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Perceived ill-health and health seeking behavior in two communities in the nam theun 2 hydroelectric project area in Lao Peoples Democratic Republic

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 63-70页

作者： Sayasone S Erlanger TE kaul S Sananikhom P Tanner M Utzinger J Odermatt P Department of Public Health and Epidemiology Swiss Tropical InstituteBaselSwitzerland Institut de la Francophonie pour la Medecine Tropicale VientianeLao PDR International SOS Singapore Nam Theun 2 Power CompanyVientianeLao PDR Nam Theun 2 Power Company VientianeLao PDR

Objective:To compare perceived ill-health and health seeking behavior between two communities affected by the large Nam Theun 2 hydroelectric project in central Lao People’s Democratic Republic(PDR).Methods: Two different affected areas;Nakai plateaubeing remote,sparcely populated and mountainous,and Xe Bang Fai lowland plains,more densely populated and comparatively affluent were *** were obtained from two cross-sectional household-based health and socio-economic ***:We found pronounced differences in the frequency of self-reported fever,cough,headache and myalgia according to *** the Nakai plateau,45.1%of the individuals with ill-health report(recall period;2 weeks) went to a local health volunteer compared to only 7.2%in the Xe Bang Fai area(P < 0.001 ).In Nakai,there were disproportionately more illiterates seeking help from local health volunteers when compared to those who attended at least primary schooling(49.2%versus 17.5%,P <0.01 ).Self-medication with antimalarials was more common in Xe Bang Fai than on Nakai(32.3%versus 7.0%,P < 0.001).The mean amount of money spent per health consultation was US $ 1.7 in Nakai and US $ 7.2 in Xe Bang ***:The observed differences in self-reported ill-health and health seeking behavior among these two Lao communities need to be considered when implementing setting-specific mitigation measures as part of the public health action plan of the Nam Theun 2 hydroelectric project.

关键词： Self-reported ill-health Health seeking behavior Lao PDR Nam Theun 2 hydroelectric project

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Practical considerations of dietary therapies for epilepsy in adults

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Acta Epileptologica 2021年第1期3卷 101-107页

作者： Neha kaul John-Paul Nicolo Terence J.O’Brien Patrick Kwan Department of Nutrition and Dietetics Alfred Hospital55 Commercial RoadMelbourneVIC 3004Australia Department of Allied Health(Clinical Nutrition) Royal Melbourne HospitalParkvilleAustralia Departments of Neurosciences and Neurology Alfred Hospital and Monash UniversityMelbourneAustralia Departments of Medicine and Neurology Royal Melbourne HospitalUniversity of MelbourneMelbourneAustralia Chongqing Key Laboratory of Neurology The First Affiliated HospitalChongqing Medical UniversityChongqingChina

Despite the increasing number of anti-seizure medications becoming available,the proportion of patients with drug-resistant epilepsy remains *** therapy for epilepsy is well-established practice in paediatric care,but relatively underutilised in ***,international recommendations have been published to guide the treatment of adults receiving dietary therapy for *** review focuses on the specific aspects of care unique to the management of adults receiving dietary therapy for epilepsy,including patient selection,diet composition,initiation,monitoring and cessation of dietary *** emphasise the need for a multidisciplinary team approach with appropriately trained neurologists and dietitians to provide holistic care while the patients are receiving dietary *** research should focus on the optimal diet composition and meeting the psychosocial needs of adults with epilepsy to maximise efficacy and adherence to dietary treatment.

关键词： Ketogenic diet Epilepsy Diet Drug-resistant epilepsy Nutrition

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Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 794-796页

作者： Muhammad Shakil Muhammad Ikram Ullah Shabbir Hussain Sabika Firasat Saqib Mahmood Haiba kaul Department of Biochemistry University of Health Sciences Department of Biochemistry Faculty of Biological sciencesQuaid i Azam University Department of Animal Sciences Quaid i Azam University Department of Human Genetics and Molecular Biology University of Health Sciences

Dear Sir,Iam Haiba kaul,from the Department of Biochemistry,University of Health Sciences,Lahore,Pakistan.I write to present a study of oculocutaneous albinism（OCA）in consanguineous Pakistani *** is a genetic defect... 详细信息

关键词： TYR Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene

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Coronary heart disease:Significance of liver X receptor α genomics

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World Journal of Cardiology 2010年第6期2卷 140-149页

作者： Vivek Priy Dave Deepak kaul Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research

Crosstalk between lipid peroxidation and inflammation is known to be a pathognomonic feature for the development of coronary heart disease(CHD).In this regard ligand activated liver X receptor(LXR)-α has emerged as a key molecular switch by its inherent ability to modulate an array of genes involved in these two fundamental cellular *** addition,LXR-α has also been found to play a role in hepatic lipogenesis and innate *** several lines of evidence in experimental model systems have established the atheroprotective nature of LXR-α,human subjects have been reported to possess a paradoxical situation in which increased blood cellular LXR-α gene expression is always accompanied by increased coronary *** apparent paradox was resolved recently by the finding that CHD patients possess a deregulated LXR-α transcriptome due to impaired ligand-receptor *** blood cellular mutated LXR-α gene ex- pression correlated specifically with the extent of coro- nary occlusion and hence need is felt to devise new synthetic ligands that could restore the function of this mutated LXR-αprotein in order to modulate genes involved in reverse cholesterol transport and suppression of the inflammatory response leading to the effective treatment of CHD.

关键词： Coronary heart disease Liver X receptor Lipid metabolism Inflammation

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干扰素激活基因15作为一种急性和慢性神经损伤的通用标记(英文)

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生理学报 2012年第5期64卷 577-583页

作者：王仁刚 kaul Marcus 张东贤 Del E.Webb神经科学、衰老与干细胞研究中心感染与免疫疾病中心 Sanford-Burnham医学研究所La JollaCA92037美国

在中枢神经系统中干扰素(interferon,IFN)信号系统的激活通常与炎症相关。但是,在肌萎缩性侧索硬化症(amyotrophic lateral sclerosis,ALS)动物模型SOD1(G93A)小鼠的脊髓中,症状前阶段I型IFN激活基因(IFN-stimulated genes,ISGs)的高度激活可在没有明显炎症的情况下发生。为了确定同样的信号系统是否在其它神经损伤中也有增强,我们检测了一种IFN激活基因ISG15在急性和慢性神经损伤的小鼠模型中的蛋白表达水平。我们观察到ISG15蛋白在经受全脑缺血或创伤性脑损伤的小鼠以及过度表达HIV gp120蛋白的转基因小鼠的大脑中显著增加。以上结果提示,ISGs的激活是神经损伤的一种普遍特性,并且ISG15可成为一种适用于检测中枢神经系统神经损伤的生物标志。

关键词：干扰素激活基因15 神经损伤生物标志

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Using Boronic Acid as Sensors for Carbohydrate

Using Boronic Acid as Sensors for Carbohydrate

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中国资源生物技术与糖工程学术研讨会

作者： Gurpreet kaul Sandra Craig Department of Chemistry George State University AtlantaUSA30303 Department of Chemistry George State University AtlantaUSA30303

＜正＞Carbohydrates play an important role in numerous critical biological processes including cell-cell adhesion and communication, embryo development, immune response, etc. Boronic acid-based sensors for such carbohydrates have a wide range of potential applications including glucose concentration determination, cell labeling and targeting based on

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Coronary atherosclerosis:Significance of autophagic armour

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World Journal of Cardiology 2012年第9期4卷 271-274页

作者： Mansi Arora Deepak kaul Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Autophagy is a lysosomal degradation pathway of cellular components such as organelles and long-lived *** a protective role for autophagy has been established in various patho-physiologic conditions such as cancer,neurodegeneration,aging and heart failure,a growing body of evidence now reveals a protective role for autophagy in atherosclerosis,mainly by removing oxidatively damaged organelles and proteins and also by promoting cholesterol egress from the lipid-laden *** studies by Razani et al and Liao et al unravel novel pathways that might be involved in autophagic protection and in this commentary we highlight the importance of autophagy in atherosclerosis in the light of these two recent papers.

关键词： Atherosclerosis Autophagy Inflammasome Reactive oxygen species Apoptosis Efferocytosis

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估算放射性核素所致内照射剂量的ICRP剂量学和生物动力学模型

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辐射防护 1999年第1期19卷 12-22页

作者： kaul,A 周永增德国联邦辐射防护办公室

１引言源器官中某一放射性核素对靶器官产生的当量剂量与该源器官中放射性核素的核变化总数和在靶器官中被吸收的发射能量的份额成比例。在所考虑的时间间隔内体内任一源器官或组织的核变化数是在这段时间内那个器官或组织中放射性核素... 详细信息

１引言源器官中某一放射性核素对靶器官产生的当量剂量与该源器官中放射性核素的核变化总数和在靶器官中被吸收的发射能量的份额成比例。在所考虑的时间间隔内体内任一源器官或组织的核变化数是在这段时间内那个器官或组织中放射性核素活度的时间积分。靶器官或组织从源器...

关键词： ICRP 剂量生物动力学放射性核素内照射剂量

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Effects of Nitroglycerine on Erythrocyte Rheology:A Novel Mechanism to Explain the Enhancement of Nutrient Blood Flow to Ischemic Zones

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South China Journal of Cardiology 2007年第3期8卷 138-146页

作者： D.Elizabeth Le Sanjiv kaul Cardiovascular Division Oregon Health and Science UniversityPortland

Objectives Nitroglycerine (NTG) enhances coronary blood flow to compromised myocardium is important in relieving ischemia. However, the mechanism for this increase in myocardial blood flow (MBF) is not well defined. In small vessels and capillaries, relative blood viscosity plays a very important role in determining myocardial vascular resistance (MVR). MVR reduce is due partly to the increase in negative charge of erythrocyte surface. We therefore hypothesized that the enhancement of nutrient blood flow to zones of myocardial ischemia during NTG is partly secondary to reduced MVR and blood flow viscosity. The latter is affected by the negative charge of erythrocyte surface. Methods 6 dogs with LAD flow-limiting stenosis (group 1) and 6 dogs with LAD flow-limiting stenosis and LCx occmusion (group 2) were studied. At baseline and during intracoronary infusions of NTG (0.3-0.6 μg·kg-1·min-1), hemodynamics, MBF (mL·min-1·g-1), whole blood viscosity (WBη, mPa. S), elongation index (EI), eletrophoretic mobility of erythocytes (EME, [μ.s-1)/(***-1)]) and percent wall thickening (%WT) were determined. MVR was calculated using driving pressure/MBF. Results As compared to baseline, no changes in hemodynamics were seen during NTG. MBF increased and MVR decreased significantly in normal bed, the central 25% and the entire of stenosed bed (P<0.05), with a decrease in WBη in both group 1 and group 2 dogs (18.6±9.7 % and 19.2±14.5 %, respectively). However, the % decrease in WBη was proportioned to the % increase in MBF or the % decrease in MVR only in the central 25% of stenosed bed (r=0.87, P<0.001), but not in the entire stenosed bed and normal bed. EI did not show statistically significant differences between during NTG and at baseline, but EME did increase. And the % decrease in WBη during NTG was related to the % increase in EME (r=0.83, P=0.01). Conclusions NTG reduced myocardial vascular resistance and blood viscosity due to the change of negative charge of erythrocyte

关键词： nitroglycerine myocardial blood flow myocardial vascular resistance whole blood viscosity erythrocyte rheology

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Heart and Brain:A neutro-genomic link

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World Journal of Biological Chemistry 2013年第2期4卷 16-17页

作者： Vivek Priy Dave Deepak kaul Boditech Med Inc Central LabR and D Center Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research

The philosophy of heart and brain are very ancient in our literature where the things good for the heart are not suggested good for the brain and *** medicine is characterized by a high degree of specialization and the heart-brain connection that could be targeted to treat these complex cardiovascular/brain *** idea that adverse diet/genome interactions can cause disease is not *** the recent era the science of nutritional genomics have increased our understanding of diet-health-gene interactions and have provided a number of benefits for individuals,groups and *** dietary chemicals are regularly ingested and participate indirectly and directly in regulating gene expression,it follows that a subset of genes regulated by diet must be involved in disease initiation,progression,and *** this regards Liver X Receptor(LXR)-a,a key transcription factors,associated with the several chronic pathological situation including coronary heart disease and neurodegenerative diseases have recently been found to be regulated by the dietary *** crucial findings at molecular biology unit,Post Graduate Institute of Medical Education and Research(PGIMER),Chandigarh,INDIA have not only forced us to explore nutritional genomics as a holistic systems approach to understand the relationship between diet and health,but also to look into the disease preventing and health promoting foods that match our lifestyles,cultures and *** all,we are what we eat.

关键词： Heart Brain Nutrition Gene interaction Liver X Receptor

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