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Evaluation of a complex couplet care intervention in a neonatal intensive care unit:A mixed methods study protocol

Pediatric Investigation 2024年第2期8卷 139-148页

作者： Michella Bjerregaard Anna Axelin Emma louise Malchau Carlsen Hans Okkels Birk Ingrid Poulsen Patrick Palisz Thomas Kallemose anne Brødsgaard Department of Paediatric and Adolescent Medicine Copenhagen University Hospital Amager HvidovreHvidovreDenmark Department of Public Health Faculty of HealthResearch Unit for Nursing and HealthcareUniversity of AarhusAarhusDenmark Department of Nursing Science University of TurkuTurkuFinland Department of Clinical Medicine Faculty of Health and Medical ScienceUniversity of CopenhagenCopenhagenDenmark Department of Public Health Section of Health Service ResearchUniversity of CopenhagenCopenhagenDenmark Department of People and Technology Roskilde UniversityRoskildeDenmark Department of Clinical Research Copenhagen University Hospital Amager HvidovreHvidovreDenmark Department of Gynaecology and Obstetrics Copenhagen University Hospital Amager HvidovreHvidovreDenmark

Background:Families with an infant in need of intensive care most often experience a harmful separation after *** is due to a division of medical specialties into neonatal care and maternal ***,a couplet care intervention is implemented for mother-infant dyads in a neonatal intensive care *** study protocol provides a comprehensive evaluation of the *** aim is to evaluate the effect and implementation of a complex couplet care intervention to promote zero separation between mother and ***:The couplet care intervention is a family-centered model of care,where treatment-requiring mother-infant dyads will be admitted together and receive couplet care by neonatal *** study adheres to the framework of the Medical Research Council and will use a mixed methods embedded design comprising a quasi-experimental trial and a qualitative process ***,a health economic evaluation will be conducted to assess the cost-effectiveness of this complex couplet care ***:Separation of mother-infant dyads after birth has an adverse impact on family health and *** study protocol evaluates a complex couplet care *** this study,a first step is taken to help bridge the gap between current practices and a new care model to prevent the separation of mothers and their infants.

关键词： Complex interventions Couplet care Family-centered care Neonatology Zero separation

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对服用口服降糖药的2型糖尿病患者加用每日一次地特胰岛素治疗的安全性和有效性研究——SOLVETM全球研究结果

对服用口服降糖药的2型糖尿病患者加用每日一次地特胰岛素治疗的...

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中华医学会第十一次全国内分泌学学术会议

作者： LUIGI MENEGHINI SALVATORE CAPUTO 潘长玉 anne louise svendsen KAMLESH KHUNTI University of Miami Miller School of Medicine MiamiFLUSA

目的:SOLVE(Study ofOnce-daily LeVEmir)国际研究是一项多中心观察性研究,目的在于评价对口服降糖药治疗失效的2型糖尿病患者起始加用地特胰岛素治疗的安全性和有效性。本研究报导的是SOLVE全球研究结果。方法:对正在服用一种或多种口...

目的:SOLVE(Study ofOnce-daily LeVEmir)国际研究是一项多中心观察性研究,目的在于评价对口服降糖药治疗失效的2型糖尿病患者起始加用地特胰岛素治疗的安全性和有效性。本研究报导的是SOLVE全球研究结果。方法:对正在服用一种或多种口服降糖药的2型糖尿病患,起始加用每日一次地特胰岛素治疗,收集并分析包

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STING palmitoylation as a therapeutic target

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Cellular & Molecular Immunology 2019年第3期16卷 236-241页

作者： anne louise Hansen Kojiro Mukai Francisco J.Schopfer Tomohiko Taguchi Christian K.Holm Department of Biomedicine Aarhus University8000 Aarhus CDenmark Laboratory of Organelle Pathophysiology Department of Integrative Life SciencesGraduate School of Life SciencesTohoku UniversitySendai 980-8578 MiyagiJapan Department of Pharmacology and Chemical Biology University of PittsburghPittsburghPA 15213USA

Gain-of-function mutations in the STING-encoding gene TMEM173 are central to the pathology of the autoinflammatory disorder STING-associated vasculopathy with onset in infancy(SAVI).Furthermore,excessive activity of the STING signaling pathway is associated with autoinflammatory diseases,including systemic lupus erythematosus and Aicardi–Goutières syndrome(AGS).Two independent studies recently identified pharmacological inhibitors of ***,both types of compounds are reactive nitrocontaining electrophiles that target STING palmitoylation,a posttranslational modification necessary for STING *** a consequence,the activation of downstream signaling molecules and the induction of type I interferons were *** compounds were effective at ameliorating inflammation in a mouse model of AGS and in blocking the production of type I interferons in primary fibroblasts from SAVI *** mini-review focuses on the roles of palmitoylation in STING activation and signaling and as a pharmaceutical target for drug development.

关键词： STING Palmitoylation Inflammation SAVI Interferonopathies

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Global transcriptional changes in response to cGAMP depend on STING in human THP-1 cells

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Cellular & Molecular Immunology 2018年第11期15卷 983-985页

作者： anne louise Hansen Aske M.Brandtoft Mette Nyegaard anne L.Thielke David Olagnier Christian K.Holm Department of Biomedicine Aarhus Research Center for Innate ImmunologyAarhus UniversityAarhusDenmark

Cytosolic detection of foreign or misplaced self-DNA through the cGAS-STING pathway leads to cGAS-mediated synthesis of the second messenger molecule *** immune signaling molecule STING binds cGAMP directly,and thus functions as a cGAMP *** of cGAMP induces the activation of STING with the subsequent induction of anti-viral and proinflammatory ***,it is not known whether STING is the only cellular sensor of cGAMP,and it has not been reported whether stimulation with cGAMP can induce gene transcription independently of *** we analyzed the global cGAMP-induced transcriptional gene program in STING-deficient human monocyte-derived THP-1 *** found that the global cGAMP-induced transcriptional response was dependent on STING and failed to identify groups of genes that were affected by cGAMP in the absence of *** data therefore strongly indicate that STING is the sole receptor for cGAMP in human macrophages.

关键词： stimulation STING transcriptional

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Using motion capture to assess colonoscopy experience level

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World Journal of Gastrointestinal Endoscopy 2014年第5期6卷 53-59页

作者： Morten Bo svendsen louise Preisler Jens Georg Hillingsoe Lars Bo svendsen Lars Konge Centre for Clinical Education University of Copenhagen and the Capital Region of Denmark Department of Surgical Gastroenterology Rigshospitalet and University of Copenhagen

AIM: To study technical skills of colonoscopists using a Microsoft Kinect? for motion analysis to develop a tool to guide colonoscopy ***: Ten experienced endoscopists(gastroenterologists, n = 2; colorectal surgeons, n = 8) and 11 novices participated in the study. A Microsoft Kinect? recorded the movements of the participants during the insertion of the colonoscope. We used a modified script from Microsoft to record skeletal data. Data were saved and later transferred to MatLab for analysis and the calculation of statistics. The test was performed on a physical model, specifically the "Kagaku Colonoscope Training Model"(Kyoto Kagaku Co. Ltd, Kyoto, Japan). After the introduction to the scope and colonoscopy model, the test was performed. Seven metrics were analyzed to find discriminative motion patterns between the novice and experienced endoscopists: hand distance from gurney, number of times the right hand wasused to control the small wheel of the colonoscope, angulation of elbows, position of hands in relation to body posture, angulation of body posture in relation to the anus, mean distance between the hands and percentage of time the hands were approximated to each ***: Four of the seven metrics showed discriminatory ability: mean distance between hands [45 cm for experienced endoscopists(SD 2) vs 37 cm for novice endoscopists(SD 6)], percentage of time in which the two hands were within 25 cm of each other [5% for experienced endoscopists(SD 4) vs 12% for novice endoscopists(SD 9)], the level of the right hand below the sighting line(z-axis)(25 cm for experienced endoscopists vs 36 cm for novice endoscopists, P < 0.05) and the level of the left hand below the z-axis(6 cm for experienced endoscopists vs 15 cm for novice endoscopists, P < 0.05). By plotting the distributions of the percentages for each group, we determined the best discriminatory value between the groups. A pass score was set at the intersection of the distributions, and

关键词： Colonoscopy Assessment Simulation Motion-capture Motion-analysis

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新编剑桥商务英语自测练习与解答初级

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丛书名：新编剑桥商务英语考试BEC用书系列

2004年

作者：（英）anne Williams （英）louise Pile

英国剑桥大学考试委员会推荐:本自测练习书包含有三套完整的自测试题；提供了如何完成考试中每项测试题的诸多忠告，以及完整的剑桥大学考试委员会答题页的范样等内容。

ISBN: (纸本)7505842129

关键词：英语商务习题

来源：畅想之星图书光盘版（南... 评论

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部分纤维肌痛症患者存在小纤维多神经病变的客观依据

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中国疼痛医学杂志 2014年第9期20卷 614-615,619页

作者： anne louise Oaklander 李银桥

1.背景介绍纤维肌痛综合征（fibromyalgia syndrome,FMS）是一组包括慢性广泛性疼痛（chronic widespread pain,CWP）在内的疾病综合征,在西方国家的发病率为1%~5%,女性患病率是男性的3~4倍。FMS的生物学病因至今尚未明确。小纤维多神... 详细信息

1.背景介绍纤维肌痛综合征（fibromyalgia syndrome,FMS）是一组包括慢性广泛性疼痛（chronic widespread pain,CWP）在内的疾病综合征,在西方国家的发病率为1%~5%,女性患病率是男性的3~4倍。FMS的生物学病因至今尚未明确。小纤维多神经病（small-fiber polyneuropathy,SFPN）是一种导致CWP的神经病学病因。与FMS不同的是,SFPN具有明确的病理生理及病因,因而明确是一种疾病。

关键词：多神经病伤害性感受疾病综合征 polyneuropathy 女性患病率髓鞘功能失调病理生理轴索肌痛症

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Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-results from the Hammersmith Study

Long-term follow-up of cervical abnormalities among women sc...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Jack Cuzick anne Szarewski David Mesher louise Cadman Janet Austin Karen Perryman Linda Ho George Terry Peter Sasieni William Pat Soutter Wolfson Institute of Preventive Medicine Wolfson Institute of Preventive Medicine Wolfson Institute of Preventive Medicine Wolfson Institute of Preventive Medicine Wolfson Institute of Preventive Medicine Department of Gynaecological Oncology Wolfson Institute of Preventive Medicine Wolfson Institute of Preventive Medicine Wolfson Institute of Preventive Medicine Department of Gynaecological Oncology

＜正＞Background:Several studies have shown that HPV testing is substantially more sensitive than cytology for primary cervical ***,little data exist concerning the duration of i°protectioni±afforded by a negative HPV test compared to a normal cytotogic *** we report the long-term findings from the Hammersmith HPV screening study in women aged 35 or more.

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基于碳纳米管型油墨的印刷电子柔性基材预处理技术研究

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中国印刷与包装研究 2013年第2期5卷 66-71页

作者： AURORE Denneulin JULIEN Bras anne Blayo CHARLES Neuman 谭姣姣 Polypore-27 bd Louise MichelF-92230 GennevilliersFrance Laboratory of Pulp and Paper Science and Graphic Arts(LGP2)(UMR 5518 CNRS-CTP-INPG) Grenoble Institute of Technology(INP Grenoble-PAGORA)461 Rue de la PapeterieBP 6538402 St Martin d'Heres CedexFrance

0 引言在印刷过程中，紫外固化可通过化学交联反应将基材上的液体悬浮液转化为固体状态，它具有节能、无溶剂挥发和加工快速等多重优势，可在不到1s的时间内完成固化，因此其适用于工业化生产。而喷墨印刷因其灵活性和可局部处理的优点... 详细信息

0 引言在印刷过程中，紫外固化可通过化学交联反应将基材上的液体悬浮液转化为固体状态，它具有节能、无溶剂挥发和加工快速等多重优势，可在不到1s的时间内完成固化，因此其适用于工业化生产。而喷墨印刷因其灵活性和可局部处理的优点被广泛用于印刷电子制造领域。如图1所示，喷墨印刷可作为一个工作单元插入生产线中，并可通过计算机控制印刷过程，快速生成图案。

关键词：印刷过程碳纳米管基材电子预处理技术油墨喷墨印刷

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