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Critical Review on Balanites aegyptiaca Delile:Phytoconstituents,Pharmacological Properties and Nanointerventions

Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： Surendra kumar Gautam Rakesh kumar Paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanBandarsindriAjmerRajasthan305817India University Institute of Pharmaceutical Sciences Panjab UniversityChandigarh160014India

Balanites aegyptiaca Delile(BA)is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot).It belongs to the family Zygophyllaceae,which is specific to be drought areas of Nigeria,Africa,South Asia and India(Rajasthan).In Ayurveda,this traditional medicinal plant is reported for the management of jaundice,syphilis,yellow fever,metabolic disorders,liver,and spleen *** main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of *** per the literature survey,various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence,chemical constituents,nano-formulations,commercialized products,and clinical *** remarkable scaffolds and isolated compounds like diosgenin,yamogenin,balanitin1/2,balanitin 3,bal4/5,bal6/7,rutin-3-glycosides,3,7-diglycosides,(3,12,14,16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been ***,this traditional plant has been scientifically proven by in vitro and in *** on the complete review of this plant,most of the compounds have been isolated from the fruit and kernel ***,based on the literature,a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological *** a spinous desert dates,this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

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Negative Stiffness Mechanism on An Asymmetric Wave Energy Converter by Using A Weakly Nonlinear Potential Model

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China Ocean Engineering 2024年第4期38卷 689-700页

作者： Sunny kumar POGULURI Dongeun KIM Yoon Hyeok BAE Department of Ocean Engineering IIT MadrasChennaiIndia Multidisciplinary Graduate School Program for Wind Energy Jeju National UniversityJejuRepublic of Korea Mechanical and System Design Engineering Hongik UniversitySeoulRepublic of Korea

Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave *** can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow *** model was initially validated by comparing it with published experimental and numerical computational fluid dynamics *** current results were in good agreement with the published *** was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular *** irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately *** findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.

关键词： asymmetric wave energy converter negative stiffness mechanism weakly nonlinear potential flow power

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Genetic variability and trait association analysis in linseed(Linum usitatissimum L.)for yield and related traits

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Oil Crop Science 2024年第3期9卷 151-159页

作者： Sandeep kumar Yadav Neha Singh Hemant kumar Yadav CSIR-National Botanical Research Institute Rana Pratap MargLucknow226001UPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad201002India State Planning Commission LucknowUPIndia

Diversity information mining about a crop for different attributes is an essential step for effective breeding *** present investigation evaluates the quantum of genetic variability and determines the relationship among the important agro-economic traits based on two years of phenotypic data of 210 accessions of *** traits,capsule weight per plant,capsule per plant,husk weight per plant,and seed weight per plant exhibited comparatively higher genetic coefficient of variation(GCV)and phenotypic coefficient of variation(PCV).In contrast,oil content and seed per capsule exhibited a lower *** high magnitude of broad sense heritability was observed for all traits except seeds per capsule and husk weight per *** trait,capsules per plant,plant height,and days to 50%flowering showed high genetic advance coupled with high *** cluster analysis grouped 210 accessions into six distinct *** of 210,144(68.57%)accessions were grouped into three clusters(I,II,and III),in which cluster-III was the largest,containing 64 accessions followed by cluster II and *** highest inter-cluster distance was observed between clusters-I and V(127.85),while the lowest was between clusters-II and IV(27.09).The positive correlation of capsule weight per plant with the seed weight per plant and a negative correlation with the days to 50%flowering indicates that high yielding linseed varieties with early flowering/maturity could be developed through direct and indirect ***,seed yield and oil content could be enhanced together as indicated by ghe positive association among these two important *** this study,high yielding accessions with moderate to high oil content such as GP36,GP31,GP14,GP54,GP26,GP24,GP34,GP21,GP37 and GP27 and early flowering(less than 70 days)accessions such as GP2,GP26,GP27,CG33,CG44,CG42,CG132,and CG31 identified as potential genetic materials that could be exploited for developing early matu

关键词： Linseed Genetic variability Heritability Genetic advance PCA Dendrogram

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Detection of internal crack growth in polyethylene pipe using guided wave ultrasonic testing

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 319-329页

作者： Jay kumar Shah Hao Wang Said El-Hawwat Centre of Advanced Infrastructure and Transportation RutgersThe State University of New JerseyNJ 08854USA Department of Civil and Environmental Engineering RutgersThe State University of New JerseyNJ 08854USA

Despite the success of guided wave ultrasonic inspection for internal defect detection in steel pipes,its application on polyethylene(PE)pipe remains relatively *** growth of internal cracks in PE pipe severely affects its pressure-holding capacity,hence the early detection of internal cracks is crucial for effective pipeline maintenance *** study extends the scope of guided wave-based ultrasonic testing to detect the growth of internal cracks in a natural gas distribution PE *** experiments and a finite element model were planned to study the wave-crack interaction at different stages of axially oriented internal crack growth with a piezoceramic transducer-based setup arranged in a pitch-catch *** dispersion analysis supplemented with preliminary experiments was performed to isolate the optimal inspection frequency,leading to the selection of the T(0,1)mode at 50-kHz for the investigation.A transmission index based on the energy of the T(0,1)mode was developed to trace the extent of simulated crack *** findings revealed an inverse linear correlation between the transmission index and the crack depth for crack growth beyond 20%crack depth.

关键词： polyethylene pipes internal cracks guided wave ultrasonic testing torsional modes finite element modeling

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Colorectal cancer cell dormancy:An insight into pathways

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World Journal of Gastroenterology 2024年第33期30卷 3810-3817页

作者： Anil kumar Lekha Saha Department of Pharmacology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Cancer cell dormancy(CCD)in colorectal cancer(CRC)poses a significant challenge to effective *** CRC,CCD contributes to tumour recurrence,drug resistance,and amplifying the disease's *** molecular mechanisms governing CCD and strategies for eliminating dormant cancer cells remain largely ***,understanding the molecular mechanisms governing dormancy is crucial for improving patient outcomes and developing targeted *** editorial highlights the complex interplay of signalling pathways and factors involved in colorectal CCD,emphasizing the roles of Hippo/YAP,pluripotent transcription factors such as NANOG,HIF-1αsignalling,and Notch signalling ***,ERK/p38α/β/MAPK pathways,AKT signalling pathway,and Extracellular Matrix Metalloproteinase Inducer,along with some potential less explored pathways such as STAT/p53 switch and canonical and non-canonical Wnt and SMAD signalling,are also involved in promoting colorectal *** their clinical significance,these findings may offer the potential for identifying key dormancy regulator pathways,improving treatment strategies,surmounting drug resistance,and advancing personalized medicine ***,insights into dormancy mechanisms could lead to the development of predictive biomarkers for identifying patients at risk of recurrence and the tailoring of targeted therapies based on individual dormancy *** is essential to conduct further research into these pathways and their modulation to fully comprehend CRC dormancy mechanisms and enhance patient outcomes.

关键词： Colorectal cancer Colorectal cancer cell dormancy Cancer cell dormancy Pathways in colorectal cancer dormancy

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Gravity-driven powder flow and the influence of external vibration on flow characteristics

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Particuology 2024年第5期88卷 201-209页

作者： Muhammad Shahid Ansari Ratna kumar Annabattula Sathyan Subbiah Department of Mechanical Engineering Indian Institute of Technology MadrasChennai 600036India

The controlled and homogeneous flow of dry granular powders through hoppers is essential for applications,namely,packaging of food grains,fertilizers and additive manufacturing processes such as directed energy deposition for better product *** of the major issues encountered in the granular flows through hoppers is flow stagnation due to the well-known arching ***-assisted granular flow through hoppers is one of the mechanisms used for better mass flow *** this work,the influence of external mechanical vibration on the powder flow is investigated experimentally and using discrete element ***,the mass flow rate through the hopper increases with an increase in vibration amplitude and then decreases,signifying the existence of an optimal amplitude of *** DEM simulations explained the underlying mechanisms for the existence of an optimal amplitude of vibration corresponding to the maximum mass flow rate.A range of vibration amplitudes from 0 mm to 3.5 mm is used to study the flow behaviour;the maximum flow of around 33 g/s to 35 g/s is observed for 0.75 mm to 1.25 mm vibration amplitude for the hopper-particle combination studied in this *** work also reports the influence of vibration frequency,hopper,and particle dimension on the flow *** research facilitates the effective use of mechanical vibration to enhance powder flow that can further be extended to non-spherical and multi-material particles.

关键词： Discrete element method Flow rate Granular flow Path tracking Vibration intensity

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Guardians of the fragrance:Uncovering the genetics behind citrus oil glands

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Plant Communications 2024年第5期5卷 97-99页

作者： Sunil kumar Sahu Muhammad Imran State Key Laboratory of Agricultural Genomics Key Laboratory of GenomicsMinistry of AgricultureBGI ResearchShenzhen 518083China BGI Research Wuhan 430074China State Key Laboratory for Conservation and Utilization of Subtropical AgroBioresources College of AgricultureSouth China Agriculture UniversityGuangzhou 510642China Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China

The colorful,nutrient-rich peels of citrus fruits have long been valued for their tangy flavors and aromatic *** oils are produced and stored in special secretory structures called oil glands,which are prevalent across citrus varieties(Knight et al.,2001).Oil glands serve as"reservoirs"for diverse metabolites such as terpenes and flavonoids that give citrus fruits their characteristic aroma(Mahato et al.,2019;Voo et al.,2012;Xian et al.,2022).Many of these compounds also act as chemical defenses against pest and pathogens(Fisher and Phillips,2008).

关键词： citrus Guard reservoirs

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Automated Time Based Multi-Criteria Bug Triage Approach:Developer Working Efficiency and Social Network Based Developer Recommendation

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 566-578页

作者： YADAV Asmita SINGH kumar Sandeep Krishna Engineering College Ghaziabad 201007India JIIT Noida 201309India

In software development projects,bugs are common *** report bugs in open source *** is a need to develop high quality developer prediction model that considers developer work satisfaction,keep within limited development cost,and improve bug resolution *** address and resolve bug report as soon as possible is the main focus of triager when a new bug is ***,developer work efficiency is an important factor in *** address these issues,a proposed approach recommends a set of developers that could potentially share their knowledge with each other to fix new bug *** proposed approach is called developer working efficiency and social network based developer recommendation(DweSn).It is a composite model that builds developers'profile by using developer average bug fixing time,work efficiency to fix variety of bugs,as well as the developer's social interactions with other developers.A similarity measure is applied between new bug and bugs in corpus to extract the list of capable developers from the *** proposed approach only selects those developers who are active and less loaded with *** developer with the highest profile score is assigned the *** evaluated our approach on the subset of five large open-source projects including Mozilla,Netbeans,Eclipse,Firefox and OpenOffice,and compared it with the *** results demonstrate that combination of developers'efficiency with their average bug fixing time and interactions in their social network gives good accuracy and efficiently reduces bug tossing *** approach shows an improvement in prediction accuracy,precision,recall,F-score and reduced bug tossing length up to 93.89%,93.12%,93.46%,93.27%and 93.25%,*** proposed approach achieved a 93%hit ratio and 93.34%mean reciprocal rank,indicating that our proposed triager is able to efficiently assign bugs to correct developers.

关键词： open-source repository bug report bug assignment tossing length bug triager developer social network developer recommendation

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Special Issue:International Conference on Sustainable Energy Sources,Technologies and Systems 2023(ICSESTS-2023)

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Clean Energy 2024年第3期8卷 136-137页

作者： Ravinder kumar Mohammad Hossein Ahmadi School of Mechanical Engineering Lovely Professional UniversityPhagwra-144411PunjabIndia Faculty of Mechanical Engineering Shahrood University of TechnologyShahroodIran

The Division of Research and Development at Lovely Professional University,Punjab organized the International Conference on Sustainable Energy Sources,Technologies and Systems 2023(ICSESTS-2023),which took place on 3-... 详细信息

关键词： solar energy storage wind energy geothermal hydropower biofuels batteries

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Enhancing Critical Path Problem in Neutrosophic Environment Using Python

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2957-2976页

作者： M.Navya Pratyusha Ranjan kumar VIT-AP University InavoluBesides AP SecretariatAmaravati APIndia

In the real world,one of the most common problems in project management is the unpredictability of resources and *** efficient way to resolve uncertainty problems and overcome such obstacles is through an extended fuzzy approach,often known as neutrosophic *** rigorous proposed model has led to the creation of an advanced technique for computing the triangular single-valued neutrosophic *** innovative approach evaluates the inherent uncertainty in project durations of the planning phase,which enhances the potential significance of the decision-making process in the *** proposed method,for the first time in the neutrosophic set literature,not only solves existing problems but also introduces a new set of problems not yet explored in previous research.A comparative study using Python programming was conducted to examine the effectiveness of responsive and adaptive planning,as well as their differences from other existing models such as the classical critical path problem and the fuzzy critical path *** study highlights the use of neutrosophic logic in handling complex projects by illustrating an innovative dynamic programming framework that is robust and flexible,according to the derived results,and sets the stage for future discussions on its scalability and application across different industries.

关键词： Classical critical path problem fuzzy critical path problem uncertainty neutrosophic triangular single-valued neutrosophic number neutrosophic critical path problem python programming languag

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