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Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?

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Neural regeneration research 2019年第10期14卷 1678-1683页

作者： anthony Davies Guido Wassink Laura Bennet Alistair j.Gunn joanne O.Davidson Department of Physiology The University of Auckland

Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and *** hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and *** guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic *** clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong *** are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic *** studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of *** this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes.

关键词： hypoxia-ischemia hypoxic-ischemic encephalopathy therapeutic hypothermia neuroprotection therapeutic strategies randomized controlled trials animal models fetal sheep piglets

On the effects of landscape configuration on summer diurnal temperatures in urban residential areas: application in Phoenix, AZ

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Frontiers of Earth Science 2019年第3期13卷 445-463页

作者： Yiannis KAMArIANAKIS Xiaoxiao LI B. L. TUrNEr II anthony j. BrAZEL School of Mathematical and Statistical Sciences Arizona State UniversityTempe AZ 85287USA School of Geographical Sciences and Urban Planning Arizona State UniversityTempe AZ 85298USA School of Sustainability Arizona State UniversityTempe AZ 85298USA Global Institute of Sustainability Arizona State UniversityTempe AZ 85287USA

The impacts of land-cover composition on urban temperatures, including temperature extremes, are well documented. Much less attention has been devoted to the consequences of land-cover configuration, most of which addresses land surface temperatures. This study explores the role of both composition and configuration—or land system architecture—of residential neighborhoods in the Phoenix metropolitan area, on near-surface air temperature. It addresses two-dimensional, spatial attributes of buildings, impervious surfaces, bare soil/ rock, vegetation and the “urbanscape” at large, from 50 m to 550 m at 100 m increments, for a representative 30-day high sun period. Linear mixed-effects models evaluate the significance of land system architecture metrics at different spatial aggregation levels. The results indicate that, controlling for land-cover composition and geographical variables, land-cover configuration, specifically the fractal dimension of buildings, is significantly associated with near-surface temperatures. In addition, statistically significant predictors related to composition and configuration appear to depend on the adopted level of spatial aggregation.

关键词： land system architecture urban heat island effect linear mixed-effects models near-surface air temperature land-cover configuration

Interactive Effect of Blackeye cowpea mosaic virus and Cucumber mosaic virus on Vigna unguiculata

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Horticultural Plant journal 2019年第2期5卷 88-92页

作者： Ayodele anthony Fajinmi Faculty of Agriculture Department of Crop Science and Horticulture Federal UniversityOye-Ekiti P.M.B. 374 Nigeria

This research tries to demonstrate physiological effect of combined infection of two viruses on growth parameter of cowpea plant as demonstrated through symptom expression. Blackeye cowpea mosaic virus(BlCMV) and Cucumber mosaic virus(CMV) were transmitted to cowpea plants by mechanical rub inoculation. This study showed that the differences in stem height and final aboveground fresh weight of cowpea plants inoculated with mixed infection with CMV and BlCMV were significantly less than those of plants inoculated with a single virus. Likewise cowpea plants inoculated with either virus alone or with CMV and BlCMV mixed infection had less stem height and aboveground fresh weight than the control. The mixed infection of BlCMV and CMV caused significant increase in the severity of symptoms in cowpea and also in the height using factors analysis and Abbott's equation. Symptom severity rating scale used, demonstrated statistical proof for physiological effect based on symptom severity for co-infection. A three phase disease symptom severity expression revealed disease severity for each viral treatment associated with host plant.

关键词： cowpea virus mixed infection interaction severity symptom

Two-stage corrective operation for the treatment of pes cavovarus in patients with spina bifida

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World journal of Orthopedics 2024年第7期15卷 618-626页

作者： anthony Mack Padgett Ezan Kothari Michael j Conklin Department of Orthopedics Indiana UniversityIndianapolisIN 46202United States Department of Orthopaedic Surgery University of Alabama at BirminghamBirminghamAL 35233United States Department of Orthopedic Surgery Children’s of AlabamaBirminghamAL 35233United States

BACKGrOUND Pes cavovarus has an estimated incidence of 8%-17%in patients with spina bifida(SB).The majority of the current literature on surgical treatment of cavovarus feet in children and adolescents includes a variety of *** are currently no case series describing a treatment algorithm for deformity correction in this specific patient *** authors of this study present the results of a retrospective case series performed to assess the radiographic outcomes of two-stage corrective surgery in patients with *** retrospective chart review was performed on patients with SB with a diagnosis of pes cavovarus at a freestanding children’s hospital who underwent surgical correction of the *** were excluded for lack of two-stage corrective operation,nonambulatory status,lack of at least six months follow-up,and age>18 years at the time of *** resulted in a cohort of 19 *** analysis was performed on 11 feet that had a complete series of preoperative and postoperative weightbearing *** and postoperative radiographic outcome measurements were compared using a two-sample *** Significant changes between the preoperative and postoperative measurements were seen in Meary’s angle,the anteroposterior talo-first metatarsal(AP TMT1)angle,and the talonavicular *** values of Meary’s angle were 17.9±13.1 preoperatively and 4.7±10.3 postoperatively(P=0.016).Mean AP TMT1 angle was 20.6±15.1 preoperatively and 9.3±5.5 postoperatively(P=0.011).Mean talonavicular coverage values were-10.3±9.6 preoperatively and-3.8±10.1 postoperatively(P=0.025).CONCLUSION The two-stage corrective procedure demonstrated efficacy in correcting cavovarus deformity in patients with *** should strongly consider employing the staged surgical algorithm presented in this manuscript for management of these patients.

关键词： Cavovarus Spina bifida Osteotomy Plantar release radiographs Pediatrics

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半导体激光抽运探针源

中国激光 2000年第12期27卷 1085-1088页

作者：阎平 anthony j.Vickers 北京理工大学光电工程系北京100081 德国爱塞克斯大学电子工程系

从理论上和系统实验上阐述了一种新型全固化半导体激光抽运探针源。此抽运探针源利用激光增益开关控制的原理 ,通过控制直流偏置电流和射频驱动电流可产生两列重复频率在 1GHz左右 ,脉宽约为 50 ps的激光脉冲序列 ,并且两脉冲序列间的... 详细信息

从理论上和系统实验上阐述了一种新型全固化半导体激光抽运探针源。此抽运探针源利用激光增益开关控制的原理 ,通过控制直流偏置电流和射频驱动电流可产生两列重复频率在 1GHz左右 ,脉宽约为 50 ps的激光脉冲序列 ,并且两脉冲序列间的时间延迟在 2 0 0 ps范围可调。

关键词：半导体激光器抽运探针激光脉冲集成电路

Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

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International journal of Mechanical System Dynamics 2023年第1期3卷 48-57页

作者： Harry j.Carpenter Mergen H.Ghayesh anthony C.Zander Peter j.Psaltis School of Electrical and Mechanical Engineering University of AdelaideAdelaideSouth AustraliaAustralia Vascular research Centre Lifelong Health ThemeSouth Australian Health and Medical Research Institute(SAHMRI)AdelaideSouth AustraliaAustralia Adelaide Medical School University of AdelaideAdelaideSouth AustraliaAustralia Department of Cardiology Central Adelaide Local Health NetworkAdelaideSouth AustraliaAustralia

In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)*** one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its *** can include the unique dynamical factors present in the coronary *** investigate the impact of these dynamical factors,we study an idealized artery model with sequential *** transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary *** compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI *** suggest that the motion of the artery can impact downstream patterns in both divergence and *** magnitude is also decreased by up to 57%due to motion in some *** divergence patterns varied most significantly between simulations over the systolic period,the time of the largest *** investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

关键词： computational fluid dynamics divergence fluid–structure interaction topology wall shear stress

Potassium carbonate-based ternary transition temperature mixture(deep eutectic analogues)for CO_(2)absorption:Characterizations and DFT analysis

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Frontiers of Environmental Science & Engineering 2022年第7期16卷 113-124页

作者： Hosein Ghaedi Payam Kalhor Ming Zhao Peter T.Clough Edward j.anthony Paul S.Fennell School of Environment Tsinghua UniversityBeijing100084China Department of Chemistry Tsinghua UniversityBeijing100084China Energy and Power Theme Cranfield UniversityCranfieldBedfordshireMK430ALUK Department of Chemical Engineering Imperial College LondonSouth KensingtonLondonSW72AZUK

Is it possible to improve CO_(2)solubility in potassium carbonate(K_(2)CO_(3))-based transition temperature mixtures(TTMs)?To assess this possibility,a ternary transition-temperature mixture(TTTM)was prepared by using a hindered amine,2-amino-2-methyl-1,3-propanediol(AMPD).Fourier transform infrared spectroscopy(FT-Ir)was employed to detect the functional groups including hydroxyl,amine,carbonate ion,and aliphatic functional groups in the prepared *** thermogravimetric analysis(TGA),it was found that the addition of AMPD to the binary mixture can increase the thermal stability of *** viscosity findings showed that TTTM has a higher viscosity than TTM while their difference was decreased by increasing *** addition,Eyring’s absolute rate theory was used to compute the activation parameters(∆G^(*),∆H^(*),and ∆S^(*)).The CO_(2)solubility in liquids was measured at a temperature of 303.15 K and pressures up to 1.8 *** results disclosed that the CO_(2)solubility of TTTM was improved by the addition of *** the pressure of about 1.8 MPa,the CO_(2)mole fractions of TTM and TTTM were 0.1697 and 0.2022,*** confirm the experimental data,density functional theory(DFT)was *** the DFT analysis,it was found that the TTTM+CO_(2)system has higher interaction energy(|∆E|)than the TTM+CO_(2)system indicating the higher CO_(2)affinity of the former *** study might help scientists to better understand and to improve CO_(2)solubility in these types of solvents by choosing a suitable amine as HBD and finding the best combination of HBA and HBD.

关键词： Ternary transition-temperature mixture FT-Ir and thermal stability analysis Viscosity and correlation study Eyring’s absolute rate theory CO_(2)solubility Density functional theory(DFT)

PacBio Sequencing and Its Applications

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Genomics, Proteomics & Bioinformatics 2015年第5期13卷 278-289页

作者： anthony rhoads Kin Fai Au Department of Biostatistics University of Iowa Department of Internal Medicine University of Iowa

Single-molecule, real-time sequencing developed by Pacific BioSciences offers longer read lengths than the second-generation sequencing （SGS） technologies, making it well-suited for unsolved problems in genome, transcriptome, and epigenetics research. The highly-contiguous de novo assemblies using PacBio sequencing can close gaps in current reference assemblies and characterize structural variation （SV） in personal genomes. With longer reads, we can sequence through extended repetitive regions and detect mutations, many of which are associated with dis- eases. Moreover, PacBio transcriptome sequencing is advantageous for the identification of gene isoforms and facilitates reliable discoveries of novel genes and novel isoforms of annotated genes, due to its ability to sequence full-length transcripts or fragments with significant lengths. Addition- ally, PacBio＇s sequencing technique provides information that is useful for the direct detection of base modifications, such as methylation. In addition to using PacBio sequencing alone, many hybrid sequencing strategies have been developed to make use of more accurate short reads in conjunction with PacBio long reads. In general, hybrid sequencing strategies are more affordable and scalable especially for small-size laboratories than using PacBio Sequencing alone. The advent of PacBio sequencing has made available much information that could not be obtained via SGS alone.

关键词： Third-generation sequencing De novo assembly Gene isoform detection Methylation Hybrid sequencing

Color Cherenkov imaging of clinical radiation therapy

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Light(Science & Applications) 2021年第12期10卷 2380-2386页

作者： Daniel A.Alexander anthony Nomezine Lesley A.jarvis David j.Gladstone Brian W.Pogue Petr Bruza Thayer School of Engineering Dartmouth CollegeHanoverNHUSA DoseOptics LLC LebanonNHUSA Geisel School of Medicine Dartmouth CollegeHanoverNHUSA Norris Cotton Cancer Center DartmouthHitchcock Medical CenterLebanonNHUSA

Color vision is used throughout medicine to interpret the health and status of *** radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect,and this light is attenuated by tissue features as it leaves the *** this study,a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during *** spectral content was interpreted by comparison with imaging calibrated tissue *** shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume,oxygen saturation and major vessels within the body.

关键词： therapy clinical Color