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Asian j.urnal of Andrology 2008年第1期10卷 54-59页

作者： anthony j. Bella Guiting Lin Ilias Cagiannos Tom F. Lue Department of Surgery Division of UrologyUniversity of Ottawa Ottawa KIY4E9 Canada Department of Neuroscience Ottawa Health Research Institute University of Ottawa Ottawa KIY4E9 Canada Knuppe Molecular Urology Laboratory San Francisco CA 94143 USA Department of Urology University of California San Francisco CA 94143 USA

Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies for the cavernous nerves （CNs）, as therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function. Nitric oxide released from the axonal end plates of these nerves within the corpora cavernosa causes relaxation of smooth muscle, initiating the haemodynamic changes of penile erection as well as contributing to maintained tumescence; the loss of CN function is primarily responsible for the development of erectile dysfunction （ED） after pelvic surgery and serves as the primary target for potential neuroprotective or regenerative strategies. Evidence from pre-clinical studies for select neuromodulatory approaches is reviewed, including neurotrophins, glial cell line-derived neurotrophic factors （GDNF）, bone morphogenic proteins, immunophilin ligands, erythropoetin （EPO）, and stem cells.

关键词： erectile dysfunction prostate cancer radical prostatectomy postoperative complications neuroprotection nerve regeneration neurotrophins brain-derived nerve growth factor immunophilin ligands stem cells

Interactive Effect of Blackeye cowpea mosaic virus and Cucumber mosaic virus on Vigna unguiculata

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Horticultural Plant j.urnal 2019年第2期5卷 88-92页

作者： Ayodele anthony Faj.nmi Faculty of Agriculture Department of Crop Science and Horticulture Federal UniversityOye-Ekiti P.M.B. 374 Nigeria

This research tries to demonstrate physiological effect of combined infection of two viruses on growth parameter of cowpea plant as demonstrated through symptom expression. Blackeye cowpea mosaic virus(BlCMV) and Cucumber mosaic virus(CMV) were transmitted to cowpea plants by mechanical rub inoculation. This study showed that the differences in stem height and final aboveground fresh weight of cowpea plants inoculated with mixed infection with CMV and BlCMV were significantly less than those of plants inoculated with a single virus. Likewise cowpea plants inoculated with either virus alone or with CMV and BlCMV mixed infection had less stem height and aboveground fresh weight than the control. The mixed infection of BlCMV and CMV caused significant increase in the severity of symptoms in cowpea and also in the height using factors analysis and Abbott's equation. Symptom severity rating scale used, demonstrated statistical proof for physiological effect based on symptom severity for co-infection. A three phase disease symptom severity expression revealed disease severity for each viral treatment associated with host plant.

关键词： cowpea virus mixed infection interaction severity symptom

Rare earth elements:Properties and applications to methanol synthesis catalysis via hydrogenation of carbon oxides

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j.urnal of Rare Earths 2018年第11期36卷 1127-1135页

作者： anthony R.Richard Maohong Fan Department of Chemical Engineering University of WyomingLaramieWY 82071USA School of Energy Resources University of WyomingLaramieWY 82071USA

Methanol （CH3OH） is an important industrial chemical with a wide variety of uses. Industrial methanol synthesis catalysts are typically composed of Cu, Zn, and AI, but the use of catalysts incorporating rare earth elements has been shown to improve the catalytic performance. Due to their unique chemical and physical properties, the use of rare earth elements （scandium, yttrium, and the lanthanides） in catalysis in general has continued to increase over the past few decades, while the use of rare earth in methanol synthesis catalysts has not, despite often improving pertbrmance. The ability of several of the rare earth elements （Pr, Ce, Eu, Tb, Yb） to easily switch between oxidation states makes them beneficial for many different types of catalysts. However, for methanol synthesis the surface basicity is an important property, and the basic nature of the rare earth elements can be used to tune the basicity of catalysts. A small number of correlations between rare earth properties and catalytic performance have been observed, but often do not apply to other catalysts. Properties such as strength of basic sites, ionic radius, and etec- tronegativity have been found to correlate with performance results such as activity or selectivity.

关键词： Methanol synthesis Rare earth Lanthanides Catalysis Hydrogenation

Two-stage corrective operation for the treatment of pes cavovarus in patients with spina bifida

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World j.urnal of Orthopedics 2024年第7期15卷 618-626页

作者： anthony Mack Padgett Ezan Kothari Michael j.Conklin Department of Orthopedics Indiana UniversityIndianapolisIN 46202United States Department of Orthopaedic Surgery University of Alabama at BirminghamBirminghamAL 35233United States Department of Orthopedic Surgery Children’s of AlabamaBirminghamAL 35233United States

BACKGROUND Pes cavovarus has an estimated incidence of 8%-17%in patients with spina bifida(SB).The maj.rity of the current literature on surgical treatment of cavovarus feet in children and adolescents includes a variety of *** are currently no case series describing a treatment algorithm for deformity correction in this specific patient *** authors of this study present the results of a retrospective case series performed to assess the radiographic outcomes of two-stage corrective surgery in patients with *** Retrospective chart review was performed on patients with SB with a diagnosis of pes cavovarus at a freestanding children’s hospital who underwent surgical correction of the *** were excluded for lack of two-stage corrective operation,nonambulatory status,lack of at least six months follow-up,and age>18 years at the time of *** resulted in a cohort of 19 *** analysis was performed on 11 feet that had a complete series of preoperative and postoperative weightbearing *** and postoperative radiographic outcome measurements were compared using a two-sample *** Significant changes between the preoperative and postoperative measurements were seen in Meary’s angle,the anteroposterior talo-first metatarsal(AP TMT1)angle,and the talonavicular *** values of Meary’s angle were 17.9±13.1 preoperatively and 4.7±10.3 postoperatively(P=0.016).Mean AP TMT1 angle was 20.6±15.1 preoperatively and 9.3±5.5 postoperatively(P=0.011).Mean talonavicular coverage values were-10.3±9.6 preoperatively and-3.8±10.1 postoperatively(P=0.025).CONCLUSION The two-stage corrective procedure demonstrated efficacy in correcting cavovarus deformity in patients with *** should strongly consider employing the staged surgical algorithm presented in this manuscript for management of these patients.

关键词： Cavovarus Spina bifida Osteotomy Plantar release Radiographs Pediatrics

Compressible and Choked Flows in Rotating Passages

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Open j.urnal of Fluid Dynamics 2019年第1期9卷 1-21页

作者： Nolan j. Dyck anthony G. Straatman The Department of Mechanical and Materials Engineering Western University London Canada

The present study revisits the rotating duct problem examined by Polihronov and Straatman (j. Polihronov and A. G. Straatman, Phys. Rev. Lett. v. 109, p. 054504 (2012)). Starting from the general compressible Euler equations in a non-stationary reference frame closed form expressions for velocity, temperature, density and pressure along the duct are determined. The present results are more general than those obtained by Polihronov and Straatman, as the change of in-frame kinetic energy has been retained. The improvement of the present results over Polihronov and Straatman’s is demonstrated by comparison with the results of a computational fluid dynamics study. The new results have been further generalized to the case of a rotating duct with varying cross-sectional area, and again for a general curved passage in three-dimensional space. The work required or derived from the rotating duct has also been computed. The choked flow condition within the passage of varying cross-sectional area has been identified, along with the constraints which must be placed on the Mach, Rossby, and tip Mach numbers to avoid choked flow. Finally, a straightforward technique to identify any locations where an ideal rotating flow in a constrained passage will become sonic has been presented.

关键词： Compressible Flows Rotational Flows

Sensitivity Analysis of Computations of the Vapor-Liquid Equilibria of Methane + Methanol or Glycols at Gas Hydrate Formation Conditions

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Modeling and Numerical Simulation of Material Science 2019年第1期9卷 1-15页

作者： Christopher E. Ozigagu anthony j. Duben Department of Chemistry and Biochemistry Stephen F. Austin State University Nacogdoches TX USA

The Soave-Redlich-Kwong (SRK-EOS) and Peng-Robinson (PR-EOS) equations of state are used often to describe the behavior of pure substances and mixtures despite difficulties in handling substances, like water, with high polarity and hydrogen bonding. They were employed in studying the binary vapor-liquid equilibria (VLE) of methane + methanol, monoethylene glycol (MEG), and triethylene glycol (TEG). These liquids are used to inhibit the formation of gas hydrates. The investigation focused on the conditions at which methane-water clathrates can form 283.89?K to 323.56?K and 5.01?MPa to 18.48?MPa. The pressure of methane in methanol is overestimated by a factor of two by either the SRK-EOS or the PR-EOS. In the methane + MEG system, the predicted pressures for both equations of state are generally less than experimental pressure except for the highest concentration of methane in MEG calculated by the SRK-EOS. In the methane + TEG system, the predictions of both models are close and trend similarly. Because of the comparative lack of extensive experimental methane + TEG data, the similarity of the methane + TEG computed results can be used as a basis for further study of this system experimentally.

关键词： Vapor-Liquid Equilibrium Cubic Equations of State Clathrate Glycols

Gabapentin prevalence:clinical and forensic experience in ***,Missouri,USA

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Forensic Sciences Research 2021年第4期6卷 218-223页

作者： Sarah B.Riley Kelsie Garbutt Chelsea Crow T.Scott Isbell anthony j.Scalzo school of Medicine Department of Pathology saint Louis Universityst.LouisMissouriUs school of Medicine Department of Pediatrics saint Louis Universityst.LouisMissouriUs Department of sociology and anthropology Forensic sciences Programsaint Louis Universityst.LouisMissouriUSA

Gabapentin(Neurontin)is an anti-epileptic drug that has had wide off-label prescription use since market release due to presumed negligible abuse ***,trends in drug misuse have demonstrated that gabapentin misuse is occurring,particularly in those with a history of opioid *** is concerning,because although gabapentin has no direct ligand activity at opioid receptors,it does potentiate the analgesic effect of opioids,and concurrent use of gabapentin and opioids may increase the risk of respiratory depressive effects of *** study investigates the incidence of gabapentin detected in urine samples collected for clinical drug screening purposes in a local hospital emergency department and in postmortem samples submitted by medical examiners in the *** metropolitan *** prevalence of gabapentin and co-detected drugs in both populations is contrasted,compared,and *** study found that 30%of urine samples collected from patients with suspected drug intoxication presenting to SSM Health Saint Louis University Hospital,a quaternary care medical center,were positive for gabapentin,and nearly two thirds of those were also positive for *** a 6-month period,the incidence of gabapentin positive postmortem cases increased from 18%to 20%.Nearly all gabapentin positive postmortem cases were also positive for an opioid,the most significant being fentanyl,suggesting that gabapentin misuse may be due to its potentiating effect of opioid drug *** study also highlights the limited utility of immunoassay-based urine drug screens.

关键词： Forensic toxicology clinical toxicology substance misuse gabapentin urine drug screening postmortem mass spectrometry

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半导体激光抽运探针源

中国激光 2000年第12期27卷 1085-1088页

作者：阎平 anthony j.Vickers 北京理工大学光电工程系北京100081 德国爱塞克斯大学电子工程系

从理论上和系统实验上阐述了一种新型全固化半导体激光抽运探针源。此抽运探针源利用激光增益开关控制的原理 ,通过控制直流偏置电流和射频驱动电流可产生两列重复频率在 1GHz左右 ,脉宽约为 50 ps的激光脉冲序列 ,并且两脉冲序列间的... 详细信息

从理论上和系统实验上阐述了一种新型全固化半导体激光抽运探针源。此抽运探针源利用激光增益开关控制的原理 ,通过控制直流偏置电流和射频驱动电流可产生两列重复频率在 1GHz左右 ,脉宽约为 50 ps的激光脉冲序列 ,并且两脉冲序列间的时间延迟在 2 0 0 ps范围可调。

关键词：半导体激光器抽运探针激光脉冲集成电路

Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

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International j.urnal of Mechanical System Dynamics 2023年第1期3卷 48-57页

作者： Harry j.Carpenter Mergen H.Ghayesh anthony C.Zander Peter j.Psaltis School of Electrical and Mechanical Engineering University of AdelaideAdelaideSouth AustraliaAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research Institute(SAHMRI)AdelaideSouth AustraliaAustralia Adelaide Medical School University of AdelaideAdelaideSouth AustraliaAustralia Department of Cardiology Central Adelaide Local Health NetworkAdelaideSouth AustraliaAustralia

In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)*** one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its *** can include the unique dynamical factors present in the coronary *** investigate the impact of these dynamical factors,we study an idealized artery model with sequential *** transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary *** compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI *** suggest that the motion of the artery can impact downstream patterns in both divergence and *** magnitude is also decreased by up to 57%due to motion in some *** divergence patterns varied most significantly between simulations over the systolic period,the time of the largest *** investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

关键词： computational fluid dynamics divergence fluid–structure interaction topology wall shear stress

Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus

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Neural Regeneration Research 2020年第8期15卷 1546-1553页

作者： Courtney j.Mycroft-West anthony j.Devlin Lynsay C.Cooper Patricia Procter Gavin j.Miller David G.Fernig Marco Guerrini Scott E.Guimond Marcelo A.Lima Edwin A.Yates Mark Andrew Skidmore Molecular&Structural Biosciences School of Life SciencesKeele UniversityHuxley BuildingKeeleStaffordshireST55BGUK Lennard-j.nes Laboratory School of Chemical and Physical SciencesKeele UniversityKeeleStaffordshireST55BGUK Department of Biochemistry Institute of Integrative BiologyUniversity of LiverpoolCrown StreetLiverpoolL697ZBUK Istituto di Ricerche Chimiche e Biochimiche G.Ronzoni Via G.Colombo 8120133 MilanItaly School of Medicine KeeleStaffordshireST55BGUK

The pharmaceutical and anticoagulant agent heparin,a member of the glycosaminoglycan family of carbohydrates,has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target,the primary neuronalβ-secretase,β-site amyloid precursor protein cleaving enzyme 1(BACE1).The anticoagulant activity of heparin has,however,precluded the repurposing of this widely used pharmaceutical as an Alzheimer’s disease ***,a glycosaminoglycan extract,composed predominantly of 4-sulfated chondroitin sulfate,has been isolated from Sardina pilchardus,which possess the ability to inhibit BACE1(IC50[half maximal inhibitory concentration]=4.8μg/mL),while displaying highly attenuated anticoagulant activities(activated partial thromboplastin time EC50[median effective concentration]=403.8μg/mL,prothrombin time EC50=1.3 mg/mL).The marine-derived,chondroitin sulfate extract destabilizes BACE1,determined via differential scanning fluorimetry(ΔTm–5°C),to a similar extent as heparin,suggesting that BACE1 inhibition by glycosaminoglycans may occur through a common mode of action,which may assist in the screening of glycan-based BACE1 inhibitors for Alzheimer’s disease.

关键词： amyloid-β aspartyl protease carbohydrates galactosaminoglycans heparan sulfate heparin marine polysaccharide pilchards sardines therapeutics