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Gender influence on defecographic abnormalities in patients with posterior pelvic floor disorders

World Journal of Gastroenterology 2010年第4期16卷 462-466页

作者： Céline Savoye-Collet Guillaume Savoye Edith Koning anne-marie leroi Jean-Nicolas Dacher Radiology Department QUANT-IF LITIS EA 4108Rouen University Hospital Charles Nicolle1 rue de GermontF76031 RouenFrance Gastroenterology Department ADEN EA 4311Rouen University Hospital Charles Nicolle1 rue de GermontF-76031 RouenFrance Physiology Department ADEN EA 4311Rouen University Hospital Charles Nicolle1 rue de GermontF-76031 RouenFrance

AIM:To compare defecographic abnormalities in symptomatic men and women and to analyze differences between men and age-and symptom-matched ***:Sixty-six men(mean age:55.4 years,range:20-81 years) who complained of constipation and/or fecal incontinence and/or pelvic pain underwent defecography after intake of a barium *** were analyzed for the diagnosis of rectocele,enterocele,intussusception and perineal *** were compared with age-and symptom-matched women(n = 198) who underwent defecography during the same ***:Normal defecography was observed in 22.7% of men vs 5.5% of women(P < 0.001).Defecography in men compared with women showed 4.5%vs 44.4%(P < 0.001) rectocele,and 10.6% vs 29.8%(P < 0.001) enterocele,*** difference was observed for the diagnosis of intussusception(57.6% vs 44.9%).Perineal descent at rest was more frequent in women(P < 0.005).CONCLUSION:For the same complaint,diagnosis of defecographic abnormalities was different in men than in women:rectocele,enterocele and perineal descent at rest were observed less frequently in men than in women.

关键词： Fecal incontinence Defecography Rectocele Hernia Pelvic floor Constipation

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Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders

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World Journal of Gastroenterology 2017年第11期23卷 2029-2036页

作者： Clémence Bildstein ChloéMelchior Guillaume Gourcerol Estelle Boueyre Valérie Bridoux Eric Vérin anne-marie leroi INSERM U1073 Service de Physiologie DigestiveCHU Rouen INSERM U1073 Service de Chirurgie DigestiveCHU Rouen EA 3830 Pole 3RCHU RouenGroupe de Recherche sur le Handicap Ventilatoire INSERM CIC 0204

AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for *** The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of *** Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI.

关键词： Neurogenic bowel dysfunction Fecal incontinence Constipation Obstructed defecation Transanal irrigation

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Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice

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World Journal of Gastroenterology 2022年第48期28卷 6935-6949页

作者： Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu anne-marie leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol Nutrition Gut and Brain Unit(Inserm U1073)Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Gastroenterology and Hepatology UniversitéCatholique de LouvainCHU UCL NamurYvoir 5530Belgium Department of Physiology CHU RouenUniversitéde Rouen NormandieRouen 76031France Department of Urology CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm UMR 1245Team Epigenetics and Pathophysiology of Neurodevelopmental DisordersUniversitéde Rouen NormandieRouen 76000France Behavioural Analysis Platform(SCAC) HeRacLeS Inserm US51-CNRS UAR2026Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Nutrition CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm U1107 NeuroDolClermont Auvergne UniversityClermont-Ferrand 63000France

BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral *** pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the *** precise pathophysiology remains poorly *** To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms *** Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane *** sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal ***,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using *** fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal *** expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western *** Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d *** increased permeability or inflammation was shown in the bladder or colon 7 d *** hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after

关键词： Cross-organ sensitization MAPK-p38 Microglia NK1 receptor Pain Visceral hypersensitivity

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Mass Spectrometry-Based Proteomics:From Structure and Energetics of Peptide Ions to Prognostic Cancer Biomarkers

Mass Spectrometry-Based Proteomics:From Structure and Energe...

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第五届全国原子光谱及相关技术学术会议

作者： Ajay Matta leroi V.DeSouza Jason T.K.Hwang Ranju Ralhan Kenneth P.H.Pritzker K.H.Brian Lam Justin K.-C.Lau Cheuk-Kuen Lai Alan C.Hopkinson K.W.Michael Siu University of Windsor

＜正＞Tandem mass spectrometry（MS/MS）is the enabling technology in mass spectrometry-based *** coupled with a protein database,the MS/MS peak lists can often lead to peptide sequence information and unambiguous identification of the peptides and the proteins from which they *** methodology is effective,mainly due to the redundancy of identification information encoded in the sequence,the generally well-behaving fragmentation chemistry of

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新考古学的进展

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世界科学 1979年第12期 47-47页

作者： André leroi-Gourhan 朱建中法国公学

当前,考古学的目标是重现古人的完整形象及其生活方式。十年来,史前研究,广言之,考古研究获得了显著的进展。在法国由于缺乏保护措施,建筑材料开采工程迅速破坏了许多遗址,然而,非常荣幸的是法国在考古学的一般发展中还是占有一定的地位。

关键词：新考古学史前研究考古研究

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