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ON AN EQUATION CHARACTERIZING MULTI-CAUCHY-JENSEN MAPPINGS AND ITS HYERS-ULAM STABILITY

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Acta Mathematica Scientia 2015年第6期35卷 1349-1358页

作者： anna BAHYRYCZ Krzysztof CIEPLINSKI Jolanta OLKO Institute of Mathematics Pedagogical University AGH University of Science and Technology Faculty of Applied Mathematics

In this paper, we give two characterizations of multi-Cauchy-Jensen mappings. One of them reduces the system of n equations defining these mappings to a single functional equation. We also prove, using the fixed point... 详细信息

关键词： multi-Cauchy-Jensen mapping (generalized) Hyers-Ulam stability Cauchy'sfunctional equation Jensen's functional equation fixed point method

The endogenous progenitor response following traumatic brain injury:a target for cell therapy paradigms

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Neural Regeneration Research 2022年第11期17卷 2351-2354页

作者： anna Badner Brian J.Cummings Department of Psychiatry and Behavioral Sciences Stanford UniversityPalo AltoCAUSA Sue and Bill Gross Stem Cell Center University of California-IrvineIrvineCAUSA Institute for Memory Impairments and Neurological Disorders University of California-IrvineIrvineCAUSA Physical Medicine and Rehabilitation University of California-IrvineIrvineCAUSA Department of Anatomy and Neurobiology University of California-IrvineIrvineCAUSA

Although there is ample evidence that central nervous system progenitor pools respond to traumatic brain injury,the reported effects are variable and likely contribute to both recovery as well as *** a better understanding of the diverse progenitor populations in the adult brain and their niche-specific reactions to traumatic insult,treatments can be tailo red to enhance the benefits and dampen the deleterious effects of this *** review provides an overview of endogenous precursors,the associated effects on cognitive recovery,and the potential of exogenous cell therapeutics to modulate these endogenous repair *** the hippocampal dentate gyrus and subventricular zone of the lateral ventricles,more recently identified sites of adult neurogenesis,the meninges,as well as circumventricular organs,are also discussed as targets for endogenous ***,this review highlights that progenitor prolife ration alone is no longer a meaningful outcome and studies must strive to better chara cterize precursor spatial localization,transcriptional profile,morphology,and functional synaptic *** improved insight and a more targeted approach,the stimulation of endogenous neurogenesis remains a promising strategy for recovery following traumatic brain injury.

关键词： cell therapy endogenous repair neurogenic niche progenitors traumatic brain injury

Applications and roles of the CRISPR system in genome editing of plants

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Journal of Forestry Research 2017年第1期28卷 15-28页

作者： Wei Tang anna Y.Tang College of Arts and Science East Carolina UniversityGreenvilleNC 27858USA University of North Carolina at Chapel Hill 101 Stadium DriveChapel HillNC 27514USA

Genome editing is a valuable tool to target specific DNA sequences for mutagenesis in the genomes of microbes, plants, and animals. Although different genome editing technologies are available, the clustered regularly interspaced short palindromic repeats/Cas9 （CRISPR/ Cas9） system, which utilizes engineered endonucleases to generate a double-stranded DNA break （DSB） in the target DNA region and subsequently stimulates site-specific mutagenesis through DNA repair machineries, is emerging as a powerful genome editing tool for elucidating mecha- nisms of protection from plant viruses, plant disease resistance, and gene functions in basic and applied research. In this review, we provide an overview of recent advances in the CRISPR system associated genome editing in plants by focusing on application of this technology in model plants, crop plants, fruit plants, woody plants and grasses and discuss how genome editing associated with the CRISPR system can provide insights into genome modifications and functional genomics in plants.

关键词： CRISPR system break Functional genomics modifications Double-stranded DNA Genome editing Genome

Surface tracking assessment and interaction in texture space

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Computational Visual Media 2018年第1期4卷 3-15页

作者： Johannes Furch anna Hilsmann Peter Eisert Fraunhofer HHI Berlin10587Germany Humboldt University Berlin10099Germany

In this paper, we present a novel approach for assessing and interacting with surface tracking algorithms targeting video manipulation in postproduction. As tracking inaccuracies are unavoidable,we enable the user to provide small hints to the algorithms instead of correcting erroneous results afterwards. Based on 2D mesh warp-based optical flow estimation, we visualize results and provide tools for user feedback in a consistent reference system, texture space. In this space, accurate tracking results are reflected by static appearance, and errors can easily be spotted as apparent change. A variety of established tools can be utilized to visualize and assess the change between frames. User interaction to improve tracking results becomes more intuitive in texture space, as it can focus on a small region rather than a moving *** show how established tools can be implemented for interaction in texture space to provide a more intuitive interface allowing more effective and accurate user feedback.

关键词： surface tracking assessment interaction mesh warp optical flow

Methyltransferase-like 3(METTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-PD1 therapy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： anna Brichkina Roman Suezov Magdalena Huber Institute of Systems Immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

In a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase METTL3 induced a formation of immunostimulatory doublestranded mRNAs(dsRNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of METTL3 synergized with anti-PD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： PD1 immunity

Transgenic woody plants for biofuel

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Journal of Forestry Research 2014年第2期25卷 225-236页

作者： Wei Tang anna Y.Tang Department of Biology East Carolina University 101 Stadium Drive University of North Carolina at Chapel Hill

Transgenic trees as a new source for biofuel have brought a great interest in tree biotechnology. Genetically modifying forest trees for ethanol production have advantages in technical challenges, costs, environmental concerns, and financial problems over some of crops. Genetic engineering of forest trees can be used to reduce the level of lignin, to produce the fast-growing trees, to develop trees with higher cellulose, and to allow the trees to be grown more widely. Trees can establish themselves in the field with less care of farmers, compared to most of crops. Transgenic crops as a new source for biofuel have been recently reviewed in several reviews. Here, we overview transgenic woody plants as a new source for biofuel including genetically modified woody plants and environment; main focus of woody plants genetic modifications; solar to chemical energy transfer; cellulose biosynthesis; lignin biosynthesis; and cellulosic ethanol as biofuel.

关键词： biofuel cell wall cellulose lignin transgenic tree

Three-dimensional in vitro models of neuromuscular tissue

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Neural Regeneration Research 2022年第4期17卷 759-766页

作者： Paolo Raffa Maria Easler anna Urciuolo Institute of Pediatric Research IRP PadovaItaly Molecular Medicine Department University of PadovaPadovaItaly

Skeletal muscle is a dynamic tissue in which homeostasis and function are guaranteed by a very defined three-dimensional organization of myofibers in respect to other nonmuscular components,including the extracellular matrix and the nervous *** particular,communication between myofibers and the nervous system is essential for the overall correct development and function of the skeletal muscle.A wide range of chronic,acute and genetic-based human pathologies that lead to the alteration of muscle function are associated with modified preservation of the fine interaction between motor neurons and myofibers at the neuromuscular *** advancements in the development of in vitro models for human skeletal muscle have shown that three-dimensionality and integration of multiple cell types are both key parameters required to unveil pathophysiological relevant ***,we describe recent achievement reached in skeletal muscle modeling which used biomaterials for the generation of three-dimensional constructs of myotubes integrated with motor neurons.

关键词： 3D organization bioengineering biomaterials motor neurons neuromuscular junction skeletal muscle models

Transcriptional mechanisms regulating gene expression and determining cell fates in plant development

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Journal of Forestry Research 2017年第5期28卷 863-880页

作者： Wei Tang anna Y.Tang College of Arts and Science East Carolina University University of North Carolina at Chapel Hill

Transcriptional regulatory mechanisms that control transcriptional regulators, target genes, and their interactions provide new insights into general development processes throughout the life cycle of the plant. Although different molecular mechanisms that regulate plant growth and development have been identified, detailed transcriptional mechanisms that control gene expression, modulate developmental programmes, and determine cell fates in plant development are not fully understood. To increase our understanding on transcriptional mechanisms regulating diverse processes in plant development, we have reviewed the regulation of transcription during the process of development including transcriptional mechanisms regulating root, stem, leaf, flower, seed, embryo, endosperm, ovule, fruit, and chloroplast development. We have summarized the interaction, expression, transport, signaling events of transcriptional regulators and their targets in a number of model plants and highlighted the involvement of hormones and microRNAs in plant development. Understanding the precise transcriptional mechanisms regulating gene expression in plant development will be valuable for plant molecular breeding.

关键词： MicroRNAs Molecular breeding Plant development Root formation Transcriptional regulators

Pediatric non-alcoholic fatty liver disease:Preventive and therapeutic value of lifestyle intervention

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World Journal of Gastroenterology 2009年第48期15卷 6017-6022页

作者： Valerio Nobili anna Alisi Massimiliano Raponi Liver Unit Research InstituteBambino Gesù Children's Hospital Liver Unit Research InstituteBambino Gesù Children’s Hospital Health Planning Department Research Institute Bambino Gesù Children’s Hospital

Nonalcoholic fatty liver disease(NAFLD),ranging from simple steatosis to nonalcoholic steatohepatitis(NASH),and eventually cirrhosis and liver failure,is seen to be increasing amongst Western *** rates are rising in parallel with the epidemic of childhood obesity,and in particular,fatty liver evolves more easily in NASH when poor dietary habits and sedentary lifestyle are *** fact,its general prevalence in the child population varies between 2.6% and 10%,but increases up to 80% in obese *** NASH is expected to become the most common cause of pediatric chronic liver disease in the near future,there is broad interest amongst clinical researchers to move forward,both in diagnosis and ***,to date,the expensive and invasive procedure of liver biopsy is seen as the gold standard for NASH diagnosis and few noninvasive diagnostic methods can be applied ***,there are still no approved pharmacological interventions for NAFLD/***,current management paradigms are based upon the presence of associated risk factors and aims to improve an individual's quality of life,thus reducing NAFLD-associated morbidity and ***,lifestyle intervention(diet and exercise) is the treatment of choice for NAFLD/ *** far,no study has evaluated the potential preventive effect of lifestyle intervention on children at risk of NAFLD/*** studies will be required in this area with the perspective of developing a national program to promote nutrition education and increase physical activity as means of preventing the disease in individuals at ***,we outline the clinical course,pathogenesis and management of NAFLD in children,highlighting the preventive and therapeutic value of lifestyle intervention.

关键词： Fatty liver Children Lifestyle Diet Exercise Prevention