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A recurrent homozygous missense mutation in CCDC103 causes asthenoteratozoospermia due to disorganized dynein arms

Asian Journal of Andrology 2022年第3期24卷 255-259页

作者： Muhammad Zubair Ranjha Khan Ao Ma Uzma Hameed Mazhar Khan Tanveer Abbas Riaz Ahmad Jian-Teng Zhou Wasim Shah ansar hussain Nisar Ahmed Ihsan Khan Khalid Khan Yuan-Wei Zhang Huan Zhang Li-Min Wu Qing-Hua Shi The First Affiliated Hospital of USTC The CAS Key Laboratory of Innate Immunity and Chronic DiseasesSchool of Life SciencesCAS Center for Excellence in Molecular Cell ScienceCollaborative Innovation Center of Genetics and DevelopmentUniversity of Science and Technology of ChinaHefei 230027China Institute of Industrial Biotechnology Government College UniversityLahore 54000Pakistan Medical Genetics Research Laboratory Department of BiotechnologyQuaid-i-Azam UniversityIslamabad 45320Pakistan

Asthenoteratozoospermia is one of the most severe types of qualitative sperm *** cases are due to mutations in genes encoding the components of sperm flagella,which have an ultrastructure similar to that of motile ***-coil domain containing 103(CCDC103)is an outer dynein arm assembly factor,and pathogenic variants of CCDC103 cause primary ciliary dyskinesia(PCD).However,whether CCDC103 pathogenic variants cause severe asthenoteratozoospermia has yet to be ***-exome sequencing(WES)was performed for two individuals with nonsyndromic asthenoteratozoospermia in a consanguineous family.A homozygous CCDC103 variant segregating recessively with an infertility phenotype was identified(ENST00000035776.2,c.461A>C,***154Pro).CCDC103 ***154Pro was previously reported as a high prevalence mutation causing PCD,though the reproductive phenotype of these PCD individuals is *** electron microscopy(TEM)of affected individuals’spermatozoa showed that the mid-piece was severely damaged with disorganized dynein arms,similar to the abnormal ultrastructure of respiratory ciliary of PCD individuals with the same ***,our findings expand the phenotype spectrum of CCDC103 ***154Pro as a novel pathogenic gene for nonsyndromic asthenospermia.

关键词： asthenoteratozoospermia CCDC103 dynein arms male infertility

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Hydrometallurgical leaching and kinetic modeling of low-grade manganese ore with banana peel in sulfuric acid

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International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 193-200页

作者： Sajjad Ali Yaseen Iqbal Inamullah Khan ansar Ullah Muhammad Sadiq Muhammad Fahad Khizar hussain Shah Materials Research Laboratory Department of PhysicsUniversity of Peshawar25120 PeshawarPakistan Department of Electrical and Computer Engineering COMSATS University IslamabadAbbottabad CampusUniversity Road 22060 AbbottabadPakistan Department of Chemistry COMSATS University IslamabadAbbottabad CampusUniversity Road 22060 AbbottabadPakistan

Manganese was leached from a low-grade manganese ore(LGMO)using banana peel as the reductant in a dilute sulfuric acid *** effects of banana peel amount,H2SO4 concentration,reaction temperature,and time on Mn leaching from the complex LGMO were studied.A leaching efficiency of~98%was achieved at a leaching time of 2 h,banana peel amount of 4 g,leaching temperature of 120°C,manganese ore amount of 5 g,and sulfuric acid concentration of 15vol%.The phase,microstructural,and chemical analyses of LGMO samples before and after the leaching process confirmed the successful leaching of ***,the leaching process followed the shrinking core model and the leaching rate was controlled by a surface chemical reaction(1−(1−x)^1/3=kt)mechanism with an apparent activation energy of 40.19 kJ·mol^−1.

关键词： low-grade manganese ore glucose leaching kinetics activation energy

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Crop photosynthetic response to light quality and light intensity

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Journal of Integrative Agriculture 2021年第1期20卷 4-23页

作者： Iram SHAFIQ Sajad hussain Muhammad Ali RAZA Nasir IQBAL Muhammad Ahsan ASGHAR Ali RAZA FAN Yuan-fang Maryam MUMTAZ Muhammad SHOAIB Muhammad ansar Abdul MANAF YANG Wen-yu YANG Feng College of Agronomy Sichuan Agricultural UniversityChengdu 611130P.R.China Sichuan Engineering Research Center for Crop Strip Intercropping Chengdu 611130P.R.China College of Resources Sichuan Agricultural UniversityChengdu 611130P.R.China Department of Agronomy Pir Mehr Ali Shah Arid Agriculture University RawalpindiPunjab 46300Pakistan

Under natural conditions, plants constantly encounter various biotic and abiotic factors, which can potentially restrict plant growth and development and even limit crop productivity. Among various abiotic factors affecting plant photosynthesis, light serves as an important factor that drives carbon metabolism in plants and supports life on earth. The two components of light(light quality and light intensity) greatly affect plant photosynthesis and other plant's morphological, physiological and biochemical parameters. The response of plants to different spectral radiations and intensities differs in various species and also depends on growing conditions. To date, much research has been conducted regarding how different spectral radiations of varying intensity can affect plant growth and development. This review is an effort to briefly summarize the available information on the effects of light components on various plant parameters such as stem and leaf morphology and anatomy, stomatal development, photosynthetic apparatus, pigment composition, reactive oxygen species(ROS) production, antioxidants, and hormone production.

关键词： light intensity light quality photosynthesis stomatal development pigment composition reactive oxygen species antioxidants plant hormones

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Smart Dynamic Trafc Monitoring and Enforcement Syste

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Computers, Materials & Continua 2021年第6期 2797-2806页

作者： Youssef El-Hansali Fatma Outay ansar Yasar Siham Farrag Muhammad Shoaib Muhammad Imran Hammad hussain Awan Transportation Research Institute(IMOB) Universiteit HasseltHasselt3590Belgium College of Technological Innovation Zayed UniversityDubai19282UAE Department of Civil Engineering Middle East College(MEC)Muscat124Oman College of Computer and Information Sciences King Saud UniversityRiyadh12372Saudi Arabia The University of Lahore(Islamabad Campus) Islamabad44000Pakistan

Enforcement of trafc rules and regulations involves a wide range of complex tasks,many of which demand the use of modern *** speed limits(VSL)control is to change the current speed limit according to the current trafc situation based on the observed trafc *** aim of this study is to provide a simulation-based methodological framework to evaluate(VSL)as an effective Intelligent Transportation System(ITS)enforcement *** focus of the study is on measuring the effectiveness of the dynamic trafc control strategy on trafc performance and safety considering various performance indicators such as total travel time,average delay,and average number of *** Arab Emirates(UAE)was selected as a case study to evaluate the effectiveness of this strategy.A micro simulation software package VISSIM with add-on module VisVAP is used to evaluate the impacts of *** has been observed that VSL control strategy reduced the average delay time per vehicle to around 7%,travel time by 3.2%,and number of stops by 48.5%.Dynamic trafc control strategies also alleviated congestion by increasing the capacity of the bottleneck section and improving *** of this study would act as a guidance for engineers and decision makers to new trafc control system implementation.

关键词： ITS safety variable speed limits ITS VISSIM

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