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Serum ferritin and the risk of early-onset colorectal cancer

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam L Urback Kylee Martens Hannah Stowe McMurry Emerson Y Chen Caitlin Citti anil sharma Adel Kardosh Joseph J Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology&Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUND The incidence of early-onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally discovered in young adults,however,the indication for endoscopy in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study of patients<50 years with newly-diagnosed EO-CRC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 years prior to 1 year following CRC histologic *** supplement the analysis,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/mL(range<1-2759 ng/mL).Compared to HCs(n=80211),there were a higher proportion of individuals with EO-CRC with serum ferritin<20 ng/mL(female 65%,male 40%)versus HCs(female 32.1%,male 7.2%)age 29-39 years(P=0.002 and P<0.00001,respectively).Stage IV disease was associated with significantly higher serum ferritin compared to less advanced stages(P<0.001).Serum ferritin obtained before or at the time of diagnosis was lower than levels obtained after *** findings were confirmed in the sensitivity *** Severe iron deficiency may indicate an increased risk of EO-CRC,particularly at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Early-onset Young-onset Colorectal cancer Age Ferritin Iron deficiency

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Flavonoids: emerging trends and potential health benefits

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Journal of Chinese Pharmaceutical Sciences 2014年第12期23卷 815-822页

作者： Raj K.Keservani anil K.sharma School of Pharmaceutical Sciences Rajiv Gandhi Proudyogiki Vishawavidyalaya Department of Pharmaceutics Delhi Institute of Pharmaceutical Sciences and Research

Flavonoids are widely used in industry for the prevention of various diseases. In daily life we are directly in touch with flavonoids due to their presence in different beverages, fruits and vegetables. Flavonoids are mainly used as a coloring agent in plants, antioxidant and nutritional food for human. Flavonoids have explicit role in UV filtration, symbiotic nitrogen fixation and floral pigmentation. Flavonoids have potential for different biological activities like chelation of metals, decreasing platelets aggregation and cell signaling etc.

关键词： Flavones Antioxidant Flavonols Nutraceutical

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Drought-Tolerant Pseudomonas spp. Improve the Growth Performance of Finger Millet(Eleusine coracana(L.) Gaertn.)Under Non-Stressed and Drought-Stressed Conditions

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Pedosphere 2018年第2期28卷 227-240页

作者： Dinesh CHANDRA Rashmi SRIVASTAVA Bernard R.GLICK anil K.sharma Department of Biological Science College of Basic Sciences and Humanities Govind Ballabh Pant University of Agriculture and Technology Department of Biology University of Waterloo

Application of plant growth-promoting bacteria(PGPB)is an environmentally sustainable option to reduce the effects of abiotic and biotic stresses on plant growth and *** 1-aminocyclopropane-1-carboxylic acid(ACC)deaminase-producing drought-tolerant bacteria were isolated from a rain-fed agriculture field in the Central Himalaya of Kumaun region,Uttarakhand,India and evaluated for their efficiency in improving finger millet(Eleusine coracana(L.)Gaertn.)plant growth under non-stressed and drought-stressed *** bacteria withstood a substrate metric potential of -1.0 MPa(30% polyethylene glycol 8000)and therefore were considered *** strains were identified as Pseudomonas *** fatty acid methyl ester analysis and 16S rRNA gene *** ACC deaminase activity of these strains was characterized at the biochemical level,and the presence of acd S gene,the structural gene for ACC deaminase,was confirmed by the polymerase chain *** sets of pot trials in glass house were set up,one for normal(non-stressed)and the other for drought-stressed *** 5 weeks,one set of plants was subjected to drought stress for 5 d,while the other set continued to be *** same growth parameters were recorded for both sets of plants after 40 d of plant *** results of pot trials showed that treatments inoculated with ACC deaminase-producing bacterial strains significantly improved the growth performance of finger millet plants and foliar nutrient content as compared to uninoculated treatments under both non-stressed and drought-stressed *** addition,a significant increase in antioxidant activity was observed,wherein bacterial stain inoculation improved plant fitness by protecting it from oxidative damage induced by drought.

关键词： antioxidant enzymes fatty acid methyl ester analysis plant growth-promoting bacteria polyethylene glycol polymerasechain reaction

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Influence of peach(Prunus persica Batsch)phenological stage on the short-term changes in oxidizable and labile pools of soil organic carbon and activities of carbon-cycle enzymes in the North-Western Himalayas

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Pedosphere 2020年第5期30卷 638-650页

作者： Sovan DEBNATH Brij Lai ATTRI anil KUMAR Arun KISHOR Raj NARAYAN Kanchan SINHA Arpan BHOWMIK anil sharma Desh Beer SINGH Indian Council of Agricultural Research(lCAR)-Central Institute of Temperate Horticulture Regional StationMukteshwarNainitalUttarakhand 263138(India) Department of Agricultural Chemistry and Soil Science Faculty of AgricultureBidhan Chandra Krishi ViswavidyalayaMohanpurWest Bengal 741252(India) Indian Council of Agricultural Research(ICAR)-Directorate of Mushroom Research SolanHimachal Pradesh 173213(India) A Indian Council of Agricultural Research(ICAR)-Indian Agricultural Statistics Research Institute New Delhi 110012(India) Department of Agricultural Statistics Faculty of AgricultureBidhan Chandra Krishi ViswavidyalayaMohanpurWest Bengal 741252(India) Indian Council of Agricultural Research(ICAR)-Central Institute of Temperate Horticulture SrinagarJammu and Kashmir 190007(India)

The labile organic carbon(C)and C-related enzymes are sensitive indicators capturing alterations of soil organic matter(SOM),even in a short-time *** the effects of crop husbandry and land use change on these attributes have been well studied,there is no consensus about how plant phenology may impact *** study aimed to determine the short-term effect o f six distinct phenological stages(PS-1:full bloom;PS-2:fruit set;PS-3:pit hardening;PS-4:physiological maturity;PS-5:60 d after physiological maturity;and PS-6:fall)o f peach on the changes in soil organic carbon(SOC)fractions of different oxidizability,labile C pools,and C-cycle enzyme activities in soils,for two consecutive years(2015 and 2016)in the North-Western Himalayas(NWH).Peach rhizosphere soils were sampled at the topsoil(0-15 cm)and subsoil(16-30 cm)layers,along with rhizosphere soils from adjacent perennial grasses,which served as a *** for most of the assessed parameters,including very labile C,labile C,microbial biomass C,permanganate oxidizable C,dissolved organic C,mineralizable C,amylase activity,and carboxymethyl-cellulase activity,were significantly(P<0.05)higher at PS-3 than at other phenological stages of ***,a sudden decline in these soil variables was recorded at PS-5,followed by a slight buildup at PS-6,particularly in the topsoil of the peach ***-term changes in organic C fractions of different oxidizability,influenced by peach phenological stage,significantly(P<0.05)affected C management index,C pool index,and lability *** the C management index and lability index showed their highest values at PS-3 and their lowest values at PS-5,clearly indicating short-term accretion and depletion of SOC,in tandem with the peach phenological *** component analysis suggested that a composite of soil indicators,including microbial biomass C,dissolved organic C,amylase,and invertase,could help detect short-term changes in SOC *** i

关键词： carbon fractions fruit orchard Indian Himalaya plant phenology rhizosphere soil soil biological indicators

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Biochemical and histopathological changes in sheep fed different detoxified karanj(Pongamia glabra)seed cake as partial protein supplements

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Animal Nutrition 2017年第2期3卷 164-170页

作者： Nira M.Soren anil K.sharma Vadali R.B.Sastry Division of Animal Nutrition ICAR-Indian Veterinary Research Institute Animal Nutrition Division ICAR-National Institute of Animal Nutrition and Physiology Division of Pathology ICAR-Indian Veterinary Research Institute

The study investigated the long-term effect of feeding processed solvent extracted karanj(Pongamia glabra) cake(SKC) on gross pathology and histopathological changes in some vital organs, and on the activities of serum enzymes in Jalauni lambs. Twenty-four male lambs were divided into 4 groups and allotted randomly to a soybean meal(SBM) based control(CON) and 3 treatment groups receiving concentrate mixtures, containing water washed(WW), 2.5% lime(LM) and 0.4% binder(BN) treated SKC replacing 50% nitrogen of SBM to meet the protein requirements. Blood was collected after 150 days from all the lambs and serum activities of aspartate aminotransferase(AST), alanine aminotransferase(ALT)and lactate dehydrogenase(LDH) were assayed. All lambs were sacrificed after 196 days, and vital organs screened for gross pathological lesions. The representative tissues of liver, intestine, parathyroid gland,testis, and epididymis were sampled, preserved in 10% formalin and processed to examine histopathological changes by staining with haematoxylin and eosin(HE). The serum enzyme activities of AST and ALT were similar in the treatments, but the activity of LDH was higher(P < 0.01) in processed SKC-fed groups than the control. The weight and size of the liver were decreased in BN group, while those of testes were decreased in both LM and BN groups. The histological sections of the testes and epididymis of lambs from LM group showed hypoplastic seminiferous tubules and empty ductules, respectively. The histological sections of the parathyroid gland in the same diet revealed smaller and non-secretory chief cells. The small intestine of lambs from BN group showed infiltration of mononuclear cells(MNC) in lamina propria with mild fibroplasia in intervillous areas. The histological section of liver from this group showed MNC infiltration in portal areas. The inclusion of water washed SKC in the concentrate mixture of lambs did not show gross pathological and histological alterations in th

关键词： Karanj cake Enzymatic profile Histopathology Lambs Liver Testis

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Phytochemical screening and wound healing potential of Cuscuta reflexa

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Journal of Chinese Pharmaceutical Sciences 2015年第5期24卷 292-302页

作者： Tapsya Gautam Surya Prakash Gautam Raj K.Keservani anil Kumar sharma School of Pharmaceutical Sciences Shoolini University Department of Pharmaceutics CT Institute of Pharmaceutical Sciences School of Pharmaceutical Sciences Rajiv Gandhi Proudyogiki Vishwavidyalaya Department of Pharmaceutics Delhi Institute of Pharmaceutical Sciences and Research

The present study was to investigate pharmacognostical, phytochemical and pharmacological properties of extracts from stem of Cuscuta reflexa Roxb. Standard procedures have been followed to evaluate the pharmacognostical properties and preliminary screening of phytochemicals of Cuscuta reflexa Roxb. Albino Wistar rats(either sex) weighing 150–200 g were taken and made to acclimatize by providing them with the appropriate room conditions in the experimental room. Excision wound model has been selected for analgesic and wound healing activity for evaluating potential of the water-extract and ethanolic extract from the stem of Cuscuta reflexa Roxb. The macroscopic and microscopic studies showed the various characteristic features of stems. Preliminary screening of phytochemicals reveled that alkaloids, glycosides, flavonoids were the major groups of phytochemicals present in the successive extracts. Water and ethanolic extracts from stem of Cuscuta reflexa Roxb at 200 mg/kg and 400 mg/kg were able to alleviate pain and wounds. It is concluded that the stems of Cuscuta reflexa Roxb have a markedly therapeutic potential to heal wound and may provide the pharmacological basis for its folk uses.

关键词： Pharmacognostical Phytochemical Soframycin Analgesic Wound healing Stem Cuscuta reflexa Roxb

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Quantifying Embodied Energy Using Green Building Technologies under Affordable Housing Construction

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Open Journal of Energy Efficiency 2013年第4期2卷 171-175页

作者： Nand Kishore Gupta anil Kumar sharma Anupama sharma M.P. Housing & infrastructure Development Board Bhopal India Maulana Azad National Institute of Technology Bhopal India

The building construction industry is a major contributor of environmental pollution, with high levels of energy consumption and greenhouse gas emissions, all of which contribute to climate change. Housing is the single largest subsector of the construction industry. It is also a basic need associated with social and economic benefits, and its demand in most emerging economies is substantial. Hence it is a sector with significant potential not to mitigate just the negative impact of climate change on buildings and people, but also to reduce the impact of the construction industry on the natural environment. Green buildings technology has advanced greatly in recent years, but most “high performance” green buildings are capital intensive, often with high-tech applications that are not in easy reach of the mass housing market. In the developing country context, where huge segments of the population lack access to essential services or housing, the green buildings approach to addressing climate change is perceived to be largely unaffordable. For green technology to be adopted in poorer nations and have scalable impact, it will have to be low-cost and affordable. According to a 2010 report, buildings in the commercial, office and hospitality sectors are poised to grow at 8% annually over the next 10 years in India. While the retail sector has been growing rapidly at 8% per annum, the residential sector has seen growth of 5% per annum during this period. It is estimated that over 70 million New Urban Housing Units will be required over the next 20 Years.

关键词： Affordable Housing Embodied Energy Green Technology

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Influence of Exogenously Applied Epibrassinolide and Putrescine on Protein Content, Antioxidant Enzymes and Lipid Peroxidation in <i>Lycopersicon esculentum</i>under Salinity Stress

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American Journal of Plant Sciences 2012年第6期3卷 714-720页

作者： Shummu Slathia anil sharma Sikander Pal Choudhary Department of Botany University of Jammu Jammu India Department of Horticulture Zhejiang University Hangzhou China.

Brassinosteroids (BRs) and polyamines (PAs) are widely used to overcome abiotic stresses including salinity stress (NaCl) in plants. In the present investigation, we evaluated the co-application efficacy of 24-epibrassinolide (EBR, a highly active BR) and putrescine (Put, a PA) on the NaCl stress (75 mM and 150 mM) tolerance of Lycopersicon esculentum L. cv. kuber geeta plants. A small rise in protein content was recorded under salinity stress in comparison with untreated control. The NaCl stress was found to significantly enhance the activities of guaiacol peroxidase (GPOX) and superoxide dismutase (SOD);while decline in catalase (CAT) activity was recorded when compared with the untreated control. Salinity stress both at 75 mM and 150 mM was able to cause significant membrane damage as evidenced by an increase in the level of malondialdehyde (MDA) content over untreated control. The EBR and Put co-applications were able to improve protein content in NaCl stressed plants over only NaCl stressed plants. The co-applications of EBR and Put were able to significantly enhance the activities of CAT, SOD and GPOX in L. esculentum under salinity stress (75 mM and 150 mM) when compared with NaCl stressed plants alone. Major decline in the MDA level recorded for EBR and Put co-applications under NaCl stress revealed reduced membrane damages when compared with NaCl stressed plants alone. Our findings provide evidence that EBR and Put co-applications are effective in amelioration of NaCl stress in L. esculentum. Thus co-application potential of EBR and Put may acts an eco-friendly approach towards NaCl stress mitigation in economically important crops.

关键词： Lycopersicon esculentum Brassinosteroids Polyamines Salinity Stress

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<i>Conocephalum conicum</i>(L.) Dumort: A Case of Unique Reproductive Biology

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American Journal of Plant Sciences 2012年第8期3卷 1145-1149页

作者： Madhu Bhagat anil sharma Anima Langer Department of Botany University of Jammu Jammu India.

This paper reports spore-elater ratio per capsule in three populations of Conocephalum conicum collected from different regions of Jammu and Kashmir (Doda, Ladakh and Bhaderwah). Spore-elater ratio came out to be 0.40-0.43:1, far less than expected for Marchantialian taxa. The ratios thus obtained were compared with that present in herbarium specimen collected in 1958 from Kyushu. The ratios have remained constant since many decades, thereby indicating that the sex-ual reproduction has lesser role to play in the propagation of this species.

关键词： Reproductive Biology Liverworts Dioecious Sporophyte Spore-Elater Ratio

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Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats

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The Journal of Biomedical Research 2012年第3期26卷 200-210页

作者： Ashish Kumar sharma Akash sharma Rita Kumari Kunal Kishore Divya sharma Bharthu Parthsarthi Srinivasan Ashok sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra anil sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam Department of Pharmacology Gyan Vihar School of PharmacySuresh Gyan Vihar UniversityJagatpuraJaipur(Rajasthan)302025India Department of Pharmacology Delhi Institute of Pharmaceutical Sciences&ResearchPushpviharNew Delhi 110017India Department of Pharmacology Kota Collage of PharmacyRIICO Industrial AreaRanpurKota(Rajasthan)Pincode 302025India

Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu- ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide- streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly im- proved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 （P 〈 0.001）. Signif- icant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 （P 〈 0.001）. Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regen- eration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.

关键词： diabetic neuropathy nicotinamide-streptozotocin metformin pioglitazone glimipiride sitagliptin amitriptyline

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