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Phytophthora Effectors Modulate Genome-wide Alternative Splicing of Host mRNAs to Reprogram Plant Immunity

Molecular Plant 2020年第10期13卷 1470-1484页

作者： Jie Huang Xinyu Lu Hongwei Wu Yuchen Xie Qian Peng Lianfeng Gu Juyou Wu Yuanchao Wang anireddy snreddy Suomeng Dong Department of Plant Pathology Nanjing Agricultural UniversityNanjing 210095China Basic Forestry and Proteomics Research Center College of ForestryFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Crop Genetics and Germplasm Enhancement College of HorticultureNanjing Agricultural UniversityNanjing 210095China Colorado State University Program in Cell and Molecular BiologyFort CollinsCO 80523USA Key Laboratory of Integrated Management of Crop Diseases and Pests(Ministry of Education) Nanjing 210095China The Key Laboratory of Plant Immunity Nanjing Agricultural UniversityNanjing 210095China

Alternative splicing(AS)of pre-mRNAs increases transcriptome and proteome diversity,regulates gene expression through multiple mechanisms,and plays important roles in plant development and stress ***,the prevalence of genome-wide plant AS changes during infection and the mechanisms by which pathogens modulate AS remain poorly ***,we examined the global AS changes in tomato leaves infected with Phytophthora infestans,the infamous Irish famine *** show that more than 2000 genes exhibiting significant changes in AS are not differentially expressed,indicating that AS is a distinct layer of transcriptome reprogramming during plant-pathogen ***,our results show that *** subverts host immunity by repressing the AS of positive regulators of plant immunity and promoting the AS of susceptibility *** study the underlying mechanism,we established a luminescence-based AS reporter system in Nicotiana benthamiana to screen pathogen effectors modulating plant *** identified nine splicing regulatory effectors(SREs)from 87 *** *** studies revealed that SRE3 physically binds U1-70K to manipulate the plant AS machinery and subsequently modulates AS-mediated plant *** study not only unveils genome-wide plant AS reprogramming during infection but also establishes a novel AS screening tool to identify SREs from a wide range of plant pathogens,providing opportunities to understand the splicing regulatory mechanisms through which pathogens subvert plant immunity.

关键词： late blight Phytophthora infestans alternative splicing splicing regulatory effectors plant immunity tomato

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