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Investigation of micro-scale shear response of sand–rubber granule mixture in terms of particle shape and grain scale deformability effects

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Particuology 2024年第7期90卷 452-469页

作者： Abdulmuttalip ari Suat Akbulut Department of Civil Engineering Yildiz Technical UniversityIstanbul34220Turkey

In this study,the effects of particle shape of rigid sand and soft rubber materials on macro-scale shear response were reasoned based on micro-scale *** this purpose,first,the shape properties of three different sand and two different rubber samples were quantified using image processing techniques,and the contact model parameters were calibrated through physical *** direct shear test was simulated in a two-dimensional discrete element software with realistic particle *** soft nature of rubber particles was reflected using body-centered cubic packing with a linear-parallel bond contact *** a result,coordination number,distribution of contact forces(i.e.,strong contact,and fabric anisotropy),and contact sliding were derived by the numerical *** has been observed that the particle shape leads to distinctive micro-scale responses due to the variations in the stiffness of the contacts.

关键词： Particle shape Sand Rubber Shear response Micro-scale response Discrete element method

Ophthalmic exam and ophthalmology residents’ subspecialty preference

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 359-364页

作者： ari Leshno Daf Shalev Daphna Landau Prat Goldschleger Eye Institute Sheba Medical CenterTel Hashomer 5262000Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6997801Israel Department of Ophthalmology Edith Wolfson Medical CenterHolon 5822012Israel

AIM:To evaluate residents’perceptions and attitudes toward the various aspects of a comprehensive ophthalmic examination,and to determine if these factors correlate with their choices for fellowship and future career ***:This is a cross-sectional study.A questionnaire on the perception of the ophthalmic exam was sent via SurveyMonkey to ophthalmology residents throughout *** of them(one-half of all ophthalmology residents in 2019)completed *** first part related to how they perceived each component of the ophthalmic *** second part related to their future fellowship *** Chi-squared test was used to compare categorical variables and Student’s t-test and One-way ANOVA were used to compare continuous *** logistic regression analysis was applied as needed to detect interactions between variables and to exclude confounder ***:Slit-lamp examination of the anterior and posterior segments ranked as the most likeable aspects,whereas gonioscopy,ocular motility examination and visual acuity assessment were least *** segment and retina subspecialties were the ones most sought ***-nine respondents(61.3%)noted a direct correlation between their preferred parts of comprehensive ophthalmic evaluations and their choice of *** of selected components of those evaluations were significantly associated with responders’intentions to pursue anterior segment,retina,or oculoplastic fellowships(P<0.05).CONCLUSION:Perspectives of residents toward the ophthalmic examination,and most specifically its individual components,play an important role in their choice of subspecialty training.

关键词： residency subspecialty ophthalmic examination career choice ophthalmology

Assessment of corrected time-step method for nominal ionospheric gradient calculation: A comparative analysis with spatial approaches

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Earth and Planetary Physics 2024年第4期8卷 641-649页

作者： Slamet Supriadi Prayitno Abadi Susumu Saito Harry Bangkit Dwiko Unggul Prabowo Adi Purwono Ginaldi ari Nugroho Research Center for Smart Mechatronics National Research and Innovation Agency(BRIN)BandungIndonesia Research Center for Climate and Atmosphere BRINBandungIndonesia School of Electrical Engineering Telkom UniversityKab.BandungIndonesia Electronic Navigation Research Institute National Institute of MaritimePort and Aviation TechnologyTokyoJapan Research Center for Space BRINBandungIndonesia

The effect of ionospheric delay on the ground-based augmentation system under normal conditions can be mitigated by determining the value of the nominal ionospheric gradient(σvig).The nominal ionospheric gradient is generally obtained from Continuously Operating Reference Stations data by using the spatial single-difference method(mixed-pair,station-pair,or satellite-pair)or the temporal single-difference method(time-step).The time-step method uses only a single receiver,but it still contains ionospheric temporal *** introduce a corrected time-step method using a fixed-ionospheric pierce point from the geostationary equatorial orbit satellite and test it through simulations based on the global ionospheric *** also investigate the effect of satellite paths on the corrected time-step method in the region of the equator,which tends to be in a more north–south direction and to have less coverage for the east–west ionospheric *** study also addresses the limitations of temporal variation correction coverage and recommends using only the correction from *** processes are developed under simulations because observational data are still difficult to *** findings demonstrate that the corrected time-step method yieldsσvig values consistent with other approaches.

关键词： ground-based augmentation system nominal ionospheric gradient time-step correction global ionospheric model

协同创新模式、网络嵌入与协同创新绩效:中国自动驾驶汽车产业fsQCA研究

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科技进步与对策 2024年

作者：周菲刘颖琦 ari Kokko 北京交通大学经济管理学院哥本哈根商学院国际经济政府与商业系

自动驾驶汽车在推动全球汽车产业颠覆性变革的同时,其技术前沿性、复杂性、跨学科性等特征使得跨界融合和协同创新成为带动产业发展的必然选择,而协同创新模式高度影响协同创新效果。利用专利工具和社会网络分析法,结合自动驾驶协同创... 详细信息

自动驾驶汽车在推动全球汽车产业颠覆性变革的同时,其技术前沿性、复杂性、跨学科性等特征使得跨界融合和协同创新成为带动产业发展的必然选择,而协同创新模式高度影响协同创新效果。利用专利工具和社会网络分析法,结合自动驾驶协同创新网络创新主体类型及其合作关系,将中国自动驾驶汽车产业协同创新模式划分为四大类:亲缘型、地缘型、业缘型和混合型。同时,不同协同创新网络存在不同的网络嵌入特征,与协同创新模式共同影响协同创新绩效。为研究不同自动驾驶产业协同创新模式和网络嵌入特征组态匹配对协同创新绩效的影响,利用fsQCA方法进行实证检验。研究发现:可将实现自动驾驶汽车产业高协同创新绩效和低协同创新绩效的协同创新模式分别概括为4类,其中亲缘型和亲缘地缘混合型协同创新模式对于自动驾驶汽车产业协同创新影响最大,且目前业缘型模式难以产生较高的协同创新绩效,而低协同创新绩效路径存在业缘关系占比较高等显著特征。基于此,对自动驾驶汽车产业协同创新发展提出4点建议。

关键词：自动驾驶汽车协同创新网络嵌入 fsQCA

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遥遥领先！超越西方数百年的中国古代数学

环球人文地理 2024年第11期 100-103页

作者：汪洋 ari 摄影师Sean Wikipedia 摄图网

以盈补虚、因木望山、幻方、珠算、隙积术……华夏沃土不仅绽放着多彩的文化之花，也厚植了无数启迪心智的智慧之树。我们的祖先在长期生产劳动中掌握了丰富且实用的数学知识，应用在天文历法、土地测量、买卖交易、器物制作与织绣纹样...

以盈补虚、因木望山、幻方、珠算、隙积术……华夏沃土不仅绽放着多彩的文化之花，也厚植了无数启迪心智的智慧之树。我们的祖先在长期生产劳动中掌握了丰富且实用的数学知识，应用在天文历法、土地测量、买卖交易、器物制作与织绣纹样等领域，不仅解决了许多生存与生活难题，也在世界数学史上留下瞩目成就。

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Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality

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Neural Regeneration Research 2023年第3期18卷 497-502页

作者： Yulia Mitiagin ari Barzilai Department of Neurobiology the School of NeurobiologyBiophysicsMolecular Biology and BiochemistryGeorge S.WiseFaculty of Life SciencesTel Aviv UniversityTel AvivIsrael Sagol School of Neurosciences Tel Aviv UniversityTel AvivIsrael

Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic ***,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still *** this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar *** addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular *** discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox ***,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.

关键词： ataxia telangiectasia ATM cerebellum DNA damage response double-strand breaks mitochondrial dysfunction oxidative stress single-strand breaks

Mechanisms of action of BCL6 during germinal center B cell development

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Science China(Life Sciences) 2015年第12期58卷 1226-1232页

作者： HUANG ChuanXin MELNICK ari Shanghai Institute of Immunology & Department of Immunobiology and Microbiology Shanghai Jiao Tong University School of Medicine Division of Hematology and Medical Oncology Department of Medicine Weill Cornell Medical College

The transcriptional repressor B cell lymphoma 6(BCL6) controls a large transcriptional network that is required for the formation and maintenance of germinal centers(GC). GC B cells represent the normal counterpart of most human B-cell lymphomas, which are often characterized by deregulated BCL6 expression or BCL6-mediated pathways. BCL6 suppresses gene transcription largely through recruitment of its co-repressors through its distinct repression domain. Understanding the precise biological roles of each repression domain in normal and malignant B cells is helpful for development of targeted inhibition of BCL6 functions that is emerging as the basis for design of anti-lymphoma therapies. This review focuses on recent progress in the molecular mechanisms of action of BCL6 in B cells and discusses remaining unresolved questions related to how these mechanisms are linked to normal and malignant B cell development.

关键词： BCL6 germinal center co-repressor lymphoma

New Relationship for Estimation of Wave Overtopping on Vertical Walls

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China Ocean Engineering 2017年第1期31卷 48-54页

作者： ESKAND ari Hojjatollah KAMALIAN Ulrich Reza Coastal Engineering Group University of Qom Qom *** Iran

Soft computing tools in the form of combination of multiple nonlinear regression and M5′ model tree were used for estimation of overtopping rate at the vertical coastal structures. For reliable and precise estimation of overtopping rate, the experimental data available in the database CLASH were used. The dimensionless overtopping rate was estimated in terms of conventional dimensionless parameters including the relative crest freeboard Rc/Hs, seabed slope tanθ, deep water wave steepness S（om）, surf similarity ξ（om） and local relative water depth ht/Hs. The accuracy of the new model was compared with other existing models and also evaluated with some field measurements. The results indicated that the model presented in this paper is more accurate than other existing models. With statistical parameters, it is shown that the accuracy of predictions in the new model is better than that of other models.

关键词： similarity dimensionless precise Walls crest formulae trained coastal separate correction

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提高大学生篮球队训练效果的思考

科教导刊 2024年第22期 53-55页

作者：阿日并格希格内蒙古民族幼儿师范高等专科学校内蒙古鄂尔多斯017000

高校篮球队建设对于培育崇尚运动的校园文化、提升学生的综合素质起到了积极的推动作用。提高篮球队训练效果,不仅能够提升学生篮球技能,也能够促进学生身体素质、精神思想、社交能力等各个方面的发展。因此,文章从篮球队训练对大学生... 详细信息

高校篮球队建设对于培育崇尚运动的校园文化、提升学生的综合素质起到了积极的推动作用。提高篮球队训练效果,不仅能够提升学生篮球技能,也能够促进学生身体素质、精神思想、社交能力等各个方面的发展。因此,文章从篮球队训练对大学生的意义入手探讨提高大学生篮球队训练效果的策略,提出因材施教、营养餐饮指导、身体技术训练、思想品德意志培养、战术意识培养等方面的具体措施,以进一步打造一支优秀的大学生篮球队,促进大学生实现全面长远的发展。

关键词：大学生篮球队训练效果