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脂肪移植的研究：V部分，能提高脂肪移植成活量的辅助细胞脂肪移植是有剂量依赖性的

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中国美容整形外科杂志 2015年第10期26卷 I0008-I0014页

作者： KevinJ.Paik Elizabeth R. Zielins David A. Atashroo Zeshaan n. Maan Dominik Duscher anna Luan Graham G. Walmsley Arash Momeni Stephanie Vistnes Geoffrey C. Gurtner Michael T. Longaker Derrick C. Wan 叶美辰高景恒张晨袁继龙美国加利福尼亚州斯坦福斯坦福大学医学院小儿再生医学Hagey实验室整形与重建外科外科病区干细胞生物和再生医学研究所《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科辽宁省人民医院整形外科

背景辅助细胞脂肪移植能提高脂肪移植的成活量。但能显著提高脂肪保留量的基质血管细胞群最佳浓度尚未得知。方法将获得的一部分脂肪待移植，另一部分提取基质血管细胞群。然后将提取出的不同浓度细胞（每200μl的脂肪含有1×10^4-1X10^... 详细信息

背景辅助细胞脂肪移植能提高脂肪移植的成活量。但能显著提高脂肪保留量的基质血管细胞群最佳浓度尚未得知。方法将获得的一部分脂肪待移植，另一部分提取基质血管细胞群。然后将提取出的不同浓度细胞（每200μl的脂肪含有1×10^4-1X10^7个细胞）与脂肪混合进行移植。移植后第8周，通过计算机断层扫描测定脂肪移植的成活量，并将移植的脂肪取出，比较结构和血管的组织学改变。结果加入的细胞浓度为每200μl脂肪含有1×10^4个细胞时，脂肪移植的成活量最大。加入的细胞量过多对脂肪移植的存活是不利的，加入1×10’个细胞时，脂肪的成活量最低，甚至比单纯脂肪移植更低。有趣的是，加入1×10^4个细胞时，血管化明显增加，炎症反应降低；而加入1×10^7个细胞与单纯脂肪移植相比，发生明显脂肪变性。结论我们的研究表明，可加入适量的基质血管细胞群以提高脂肪移植的成活量。虽然辅助细胞脂肪移植能促进移植脂肪的存活，但加入的细胞后期会与脂肪细胞争夺养分，因此，加人的细胞数量与其代谢要平衡。

关键词：脂肪移植辅助细胞剂量依赖性成活计算机断层扫描最佳浓度组织学改变血管化

免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究

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中国肺癌杂志 2022年第4期25卷 I0007-I0022页

作者： Silvia SCOCCIAnTI Emanuela OLMETTO Valentina PInZI Mattia Falchetto OSTI Rossella Di FRAnCO Saverio CAInI Paola AnSELMO Paolo MATTEUCCI Davide FRAnCESCHInI Cristina MAnTOVAnI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUnI Paolo TInI Emilia GIUDICE Patrizia CIAMMELLA anna MERLOTTI Sara PEDRETTI Marianna TRIGnAnI Marco KREnGLI niccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARAnZAnO Laura FARISELLI Pierina nAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) Radiation Oncology Unit Ospedale Santa Maria AnnunziataDepartment of OncologyBagno a RipoliFlorenceItaly Radiation Oncology Unit Azienda Ospedaliero Universitaria CareggiDepartment of Experimental and Clinical Biomedical Sciences"Mario Serio"FlorenceItaly U.O Radioterapia Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of NeurosurgeryMilanItaly U.O.C Radioterapia A.O.U Sant'Andrea Facolta Medicina e Psicologia Universita SapienzaDepartment of MedicineSurgery and Translational MedicineRomeItaly Istituto nazionale Tumori IRCCS Fondazione G.PascaleDepartment of RadiotherapyNaplesItaly Institute for Cancer Research Prevention and Clinical Network(ISPRO)Cancer Risk Factors and Life-Style Epidemiology UnitFlorenceItaly Radiotherapy Oncology Center S.Maria HospitalDepartment of OncologyTerniItaly Humanitas Research Hospital Radiotherapy and Radiosurgery DepartmentRozzanoItaly Radiotherapy Unit Department of OncologyTurinItaly Cyberknife Centro Diagnostico Italiano Department of RadiologyMilanItaly Radiation Oncology Azienda Ospedaliero Universitaria PisanaDepartment of Translational MedicinePisaItaly Radiotherapy Unit University Hospital of ModenaDepartment of Oncology and HematologyModenaItaly Radiotherapy Unit University of SienaDepartment of Radiotherapy and OncologySienaItaly UOC di Radioterapia Policlinico Universitario Tor VergataDepartment of Onco-HaematologyRomeItaly Radioterapia Oncologica"G.Prodi "AO-IRCCS Arcispedale S.Maria NuovaDepartment of Oncology and Advanced TechnologyReggio EmiliaItaly Radiation Oncology A.S.O.S.Croce e Carle Department of Radiation OncologyCuneoItaly U.O.Radioterapia Oncologica Department of Radiation OncologyASST Spedali Civili di Brescia e Universita degli studi di BresciaBresciaItaly U.O.C.Radioterapia Oncologica Ospedale Clinicizzato SS Annunziata-Universita Chieti G.D'AnnunzioDepartment of Radiation OncologyChietiItaly Radiation Oncology University Hospital Maggiore della CaritdDepartment of Translational Medicine

背景与目的通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, nSCLC)脑转移的疗效和毒性。方法对来自19个意大利中心接受SRT+IT的nSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。

关键词：立体定向放疗回顾性研究脑转移倾向性评分临床肿瘤学免疫疗法放射治疗

ResCD-FCn:Semantic Scene Change Detection Using Deep neural networks

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Journal on Artificial Intelligence 2022年第4期4卷 215-227页

作者： S.Eliza Femi Sherley J.M.Karthikeyan n.Bharath Raj R.Prabakaran A.Abinaya S.V.V.Lakshmi Department of Information Technology Anna UniversityMIT CampusChennai600044India Computer Center Anna UniversityMIT CampusChennai600044India Department of Computer Science and Engineering Anna UniversityCEG CampusChennai600025India

Semantic change detection is extension of change detection task in which it is not only used to identify the changed regions but also to analyze the land area semantic(labels/categories)details before and after the timelines are *** land change analysis is used for many real time applications for valuation *** of the research works are focused on Convolutional neural networks(Cnn)which tries to analyze changes *** information of changes appears to be missing,there by absence of communication between the different semantic timelines and changes detected over the region *** overcome this limitation,a Cnn network is proposed incorporating the Resnet-34 pre-trained model on Fully Convolutional network(FCn)blocks for exploring the temporal data of satellite images in different timelines and change map between these two timelines are *** this model achieves better results by analyzing the semantic information between the timelines and based on localized information collected from skip connections which help in generating a better change map with the categories that might have changed over a land area across *** model effectively examines the semantic changes such as from-to changes on land over time *** experimental results on SECOnD(Semantic Change detectiOn Dataset)indicates that the proposed model yields notable improvement in performance when it is compared with the existing approaches and this also improves the semantic segmentation task on images over different timelines and the changed areas of land area across timelines.

关键词： Remote sensing convolutional neural network semantic segmentation change detection semantic change detection resnet FCn

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93例春季角结膜炎患者的睫毛较长

世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 57-57页

作者： Pucci n. novembre E. Lombardi E. 刘莉 Allergy and Clinical Immunology Unit Department of Pediatrics Anna Meyer Children's Hospital Via Luca Giordano 13 50132 Florence Italy.Dr

Objective. Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that affects children mainly in temperate areas, with exacerbations in spring and summer. Eyelashes provide natural protection for the eyes from sunshine, wind, and foreign bodies. These factors induce a worsening of signs and symptoms in VKC, whereas mechanical protection of the eyes produces relief. The aim of this study was to evaluate eyelash length in a large series of VKC patients and in age-and gender-matched healthy subjects. Methods. Upper eyelash length was measured in 93 VKC patients (mean age: 8.7 years; range: 4-18 years) with a digital caliper. History, clinical form, type of presentation, degree of severity, and drug therapy were evaluated. Skin tests and serum-specific immunoglobulin E for common allergens, serum-total immunoglobulin E, peripheral blood eosinophil counts, and serum eosinophil cationic protein were determined. Two age-and gender-matched control subjects for each VKC patient underwent the same eyelash measurement. Results. The upper eyelashes were significantly longer in VKC patients than in control subjects (mean ±SD: 8.9 ±1.17mm vs 7.9 ±1.07 mm). In healthy subjects, a negative correlation was found between eyelash length and age. With multivar iate analysis, unlike control subjects, the eyelash length in VKC patients did not correlate with age, was positively correlated with the degree of severity of VKC, and was negatively correlated with the use of topical cyclosporine. Conclusions. Patients with VKC had longer eyelashes than healthy matched subjects. The ocular inflammation, by unknown chemical mediators, was likely responsible for the excessive eyelash growth. The finding may represent a defensive mechanism against physical agents that might have a crucial role in the etiopathogenesis of this disease.

关键词：春季角结膜炎睫毛长度患者健康儿童慢性结膜炎病情加重年龄性别平均年龄机械性

系统综述与网状Meta分析的PRISMA扩展声明

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中国循证心血管医学杂志 2016年第6期8卷 656-660,665页

作者：李志霞杨俊叶欣周凌波杨智荣孙凤詹思延 Brian Hutton Georgia Salanti Deborah M.Caldwell anna Chaimani Christopher H.Schmid Chris Cameron John P.A.Ioannidis Sharon Straus Kristian Thorlund Jeroen P.Jansen Cynthia Mulrow Ferrán Catalá-López Peter C.Gozsche Kay Dickersin Isabelle Boutron Douglas G.Altman David Moher 北京大学公共卫生学院北京100191 剑桥大学初级医疗中心

PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展... 详细信息

PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展,实施和报告这一类系统综述面临较大挑战。此时,针对网状META分析的PRISMA扩展声明应运而生,旨在提高网状META分析系统综述的报告质量。PRISMA扩展声明是由专家们通过DELPHI调查、面对面讨论和共识大会而最终确立的。PRISMA扩展声明是在原始PRISMA声明的报告清单的基础上经过修改,最终确定了32个条目,每个条目均与网状META分析报告的内容直接相关。本文对网状META分析的PRISMA扩展声明进行了阐述,对报告清单各条目进行了举例说明,并详细说明了在原始PRISMA声明的基础上新增和修改各条目的理由。此外,PRISMA扩展声明强调了在网状META分析的实际操作中需要重点关注的信息。本文的目标读者包括网状META分析的作者与读者,以及期刊杂志的编辑与同行评审。

关键词：系统综述 Meta分析网状 META分析 DELPHI 报告质量期刊杂志条目

The enhanced X-ray Timing and Polarimetry mission—eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 3-27页

作者： Shuangnan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas norbert Meidinger Aline Meuris Kirpal nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang nian Yu WenDa Zhang Gianluigi Zampa nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für Astronomie und Astrophysik Eberhard Karls Universität InAF-Istituto di Astrofisica e Planetologia Spaziali InFn-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Physics and Center for Astrophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Space Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espacials de Catalunya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of Astronomy University of Genevachemin d’Ecogia 16 Osservatorio di Astrofisica e Scienza Dello Spazio di Bologna Istituto Nazionale di Astofisica Astronomical Institute Czech Academy of Sciences Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1 CEA Paris-Saclay/IRFU Beijing Institute of Spacecraft System Engineering CAST Osservatorio Astronomico di Brera Istituto Nazionale di Astofisica Space Research Center Polish Academy of Sciences Key Laboratory of Advanced Material Microstructure of Education Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Physics and Center for Astrophysics Tsinghua University Universita’degli Studi di Udine Via delle Scienze 206 Mullard Space Science Laboratory University College London Department of nuclear and Particle Physics University of Geneva SROn netherlands Institute for Space Research Politecnico di Milano Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fisica e Chimica Fondazione Bruno Kessler Dr.Karl Remeis-Observatory and Erlangen Centre for Astroparticle Physics Universität Erlangen-Nürnberg University of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Physics and Astronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave *** paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.

关键词： X-ray instrumentation X-ray polarimetry X-ray timing space mission:eXTP

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奥胡斯住宅综合体

当代建筑 2020年第5期 60-69页

作者： Agne Rapkeviciute Aaron Hales Agne Tamasauskaite Alberte Danvig Aleksander Wadas Ana Vindfeldt anna Wisborg Annette Jensen Ariel Joy norback Wallner Brigitta Gulyás Claes Robert Janson Enea Michelesio Frederike Werner Hsiao Rou Huang Ioana Fartadi Scurtu Jacob Lykkefold Aaen Jakob Lange Jakob Andreassen Jakob Ohm Laursen Jan Magasanik Jesafa Templo Jesper Boye Andersen Kamilla Heskje Katarina Mácková Katerina Joannides Katrine Juul Kekoa Charlot Kristoffer negendahl Lise Jessen Lucian Racovitan Lucian Tofan Roberto Outumuro Sergiu Calacean Sofie Maj S?rensen Spencer Hayden Teodor Javanaud Emden Tobias Hjortdal Tore Banke Xuefei Yan Yehezkiel Wiliardy Ella Murphy Ricardo Oliveira Dominiq Oti BIG建筑设计事务所

项目名称:奥胡斯住宅综合体建设地点:丹麦奥胡斯业主:Kilden&Mortensen APS设计单位:BIG建筑设计事务所用地面积:26 500 m2合作设计:MT H?jgaard建筑设计公司,MOE建筑设计公司主管合伙人:Bjarke Ingels, Finn n?rkj?r, Andreas Klok Ped...

项目名称:奥胡斯住宅综合体建设地点:丹麦奥胡斯业主:Kilden&Mortensen APS设计单位:BIG建筑设计事务所用地面积:26 500 m2合作设计:MT H?jgaard建筑设计公司,MOE建筑设计公司主管合伙人:Bjarke Ingels, Finn n?rkj?r, Andreas Klok Pedersen项目负责人:S?ren Martinussen项目经理:Ali Arvanaghi, Jesper Bo Jensen

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