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Evaluation of markers of outcome in realworld treatment of diabetic macular edema

Eye and Vision 2018年第1期5卷 240-249页

作者： antónio Campos Elisa J Campos Anália do Carmo francisco Caramelo João Martins João P Sousa antónio francisco ambrósio Rufino Silva Coimbra Institute for Clinical and Biomedical Research(iCBR) Faculty of MedicineUniversity of CoimbraAzinhaga de Santa CombaCelas3000-548 CoimbraPortugal CNC.iCBR Consortium University of CoimbraCoimbraPortugal Department of Ophthalmology Leiria HospitalLeiriaPortugal Clinical Pathology Department Centro Hospitalar Universitário de Coimbra(CHUC)CoimbraPortugal Laboratory of Biostatistics and Medical Informatics Faculty of MedicineUniversity of CoimbraCoimbraPortugal Medical Sciences Department Faculty of Health SciencesUniversity of Beira InteriorCovilhãPortugal Association for Innovation and Biomedical Research on Light and Image(AIBILI) CoimbraPortugal Department of Ophthalmology Centro Hospitalar Universitário de Coimbra(CHUC)CoimbraPortugal

Objective:To evaluate short-term markers of outcome in diabetic macular edema(DME).Methods:Prospective interventional case series included 122 eyes of 122 patients with recently diagnosed *** were treated with a 3-monthly loading dose of ranibizumab or aflibercept and pro re nata *** enhanced deep imaging SD-OCT high resolution scans were used to measure subfoveal choroidal thickness(SFCT)and central retinal thickness(CRT).Anatomic(10%CRT decrease)and functional responses(best corrected visual acuity,BCVA gain≥5 letters)were assessed at 3 months and 6 months using univariate and multivariate *** tested were gender,duration of diabetes,HbA1c,hypertension,CRT,SFCT,BCVA,ellipsoid zone(EZ)status,subfoveal neuroretinal detachment(SND),anti-VEGF used and laser naivety.A logistic regression model was applied to find independent markers ***:BCVA increased,CRT and SFCT decreased at 3 months and 6 *** metabolic control(p=0.003),intact baseline EZ(p=0.030),EZ re-grading at 3 M(psion model showed that baseline SND and CRT are predictors of anatomic response,while lower baseline BCVA and intact EZ are predictors of functional ***:The presence of SND predicts anatomic response only,while an intact EZ is critical to achieve a good functional outcome in DME.

关键词： Diabetic macular edema Outcome factors Spectral-domain optical coherence tomography antivascular endothelial growth factor Laser

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Calculations of Optical Rotation from Density Functional Theory

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Chinese Physics Letters 2007年第5期24卷 1207-1209页

作者： antǒnio Canal Neto francisco Elias Jorge Departamento de Fisica Universidade Federal do Espírito Santo 29060-900 Vitória ES Brazil

Density function theory calculations of frequency-dependent optical rotations [α]ω for three rigid chiral molecules are reported. Calculations have been carried out at the sodium D line frequency, using the ADZP basis set and a wide variety of functionals. Gauge-invariant atomic orbitals are used to guarantee origin-independent values of [ω]D. In addition, study of geometry dependence of [ω]D is reported. Using the geometries optimized at the B3LYP/ADZP level, the mean absolute deviation of B3LYP/ADZP and experimental laiD values yields 60.1°/（dm g/cm^3）. According to our knowledge, this value has not been achieved until now with any other model.

关键词： MOLECULAR WAVE-FUNCTIONS BASIS-SETS MP2 HF

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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All-electron ZORA triple zeta basis sets for the elements Cs-La and Hf-Rn

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Chinese Physics B 2023年第9期32卷 242-249页

作者： antônio Canal Neto francisco E.Jorge Henrique R.Cda Cruz Departamento de Física Universidade Federal do Espírito Santo29075-910 VitóriaESBrazil

Segmented all-electron basis set of triple zeta valence quality plus polarization functions(TZP)for the elements of the fifth row to be used together with the zero-order regular approximation(ZORA)is carefully *** correctly describe electrons distant from atomic nuclei,the basis set is augmented with diffuse functions giving rise to a set designated as *** the ZORA-B3LYP theoretical level,these sets are used to calculate the ionization energy and mean dipole polarizability of some atoms,bond length,dissociation energy,and harmonic vibrational frequency of diatomic ***,these results are compared with the theoretical and experimental data found in the *** considering that our sets are relatively compact,they are sufficiently accurate and reliable to perform property calculations involving simultaneously electrons from the inner shell and outer *** performances of the ZORA and second-order Douglas-Kroll-Hess Hamiltonians are evaluated and the results are also discussed.

关键词： TZP-ZORA and ATZP-ZORA basis sets ZORA-B3LYP method Cs-La and Hf-Rn elements atomic and molecular properties

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Acute abdomen in pregnancy due to isolated Fallopian tube torsion: The laparoscopic treatment of a rare case

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World Journal of Clinical Cases 2014年第11期2卷 724-727页

作者： Zacharoula Sidiropoulou antónio Setúbal General Surgery Department Hospital S?o Francisco Xavier-CHLO 1449-005 Lisbon Portugal Gynecology and Obstetrics Department Hospital da Luz 1500-650 Lisbon Portugal

In the last years, operative laparoscopy became a standard approach in gynaecology and general surgery. Even in pregnancy its use is becoming more widely accepted. In fact, it offers advantages similar to those in no pregnant women, associated with good maternal and fetal outcomes. Around 0.2% of pregnant women require abdominal surgery. The most common indications of laparoscopy in pregnancy are cholelithiasis complications, appendicitis, persistent ovarian cyst and adnexal torsion. Authors describe a very rare case of acute abdomen due to isolated Fallopian tube torsion in a 24 th weeks pregnant woman, managed by laparoscopic salpingectomy.

关键词： Fallopian tube torsion Acute abdomen Pregnancy Laparoscopy

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Control of inherited structural fabric on the development and exhumation of passive margins-Insights from the AraçuaíOrogen(Brazil)

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Geoscience Frontiers 2023年第6期14卷 30-48页

作者： Ana Fonseca Tiago Novo Tobias Fonte-Boa Matheus Kuchenbecker Daniel Galvão Carnier Fragoso Daniel Peifer antônio Carlos Pedrosa-Soares Johan De Grave Laboratory for Mineralogy and Petrology Department of GeologyGhent UniversityKrijgslaan 281 S89000 GhentBelgium Universidade Federal de Minas Gerais Programa de Pós-Graduação em GeologiaCPMTC-IGCCampus PampulhaBelo HorizonteMGBrazil Centro de Pesquisas Professor Manoel Teixeira da Costa Instituto de GeociênciasUniversidade Federal de Minas GeraisBelo HorizonteBrazil Universidade Federal dos Vales do Jequitinhonha e Mucuri Instituto de Ciência e TecnologiaCentro de Estudos em GeociênciasLaboratório de Estudos TectônicosDiamantinaBrazil Petrobras Rio de JaneiroRJBrazil Instituto de Geociências Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Department of Geosciences University of TübingenSchnarrenbergstr.94-9672076 TübingenGermany

The AraçuaíOrogen,in eastern Brazil,was formed during the Neoproterozoic–Cambrian amalgamation of West *** the Mesozoic–Cenozoic opening of the South Atlantic Ocean,and the associated divergent tectonics,the orogen developed as basement to the passive margin of South America and was progressively covered by thick offshore sedimentary basins,particularly the Espírito Santo,Mucuri,and Cumuruxatiba basins,in which hydrocarbon systems have been *** understanding of the AraçuaíOrogen’s passive margin evolution,erosion,and sediment transfer to these basins ultimately depends on constraining the onshore exhumation in response to Mesozoic–Cenozoic ***,new and previously published data from apatite fission-track(AFT)analyses and inverse thermal history modelling of(Pre)Cambrian basement rocks from the AraçuaíOrogen resolve three discrete basement cooling and associated erosional exhumation *** the Pre-Rift phase,Jurassic–Hauterivian erosion of the AraçuaíOrogen is most likely related to the adjoining intra-continental West Gondwana flexural subsidence,which increased hillslope and river erosion *** the Rift and Transitional phases,Barremian–Albian accelerated phase of erosion is associated with the uplift of the Atlantic rift shoulders and the establishment of an oceanic *** the Drift phase,reactivations in response to far-field stresses likely triggered a Late Cretaceous–Paleocene rapid erosion *** rates at which these events unfolded vary spatially and are controlled by inherited *** AraçuaíOrogen experienced slower denudation rates in areas closer to the São francisco Craton,which suggests that the tectonic reactivation and related surface uplift during the Mesozoic–Cenozoic is in first-order controlled by lithospheric ***,the structural framework of the Paramirim and Pirapora aulacogens and NE-oriented shear zones in the orogen’s southeast facilitated later *** the spati

关键词： Thermal history Denudation Tectonic inheritance Reactivations South Atlantic Hydrocarbons

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SARS-CoV-2 Pandemic Impact Assessment for Hearing Impaired Patients

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Advances in Infectious Diseases 2021年第3期11卷 261-268页

作者： Natalia Chilinque Zambã o da Silva Manoela Moreira de Oliveira Vitória francisco Pereira Ana Carolina antônio Correia Universidade Estácio de Sá Presidente Vargas Rio de Janeiro Brazil Universidade Estácio de Sá Campus Presidente Vargas Rio de Janeiro Brazil

COVID-19 is a systemic infectious disease caused by the new SARS-CoV-2 coronavirus. The COVID-19 pandemic has caused social, economic, political, and cultural repercussions for humanity. Although Brazilian Sign Language (Libras) has been recognized since 2002 as a legal means of communication and expression, most individuals with hearing impairment in Brazil do not have access to accurate information about SARS-CoV-2 available to them in Libras. Between July 2020 and November 2020, the impact of COVID-19 on deaf and hearing impaired individuals was assessed through a closed questionnaire, using Libras, via a digital platform. Deaf and hearing impaired individuals over 18 years of age and living in the Metropolitan Region II of Rio de Janeiro were eligible to participate. Frequencies were calculated for categorical variables. From the total questionnaires submitted, 55.5% of respondents claim to have “a lot” of knowledge regarding COVID-19, and 44.4% of those individuals indicated they gained this knowledge through social media. Additionally, the main difficulties encountered by the deaf and hearing impaired population during the pandemic were: communicating with others wearing masks, and poor access to medical care. Thus, for full physical, mental, and social well-being, the state must invest in the inclusion of this population through public health measures.

关键词： COVID-19 Deafness Pandemic

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Understanding Tremor in Rapid Upper Limb Movements Using 3D Accelerometers Data

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Neuroscience & Medicine 2014年第5期5卷 205-213页

作者： Paula Pascoal-Faria Miguel Patrício Adriana Leal francisco Caramelo antónio Freire Cristina Januário Miguel Castelo-Branco Center for Rapid and Sustainable Product Development (CDRSP) School of Technology and Management (ESTG) of the Polytechnic Institute of Leiria (IPLeiria) Leiria Portugal IBILI Faculty of Medicine University of Coimbra Coimbra Portugal Laboratory of Biostatistics and Medical Informatics IBILI Faculty of Medicine University of Coimbra Coimbra Portugal Neurology Department Coimbra University Hospital Centre (CHUC) Coimbra Portugal

Tremor is a manifestation of a variety of human neurodegenerative diseases, notably Parkinson’s disease (PD) and Essential Tremor (ET), both affecting millions worldwide. PD is primarily caused by a progressive loss of dopamine neurons in the nigrostriatal system that leads to widespread motor symptoms such as bradykinesia, rigidity, tremor and postural instability. ET typically involves a tremor of the arms, hands or fingers. No definitive test or biomarker is yet available for PD or ET, so the rate of misdiagnosis is relatively high. As tremor is a very common feature at the onset of both diseases, it is crucial to be able to characterize it. This is made possible using acce?lerometers to quantify the tremor amplitude and frequency. In this work we aim to find tasks involving upper limb movements that are suitable to modulate both types of tremor. Four tasks were tested, differing on whether the arms moved together or alternatingly and whether loads were added. Significant differences in tremor measures were found when patients were asked to perform simultaneous rapid arms movements with loads placed on their wrists. These results may allow the design of an efficient fMRI protocol for identifying the cortical circuits responsible for the modulation of tremor.

关键词： Disease Essential Tremor Tremor Quantification Tremor Modulation Accelerometers

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