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Harnessing macrophages in thermal and non-thermal ablative therapies for urologic cancers-Potential for immunotherapy

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第1期1卷 5-11页

作者： Vinodh-Kumar-Adithyaa Arthanareeswaran Mandy Berndt-Paetz Roman Ganzer Jens-Uwe Stolzenburg Abinaya Ravichandran-Chandra annegret glasow Jochen Neuhaus Department of Urology University Hospital LeipzigLeipzigGermany Department of Urology Research LaboratoryUniversity of LeipzigLeipzigGermany Asklepios Stadtklinik Bad T€olzGermany Department of Radiation Therapy University of LeipzigLeipzigGermany

Prostate and bladder cancers are one of the cancers occurring *** addition to radical surgery,the past decade has also focused on targeted therapy of overexpressed cancer proteins that are lethal and critical for cancer cell ***,targeted therapy cannot adapt for changing of cancer molecular characteristics and,ultimately,a clone that bypasses the targeted therapy *** can be overcome by *** studies on ablative therapy of cancers show presence of immunomodulatory effect in these *** ablation prime the immune system for further destruction of persistent primary tumor in addition to destruction of concurrent metastatic disease and also reduce *** therapies can achieve a state of increased *** combination with a novel macrophage targeted therapy may enhance immune priming,trafficking,and/or effector phases;thereby improving clinical *** associated macrophages or M2 phenotype are now known to mediate this immunosuppressive pro-tumorigenic *** of macrophage differentiation may enhance tumor destruction of ablative *** breakthrough in immunotherapy opens up arenas for further robust clinical trials on combinatorial *** the present review,we aim to elucidate the major aspects of immune stimulatory minimal invasive approaches by combining with macrophage directed pathways.

关键词： Urologic cancers Macrophage High Intensity Focused Ultrasound Cryotherapy Focal laser ablation Photodynamic therapy Anti PD-L1 antibody Agonist CD40 antibody

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