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Exploring the effects of dietary inulin in rainbow trout fed a high‑starch,100%plant‑based diet

Journal of Animal Science and Biotechnology 2024年第2期15卷 713-732页

作者： Raphaël Defaix Jep Lokesh Laura Frohn Mickael Le Bechec Thierry Pigot Vincent Veron anne Surget Sandra Biasutti Frederic Terrier Sandrine Skiba-Cassy Jerome Roy Stephane Panserat Karine Ricaud Universite de Pau Et Des Pays de L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance Universite de Pau Et Des Pays de L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance Universite de Pau Et Des Pays de L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and ***,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and *** tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture *** a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow *** assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding *** The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing *** were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with *** high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune ***,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary *** With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO wh

关键词： Aquaculture Fish nutrition Gut microbiota Immune markers Intermediary metabolism Inulin Prebiotic Rainbow trout Short-chain fatty acids

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Correlation between non-alcoholic fatty liver disease and metabolic parameters in persons with newly diagnosed type 2 diabetes mellitus

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World Journal of Hepatology 2024年第8期16卷 1120-1130页

作者： Supriyo Mukherjee Sushmita Mukherjee Chun Shing Kwok anne Phillips Department of Medicine Research Centre for Diabetes Hypertension and ObesitySamastipur 848101India Department of Clinical Ultrasonography Research Centre for Diabetes Hypertension and ObesitySamastipur 848101India Cardiology Registrar University Hospitals of North Midlands NHS Trust United KingdomStaffordshire ST46QGUnited Kingdom Faculty of Health Education and Life Sciences Department of Post-Qualifying Healthcare PracticeBirmingham City UniversityBirmingham B47APUnited Kingdom

BACKGROUND There are limited studies investigating the association between type 2 diabetes mellitus(T2DM)and non-alcoholic fatty liver disease(NAFLD)in the region of Bihar,*** To estimate the prevalence of NAFLD in persons with newly diagnosed T2DM in the population of North Bihar,*** This single centre cross-sectional study was undertaken in the Research Centre for Diabetes Hypertension and Obesity,Samastipur,Bihar,*** were collected from persons newly diagnosed with T2DM or those diagnosed within 6 months of when the study was conducted between December 2022 to May *** A total of 148 people with newly diagnosed T2DM were included(median age 47 years,46.6%female)and 109 patients with liver disease on ultrasound *** persons with liver disease consumed more fats and oils(88.1%vs 74.4%,P=0.042)and they had significantly greater body mass index(27.4 vs 23.0,P<0.001),waist circumference(37 vs 33,P<0.001),and waist-to-hip ratio(1.00 vs 0.70,P=0.025).Females were associated with greater liver disease[odds ratio(OR):3.09,95%confidence interval(CI):1.09-8.80,P=0.32].Waist circumference(OR:1.42,95%CI:1.22-1.66,P<0.001)and low-density lipoprotein cholesterol(OR:1.01,95%CI:1.01-1.02,P=0.048)were associated with any liver *** factors most associated with grade 2/3 liver disease was right upper quadrant pain or heaviness(OR:5.22,95%CI:1.40-19.41,P=0.14),greater income(OR:3.58,95%CI:1.28-10.04,P=0.015)and waist circumference(OR:1.31,95%CI:1.02-1.69,P=0.036).CONCLUSION NAFLD is common in new/recently diagnosed T2DM and disease burden is high and common among patients who are either high consumers of fats and oils or have obesity-associated markers.

关键词： Type 2 diabetes mellitus Non-alcoholic fatty liver disease Prevalence Waist circumference Obesity

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Lipoprotein(a) and cardiovascular disease

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四川生理科学杂志 2024年第9期46卷 1977-1977页

作者： Nordestgaard, Børge G, Prof Langsted, anne, DMSc Department of Clinical Biochemistry Copenhagen University Hospital–Herlev and Gentofte Copenhagen Denmark Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

One in five people are at high risk for atherosclerotic cardiovascular disease and aortic valve stenosis due to high lipoprotein(a).Lipoprotein(a)concentrations are lowest in people from east Asia,Europe,and southeast Asia,intermediate in people from south Asia,the Middle East,and Latin America,and highest in people from *** are more than 90%genetically determined and 17%higher in post-menopausal women than in *** at a higher cardiovascular risk should have lipoprotein(a)concentrations measured once in their lifetime to inform those with high concentrations to adhere to a healthy lifestyle and receive medication to lower other cardiovascular risk *** no approved drugs to lower lipoprotein(a)concentrations,it is promising that at least five drugs in development lower concentrations by 65-98%,with three currently being tested in large cardiovascular endpoint trials.

关键词： cardiovascular (a) southeast

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Dual inhibition of sirtuins 1 and 2:reprogramming metabolic energy dynamics in chronicmyeloid leukemia as an immunogenic anticancer strategy

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Cancer Communications 2024年第8期44卷 921-925页

作者： Michael Schnekenburger anne Lorant Sruthi Reddy Gajulapalli Ridhika Rajora Jin-Young Lee Aloran Mazumder Haeun Yang Christo Christov Hyoung Jin Kang Bernard Pirotte Marc Diederich Laboratoire de Biologie Moleculaire et Cellulaire du Cancer LuxembourgLuxembourg Research Institute of Pharmaceutical Sciences&Natural Products Research Institute College of PharmacySeoul National UniversitySeoulRepublic of Korea Faculte de Medecine Universite de LorraineVandoeuvre-les-NancyFrance Department of Pediatrics Seoul National University College of MedicineSeoul National University Cancer Research InstituteSeoul National University Children’s HospitalSeoulRepublic of Korea Laboratory of Medicinal Chemistry Center for Interdisciplinary Research on Medicines(CIRM)University of LiegeLiegeBelgium

Chronicmyeloid leukemia(CML)is a lethal hematopoietic malignancy with a global incidence primarily attributed to the breakpoint cluster region-Abelson(BCR-ABL1)fusion oncogene in over 95%of *** introduction of tyrosine kinase inhibitors(TKIs)has revolutionized CML management;however,a subset of patients encounters challenges such as resistance and relapse,hindering the achievement of complete *** these challenges in CML also requires addressing persistent leukemia stem cells(LSCs)with inherent resistance *** regulators of LSC metabolism,proliferation,and survival,as well as genetic and epigenetic alterations,provide potential targets[1].

关键词： metabolism myeloid alterations

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Supportive care in transplantation: A patient-centered care model to better support kidney transplant candidates and recipients

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World Journal of Transplantation 2024年第4期14卷 15-28页

作者： Anita Slominska Katya Loban Elizabeth anne Kinsella Julie Ho Shaifali Sandal MEDIC Program Research Institute of the McGill University Health CentreMontreal H4A3J1QCCanada Institute of Health Sciences Education Faculty of Medicine and Health SciencesMcGill UniversityMontreal H4A3J1QCCanada Department of Medicine University of ManitobaWinnipeg R3A1R9MBCanada Department of Medicine McGill University Health CentreMontreal H4A3J1QCCanada

Kidney transplantation(KT),although the best treatment option for eligible patients,entails maintaining and adhering to a life-long treatment regimen of medications,lifestyle changes,self-care,and *** patients experience uncertain outcome trajectories increasing their vulnerability and symptom burden and generating complex care *** when transplants are successful,for some patients the adjustment to life post-transplant can be challenging and psychological difficulties,economic challenges and social isola-tion have been *** 50%of patients lose their transplant within 10 years and must return to dialysis or pursue another transplant or conservative *** paper documents the complicated journey patients undertake before and after KT and outlines some initiatives aimed at improving patient-centered care in transplantation.A more cohesive approach to care that borrows its philosophical approach from the established field of supportive oncology may improve patient experiences and *** propose the"supportive care in transplantation"care model to operationalize a patient-centered approach in *** model can build on other ongoing initiatives of other scholars and researchers and can help advance patient-centered care through the entire care continuum of kidney transplant recipients and ***-dimensionality,multi-disciplinarity and evidence-based approaches are proposed as other key tenets of this care *** conclude by proposing the potential advantages of this approach to patients and healthcare *** Tip:Kidney transplant recipients and candidates face several uncertainties in their care journey and have several expressed unmet healthcare *** recommend a structured and comprehensive approach to transplant care across the entire continuum of a transplant patient’s journey similar to what has been developed in the field of *** supportive care in transplantation model can operational

关键词： Supportive care Kidney transplantation Death Graft failure Adverse outcomes Kidney transplant recipients

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Analysis and Strategy Research on Influencing Factors of Classroom Teaching Quality in Higher Vocational Colleges

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Journal of Contemporary Educational Research 2024年第4期8卷 199-203页

作者： Qian Qian Wang Ma.Agatha anne D.Dizon Graduate School Angeles University FoundationAngeles 2009Philippines Quality Management Office Shandong Institute of Commerce and TechnologyJinan 250103Shandong ProvinceChina

In this study,the questionnaire“Influencing Factors of Classroom Quality in Higher Vocational Education”was *** using the questionnaire survey method,the research conclusion was drawn that the main factors affecting the classroom teaching quality in higher vocational education were teaching and student factors,teacher factors,and classroom factors based on 2,683 *** to the research results,the measures to improve the quality of classroom teaching are put forward,in order to provide guidance for improving the quality of teaching in higher vocational colleges.

关键词： Higher vocational colleges Classroom teaching quality Influencing factor

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Extension of the theory of adherence to treatment in patients with coronary heart disease

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Chronic Diseases and Translational Medicine 2024年第3期10卷 227-237页

作者： Outi Kähkönen Hannu Vähänikkilä Leila Paukkonen anne Oikarinen Department of Nursing Science University of Eastern FinlandKuopioFinland Northern Finland Birth Cohorts Arctic BiobankInfrastructure for Population StudiesFaculty of MedicineUniversity of OuluOuluFinland Reseach Unit of Health Sciences and Technology Faculty of MedicineUniversity of OuluOuluFinland Medical Research Center Oulu(MRC Oulu) Faculty of medicineUniversity of OuluOuluFinland

Background: Increased knowledge of the concept of adherence is needed for development patient-centered care, nursing interventions, and guidelines for patients with coronary heart disease (CHD). The aim of this study was to test and extend the Theory of Adherence to Treatment regarding informational support in patients with ***: The study utilized an explanatory and descriptive survey. The study was conducted in 2013 and involved 416 patients in five hospitals in Finland. The Adherence of Patients with Chronic Disease instrument and the Social Support for People with CHD instrument were used. The model was tested using structural equation modeling (SEM).Results: SEM confirmed direct associations between motivation (β = 0.49,p < 0.001) and results of care (β = 0.29,p < 0.01), and indirect associations between sense of normality, fear of complications, support from nurses and next of kin, and informational support to adherence to a healthy lifestyle and medication. Informational support included information and advice on CHD risk factors, physical exercise, chest pain, medication, continuum of care, and rehabilitation. Indirect standardized path coefficients varied between 0.14 and 0.45. The model explained 45% of adherence to a healthy lifestyle and ***: The results of this study showed that informational support is a justified extension to the original Theory of Adherence to Treatment in Patients with CHD. Informational support seems to offer a new perspective that can be used to develop patient-centered nursing interventions and thus support adherence to treatment by patients with a lifelong disease such as CHD.

关键词： adherence to treatment cardiovascular nursing Nursing theory

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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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猫咪这么可爱，能有坏心思?

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新民周刊 2024年第27期 38-39页

作者： anne

关于猫的中国古籍可真不少。如署名俞宗本的《纳猫经》、署名沈清瑞的《相猫经》、王初桐的《猫乘》、孙荪意的《衔蝉小录》、黄汉的《猫苑》等。近期两则新闻，实际一个主角。第一则新闻是尘埃落定的英国大选，工党并无悬念地成为新一...

关于猫的中国古籍可真不少。如署名俞宗本的《纳猫经》、署名沈清瑞的《相猫经》、王初桐的《猫乘》、孙荪意的《衔蝉小录》、黄汉的《猫苑》等。近期两则新闻，实际一个主角。第一则新闻是尘埃落定的英国大选，工党并无悬念地成为新一届执政党，而基尔·斯塔默将成为英国八年来上任的第六位首相。流水的“一把手”铁打的“捕鼠大臣”，流浪猫拉里自打住进唐宁街十号，就一直是英国人最偏爱的公务员，如今俨然资历深厚、声名远扬的五朝元老了。第二则新闻是即将拉开帷幕的“金字塔之巅：古埃及文明大展”，配套推出“博物馆奇‘喵’夜”活动，邀请观众携宠物猫同行。

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繁花的颜值巅峰，其实在恽寿平的画笔下

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新民周刊 2024年第3期 48-49页

作者： anne

玉净花明南田画，颠沛流离谁体察。烈火烹油，鲜花着锦。说的是从小说到电视剧，“繁花”这个大IP最近狂飙的热度，张扬的声势。美人如花，世相千机幻变亦如花。花非花，雾非雾。来如春梦几多时，去似朝云无觅处。浮生苦短，恰似花期春...

玉净花明南田画，颠沛流离谁体察。烈火烹油，鲜花着锦。说的是从小说到电视剧，“繁花”这个大IP最近狂飙的热度，张扬的声势。美人如花，世相千机幻变亦如花。花非花，雾非雾。来如春梦几多时，去似朝云无觅处。浮生苦短，恰似花期春梦。不过，难以否认的是，意兴阑珊或萧索低沉之时，若推窗闻香、开门见林，桃李芬芳怒放枝头，清脆的莺啼声隐于片片翠叶之中，那么，你的心情自然而然会变得明朗、舒展起来。

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