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Association between Epilepsy and Psychogenic Non-Epileptic Seizures: A Case Report

Open Journal of Psychiatry 2017年第1期7卷 40-50页

作者： Diana Galletta Monica Confuorto Ilaria Lauria Valentina Suarato annamaria califano Anna Maria Mastrola Fausta Micanti Department of Neurosciences and Reproductive and Odontostomatological Sciences University of Naples Federico II Naples Italy

Epilepsy is a very complex disorder of the central nervous system. It is characterized by a sudden, disordered and excessive neuronal shock that causes different clinical evidences with specific related electroencephalogram (EEG). Psychogenic Non-Epileptic Seizures (PNES) can seriously complicate the diagnosis of epilepsy. The separoxysmal events have the same clinical evidences of epilepsy, such as an impairment of the self-control and a range of sensory, motor and mental manifestations, without the typical related electroencephalogram (EEG) because of the absence of an organic cause. The overwhelming majority of Psychogenic Non-Epileptic Seizures are related to psychological factors like dissociation. This is a defense mechanism used to cope stressful events or emotional conflicts. Psychological or psychiatric disorders, like Post Traumatic Stress Disorder (PTSD), are frequently associated to Psychogenic Non-Epileptic Seizures. In this article, we present a case report of epilepsy combined with Psychogenic Non-Epileptic Seizures. A joint intervention is of great significance in this occurrence. The subject received a psychological assessment including psychometric and projective tools. He stood MMPI-2, Wais-R, SCL-90, Rorschach test and graphic tests. A psychological disorder related to defense mechanisms was identified. The subject presents a tendency to convert his fears and emotive pains in rational and more socially acceptable problems, using his body to express his discomfort. Patient with epileptic seizures should receive a psychological assessment to exclude Psychogenic Non-Epileptic Seizures. Further studies should propose guidelines to integrate neurological, psychiatric and psychological intervention.

关键词： Epilepsy Psychogenic Non-Epileptic Seizures PNES Dissociation PTSD

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Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi califano Celeste Manfredi Giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU Working Group Sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before *** found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

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Reverse engineering microRNA-related regulatory networks

Reverse engineering microRNA-related regulatory networks

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第五届全国生物信息学与系统生物学学术大会暨国际生物信息...

作者： Xuerui Yang Pavel Sumazin Wei-Jen Chung Hua-Sheng Chiu Andrea califano Center for Computational Biology and Bioinformatics Columbia Initiative in Systems Biology Columbia University

Background:microRNAs(miRs) have emerged as key regulators of both normal and pathologic phenotypes,including *** activities and biogenesis of miRs are heavily *** of physiologic miR activity and biogenesis has been shown to play an important role in tumor initiation and ***,few modulators of miR activity and biogenesis have been characterized,and both the extent and relevance of their role in controlling normal cell physiology and pathogenesis are poorly understood. Methods:Systematic approaches were exploited to dissect microRNA-related post- transcriptional regulatory networks that are associated with human ***,by analyzing mRNA and miR expression profiles of a large set of glioblastoma patient samples, miR activity and biogenesis regulations have been studied in a genome-wide scale. Results:First,genome-wide screening of miR activity regulators uncovered a previously-uncharacterized layer of post-transcriptional regulation,involving 7,000 RNAs that act as miR "sponges" and participate in more than 248,000 miR program-mediated (mPM) *** regulation layer also includes 148 genes that regulate individual miR activity on its targets through alternative,nonsponge *** mPM interactions as a network mediate crosstalk between canonical oncogenic pathways and connect genetically distant genes,which was experimentally validated in tumor cell *** mPM interactions also provide mechanistic rationales for regulation of key genes in cancer,and largely explain missing genetic variations in various patient *** interaction networks were also reconstructed for breast,prostate,and ovarian ***,hundreds of novel regulators of miR biogenesis were discovered through a genome-wide screening using the same dataset as above.A subset of these regulators have been experimentally validated via high-,mid-,and low-throughput profiling of primary,precursor,and mature miRs in additio

关键词： microRNA activity biogenesis sponge regulation post-transcriptional

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肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)

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中华神经外科疾病研究杂志 2010年第1期9卷 22-22页

作者： Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea califano Antonio Iavarone

The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.

关键词：脑瘤细胞分子生理学临床分析

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