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Multifunctional interstitial-carbon-doped FeCoNiCu high entropy alloys with excellent electromagnetic-wave absorption performance

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Journal of Materials Science & Technology 2022年第18期113卷 61-70页

作者： Jianping Yang Linwen Jiang Zhonghao Liu Zhuo Tang anhua wu State Key Laboratory Base of Novel Functional Materials and Preparation Science Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang ProvinceNingbo UniversityNingbo 315211China Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology CAS Key Laboratory of Magnetic Materials and DevicesNingbo Institute of Materials Technology&EngineeringChinese Academy of SciencesNingbo 315201China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201800China

Electromagnetic-wave absorbing(EMA)materials that have efficient absorption performances,great me-chanical properties and chemical stability are rare and yet essential for communication security and ***,flaky interstitial-carbon-doped FeCoNiCu high entropy alloys(HEAs)as novel EMA ma-terials were successfully prepared by high-energy ball-milling ***-carbon doping as a modulating approach impacted the phase forming,morphology and electromagnetic properties of Fe-CoNiCu *** matching was significantly optimized via tuning interstitial carbon *** carbon-doped FeCoNiCu HEAs with appropriate carbon contents delivered superior EMA performance compared with other HEAs EMA *** reflection loss as low as-61.1 dB in the Ku band,broad effective absorption bandwidth of 5.1 GHz was achieved for FeCoNiCuC_(0.04).Moreover,the carbon-doped FeCoNiCu HEAs exhibited excellent mechanical hardness and chemical *** work not only suggests that interstitial-carbon doping is an available approach to tuning electromagnetic properties of HEAs,but also presents carbon-doped FeCoNiCu HEAs as promising EMA materials for civilian and mili-tary due to the efficient absorption,broad bandwidth,great durability and stability.

关键词： Microwave absorption High entropy alloys FeCoNiCu Carbon-doping Impedance match

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氟化物磁光晶体的研究进展与应用

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量子电子学报 2024年第2期41卷 194-206页

作者：吴振张中晗张振周声耀苏良碧武安华中国科学院赣江创新研究院材料与化学研究所江西赣州341119 中国科学技术大学稀土学院安徽合肥230026 中国科学院上海硅酸盐研究所人工晶体研究中心上海201899

光通信技术发展迅速,激光平均功率不断提高,磁光隔离器是保证激光单向传输、维持光学系统稳定高效工作的基础,而磁光介质作为磁光隔离器的核心部件也因此得以快速发展。首先简要介绍了几种磁光材料以及当前广泛应用的石榴石磁光晶体的... 详细信息

光通信技术发展迅速,激光平均功率不断提高,磁光隔离器是保证激光单向传输、维持光学系统稳定高效工作的基础,而磁光介质作为磁光隔离器的核心部件也因此得以快速发展。首先简要介绍了几种磁光材料以及当前广泛应用的石榴石磁光晶体的缺点、法拉第效应的原理和应用,随后系统分析了作为新一代磁光晶体的各类氟化物磁光晶体的优缺点,最后展望了CeF_(3)磁光晶体潜在的应用前景以及未来氟化物磁光晶体的发展趋势。

关键词：激光技术磁光晶体磁光隔离器法拉第效应氟化物磁光晶体 CeF_(3)

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Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation

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Bio-Design and Manufacturing 2022年第2期5卷 348-357页

作者： Zhizhong Jin Xinda Li Boxun Liu Xinru Yan Shuai Han Tao Xu anhua wu Department of Neurosurgery The First Hospital of China Medical UniversityShenyang 110001China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Precision Medicine and Healthcare Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China East China Institute of Digital Medical Engineering Shangrao 334000China

Due to their special anatomical and physiological features,central nervous system diseases still presented challenges,despite the fact that some advances have been made in early diagnosis and precision *** of the complexities in treating tumors is the tumor microenvironment,which includes mesenchymal stem cells(MSCs)that exhibit tumor tropism and can be used for cell ***,whether MSCs promote or suppress gliomas is still unclear,especially in glioma *** this study,a coaxial microfiber was designed to mimic the tumor microenvironment and to reveal the effect of MSCs on glioma *** fiber shell was composed of MSCs and alginate,and the core was filled with U87 MG(glioblastoma)cells and gelatin *** Shell-MSC/Core-U87 MG microenvironment improved the proliferation,survival,invasion,metastasis,and drug resistance of glioma cells,while simultaneously maintaining the stemness of glioma *** summary,coaxial extrusion bioprinted Shell-MSC/Core-U87 MG microfiber is an ideal platform for tumor and stromal cell coculture to observe tumor biological behavior in vitro.

关键词： Coaxial bioprinting GBM microenvironment MSC Coculture

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Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function

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Acta Metallurgica Sinica(English Letters) 2022年第12期35卷 2069-2081页

作者： Yangyang Yan Na Li Feng Guo anhua wu Wei Jin Rui Yang Yun Bai Xing Zhang Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China College of Life Science and Engineering Shenyang UniversityShenyang 110044China Department of Neurosurgery The First Affi liated Hospital of China Medical UniversityShenyang 110001China

Intracranial vascular stenting has been widely used for ischemic ***,there are complication risks with stent implantation,such as poor wall apposition,stent migration,thromboembolism and stent restenosis,due to the mismatched radial force and conformability of the stents."Therefore,a novel intracranial vascular nitinol stent was fabricated in order to improve mechanical property and endothelialization *** bending moment of the stents was calculated to be 0.346 N mm,which shows improved *** radial force of the stents evaluated by the flat plate test was0.0112 N/mm,within the range of the commercially available stent force(0.0065-0.0116 N/mm).Furthermore,the TyrIle-Gly-Ser-Arg(YIGSR)peptide derived from laminin was grafted onto the stent surfaces to promote endothelialization on vascular stents evaluated by the proliferation,adhesion and migration of human umbilical vein endothelial cells in *** nitinol stents with improved mechanical property and endothelialization function are expected to reduce the recurrence risk of ischemic stroke after implantation.

关键词： Nitinol stents Conformability Radial force Endothelialization Intracranial stenosis treatment

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Comparative profiling of immune genes improves the prognoses of lower grade gliomas

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Cancer Biology & Medicine 2022年第4期19卷 533-550页

作者： Zhiliang Wang Wen Cheng Zheng Zhao Zheng Wang Chuanbao Zhang Guanzhang Li anhua wu Tao Jiang Department of Neurosurgery Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100050China Department of Neurosurgery The First Hospital of China Medical UniversityShenyang 110001China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Objective:Lower grade gliomas(LGGs),classified as World Health Organization(WHO)grade II and grade III gliomas,comprise a heterogeneous group with a median survival time ranging from 4–13 *** prediction of the survival times of LGGs remains a major challenge in clinical ***:We reviewed the expression data of 865 LGG patients from 5 transcriptomics *** comparative profile of immune genes was analyzed for signature identification and ***-house RNAseq and microarray data from the Chinese Glioma Genome Atlas(CGGA)dataset were used as training and internal validation cohorts,*** samples from The Cancer Genome Atlas(TCGA)and GSE16011 cohorts were used as external validation cohorts,and the real-time PCR of frozen LGG tissue samples(n=36)were used for clinical ***:A total of 2,214 immune genes were subjected to pairwise comparison to generate 2,449,791 immune-related gene pairs(IGPs).A total of 402 IGPs were identified with prognostic values for *** HOXA9-related and CRH-related scores facilitated identification of patients with different *** immune signature based on 10 IGPs was constructed to stratify patients into low and high risk groups,exhibiting different clinical outcomes.A nomogram,combining immune signature,1p/19q status,and tumor grade,was able to predict the overall survival(OS)with c-indices of 0.85,0.80,0.80,0.79,and 0.75 in the training,internal validation,external validation,and tissue sample cohorts,***:This study was the first to report a comparative profiling of immune genes in large LGG cohorts.A promising individualized immune signature was developed to estimate the survival time for LGG patients.

关键词： Lower grade glioma immune gene pairs signature prognosis

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Correlation of tumor necrosis factor receptor superfamily 13B variation with sporadic intracranial aneurysm and clinical characteristics in Han Chinese populations

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Neural Regeneration Research 2010年第3期5卷 236-240页

作者： Pengfei wu anhua wu Yunjie Wang Department of Neurosurgery First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

BACKGROUND： Inflammatory reaction correlates with sporadic intracranial aneurysm （IA）. Variation of tumor necrosis factor receptor superfamily 13B （TNFRSF13B）, an inflammatory mediator receptor, may associate with IA. OBJECTIVE： To explore the relationship between TNFRSF13B gene and sporadic IA, as well as the clinical characteristics of sporadic IA. DESIGN, TIME AND SETTING： Case-control study of genetic association was performed at the Experimental Technology Center of China Medical University from November 2006 to January 2008. PARTICIPANTS： A total of 367 patients with IA, confirmed by three-dimensional computed tomography angiography, magnetic resonance angiography, digital subtraction angiography, and neuro surgery, were admitted to the Department of Neurosurgery, First Affiliated Hospital of China Medical University from 2006 to 2007, and were selected as the case group. All patients were Han, with no family history of IA. In addition, a total of 396 non-lA patients were selected as control subjects. METHODS： Peripheral vein blood was harvested to extract whole blood genomic DNA. Genotyping and TNFRSF13B single nucleotide polymorphism （SNP） rs11078355 G〉A allele polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism. The relationship of TNFRSF13B SNP rs11078355 G〉A polymorphisms to IA and IA clinical characteristics were analyzed using the chi-square and two-sided test. MAIN OUTCOME MEASURES： TNFRSF13B SNP rs11078355 G〉A genotype distribution. RESULTS： In the IA patients, TNFRSF13B SNP rs11078355 G〉A genotype frequency was significantly increased （X2 = 16.306, odds ratio = 1.881,95% confidence interval = 1.382 2.560, P 〈 0.001）. In IA patients aged 〉 65 years, the frequency of TNFRSF13B SNP rs11078355 GA ＋ AA genotype was significantly greater than the GG genotype （X2 = 26.604, odds ratio = 5.248, 95% confidence interval = 2.662 10.345, P 〈 0.001）. CONCLUSION： The TNFRSF13B gene may associate with sporadic IA in Ha

关键词： intracranial aneurysm single nucleotide polymorphism tumor necrosis factor receptor superfamily 13B gene

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Is type Ⅰ alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China?

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Neural Regeneration Research 2013年第5期8卷 445-451页

作者： Pengfei wu Bo Li anhua wu Yunjie Wang Department of Neurosurgery First Affiliated Hospital of China Medical University Department of Developmental Biology Key Laboratory of Cell Biology Ministry of Public Health of China China Medical University

In this study, we investigated whether a single nucleotide polymorphism （rs42524 G 〉 C） in the type I alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G 〉 C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC ＋ CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was 〉 3. In addition, the rs42524 G 〉 C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type I alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.

关键词： neural regeneration clinical practice intracranial aneurysm type I collagen gene single nucleotide polymorphism polymerase chain reaction-restriction fragment length polymorphism assay susceptibility risk factors neuroregeneration

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Optical and scintillation properties of Ce:Y_(3)Al_(5)O_(12) single crystal fibers grown by laser heated pedestal growth method

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Journal of Rare Earths 2021年第12期39卷 1533-1539,I0003页

作者： Xibin Wang Yun Dai Zhonghan Zhang Liangbi Su Huamin Kou Yangxiao Wang anhua wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049.China

The single crystal scintillating optical fibers acting as the scintillators and light conductors show potential application in scintillating fiber array detectors with high spatial *** this paper we report the growth of 0.2 at%Ce:Y_(3)Al_(5)O_(12) single crystal *** crystalline phase,surface morphology of the axialsection and cro ss-section,optical and scintillation properties of the as-grown fiber were *** Ce:Y_(3)Al_(5)O_(12) single crystal fiber has a pure YAG phase,a uniform distribution of cerium in the axialsection and cross-section *** spectrum is composed of broad bands ranging from 440 to700 *** addition,the single crystal fiber has a high light yield of 26115±2000 photons/MeV,low energy resolution of 9.44%@662 keV and decay time of a fast component of 78 ns and a slow component of 301 *** intensity ratio of fast to slow components is roughly 8:1.

关键词： Ce:Y_(3)Al_(5)O_(12) Single crystal fiber Laser heated pedestal growth method Rare earth Scintillator

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Tumor cell and nontumor cell in glioma microenvironment

Tumor cell and nontumor cell in glioma microenvironment

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中国神经科学学会第十二届全国学术会议

作者： Wen Cheng anhua wu Department of Neurosurgery the First Hospital of China Medical University

Objective: Glioma tissues consist not only of glioma cells but also gliomaassociated non-tumor cells, such as stromal cells and immune cells. These non-tumor cells dilute the purity of glioma cells and play important roles in glioma biology. Currently, the implications of variation in glioma purity are not sufficiently clarified. Methods: Here, glioma purity was inferred for 2249 cases from four databases. The role of glioma purity was systematically investigated in multidimensional conditions. Results: We found that glioma purity was highly associated with major clinical and molecular features. Low purity cases were more likely to be diagnosed as malignant entities and independently correlated with reduced survival time. Integrating glioma purity into prognostic model significantly improved the predictive validity. Moreover, most recognized prognostic indicators were no longer significantly effective under different purity conditions, verifying the necessity of considering glioma purity for precise prediction. Further analyses found distinct genomic patterns associated with glioma purity. Low purity cases were distinguished by enhanced immune phenotypes. Among the immune cell types, macrophages, microglia, and neutrophils were mutually associated and enriched in low purity gliomas, while only macrophages and neutrophils served as robust indicators for poor prognosis. Conclusion: In summary, glioma purity and relevant non-tumor cells within a microenvironment confer important clinical, genomic and biological implications, which should be fully valued for precise classification and clinical prediction.

关键词： glioma purity non-tumor cell prognosis immune cell multidimensional exploring

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新冠肺炎救治定点医院职业防护要点

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中国医院管理 2022年第5期42卷 58-60页

作者：周彬张洁吴安华国家卫生健康委医院管理研究所北京100044 徐州医科大学附属医院江苏徐州221004 中南大学湘雅医院湖南长沙410008

近期,我国新冠肺炎疫情在一些地区局部散发传播,疫情防控任务仍需常抓不懈。作为新冠肺炎救治定点医院,首要职责是隔离传染源并积极开展救治患者工作,同时也要加强对全院职工特别是医务人员的职业防护的宣传教育工作。文章着重阐述作为... 详细信息

近期,我国新冠肺炎疫情在一些地区局部散发传播,疫情防控任务仍需常抓不懈。作为新冠肺炎救治定点医院,首要职责是隔离传染源并积极开展救治患者工作,同时也要加强对全院职工特别是医务人员的职业防护的宣传教育工作。文章着重阐述作为新冠肺炎救治定点医院在职业防护工作中涉及的关键内容和防护要点。

关键词：新冠肺炎定点医院职业防护

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