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Protein & Cell 2016年第11期7卷 833-838页

作者： Joana Borges Pinto annette graham Department of Life Sciences School of Health and Life Sciences Glasgow Caledonian University Glasgow G4 0BA UK WolfsonWohl Cancer Research Centre Institute of Cancer Sciences University of Glasgow Switchback Road Bearsden Glasgow G61 1QH UK

Dear Editor, Insulin secretion by pancreatic β-cells is modulated by altering the cellular content and distribution of cholesterol, which is tightly regulated by a network of transcription factors, enzymes, receptors, transporters and cholesterol trafficking proteins. Inhibition of cellular biosynthesis by ＇statin＇ drugs, or depletion of plasma membrane cholesterol by methyl-β-cyclodextrin （MCD）, reduce glucose-stimulated insulin secretion （GSIS） and content in β-cells and islets;

关键词： Cholesterol Lutein Insulin Release Cholesterol Efflux Cholesterol Depletion

MicroRNA sequences modulating inflammation and lipid accumulation in macrophage “foam” cells: Implications for atherosclerosis

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World Journal of Cardiology 2020年第7期12卷 303-333页

作者： Richard James Lightbody Janice Marie Walsh Taylor Yvonne Dempsie annette graham Department of Biological and Biomedical Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgow G40BAUnited Kingdom

Accumulation of macrophage"foam"cells,laden with cholesterol and cholesteryl ester,within the intima of large arteries,is a hallmark of early"fatty streak"lesions which can progress to complex,multicellular atheromatous plaques,involving lipoproteins from the bloodstream and cells of the innate and adaptive immune *** accumulation triggers induction of genes encoding proteins mediating the atheroprotective cholesterol efflux *** the arterial intima,however,this mechanism is overwhelmed,leading to distinct changes in macrophage phenotype and inflammatory *** the last decade marked gains have been made in understanding of the epigenetic landscape which influence macrophage function,and in particular the importance of small non-coding micro-RNA(miRNA)sequences in this *** review identifies some of the miRNA sequences which play a key role in regulating"foam"cell formation and atherogenesis,highlighting sequences involved in cholesterol accumulation,those influencing inflammation in sterol-loaded cells,and novel sequences and pathways which may offer new strategies to influence macrophage function within atherosclerotic lesions.

关键词： Coronary heart disease Atherosclerosis Macrophage“foam”cell Cholesterol Inflammation MicroRNA

Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses

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World Journal of Cardiology 2015年第5期7卷 277-286页

作者： annette graham Anne-Marie Allen Department of Life Sciences School of Health and Life Sciences and the Institute for Applied Health Research (Diabetes Research Group)Glasgow Caledonian University

The aim of this review is to explore the role of mitochondria in regulating macrophage sterol homeostasis and inflammatory responses within the aetiology of *** generation of oxysterol activators of liver X receptors(LXRs),via sterol 27-hydroxylase,is regulated by the rate of flux of cholesterolto the inner mitochondrial membrane,via a complex of cholesterol trafficking *** are key signalling molecules,regulating the transcriptional activity of LXRs which coordinate macrophage sterol metabolism and cytokine production,key features influencing the impact of these cells within atherosclerotic *** precise identity of the complex of proteins mediating mitochondrial cholesterol trafficking in macrophages remains a matter of debate,but may include steroidogenic acute regulatory protein and translocator *** is clear evidence that targeting either of these proteins enhances removal of cholesterol via LXRα-dependent induction of ATP binding cassette transporters(ABCA1,ABCG1) and limits the production of inflammatory cytokines; interventions which influence mitochondrial structure and bioenergetics also impact on removal of cholesterol from ***,molecules which can sustain or improve mitochondrial structure,the function of the electron transport chain,or increase the activity of components of the protein complex involved in cholesterol transfer,may therefore have utility in limiting or regressing atheroma development,reducing the incidence of coronary heart disease and myocardial infarction.

关键词： Atherosclerosis Macrophage Cholesterol High density lipoproteins Apolipoproteins ATP binding cassette transporters Scavenger receptor B1 Mitochondria(dys)function Sterol 27-hydroxylase Liver X receptors

Evaluating Breed Complementarity and Sexed Semen with Maternal Use of Afrikaner Germplasm

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Agricultural Sciences 2017年第7期8卷 507-517页

作者： Razie Khorshidi Michael D. MacNeil John J. Crowley Michiel M. Scholtz annette Theunissen graham S. Plastow Livestock Genetic Department of Agricultural Food and Nutritional Science University of Alberta Edmonton Canada Delta G Miles City USA ARC-Animal Production Institute Irene South Africa Department of Animal Wildlife and Grassland Sciences University of the Free State Bloemfontein South Africa Canadian Beef Breeds Council Calgary Canada Department of Agricultural Land Reform and Rural Development Jan Kempdorp South Africa

Livestock production impacts food security of developing countries, especially where efficiency of production is compromised by environmental stressors. In South Africa, breeding with indigenous Afrikaner cattle that are genetically well adapted to subtropical environments is considered an essential strategy for sustainable beef production. Today, there is a potential for farmers to participate in commercial systems that join adapted Afrikaner germplasm, used in a specialized maternal role, with exotic terminal sires to optimize production. The objective of this study was to assess productivity of five simulated production systems: 1) straightbred Afrikaner mated naturally, 2) a straight-bred Afrikaner cow herd with two sections;one section to produce replacement females and the other to cross with Charolais terminal sires, both using natural mating, 3) similar to 2, but applying sexed semen to produce replacement females, 4) similar to 2, but using a multi-breed composite dam line with a breed combination of 50% Afrikaner, 25% Hereford and 25% Simmental, and 5) similar to 4, but again applying sexed semen to produce replacement females. Parameter estimates needed to compare these systems were extracted from the scientific literature. Relative to straightbred Afrikaner dams, the simulated composite dams were more fit producing 7.8% more calves and their progeny performance was improved by reducing feed intake (-24.4%) and increasing meat production (+11.7%). The potential benefit of allocating more cows to the terminal sire was insufficient to offset the reduction in pregnancy rate that results with the use of sexed semen. Thus, system 4 had the greatest productivity (+23.1%) while requiring 22.8% less feed for finishing the progeny to be harvested relative to the purebred Afrikaner system. The combination of increased productivity and reduced feed requirement made use of a Charolais terminal sire in conjunction with multi-breed composite females bred by natural ser

关键词： Beef Production Afrikaner Composite Dams Sexed Semen Terminal Crossbreeding

AIPL1突变患者先天性Leber黑蒙表现型

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美国医学会眼科杂志（中文版） 2005年第2期17卷 119-120页

作者： Sharola Dharmaraj Ban P. Leroy Melanie M. Sohocki Robert K. Koenekoop Isabelle Perrault Khalid Anwar Shagufta Khaliq R. Summathi Devi David G. Birch Elaine De Pool Natalio Izquierdo Lionel Van Maldergem Mohammad Ismail annette M. Payne graham E. Holder Shomi S. Bhattacharya Alan C. Bird Josseline Kaplan Irene H. Maumenee 刘欣怡（译）

目的：叙述26例先证者中芳香族羟基碳氢化合物受体蛋白样1蛋白质（AIPL1）突变的先天性Leber黑蒙（LCA）的表现型，并比较其他LCA相关性基因的表现型。叙述杂合子携带者的视网膜电图（ERG）。

关键词： Leber黑蒙表现型先天性突变患者碳氢化合物相关性基因视网膜电图受体蛋白蛋白质