priscila de Oliveira Rosso Daniela Vieira Buchaim Mariana Schutzer Ragghianti Zangrando Rogério leone Buchaim Department of Prosthodontics and Periodontics Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Department of Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Medical School University Center of AdamantinaAdamantina 17800-000Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate DepartmentUniversity of MaríliaMarília 17525-902Brazil

Bone regeneration is a critical area in regenerative medicine,particularly in orthopedics,demanding effective biomedical materials for treating bone defects.45S5 bioactive glass(45S5 BG)is a promising material because of its osteoconductive and bioactive *** research in this field continues to advance,keeping up-to-date on the latest and most successful applications of this material is *** achieve this,we conducted a comprehensive search on Pub-Med/MEDLINE,focusing on English articles published in the last *** search used the keywords“bioglass 45S5 AND bone defect”in *** found 27 articles,and after applying the inclusion criteria,we selected 15 studies for detailed *** of these studies compared 45S5 BG with other cement or scaffold *** comparisons demonstrate that the addition of various composites enhances cellular biocompatibility,as evidenced by the cells and their osteogenic ***,the use of 45S5 BG is enhanced by its antimicrobial properties,opening avenues for additional investigations and applications of this biomaterial.

关键词： Biocompatible materials Bioglass Bone regeneration

Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana Michela Londero Luca Del Giacco Riccardo Masetti Alba Di leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

Comparison Between Deep Learning Models and Traditional Machine Learning Approaches for Facial Expression Recognition in Ageing Adults

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Journal of Computer Science & Technology 2020年第5期35卷 1127-1146页

作者： Andrea Caroppo Alessandro leone Pietro Siciliano Institute for Microelectronics and Microsystems National Research Council of ItalyLecce 73100Italy

Facial expression recognition is one'of the most active areas of research in computer vision since one of the non-verbal communication methods by which one understands the lnood/mental state of a person is the expression of ***,it has been used in various fields such as human-robot interaction,security,computer graphics animation,and ambient ***,it remains a challenging task since existing approaches lack generalizability and almost all studies ignore the effects of facial attributes,such as *** expression recognition even though the research indicates that facial expression inanifestation varies with ***,a lot of progress has been made in this topic and great improvements in classification task were achieved with the emergence of deep learning *** approaches have sliown how hierarchies of features can be directly learned from original data,thus avoiding classical hand designed feature extraction methods that generally rely on manual operations witli labelled ***,research papers systematically exploring tlu4 performance of existing deep architectures for the task of classifying expression of ageing adults are absent in the *** the present work a tentative to try this gap is done considering the performance of three recent deep convolutiorial neural networks models(VGG-16,AlexNet and GoogLeNet/Inception V1)and evaluating it on four different benchmark datcisets(FACES,Lifespan,CIFE,and FER2013)which also contain facial expressions performed by elderly *** the baseline,and with the aim of making a comparison,two traditional inacliine learning approaches based on handcrafted features extraction process are evaluated on the same *** out an exhaustive and rigorous experimentation focused on the concept of "transfer learning",which consists of replacing the output level of the deep architectures considered with new output levels appropriate to the number of classes(facial expressions),

关键词： computer vision deep learning facial expression machine learning ageing adult

CNTs tuning and vertical alignment in anodic aluminium oxide membrane

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Journal of Natural Gas Chemistry 2012年第6期21卷 639-646页

作者： Maria Sarno Diana Sannino Caterina leone Paolo Ciambelli Department of Industrial Engineering and Centre NANO MATES University of Salerno

Anodic aluminium oxide （AAOM） membranes were used for template growth of carbon nanotubes （CNT） inside their pores by chemical vapour deposition （CVD） of different hydrocarbons, in the absence of transition metal catalyst. A composite material, containing one nanotube for each channel, having the same length as the membrane thickness and the external diameter close to the diameter of the membrane holes, was obtained. Yield, selectivity, and quality of CNTs in terms of diameter （up to very thin CNT）, carbon order, length, arrangement （i.e. number of tubes for each channel）, purity, that are critical requisites for several applications were optimised by investigating the effect of changing the hydrocarbon feedstock gas, also in the presence of hydrogen. The samples produced using methane as a feedstock have a well ordered structure. The role of the alumina channels surface during the CNT growth has been investigated and its catalytic activity has been proved for the first time.

关键词： catalysis chemical processes nanomaterials microreactor hydrocarbons CVD controlled CNTs synthesis

Outcomes in spasticity after repetitive transcranial magnetic and transcranial direct current stimulations

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Neural Regeneration Research 2014年第7期9卷 712-718页

作者： Aysegul Gunduz Hatice Kumru Alvaro Pascual-leone Department of Neurology Cerrahpasa School of Medicine Istanbul University Institut Guttmann Institut Universitari de Neurorehabilitació adscrit a la UAB Universitat Autonoma de Barcelona Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol Badalona Berenson-Allen Center for Noninvasive Brain Stimulation Beth Israel Deaconess Medical Center and Harvard Medical School

Non-invasive brain stimulations mainly consist of repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Repetitive transcranial magnetic stimulation exhib- its satisfactory outcomes in improving multiple sclerosis, stroke, spinal cord injury and cerebral palsy-induced spasticity. By contrast, transcranial direct current stimulation has only been studied in post-stroke spasticity. To better validate the efficacy of non-invasive brain stimulations in im- proving the spasticity post-stroke, more prospective cohort studies involving large sample sizes are needed.

关键词： reviews muscle spasticity motor cortex transcranial magnetic stimulation transcranialdirect current stimulation central nervous system stroke

Face-to-Face:The Semiotics of Online Teaching(or,in Praise of the Classroom)

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Language and Semiotic Studies 2021年第1期7卷 34-56页

作者： Massimo leone the Department of Philosophy and Educational Sciences University of TurinItaly Department of Chinese Language and Literature Shanghai UniversityChina

The paper consists in an in-depth semiotic analysis of the spatiality of present-day online teaching as compared with that of the traditional *** spatiality,the paper contends,cannot be properly digitalized,because it is strictly dependent on *** embodied spatiality of a classroom,it is argued,is nevertheless fundamental to bring about the ritual transfiguration that underpins the didactic experience and its socio-cultural ***,the urgent need to rethink digital teaching environments in relation to these crucial lacks,which only semiotics,with its specific attention to non-verbal elements of communication—including spatiality—is fully equipped to detect.

关键词： online teaching classroom spatiality temporality edusemiotics COVID-19 digitalization

The main tasks of a semiotics of artificial intelligence

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Language and Semiotic Studies 2023年第1期9卷 1-13页

作者： Massimo leone University of Turin TurinItaly Shanghai University ShanghaiChina University of Cambridge CambridgeEngland and Bruno Kessler Foundation TrentoItaly

The article indicates the essential tasks of a semiotics of artificial intelligence:studying the way it simulates the expression of intelligence;the way it produces content that is creatively endowed;the ideological assumptions of artificial intelligence within the culture that produces *** intelligence is,from a semiotic point of view,the predominant technology of fakery in the current *** the strength of its studies on the false,semiotics can therefore also be applied to the analysis of the fake that,in increasingly sophisticated forms,is produced through artificial intelligence and through the deep learning of neural *** article focuses on the adversarial ones,trying to highlight their ideological assumptions and cultural developments,which seem to indicate the entry of human societies and cultures into the‘realm of the absolute fake'.

关键词： fake generative adversarial networks simulation undecidability of the digital fake

Alcohol and hepatocellular carcinoma:A review and a point of view

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World Journal of Gastroenterology 2014年第43期20卷 15943-15954页

作者： Gianni Testino Silvia leone Paolo Borro Centro Alcologico Regionale-Regione Liguria Alcoholic UnitDepartment of General Internal and Specialist MedicineIRCCS AOU San Martino-National Institute for Cancer Research-IST Department of Internal Medicine Clinical Pharmacology and Toxicology UnitUniversity of Genoa

It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol *** in Italy and the United States concludes that the most common cause of HCC(responsible for 32%to 45%of HCC)is *** has recently been shown that a significant relationship between alcohol intake,metabolic changes,and hepatitis virus infection does *** may be a factor in the development of HCC via direct(genotoxic)and indirect mechanisms(cirrhosis).There is only one way of diagnosing HCC,which is early identification through surveillance,when curative treatments become *** stopping alcohol intake the risk of liver cancer decreases by 6%to 7%a year,and an estimated time period of 23 years is also ***,surveillance is also important in former drinkers and,in our opinion,independently from the presence of compensated *** cases of very early stage(VES)and early stage with portal hypertension,liver transplantation is the optimal option;and in cases of associated disease,percutaneous ethanol injections,radiofrequency and microwave ablation are the ideal *** the possibility of detecting microvascular invasion with HR,several studies and some randomized controlled trials revealed that overall survival and DSF rates in patients with VES HCC are much the same after ablation and ***,ablation can be regarded as a firstline choice for patients with VES *** is important to emphasize that the choice of treatment should be weighed carefully in the context of a multidisciplinary cancer team.

关键词： Alcohol Alcoholic liver disease Hepatocellular carcinoma Percutaneous ablation