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generation of oxidants and their role in the metabolism of oxygen in the survivability of filarial parasite Setaria digitata in cattle:a possible intervention strategy

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Infectious Diseases Research 2023年第1期4卷 23-27页

作者： Kochukunju pillai Jayakumar Kottayath g Nevin Department of Biochemistry PMS College of Dental Science and ResearchThiruvananthapuram 695028India Centre for Bioactive Substances from Marine Organisms Kerala University of Fisheries and Ocean StudiesKerala 682506India Department of Marine Biosciences Faculty of Ocean Science and TechnologyKerala University of Fisheries and Ocean StudiesKerala 682506India

Background:The goal of the current study was to identify the potential therapeutic targets by analyzing the production of oxidants and their effects on the antioxidant system of Setaria digitata,a filarial worm that was collected from the peritoneal cavity of recently butchered ***:*** was collected and the mitochondria-like particles(MLP),somatic isolates and the post-nuclear fraction were prepared for *** radical intensity and the antioxidant enzyme activity in these fractions were *** effect of diethylcarbamazine(DEC),Q0,omeprazole,and L-methyl arginine on NOS production in the worm was also ***:Experiments showed that coelomic fluid and whole worm showed significant levels of Nitric oxide compared to other *** cytosol of the worm showed higher NOS activity than *** dismutase and nitric oxide(NO)levels were found to be higher in MLP fraction of the *** was also found that DEC did not have any effect on the prevention of NO,while Q0,omeprazole,and L-methyl arginine treatment showed a decrease in NO production ***:The results showed that by using the existing drugs we could reduce the propagation of *** by inhibiting the production of NO.

关键词： Setaria digitata mitochondria-like particles nitric oxide L-methyl arginine

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热带地区家蚕生长的研究 Ⅱ.桑园的农艺措施对蚕的生长、产茧量及产卵量的影响

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中国蚕业 1988年第4期 36-38页

作者： S. Venugopala pillai 沈雪华

蚕茧的产量取决于蚕品种的强健度,后者又受到食桑的质量以及在饲养过程中各龄的处理方法的影响(Hussainien and Sharra wy,1962;Legay,1965;Ide等,1965;g abriel and Rapusas,1967:Ueda and Suz uki,1967,Krishnaswami,1971、1978 and V... 详细信息

关键词：家蚕品种农艺产茧量饲养成绩桑园全茧量产卵量桑品种茧层率

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大高良姜根茎提取物对小鼠的镇痛作用(英文)

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中西医结合学报 2011年第1期9卷 100-104页

作者： Sahana Devadasa Acharya Sheetal Dinkar Ullal Shivaraj Padiyar Yalla Durga Rao Kousthubha Upadhyaya Durga pillai Vishnu Raj Department of Pharmacology Kasturba Medical CollegeManipal University Department of Dravyaguna National Institute of Ayurveda

目的:评价大高良姜(Alpinia galanga)根茎的乙醇提取物对小鼠的镇痛作用并推断其可能的机制。方法:使用3个实验模型分别测定大高良姜根茎提取物对白化病小鼠(体质量25～30g)的镇痛作用。热板实验中,30只小鼠被分为5组,每组6只,分别给予... 详细信息

目的:评价大高良姜(Alpinia galanga)根茎的乙醇提取物对小鼠的镇痛作用并推断其可能的机制。方法:使用3个实验模型分别测定大高良姜根茎提取物对白化病小鼠(体质量25～30g)的镇痛作用。热板实验中,30只小鼠被分为5组,每组6只,分别给予口服3种剂量的大高良姜根茎乙醇提取物、皮下注射吗啡以及口服2%的阿拉伯树胶,记录给药30、60、90和120min后的热板实验反应时间。纳洛酮预处理热板实验中,另外30只小鼠在给予上述药物30min之前皮下注射纳洛酮,给药种类及方式同前,热板实验反应时间记录方式同前。扭体实验中,通过腹腔注射醋酸诱导小鼠产生扭体反应,随后30只小鼠被分为5组,每组6只,分别给予口服3种剂量的大高良姜根茎乙醇提取物、阿司匹林及2%的阿拉伯树胶,每只小鼠观察15min,记录扭体次数。结果:各个时间记录点的数据表明,与对照组相比,3种剂量的大高良姜根茎乙醇提取物均显著延长了热板实验中小鼠的反应时间(P<0.05,P<0.01)。经纳洛酮预处理后,实验组及阳性对照药吗啡组小鼠的热板实验反应时间较对应的前一实验中未经纳洛酮处理各组小鼠显著延长(P<0.05,P<0.01)。扭体实验中,与对照组相比,3种剂量的大高良姜根茎乙醇提取物均减少了实验小鼠的扭体次数(P<0.01)。结论:本实验证实了大高良姜根茎提取物的镇痛作用,验证了其在民族医学中治疗各种原因引起的疼痛的应用。其镇痛作用的机制可能是有效成分作用于中枢或外周神经系统。

关键词：大高良姜植物提取物镇痛药疼痛测定受体阿片样小鼠

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