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Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care

World Journal of Gastroenterology 2020年第18期26卷 2221-2231页

作者： Anuj Bohra Thomas Worland Samuel Hui Ryma Terbah ann farrell Marcus Robertson Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Department of Medicine School of Clinical SciencesMonash UniversityClayton 3168VictoriaAustralia

BACKGROUND Hepatic encephalopathy(HE)is a reversible neuropsychiatric complication of liver cirrhosis and occurs in up to 50%of cirrhotic *** examining the prognostic significance of HE are limited despite the high prevalence in *** To define the clinical outcomes of patients after an episode of HE treated with current *** All patients hospitalised with HE requiring Rifaximin to 3 tertiary centres over46-mo(2012–2016)were identified via pharmacy dispensing *** with hepatocellular carcinoma and those prescribed Rifaximin prior to admission were *** records were reviewed to determine baseline characteristics and *** Kaplan-Meier method was used to calculate survival *** survival analysis was performed with variables reaching statistical significance included in a multivariate *** primary outcome was 12-mo mortality following commencement of ***188 patients were *** age was 57 years(IQR 50-65),71%were male and median model for end stage liver disease and Child Pugh scores were 25(IQR 18-31)and 11(IQR 9-12)*** most common causes of cirrhosis were alcohol(62%),hepatitis C(31%)and non-alcoholic fatty liver disease(20%).A precipitating cause for HE was found in 92%patients with infection(43%),GI bleeding(16%),medication non-compliance(15%)and electrolyte imbalance(14%)the most *** a mean follow up period of 12±13 mo 107(57%)patients died and 32(17%)received orthotopic liver *** common causes of death were decompensated chronic liver disease(57%)and sepsis(19%).The probability of survival was 44%and 35%at 12-and 24-mo *** multivariate analysis a model for end stage liver disease>15 and international normalised ratio reached statistical significance in predicting *** Despite advances made in the management of HE patients continue to have poor ***,in all patients

关键词： Hepatic encephalopathy Cirrhosis Portal hypertension Prognosis Rifaximin Lactulose

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中美职前数学教师理想知识的比较研究——基于培养方案的分析

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数学教育学报 2015年第4期24卷 13-18页

作者：尚晓青 ann. farrell 陈晓端张筱玮陕西师范大学教育学院陕西西安710062 美国莱特州立大学数学与科学学院美国代顿45435 天津师范大学教师教育学院天津300387

以文本现象分析以及数据统计为主要的研究手段，对22组中美职前数学教师培养计划中的培养目标和课程设计进行了分析和比较．发现，中美两国职前数学教师的理想知识范围和内容，既具有国际化的共性又各具民族化特色；两国之间的差异有其... 详细信息

以文本现象分析以及数据统计为主要的研究手段，对22组中美职前数学教师培养计划中的培养目标和课程设计进行了分析和比较．发现，中美两国职前数学教师的理想知识范围和内容，既具有国际化的共性又各具民族化特色；两国之间的差异有其理论背景也受社会文化的影响；这种比较引导着教师理想知识的国际对话，有利于促进职前数学教师的专业化发展．

关键词：教师教育职前教师理想知识比较

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Alcoholic liver disease and mast cells:What's your gut got to do with it?

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Liver Research 2019年第1期3卷 46-54页

作者： Julie ann Tolefree Abigail Joy Garcia Jenee farrell Vik Meadows Lindsey Kennedy Laura Hargrove Jennifer Demieville Nicole Francis Julia Mirabel Heather Francis Department of Medical Physiology College of MedicineTexas A&M Health Science CenterTempleTXUSA Division of Research Central Texas Veterans Health Care SystemTempleTXUSA Department of Medicine Indiana UniversityIndianapolisINUSA

Alcoholic liver disease(ALD)remains one of the leading causes of liver injury and death when left *** gut microbiota has been recognized as a key regulator of a number of pathologies,including *** role of mast cells(MCs)during liver disease progression has been demonstrated in a number of animal models and in human liver *** interaction between the gut microbiota and MCs has been investigated,and links between the gut and these immune cells are being *** interplay between the gut microbiota and MCs during ALD has been evaluated and studies suggest that there could be an important link between MCs,their mediators and gut inflammation during the progression of ALD.

关键词： Alcoholic liver disease(ALD) Alcoholic steatohepatitis(ASH) Cirrhosis Steatosis Mast cells(MCs) Microbiota Gut

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