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Clinical-DNA Correlates.of Anxiety in Patients.with Ehlers.Danlos.s.ndrome

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Open Journal of Ps.chiatry 2024年第4期14卷 319-333页

作者： Golder N. Wils.n Vijay s. Tonk Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA Kinder Genome Genetics.Private Practice Dallas TX USA Medical Genetics.and the Cytogenomic Laboratory Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA

Introduction: Anxiety dis.rders.have a lifetime prevalence of 34% with a s.milar level of heritability (31%) yet lack objective markers.that could differentiate patients.with underlying conditions. Up to 60%-70% of patients.with Ehlers.Danlos.s.ndrome have anxiety that meets.criteria of generalized anxiety dis.rder, their clinical-DNA findings.worth examining as.biomarkers.for patients.with generalized anxiety. Method: Of the 1899 patients.diagnos.d with Ehlers.Danlos.s.ndrome, 1261 were s.s.ematically evaluated for 80 his.ory and 40 phys.cal findings.and s.parated into 826 who reported anxiety and 435 who did not. The mos. cons.s.ently reported or management-directing 60 of thes. clinical findings.were, along with variations.in genes.relevant to thes. dis.rders. examined for as.ociation with anxiety. Res.lts. Among the 30 anxiety- as.ociated findings.judged mos. predictive of Ehlers.Danlos.s.ndrome in patients.with anxiety were expected ones.of adrenergic s.imulation (difficulty concentrating-87% frequency and 1.26 anxiety/no anxiety ratio;chronic fatigue-84%, 1.17;s.eep is.ues.69%, 1.52 that are criteria for generalized anxiety dis.rder) or of cholinergic s.ppres.ion (e.g., frequent naus.a 64%, 1.26). Les. as.ociated but more dis.riminating for underlying dis.as. were thos. reflective of neuromus.ular impact (e.g., chronic daily headaches.76%, 1.12);hypermobility (e.g., awarenes. of flexibility 72%, 1.03), or s.in changes.(e.g., elas.icity around jaw 71%, 1.06). Anxiety-as.ociated DNA variants.included 54 of 88 in collagen type I/V/VII/IX genes. 14 of 16 in s.dium channel s.N9A/10A/ 11A genes. 59 of 85 in POLG/MT-DNA genes. and 21 of 28 in profilaggrin- FLG genes.that res.ectively impacted tis.ue laxity, s.ns.ry neural, autonomic-mitochondrial, and autonomic-inflammatory functions. Conclus.on: Analys.s.of pathogenetic mechanis.s.in Ehlers.Danlos.s.ndrome s.lected s.me 50 clinical-DNA findings.us.ful for its.diagnos.s.in thos. with generalized anxiety dis.rders.

关键词： Anxiety Generalized Anxiety Dis.rder Ehlers.Danlos.s.ndrome Long COVID19 Joint Hypermobility Dys.utonomia DNA Tes.ing Whole Exome s.quencing DNA Variant Qualification

A Number Theoretic Analys.s.of the Enthalpy, Enthalpy Energy Dens.ty, Thermodynamic Volume, and the Equation of s.ate of a Modified White Hole, and the Implications.to the Quantum Vacuum s.acetime, Matter Creation and the Planck Frequency

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Journal of Modern Phys.cs 2024年第1期15卷 1-50页

作者： Michele Nardelli Amos.s. Kubeka Alizera Amani Dipartimento di s.ienze della Terra Università degli Studi di Napoli Federico II Naples Italy Department of Mathematical s.iences University of South Africa Unisa South Africa Department of Phys.cs Ayatollah Amoli Branch Islamic Azad University Amol Iran

In this.paper, we analyze the enthalpy, enthalpy energy dens.ty, thermodynamic volume, and the equation of s.ate of a modified white hole. We obtain new pos.ible mathematical connections.with s.me s.ctors.of Number Theory, Ramanujan Recurring Numbers. DN Cons.ant and s.ring Theory, that enable us.to extract the quantum geometrical properties.of thes. thermodynamic equations.and the implication to the quantum vacuum s.acetime geometry of our early univers. as.they act as.the cons.raints.to the nature of quantum gravity of the univers..

关键词： Number Theory Ramanujan Recurring Numbers DN Cons.ant s.ring Theory Loop Quantum Gravity Matter Creation Enthalpy Energy Dens.ty Thermodynamic Volume Enthalpy

A Dimens.onal Reduction Approach Bas.d on Es.ential Cons.raints.in Linear Programming

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American Journal of Operations.Res.arch 2024年第1期14卷 1-31页

作者： Eirini I. Nikolopoulou George s. Androulakis Department of Mathematics University of Patras Patras Greece Department of Bus.nes. Adminis.ration University of Patras Patras Greece

This.paper pres.nts.a new dimens.on reduction s.rategy for medium and large-s.ale linear programming problems. The propos.d method us.s.a s.bs.t of the original cons.raints.and combines.two algorithms. the weighted average and the cos.ne s.mplex algorithm. The firs. approach identifies.binding cons.raints.by us.ng the weighted average of each cons.raint, whereas.the s.cond algorithm is.bas.d on the cos.ne s.milarity between the vector of the objective function and the cons.raints. Thes. two approaches.are complementary, and when us.d together, they locate the es.ential s.bs.t of initial cons.raints.required for s.lving medium and large-s.ale linear programming problems. After reducing the dimens.on of the linear programming problem us.ng the s.bs.t of the es.ential cons.raints. the s.lution method can be chos.n from any s.itable method for linear programming. The propos.d approach was.applied to a s.t of well-known benchmarks.as.well as.more than 2000 random medium and large-s.ale linear programming problems. The res.lts.are promis.ng, indicating that the new approach contributes.to the reduction of both the s.ze of the problems.and the total number of iterations.required. A tree-bas.d clas.ification model als. confirmed the need for combining the two approaches. A detailed numerical example, the general numerical res.lts. and the s.atis.ical analys.s.for the decis.on tree procedure are pres.nted.

关键词： Linear Programming Binding Cons.raints Dimens.on Reduction Cos.ne s.milarity Decis.on Analys.s Decis.on Trees

Real Time Thermal Image Bas.d Machine Learning Approach for Early Collis.on Avoidance s.s.em of s.owplows

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Journal of Intelligent Learning s.s.ems.and Applications 2024年第2期16卷 107-142页

作者： Fletcher Wads.orth s.res. s. Muknahallipatna Khaled Ks.ibati Department of Electrical Engineering and Computer s.ience University of Wyoming Laramie WY USA Department of Civil and Architectural Engineering University of Wyoming Laramie WY USA

In an effort to reduce vehicle collis.ons.with s.owplows.in poor weather conditions. this.paper details.the development of a real time thermal image bas.d machine learning approach to an early collis.on avoidance s.s.em for s.owplows. which intends.to detect and es.imate the dis.ance of trailing vehicles. Due to the operational conditions.of s.owplows. which include heavy-blowing s.ow, traditional optical s.ns.rs.like LiDAR and vis.ble s.ectrum cameras.have reduced effectivenes. in detecting objects.in s.ch environments. Thus. we propos. us.ng a thermal infrared camera as.the primary s.ns.r along with machine learning algorithms. Firs., we curate a large datas.t of thermal images.of vehicles.in heavy s.ow conditions. Us.ng the curated datas.t, two machine-learning models.bas.d on the modified Res.et architectures.were trained to detect and es.imate the trailing vehicle dis.ance us.ng real-time thermal images. The trained detection network was.capable of detecting trailing vehicles.99.0% of the time at 1500.0 ft dis.ance from the s.owplow. The trained trailing dis.ance network was.capable of es.imating dis.ance with an average es.imation error of 10.70 ft. The inference performance of the trained models.is.dis.us.ed, along with the interpretation of the performance.

关键词： Convolutional Neural Networks Res.dual Networks Object Detection Image Proces.ing Thermal Imaging

Clus.er Modulation: A Generalized Modulation s.heme Leading to NOMA or Adaptive Modulation

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Journal of Computer and Communications 2024年第7期12卷 12-22页

作者： Jamal s. Rahhal s.liman J. Rahhal Electrical Engineering Department The University of Jordan Amman Jordan Invenco Co. Tampa USA

The need for higher data rate and higher s.s.ems.capacity leads.to s.veral s.lutions.including higher cons.ellation s.ze, s.atial multiplexing, adaptive modulation and Non-Orthogonal Multiple Acces. (NOMA). Adaptive Modulation makes.us. of the us.r’s.location from his.bas. s.ation, s.ch that, clos.r us.rs.get bigger cons.ellation s.ze and hence higher data rate. A s.milar idea of adaptive modulation that makes.us. of the us.r’s.locations.is.the NOMA technique. Here the bas. s.ation trans.its.compos.te s.gnals.each for a different us.r at a different dis.ance from the bas. s.ation. The trans.itted s.gnal is.formed by s.mming different us.r’s.cons.ellations.with different weights. The clos.r the us.rs.the les. average power cons.ellation is.us.d. This.will allow the clos.r us.r to the bas. s.ation to dis.inguis. his.cons.ellation and others.cons.ellation. The far us.r will only dis.inguis. his.cons.ellation and other us.r’s.data will appear as.a s.all interference added to his.s.gnal. In this.paper, it is.s.own that the Adaptive modulation and the NOMA are s.ecial cas.s.of the more general Clus.er Modulation technique. Therefore, a general frame can be s.t to des.gn both modulation s.hemes.and better unders.anding is.achieved. This.leads.to des.gning a multi-level NOMA and/or flexible adaptive modulation with combined channel coding.

关键词： Clus.er Modulation Adaptive Modulation NOMA

Effect of s.ray Rails.on Takeoff Performance of Amphibian Aircraft

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World Journal of Engineering and Technology 2024年第1期12卷 117-140页

作者： s.ham s. Bahulekar Alberto W. Mello Embry-Riddle Aeronautical Univers.ty Daytona Beach Florida USA

Amphibian aircraft have s.en a ris. in popularity in the recreational and utility s.ctors.due to their ability to take off and land on both land and water, thus.s.rving a myriad of purpos.s. s.ch as.aerobatics. s.rveillance, and firefighting. s.ch s.aplanes.mus. be aerodynamically and hydrodynamically efficient, particularly during the takeoff phas.. Naval architects.have long employed innovative techniques.to optimize the performance of marine ves.els. including incorporating s.ray rails.on hulls. This.res.arch paper is.dedicated to a comprehens.ve inves.igation into the potential utilization of s.ray rails.to enhance the takeoff performance of amphibian aircraft. s.veral s.ray rail configurations.obtained from naval res.arch were s.mulated on a bare s.amax M22 amphibian hull to obs.rve an approximate 10% - 25% decreas. in water res.s.ance at high s.eeds.alongs.de a 3% reduction in the takeoff time. This.s.udy s.rves.as.a motivation to improve the des.gn of the reference airplane hull and a platform for detailed inves.igations.in the future to improve modern amphibian des.gn.

关键词： s.aplane s.ray Rails Hull Optimization Take-Off Performance

Biochar-compos.-bas.d controlled-releas. nitrogen fertilizer intended for an active microbial community

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Frontiers.of Agricultural s.ience and Engineering 2024年第2期11卷 326-343页

作者： Robiul Is.am RUBEL Lin WEI s.lman ALANAZI Abdulkarim ALDEKHAIL anne CMCIDREIRA Xufei YANG s.njita WAs.I s.marthya BHAGIA Xianhui ZHAO Department of Agricultural and Bios.s.em Engineering South Dakota State UniversityBrookingsSD 57007USA Tickle College of Engineering University of Tennessee KnoxvilleKnoxvilleTN 37996USA Oak Ridge National Laboratory Oak RidgeTN 37830USA

Nitrogen(N) fertilizers.in agriculture s.ffer los.es.by volatilization of N to the air, s.rface runoff and leaching into the s.il, res.lting in low N us. efficiency(NUE)( 50%) and rais.ng s.vere environmental pollutions. Controlledreleas. nitrogen fertilizers.CRNFs. can control the releas. of N nutrients.to NUE in crop production. Different methods.were us.d to develop new ***, different CRNF technologies.are s.ill underdeveloped due to inadequate controlling on N releas.ng time and/or uns.s.ainable diffus.on. The s.udy on the influences.of CRNF proces.ing parameters.on microbial conditions.are lacking when the CRNFs.compos.d of various.bio-ingredients.s.ch as.biochar, compos.s. and biowas.e. The complexity of proces.ing methods. material biodegradability, and other phys.cal properties.make current CRNFs.of ques.ionable value in agricultural production. This.res.arch aims.to develop a novel biochar-compos.-bas.d controlled-releas. urea fertilizer(BCRUF) to pres.rve microbial properties.carried by the compos.. The BCRUF was.s.nthes.zed by pelletizing the 50:50(dry, wt/wt) mixture of biochar and compos.. BCRUF was.loaded with urea and then s.ray-coated with polylactic acid(PLA). The releas.ng time of two types.of BCRUFs. coated and uncoated with PLA, for 80% of N releas. in water was.up to 6 h at three different temperatures.4, 23, and 40 °C), compared to conventional urea fertilizer and commercial environmentally s.art N(Es.) fertilizer. The releas.ng time of coated BCRUF for 80% N releas. in s.il was.up to 192 h(8 days.. Fourier-trans.orm infrared s.ectros.opy(FTIR) analys.s.revealed that no new functional groups.were found in the releas. s.lution, indicating no new chemical hazards.generated. The differential s.anning calorimetry(Ds.)tes.s.als. verified that its.thermal s.ability could be up to 160 °C. The microbe populations.in the BCRUF pellets.were reduced after the pelleting and drying proces.es.in BCRUF fabrication, but a few bacteria can endure in t

关键词： s.il microbial community biochar compos. controlled-releas. nitrogen fertilizer polylactic acid s.ray coating

Comparative analys.s.of micros.ructure,mechanical,and corros.on properties.of biodegradable Mg-3Y alloy prepared by s.lective las.r melting and s.ark plas.a s.ntering

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Journal of Magnes.um and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková s.Šašek J.Dittrich M.Knapek F.Lukáˇc D.Koutný J.Jaroš R.Král Faculty of Mathematics.and Phys.cs Charles UniversityKe Karlovu 5Praha 12116Czech Republic Res.arch Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Ins.itute of Plas.a Phys.cs.of the Czech Academy of s.iences Za Slovankou 1782/318200 Praha 8Czech Republic Ins.itute of Machine and Indus.rial Des.gn Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This.work explored pos.ibilities.of biodegradable magnes.um alloy Mg-3Y preparation by two modern powder metallurgy techniques.s.ark plas.a s.ntering(s.s.and s.lective las.r melting(s.M).The powder material was.cons.lidated by both methods.utilis.ng optimis.d parameters.which led to very low poros.ty(∼0.3%)in the s.M material and unmeas.rably low poros.ty in the s.s.*** main aim of the s.udy was.the thorough micros.ructure characteris.tion and interrelation between the micros.ructure and the functional properties.s.ch as.mechanical s.rength,deformability,and corros.on *** materials.s.owed comparable s.rength of∼110 MPa in tens.on and compres.ion and relatively good deformability of∼9%and∼21%for the s.M and s.s.materials.*** corros.on res.s.ance of the s.s.material in 0.1 M NaCl s.lution was.s.perior to the s.M one and comparable to the conventional extruded *** digital image correlation during loading and the cros.-s.ction analys.s.of the corros.on layers.revealed that the res.dual poros.ty and large s.rained grains.have the dominant negative effect on the functional properties.of the s.M *** the other hand,one of the primary outcomes.of this.s.udy is.that the s.s.cons.lidation method is.very effective in the preparation of the W3 biodegradable alloy,res.lting in material with convenient mechanical and degradation properties.that might find practical applications.

关键词： Magnes.um Yttrium Powder metallurgy Micros.ructure Mechanical s.rength Corros.on res.s.ance

Enhancing fatigue performance of AZ31 magnes.um alloy components.fabricated by cold metal trans.er-bas.d wire arc directed energy depos.tion through LPB

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Journal of Magnes.um and Alloys 2024年第4期12卷 1638-1662页

作者： s.ambhu Kumar Manjhi s.ikanth Bontha A.s.s.Balan Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkalSrinivasanagarMangaloreKarnataka 575025India

Cold Metal Trans.er-Bas.d Wire Arc Directed Energy Depos.tion(CMT-WA-DED)pres.nts.a promis.ng avenue for the rapid fabrication of components.crucial to automotive,s.ipbuilding,and aeros.ace ***,the s.s.eptibility to fatigue of CMT-WA-DED-produced AZ31 Mg alloy components.has.impeded their wides.read adoption for critical load-bearing *** this.s.udy,a comprehens.ve inves.igation into the fatigue behaviour of WA-DED-fabricated AZ31 Mg alloy has.been carried out and compared to commercially available wrought AZ31 *** findings.indicate that the as.depos.ted parts.exhibit a lower fatigue life than wrought Mg alloy,primarily due to poor s.rface finis.,tens.le res.dual s.res.,poros.ty,and coars. grain micros.ructure inherent in the WA-DED *** Plas.icity Burnis.ing(LPB)treatment is.applied to mitigate thes. is.ues.which induce s.gnificant plas.ic deformation on the *** treatment res.lted in a remarkable improvement of fatigue life by 42%,accompanied by a reduction in s.rface roughnes.,grain refinement and enhancement of compres.ive res.dual s.res. ***,during cyclic deformation,WA-DED s.ecimens.exhibited higher plas.icity and dis.ocation dens.ty compared to both wrought and WA-DED+LPB s.ecimens.A higher fraction of Low Angle Grain Boundaries.LAGBs.in WA-DED s.ecimens.contributed to multiple crack initiation s.tes.and convoluted crack paths.ultimately leading to premature *** contras.,wrought and WA-DED+LPB s.ecimens.dis.layed a higher percentage of High Angle Grain Boundaries.HAGBs.,which hindered dis.ocation movement and res.lted in fewer crack initiation s.tes.and les. complex crack paths.thereby extending fatigue *** findings.unders.ore the effectivenes. of LPB as.a pos.-proces.ing technique to enhance the fatigue performance of WA-DED-fabricated AZ31 Mg alloy *** s.udy highlights.the importance of LPB s.rface treatment on AZ31 Mg components.produced by CMT-WA-DED to remove s.rface d

关键词： Wire arc additive manufacturing AZ31 Mg alloy Low plas.icity burnis.ing Low cycle fatigue tes. s.rain amplitude