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Super-anti-freezing,tough and adhesive titanium carbide and L-ornithine-enhanced hydrogels

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生物质资源与工程(英文) 2023年第2期8卷 136-145页

作者： Zhangkang Li Jamie leblanc Hitendra Kumar Hongguang Zhang Weijun Yang Xiao He Qingye Lu Jeffrey Van Humbeck Keekyoung Kim Jinguang Hu Department of Biomedical Engineering University of CalgaryCalgaryUniversity Drive NWCalgaryAB T2N 1N4Canada Department of Chemistry University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Department of Mechanical and Manufacturing Engineering University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Pathology and Laboratory Medicine Cumming School of EngineeringUniversity of CalgaryHospital Drive NWT2N 4N1AlbertaCanada Department of Chemical and Petroleum Engineering University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China

Hydrogels are highly porous three-dimensional crosslinked polymer networks consisting of hy-drophilic polymers,employed most practically in medicine and industry,often as *** hydrogels suffer limitations in their mechanical properties,such as tensile and com-pression,and freeze at sub-zero temperatures,which compromise their ability as useful *** this study,the incorporation of L-ornithine-based zwitterionic monomer(OZM),titanium carbide(MXene),and glycerol within polyacrylamide hydrogels was used to prepare a novel polyacrylamide/polyL-ornithine-based zwitterion/MXene(PAM/Porn/MXene)hydrogel to im-prove the mechanical,adhesion,and anti-freezing properties of pure polyacrylamide *** study also analyzed the mechanical strength(tensile and compression),adhesion,and anti-freezing properties of a novel PAM/Porn/MXene hydrogel at 1%,4%,and 10%MXene concen-trations to establish to what extent the conductive MXene material enhanced these properties and concluded that the tensile and compressive properties improved linearly with the increase in the concentrations of MXene,adhesion decreased with the increased MXene concentrations,and syn-ergistic interaction between MXene and OZM significantly improved the anti-freezing properties up to-80°C.

关键词： Super-anti-freezing Tough Adhesive L-ornithine MXene

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Cuckoo Cafe

小学生时代（大嘴英语） 2022年第3期 16-17页

作者： Annette leblanc Cate 不详

Dual targeting nano-approaches for Alzheimer’s disease etiology

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Neural Regeneration Research 2021年第1期16卷 119-120页

作者： Sajini D.Hettiarachchi Roger M.leblanc Department of Chemistry University of Miami Coral GablesFLUSA

Alzheimer’s disease(AD)is the most common progressive neurodegenerative disorder of *** characteristic features of AD begin as mild cognitive dysfunctions,which gradually progress to the fatal delirium through a total loss of cognition and executive motor functions(Pimplikar et al.,2010).Three decades later from now,more than 100 million people will suffer from AD worldwide by making it the most expensive disease(Prince et al.,2013;Bloom,2014).The major pathological hallmarks of the AD is the extracellular amyloid-beta(Aβ)plaques deposition and the intracellular neurofibrillary tangle-aggregation of hyperphosphorylated *** the fact that Aβand tau-phosphorylation is the primary etiology for the AD,the recent concern developed on anti-amyloid mechanisms,such as cholinergic dysfunction and reactive oxygen species(ROS)*** current most prevalent clinical arena is,treating amyloid or non-amyloid hypothesis ***,the intercorrelated nature of amyloid and non-amyloid hypothesis governs the need of the intervention of combined diagnostic approaches.

关键词： Alzheimer spite aggregation

Effect of Soluble Components From Plant Aggregates on the Setting of the Lime-Based Binder

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Journal of Renewable Materials 2019年第9期7卷 903-913页

作者： Lepeng Wang Hélène Lenormand Hafida Zmamou Nathalie leblanc UniLaSalle Transformations&Agro-Resources Research UnitVAM²IN(EA 7519 UniLaSalle-Universitéd’Artois)3 rue du Tronquet76130 Mont-Saint-AignanFrance

Plant aggregate-based building materials are a viable solution for reducing greenhouse gas emissions and providing good thermal and acoustic *** this study,the investigated lightweight mortars require a hydraulic *** and on-site empirical observations about plant aggregate-based materials indicate a delay in setting time and a decrease in the mechanical performances of concretes based on plant *** natural origin of plant-aggregates causes a lot of variability in their *** studies have shown that the incompatibility between plant aggregates and cement is mainly caused by the dissolved and decomposed components of plant aggregates in alkaline ***,no research on the specific impact of each component on the setting time of lime-based binder *** this work,the impact of some soluble compounds(e.g.,sucrose,glucose,fructose,pectin)on the setting reaction of the lime matrix was studied using Vicat test,thermogravimetric analysis(TGA)and FT-IR *** results showed that carbohydrates such as glucose and sucrose not only affect the setting time but also have a long-term impact on the carbonation of *** measure of the setting time by Vicat test appears as a possible indicator to predict the compatibility between the matrix and plant aggregates.

关键词： Plant aggregates setting time lime-based binder carbohydrates hydration

Compressible Turbulent Boundary Layers on a Strongly Heated Wall

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Journal of Thermal Science 1993年第3期2卷 213-227页

作者： Doug-Bong LEE Franck SOCHELEAU Roger leblanc Department of Mechanical Engineering Inchon University Centre d’Etudes Aerodynamiques et Thermiques Université de Poitiers

This paper concerns the theoretical and experimental modelling of the flat wall,highly heated,compressible turbulent boundary *** final objective is to develop a numerical Navier-Stokes solver and to conclude on its capability to correctly represent complex aerothermic viscous flows near the *** paper presents a constructed numerical method with particular attention given to the turbulence modelling at low Reynolds number and comparisons with supersonic and transonic experimental *** the transonic experiment,very high wall temperature(Tw=1100K)is *** method of this difficult experimental set up is *** comparison between experimental and computational data conducts to the first conclusion and gives some indications for the future work.

关键词：边界层湍流热墙

Newfound Coding Potential of Transcripts Unveils Missing Members of Human Protein Communities

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Genomics, Proteomics & Bioinformatics 2023年第3期21卷 515-534页

作者： Se´bastien leblanc Marie *** Jean-Franc¸ois Jacques Amina M.Lekehal Andre´a Duclos Alexia Tremblay Alexis Bruggeman-Gascon Sondos Samandi Myle`ne Brunelle Alan A.Cohen Michelle S.Scott Xavier Roucou Department of Biochemistry and Functional Genomics Universite´de SherbrookeSherbrookeQC J1E 4K8Canada PROTEO Quebec Network for Research on Protein FunctionStructureand EngineeringQuebec CityQC G1V 0A6Canada Department of Family Medicine Universite´de SherbrookeSherbrookeQC J1H 5N4Canada

Recent proteogenomic approaches have led to the discovery that regions of the transcriptome previously annotated as non-coding regions[i.e.,untranslated regions(UTRs),open reading frames overlapping annotated coding sequences in a different reading frame,and non-coding RNAs]frequently encode proteins,termed alternative proteins(altProts).This suggests that previously identified protein–protein interaction(PPI)networks are partially incomplete because altProts are not present in conventional protein ***,we used the proteogenomic resource OpenProt and a combined spectrum-and peptide-centric analysis for the re-analysis of a highthroughput human network proteomics dataset,thereby revealing the presence of 261 altProts in the *** found 19 genes encoding both an annotated(reference)and an alternative protein interacting with each *** the 117 altProts encoded by pseudogenes,38 are direct interactors of reference proteins encoded by their respective parental ***,we experimentally validate several interactions involving *** data improve the blueprints of the human PPI network and suggest functional roles for hundreds of altProts.

关键词： Alternative protein Protein network Protein–protein interaction Pseudogene Affinity purification mass spectrometry

一种新的补偿硅电阻率/掺杂浓度模型(英文)

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Transactions of Nonferrous Metals Society of China 2011年第5期21卷 1172-1177页

作者： Dominic leblanc Karol PUTYERA Becancour Silicon Inc. Becancour G9H 2V8Canada Evans Analytical Group SyracuseNY 13211USA

硅片或硅块的电阻率与掺杂浓度的关系模型不适用于补偿硅,如精纯冶金级硅(UMG-Si)。目前尚无合适的理论模型可以准确解释补偿硅实验和观测结果间存在的差异。基于电解液理论提出一种包含电离平衡常数的新方法,可以得到单掺杂硅的电荷载... 详细信息

硅片或硅块的电阻率与掺杂浓度的关系模型不适用于补偿硅,如精纯冶金级硅(UMG-Si)。目前尚无合适的理论模型可以准确解释补偿硅实验和观测结果间存在的差异。基于电解液理论提出一种包含电离平衡常数的新方法,可以得到单掺杂硅的电荷载子迁移率Thurber曲线。当掺杂硅中包含一种以上掺杂物质时,需要采用数值算法来解决多重平衡系统。研究表明这类系统表现出一种缓冲溶液的特定行为。通过计算化合物的热力学参数获得平衡常数,并利用现有的电化学知识(Nerust方程和Butler-Volmer方程)提出一个普遍理论。因为硅/掺杂物系统构成一个弱电解质固溶体,电解质溶液理论为太阳能电池行为的认知提供了一个很好的物理模型和数学框架。

关键词：硅电阻率补偿 UMG 硼磷

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General Psychiatry 2019年第6期32卷 293-294页

作者： Nicole J leblanc Luana Marques Department of Psychiatry Massachusetts General Hospital Harvard Medical School

Despite ongoing research on the aetiology,phenomenology and treatment of anxiety disorders,these conditions continue to afflict myriads of individuals *** estimated 11.6%of the global population meets criteria for an anxiety disorder each year,1 and individuals with anxiety disorders experience both functional impairment2 and increased risk for physical health problems.3 In addition to the personal suffering associated with anxiety disorders,these conditions lead to considerable costs for society,including medical expenditures and lost work productivity.4 Moreover,although efficacious interventions for anxiety disorders are available,many individuals do not respond to these treatments5 or struggle to access evidence-based care.6 Thus,much work remains to be done to reduce the global burden of anxiety disorders.

关键词： impairment treatment etiology

Elderly patients with inflammatory bowel disease: Updated review of the therapeutic landscape

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World Journal of Gastroenterology 2019年第30期25卷 4158-4171页

作者： Jean-Frédéric leblanc Daniel Wiseman Peter L Lakatos Talat Bessissow Department of Adult Gastroenterology McGill University Health CentreMontrealQC H3G 1A4Canada Department of Medicine McGill University Health CentreMontrealQC H3G 1A4Canada 1^st Department of Medicine Semmelweis UniversityBudapest 1083Hungary

High-quality data remains scarce in terms of optimal management strategies in the elderly inflammatory bowel disease(IBD)***,available trials have been mostly retrospective,of small sample size,likely owing to underrepresentation of such a population in the major randomized controlled ***,in the last five years,there has been a steady increase in the number of published trials,helping clarify the estimated benefits and toxicity of the existing IBD *** the Everhov trial,prescription strategies were recorded over an average follow-up of 4.2 years.A minority of elderly IBD patients(1%-3%)were treated with biologics within the five years following diagnosis,whilst almost a quarter of these patients were receiving corticosteroid therapy at year five of follow-up,despite its multiple *** low use of biologic agents in real-life settings likely stems from limited data suggesting lower efficacy and higher *** minireview will aim to highlight current outcome measurements as it portends the elderly IBD patient,as well as summarize the available therapeutic strategies in view of a growing body of evidence.

关键词： Inflammatory bowel disease Elderly Outcomes Glucocorticoids Biological therapy Surgery