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Management a practical introduction

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Evaluation of latent links between irritable bowel syndrome and sleep quality

2003年

作者： Kinicki angelo

来源：畅想之星图书光盘版（南... 评论

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World Journal of Gastroenterology 2011年第46期17卷 5089-5096页

作者： Massimo Bellini angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi Gastrointestinal Unit Department of GastroenterologyUniversity of Pisa Institute of Clinical Physiology National Research Council Extreme Centre Scuola Superiore S Anna Department of Physiological Science University of Pisa Italian National Institute of Statistics

AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this *** on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary ***,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary *** was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older *** daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep ***:The unitary bowel-sleep mod

关键词： Irritable bowel syndrome Sleep disorders Item response theory model Bayesian model

PHASE DIFFERENCE BETWEEN LOW-FREQUENCY OSCILLATIONS OF CEREBRAL DEOXY-AND OXY-HEMOGLOBIN CONCENTRATIONS DURING A MENTAL TASK

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 151-158页

作者： angelo SASSAROLI FENG ZHENG MICHELE PIERRO PETER R.BERGETHON SERGIO FANTINI Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

Hemodynamic low-frequency(~0.1 Hz)spontaneous oscillations as detected in the brain by nearinfrared spectroscopy have potential applications in the study of brain activation,cerebral autoregulation,and functional *** this work,we have investigated the phase lag between oscillations of cerebral deoxy-and oxy-hemoglobin concentrations in the frequency range 0.05-0.10 Hz in a human subject during a mental workload *** have obtained a measure of such phase lag using two different methods:(1)phase synchronization analysis as used in the theory of chaotic oscillators and(2)a novel cross-correlation phasor *** two methods yielded comparable initial results of a larger phase lag between low-frequency oscillations of deoxy-and oxyhemoglobin concentrations during mental workload with respect to a control,rest condition.

关键词： Phase lag oxyhemoglobin deoxyhemoglobin phase synchronization cross-correlation phasor LFO

Imaging in liver transplantation

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World Journal of Gastroenterology 2009年第6期15卷 675-683页

作者： Settimo Caruso Roberto Miraglia Luigi Maruzzelli Salvatore Gruttadauria angelo Luca Bruno Gridelli Department of Diagnostic and Interventional Radiology Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IsMeTT)University of Pittsburgh Medical Center ItalyVia Tricomi 1Palermo 90127Italy Department of Transplantation Surgery Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IsMeTT) University of Pittsburgh Medical Center ItalyVia Tricomi 1 Palermo 90127Italy

The aim of this study was to illustrate the role of noninvasive imaging tools such as ultrasonography,multidetector row computed tomography,and magnetic resonance imaging in the evaluation of pediatric and adult liver recipients and potential liver donors,and in the detection of potential complications arising from liver transplantation.

关键词： Complications Liver donor Liver transplantation Magnetic resonance Multi detector computed tomography

Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib(Iressa^(TM))and to the antiangiogenic agent ZD6474:Cytotoxic and biomolecular effects

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World Journal of Gastroenterology 2006年第32期12卷 5140-5147页

作者： Amalia Azzariti Letizia Porcelli Jian-Ming Xu Grazia Maria Simone angelo Paradiso Clinical Experimental Oncology Laboratory National Cancer Institute Bari Italy Beijing 307 Hospital Cancer Center Beijing 100039 China

AIM： To analyze the biological effects of prolonged in vitro exposure of HT-29 and LoVo colon cancer cell lines to gefitinib （Iressa^TM）, an inhibitor of epidermal growth factor receptor （EGFR） activity, and ZD6474, an inhibitor of both KDR and EGFR activities. METHODS： Cells were treated with each drug for up to 2 wk using either a continuous or an intermittent （4 d of drug exposure followed by 3 d of washout each week） schedule. RESULTS： In both cell types, prolonged exposure （up to 14 d） to gefitinib or ZD6474 produced a similar inhibition of cell growth that was persistent and independent of the treatment schedule. The effects on cell growth were associated with a pronounced inhibition of p-EGFR and/ or p-KDR expression. Treatment with gefitinib or ZD6474 also inhibited the expression of EGFR downstream signal molecules, p-Erkl/2 and p-Akt, although the magnitude of these effects varied between treatments and cell lines. Furthermore, expression of the drug resistance-related protein ABCG2 was shown to significantly increase after 14 d of continuous exposure to the two drugs. CONCLUSION： We conclude that long-term exposure of colon cancer cells to gefitinib and ZD6474 does not modify their cytotoxic effects but it might have an effect on sensitivity to classical cytotoxic drugs.

关键词： Gefitinib ZD6474 Colon cancer Tyrosine ki-nase Chemo-resistance

Furazolidone therapy for Helicobacter pylori:Is it effective and safe?

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World Journal of Gastroenterology 2009年第15期15卷 1914-1915页

作者： Vincenzo De Francesco Enzo Ierardi Cesare Hassan angelo Zullo Gastroenterology Unit "Riuniti"Hospital Gastroenterology and Digestive Endoscopy Nuovo Regina Margherita Hospital

Some aspects related with the use of furazolidone as a rescue therapy for Helicobacter pylori （H pylorl） infection should be remarked, especially regarding its potential oncologic risk. The inclusion of furazolidone... 详细信息

关键词： Helicobacter pylori Therapy Furazolidone Rescue therapy

Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?

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World Journal of Gastroenterology 2009年第20期15卷 2456-2462页

作者： Elisabetta Colombo Anna Latiano Orazio Palmieri Fabrizio Bossa angelo Andriulli Vito Annese Unit of Gastroenterology Department of Medical Sciences IRCCS-CSS Hospital Laboratory of Genetic Research Department of Medical Sciences IRCCS-CSS Hospital Unit of Digestive Endoscopy Department of Medical SciencesIRCCS-CSS Hospital

The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic *** studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular *** this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over *** existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic *** far, however, IL23R is the only identified susceptibility gene shared by both IBD and *** functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Ankylosing spondlitis Sacroiliitis Spondyloarthropathy

HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein

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Virologica Sinica 2019年第2期34卷 211-221页

作者： Ayslan Castro Brant Vladimir Majerciak Miguel angelo Martins Moreira Zhi-Ming Zheng Tumor Virus RNA Biology Section RNA Biology Laboratory Center for Cancer Research National Cancer Institute NIH Frederick MD 21702 USA Genetics Post-Graduation Program Rio de Janeiro Federal University Rio de Janeiro Brazil Genetics Program Nacional Cancer Institute INCA Rio de Janeiro 20231-050 Brazil

Human papillomavirus 18(HPV18) E6 and E7 oncogenes are transcribed as a single bicistronic E6 E7 pre-mRNA. The E6 ORF region in the bicistronic E6 E7 pre-mRNA contains an intron. Splicing of this intron disrupts the E6 ORF integrity and produces a spliced E6*I RNA for efficient E7 translation. Here we report that the E6 intron has two overlapped branch point sequences(BPS) upstream of its 30 splice site, with an identical heptamer AACUAAC, for E6*I splicing. One heptamer has a branch site adenosine(underlined) at nt 384 and the other at nt 388. E6*I splicing efficiency correlates to the expression level of E6 and E7 proteins and depends on the selection of which branch site. In general, E6*I splicing prefers the 30 ss-proximal branch site at nt 388 over the distal branch site at nt 384. Inactivation of the nt 388 branch site was found to activate a cryptic acceptor site at nt 636 for aberrant RNA splicing. Together, these data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment.

关键词： Human papillomavirus 18 (HPV18) HPV splicing Branch point E6,E7,E6 intron HPV oncogenes

Geospatial web services pave new ways for server-based on-demand access and processing of Big Earth Data

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International Journal of Digital Earth 2018年第1期11卷 7-25页

作者： Julia Wagemann Oliver Clements Ramiro Marco Figuera angelo Pio Rossi Simone Mantovani Forecast Department European Centre for Medium-Range Weather ForecastsReadingUK Remote Sensing Group Plymouth Marine LaboratoryPlymouthUK Department of Physics and Earth Sciences Jacobs UniversityBremenGermany MEEO S.r.l. FerraraItaly

Big Earth Data has experienced a considerable increase in volume in recent years due to improved sensing technologies and improvement of numerical-weather prediction *** traditional geospatial data analysis workflow hinders the use of large volumes of geospatial data due to limited disc space and computing *** web service technologies bring new opportunities to access large volumes of Big Earth Data via the Internet and to process them at *** practical examples are presented from the marine,climate,planetary and earth observation science communities to show how the standard interface Web Coverage Service and its processing extension can be integrated into the traditional geospatial data *** service technologies offer a time-and cost-effective way to access multidimensional data in a user-tailored format and allow for rapid application development or time-series *** transport is minimised and enhanced processing capabilities are *** research is required to investigate web service implementations in an operational mode and large data centres have to become more progressive towards the adoption of geo-data standard *** the same time,data users have to become aware of the advantages of web services and be trained how to benefit from them most.

关键词： Geospatial web services interoperability Big Earth Data open data Open Geospatial Consortium(OGC)