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Eating Disorders and Pregnancy: The Case of Anorexia

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Open Journal of Psychiatry 2024年第4期14卷 353-373页

作者： anne-sophie Gautier Psychiatrist/Child Psychiatrist CH Denain Denain France

The question of the link between pregnancy and eating disorders is an important question. At the moment, there are few concrete answers for these patients. Despite common fertility challenges, patients who suffer from ED are able to access maternity. ED and pregnancy can either have an easy evolution or experience a lot of trouble. Many studies describe obstetrical and foetal complications (low birthweight, inadequate intra-uterine growth, small head circumference, miscarriage, caesarean section). Those patients are frequently reluctant to address their disease with their specialist, who also often doesn’t know how to screen the signs. The lack of official data to train the specialists further increases these difficulties. However, ED are frequent in the general population and young patients are likely to eventually want to become mothers. It is thus essential to know how to screen those patients early and accurately to improve their treatment and care. Eating disorders impact the pregnancy, the delivery and the postpartum as well as the growth of the baby. It is an important public health problem. The evolution from being a woman to becoming a mother is a difficult one, and even more so when the women is suffering from ED. Those patients must handle their nutritional fears, the anxiety about their body changing with pregnancy and the daily challenges. The early interactions with their baby have consequences on their development. It seems necessary to evaluate how to improve the screening and the patient care in ED patients. Screening should begin from the pregnancy desire to the postpartum. This patient care should be based on a multidisciplinary care team.

关键词： Eating Disorders Anorexia Pregnancy Child Postpartum

Isoform-and cell-state-specific APOE homeostasis and function

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Neural Regeneration Research 2024年第11期19卷 2456-2466页

作者： Karina Lindner anne-Claude Gavin Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland Diabetes Center Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic *** ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying *** E polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s *** this review,we discuss our current knowledge of how apolipoprotein E homeostasis,*** synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E autophagy cholesterol lipid detoxification lipid transport lysosomal failure metabolic impairment triacylglycerol

Detecting somatisation disorder via speech:introducing the Shenzhen Somatisation Speech Corpus

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Intelligent Medicine 2024年第2期4卷 96-103页

作者： Kun Qian Ruolan Huang Zhihao Bao Yang Tan Zhonghao Zhao Mengkai Sun Bin Hu Björn W.schuller Yoshiharu Yamamoto Key Laboratory of Brain Health Intelligent Evaluation and Intervention Ministry of EducationBeijing Institute of TechnologyBeijing 100081China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China The First School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong 510515China Department of Neurology Shenzhen University General HospitalShenzhenGuangdong 518055China Group on Language Audio&MusicImperial College LondonLondon SW72AZUK Embedded Intelligence for Health Care and Wellbeing University of AugsburgAugsburg 86159Germany Educational Physiology Laboratory Graduate School of EducationThe University of TokyoTokyo 113-0033Japan

Objective Speech recognition technology is widely used as a mature technical approach in many *** the study of depression recognition,speech signals are commonly used due to their convenience and ease of *** speech recognition is popular in the research field of depression recognition,it has been little studied in somatisation disorder *** reason for this is the lack of a publicly accessible database of relevant speech and benchmark *** this end,we introduced our somatisation disorder speech database and gave benchmark *** By collecting speech samples of somatisation disorder patients,in cooperation with the Shenzhen University General Hospital,we introduced our somatisation disorder speech database,the Shenzhen Somatisation Speech Corpus(SSSC).Moreover,a benchmark for SSSC using classic acoustic features and a machine learning model was proposed in our *** To obtain a more scientific benchmark,we compared and analysed the performance of different acoustic features,i.e.,the full ComPare feature set,or only Mel frequency cepstral coefficients(MFCCs),fundamental frequency(F0),and frequency and bandwidth of the formants(F1-F3).By comparison,the best result of our benchmark was the 76.0%unweighted average recall achieved by a support vector machine with formants F1–*** The proposal of SSSC may bridge a research gap in somatisation disorder,providing researchers with a publicly accessible speech *** addition,the results of the benchmark could show the scientific validity and feasibility of computer audition for speech recognition in somatization disorders.

关键词： Somatisation disorder Machine learning Healthcare Computer audition

Chrononutrition in traditional European medicine-Ideal meal timing for cardiometabolic health promotion

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Journal of Integrative Medicine 2024年第2期22卷 115-125页

作者： Nora Selena Eberli Ludivine Colas anne Gimalac Department of Traditional European Medicine Navi Institute of Research in Integrative HealthEcole Professionnelle Superieure de NaturopathieCentre Andre Henzelin1066 EpalingesSwitzerland

Meal timing plays a crucial role for cardiometabolic health,given the circadian regulation of cardiometabolic ***,to the best of our knowledge,no concept of meal timing exists in traditional European medicine(TEM).Therefore,in this narrative review,we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and explore further *** reviewing literature published between 2002 and 2022,we found that optimal timing for energy intake may be between 06:00 and 09:00,12:00 and 14:00,and between 15:00 and18:00,with high energy breakfast,medium energy lunch and low energy dinner and possibly further adjustments according to one’s chronotype and ***,timing and distribution of energy intake may serve as a novel therapeutic strategy to optimize coction,a concept describing digestion and metabolism in TEM.

关键词： Circadian rhythm Chrononutrition Naturopathy Traditional European medicine Metabolic syndrome Meal timing

A numerical model to simulate the transient frictional viscoelastic sliding contact

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Friction 2024年第2期12卷 319-339页

作者： Dongze WANG Gregory de BOER anne NEVILLE Ali GHANBARZADEH School of Mechanical Engineering University of LeedsLeeds LS29JTUK

Sliding motion has always been one of the major concerns when it comes to the analysis of viscoelastic contact problems.A new model simulating the transient sliding contact of smooth viscoelastic surfaces is developed in this *** taking the dry contact friction and the coupling between shear tractions and normal pressure into account,the effect of the early partial slip period,which is often neglected in the study of viscoelastic sliding contact problems,is investigated *** with solutions based on the frictionless assumption,the steady-state pressure profile is found to be slightly different under the effect of the partial slip regime,including a lower peak pressure and the shift of the contacting region in the direction opposite to the sliding ***,the time required for the viscoelastic contact to reach its steady state is delayed owing to the partial slip period preceding the global sliding motion.

关键词： contact mechanics frictional sliding viscoelasticity viscoelastic friction

Templated synthesis of transition metal phosphide electrocatalysts for oxygen and hydrogen evolution reactions

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Journal of Energy Chemistry 2024年第2期89卷 646-669,I0014页

作者： Rose anne Acedera Alicia Theresse Dumlao DJ Donn Matienzo Maricor Divinagracia Julie anne del Rosario Paraggua Po-Ya Abel Chuang Joey Ocon Laboratory of Electrochemical Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mechanical Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Program College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Transition metal phosphides(TMPs)have been regarded as alternative hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts owing to their comparable activity to those of noble metal-based *** have been produced in various morphologies,including hollow and porous nanostructures,which are features deemed desirable for electrocatalytic *** synthesis routes are often responsible for such *** paper reviews the latest advances and existing challenges in the synthesis of TMP-based OER and HER catalysts through templated methods.A comprehensive review of the structure-property-performance of TMP-based HER and OER catalysts prepared using different templates is *** discussion proceeds according to application,first by HER and further divided among the types of templates used-from hard templates,sacrificial templates,and soft templates to the emerging dynamic hydrogen bubble *** catalysts are then reviewed and grouped according to their ***,prospective research directions for the synthesis of hollow and porous TMP-based catalysts,such as improvements on both activity and stability of TMPs,design of environmentally benign templates and processes,and analysis of the reaction mechanism through advanced material characterization techniques and theoretical calculations,are suggested.

关键词： OER HER Transition metal phosphide Templated synthesis Electrocatalysts

Assessing gully erosion and rehabilitation using multi temporal LiDAR DEMs:Case study from the Great Barrier Reef catchments,Australia

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International Soil and Water Conservation Research 2024年第1期12卷 184-199页

作者： Sana Khan Rebecca Bartley anne Kinsey-Henderson Aaron Hawdon The Commonwealth Scientific and Industrial Research Organisation(CSIRO) Environment1 James Cook DrDouglas4814Australia The Commonwealth Scientific and Industrial Research Organisation(CSIRO) EnvironmentGPO Box 2583BrisbaneQLD4001Australia

Millions of dollars are being spent on gully rehabilitation to help reduce excess fine sediment delivery to the Great Barrier Reef(GBR).There is an urgent need for(i)prioritisation of active gullies for rehabilitation and(ii)the development of methodologies to inform the effectiveness of *** this study we analyse DEMs of Difference derived from 0.5 m resolution 2-3 year interval multi-temporal LiDAR data collected pre and post rehabilitation at three variable gully morphologies in the Burdekin *** analysis indicates that the highest annual average fine sediment erosion rates for the untreated control gullies occur at the linear gully(53.38 t ha^(-1)y^(-1))followed by linear-alluvial gully(34.24 t ha^(-1)y^(-1))and least at the alluvial gully(14.41 t ha^(-1)y^(-1)).The proportional loss or export of fine sediment from the gullies in their un-treated condition ranges from∼68 to 90%of what is eroded,and when the gullies are treated the proportion of fine sediment that is retained in the gully proportional to what is eroded increases to∼60%at all *** pre-treatment baseline erosion rates,and additional post treatment LiDAR captures,it is difficult to quantify the treatment *** results offer insights in the erosion mechanisms within different geomorphic gully morphologies and rehabilitation effects in these erosional *** study provides crucial knowledge of gully dynamics that can be coupled with other lines of evidence for better prioritisation of rehabilitation in the GBR catchments.

关键词： Digital elevation models (dis)connectivity Restoration Geomorphic change detection Geomorphic effectiveness GIS

Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brain

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Neural Regeneration Research 2024年第5期19卷 969-970页

作者： anne-Eva van der Wijk Ed VanBavel Amsterdam UMC location University of Amsterdam Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands Amsterdam Neuroscience Neurovascular Disorders ProgramAmsterdamThe Netherlands Amsterdam Cardiovascular Sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of therapeutics for brain diseases has remained challenging,in particular due to the difficulty of passing the blood-brain *** a result,the current arsenal of therapeutics targeting the brain is limited to small,lipid-soluble drugs and there is a lack of options for treating neuroblastomas,Alzheimer’s disease,and many other devastating *** the advances in strategies for crossing the blood-brain barrier such as the use of nanoparticles(Hersh et al.,2022;Duan et al.,2023),such delivery systems have not yet reached clinical ***,novel platforms for the transport of therapeutics across the blood-brain barrier remain highly *** specifically holds for large molecules such as monoclonal antibodies and recombinant proteins,as well as nucleotide-based therapeutics and cell *** efforts in this field are increasing exponentially,with thousands of publications in the last few years.

关键词： therapeutics holds spite

A novel multi-channel porous structure facilitating mass transport towards highly efficient alkaline water electrolysis

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Journal of Energy Chemistry 2024年第6期93卷 511-518,I0013页

作者： Xinge Jiang Vasileios Kyriakou Chen Song Xianbin Wang sophie Costil Chunming Deng Taikai Liu Tao Jiang Hanlin Liao Universitéde technologie de Belfort Montbéliard Centre national de la recherche scientifiqueLaboratoire Interdisciplinaire Carnot de BourgogneBelfort 90010France Department of Chemical Engineering Engineering and Technology Institute Groningen(ENTEG)University of GroningenGroningen 9747 AGThe Netherlands The Institute of New Materials Guangdong Academy of ScienceGuangzhou 510650GuangdongChina

An advantageous porous architecture of electrodes is pivotal in significantly enhancing alkaline water electrolysis(AWE)efficiency by optimizing the mass transport *** effect becomes even more pronounced when aiming to achieve elevated current ***,we employed a rapid and scalable laser texturing process to craft novel multi-channel porous ***,the obtained electrodes exhibit the lowest Tafel slope of 79 mV dec^(-1)(HER)and 49 mV dec^(-1)(OER).As anticipated,the alkaline electrolyzer(AEL)cell incorporating multi-channel porous electrodes(NP-LT30)exhibited a remarkable improvement in cell efficiency,with voltage drops(from 2.28 to 1.97 V)exceeding 300 mV under 1 A cm^(-1),compared to conventional perforated Ni plate *** enhancement mainly stemmed from the employed multi-channel porous structure,facilitating mass transport and bubble dynamics through an innovative convection mode,surpassing the traditional convection ***,the NP-LT30-based AEL cell demonstrated exceptional durability for 300 h under 1.0 A cm^(-2).This study underscores the capability of the novel multi-channel porous electrodes to expedite mass transport in practical AWE applications.

关键词： Alkaline water electrolysis Mass transport Bubble dynamics Innovative convection mode Multi-channel porous structure