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The bone marrow niche landscape:a journey through aging,extrinsic and intrinsic stressors in the haemopoietic milieu

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 526-537页

作者： Antonio Giovanni Solimando Assunta Melaccio angelo Vacca Roberto Ria Department of Biomedical Sciences and Human Oncology Section of Internal Medicine and Clinical OncologyUniversity of Bari Medical SchoolBari 70124 Italy

Inflammation and its effects in the bone marrow microenvironment represent a paradigmatic condition in which the hematopoietic niche and the immune systems,thought to properly sustain blood cell production and distinguish between friend and foe,can actively sustain a corrupted neighborhood within a chronic aberrant inflamed *** bone marrow niche hijacks the physiologic *** interactions between the hematopoietic stem cells and the niche in the bone marrow are critical determinants of *** examined several approaches to confront the available evidence;three key points emerged,pointing to the chronic inflammation process,especially the chronic infection and systemic inflammatory states,as leading causes of hematopoietic stem cell *** hematopoiesis,defined as a relative expansion of individual clones,is caused by somatic alterations in essential hematopoietic genes,which increase stem cell ***,terminal differentiation plays a significant role in progenitor loss and inflammatory signaling,promoting clonal selection and clonal hematopoiesis *** myeloid malignancies as paradigmatic examples are discussed as a condition associated with inflammation,including the 5q-syndrome,Philadelphia negative myeloproliferative neoplasms,and chronic myeloid *** with increased fitness and hematopoietic stem cell attrition,extrinsic stress,enhanced stressor-specific fitness,and intrinsic defect across the hematopoietic process represent the route for novel insights in defective *** discussion in this review also points out that the hematopoietic niches’inflammatory stimulation may affect differentiation patterns and the function of downstream cells.

关键词： Hematopoietic niche immune system inflammation tumor microenvironment

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Gastrointestinal manifestations in myotonic muscular dystrophy

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World Journal of Gastroenterology 2006年第12期12卷 1821-1828页

作者： Massimo Bellini Sonia Biagi Cristina Stasi Francesco Costa Maria Gloria Mumolo angelo Ricchiuti Santino Marchi Gastroenterology Unit Department of Internal MedicineUniversity of PisaItaly

Myotonic dystrophy （MD） is characterized by myotonic phenomena and progressive muscular weakness. Involvement of the gastrointestinal tract is frequent and may occur at any level. The clinical manifestations have previously been attributed to motility disorders caused by smooth muscle damage, but histologic evidence of alterations has been scarce and conflicting. A neural factor has also been hypothesized. In the upper digestive tract, dysphagia, heartburn, regurgitation and dyspepsia are the most common complaints, while in the lower tract, abdominal pain, bloating and changes in bowel habits are often reported. Digestive symptoms may be the first sign of dystrophic disease and may precede the rnusculo-skeletal features. The impairment of gastrointestinal function may be sometimes so gradual that the patients adapt to it with little awareness of symptoms. In such cases routine endoscopic and ultrasonographic evaluations are not sufficient and targeted techniques （electrogastrography, manornetry, electromyography, functional ultrasonography, scintigraphy, etc.） are needed. There is a low correlation between the degree of skeletal muscle involvement and the presence and severity of gastrointestinal disturbances whereas a positive correlation with the duration of the skeletal muscle disease has been reported. The drugs recommended for treating the gastrointestinal complaints such as prokinetic, antidyspeptic drugs and laxatives, are mainly aimed at correcting the motility disorders. Gastrointestinal involvement in MD remains a complex and intriguing condition since many important problems are still unsolved. Further studies concentrating on genetic aspects, early diagnostic techniques and the development of new therapeutic strategies are needed to improve our management of the gastrointestinal manifestations of MD.

关键词： Myotonic dystrophy Digestive disorders Gastrointestinal symptoms

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Helicobacter pylori infection in obesity and its clinical outcome after bariatric surgery

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World Journal of Gastroenterology 2014年第3期20卷 647-653页

作者： Marilia Carabotti Chiara D'Ercole angelo Iossa Enrico Corazziari Gianfranco Silecchia Carola Severi Department of Internal Medicine and Medical Specialties University Sapienza Department of Medical Surgical Sciences and Biotechnology University Sapienza

The present review summarizes the prevalence and active clinical problems in obese patients with Helicobacter pylori(***)infection,as well as the outcomes after bariatric surgery in this patient *** involvement of *** in the pathophysiology of obesity is still *** may be that the infection is protective against obesity,because of the gastritis-induced decrease in production and secretion of the orexigenic hormone ***,recent epidemiological studies have failed to show an association between *** infection and reduced body mass *** infection might represent a limiting factor in the access to bariatric bypass surgery,even if highquality evidence indicating the advantages of preoperative *** screening and eradication is *** clinical management of infection is complicated by the lower eradication rates with standard therapeutic regimens reported in obese patients than in the normalweight *** clinical studies to ameliorate both *** eradication rates and control the clinical outcomes of *** infection after different bariatric procedures are warranted.

关键词： Helicobacter pylori Obesity Bariatric surgery Ghrelin Antibiotic resistance

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Follow-up after curative resection for gastric cancer: Is it time to tailor it?

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World Journal of Gastroenterology 2017年第19期23卷 3379-3387页

作者： Paolo Aurello Niccolò Petrucciani Laura Antolino Diego Giulitti Francesco D'angelo Giovanni Ramacciato Division of General Surgery Department of Medical and Surgical Sciences and Translational Medicine UOC Chirurgia 3 Sapienza University St.Andrea Hospital Division of Digestive Surgery and Liver Transplantation Nice University Hospital

There is still no consensus on the follow-up frequency and regimen after curative resection for gastric ***,controversy exists regarding the utility of follow-up in improving survival,and the recommendations of experts and societies vary *** main reason to establish surveillance programs is to diagnose tumor recurrence or metachronous cancers early and to thereby provide prompt treatment and prolong *** the setting of gastric malignancies,other reasons have been put forth:(1)the detection of adverse effects of a previous surgery,such as malnutrition or digestive sequelae;(2)the collection of data;and(3)the identification of psychological and/or social problems and provision of appropriate support to the *** randomized controlled trials on the role of follow-up after curative resection of gastric carcinoma have been ***,the primary retrospective series and systematic reviews on this subject are analyzed and ***,the guidelines from international and national scientific societies are *** is recommended by the majority of institutions;however,there is no real evidence that follow-up can improve long-term survival *** studies have demonstrated that it is possible to stratify patients submitted to curative gastrectomy into different classes according to the risk of ***,promising studies have identified several molecular markers that are related to the risk of relapse and to *** on these premises,a promising strategy will be to tailor follow-up in relation to the patient and tumor characteristics,molecular marker status,and individual risk of recurrence.

关键词： Gastric cancer Follow-up Surgery Gastric carcinoma Chemotherapy Surveillance Recurrence Markers Imaging

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Supergiant Barocaloric Effects in Acetoxy Silicone Rubber over a Wide Temperature Range:Great Potential for Solid-state Cooling

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Chinese Journal of Polymer Science 2020年第9期38卷 999-1005,I0008页

作者： William Imamura Erik Oda Usuda Lucas Soares Paixao Nicolau Molina Bom angelo Marcio Gomes Alexandre Magnus Gomes Carvalho Faculdade de Engenharia Mec(a)nica UNICAMPCEP 13083-860CampinasSPBrazil Universidade Federal de Sāo Paulo UNIFESPCEP 09913-030DiademaSPBrazil Instituto de Física Gleb Wataghin UNICAMPCEP 13083-859CampinasSPBrazil Catalan Institute of Nanoscience and Nanotechnology ICN208860 BelaterraBarcelonaSpain The Institute of Photonic Sciences ICFO08193 CastelldefelsBarcelonaSpain Instituto de Física UFRJCEP 21941-972Rio de JaneiroRJBrazil Departamento de Engenharia Mec(a)nica UEMCEP 87020-900MaringáPRBrazil

Solid-state cooling based on caloric effects is considered a viable alternative to replace the conventional vapor-compression refrigeration *** barocaloric materials,recent results show that elastomers are promising candidates for cooling applications around *** the present paper,we report supergiant barocaloric effects observed in acetoxy silicone rubber—a very popular,low-cost and environmentally friendly *** values of adiabatic temperature change and reversible isothermal entropy change were obtained upon moderate applied pressures and relatively low *** huge barocaloric changes are associated both to the polymer chain rearrangements induced by confined compression and to the first-order structural *** results are comparable to the best barocaloric materials reported so far,opening encouraging prospects for the application of elastomers in near future solid-state cooling devices.

关键词： Solid-state cooling Barocaloric effect Elastomer Silicone rubber Crystalline-amorphous transition

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Carbon concentrations and carbon storage capacity of three old-growth forests in the Sila National Park,Southern Italy

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Journal of Forestry Research 2023年第1期34卷 233-242页

作者： Giovanni Di Matteo Giuseppe Luzzi Antonio Basile angelo Sposato Giada Bertini Ulderico Neri Bruno Pennelli Rosario Napoli Pierfrancesco Nardi Consiglio per la ricerca e l’analisi dell’economia agraria Research Centre for Agriculture and Environment(CREA-AA)Via della Navicella 2-400184 RomeItaly Sila National Park Via NazionaleLorica Di San Giovanni in Fiore87055 CosenzaItaly Consiglio per la ricerca e l’analisi dell’economia agraria Research Centre for Forestry and Wood(CREA-FL)Viale Santa Margherita 8052100 ArezzoItaly

Old-growth forests play a key-role in reducing atmospheric carbon dioxide(CO_(2)) concentrations by storing large CO_(2)amounts in biomass and soil over *** quantifies the carbon pool into different forest compartments in three Mediterranean old-growth forests of Southern Italy populated by Pinus laricio,Fagus sylvatica and Abies *** carbon pools have been assessed per compartment,i.e.,living trees,dead wood,litterfall(foliar and woody),roots and 0-20 cm topsoil,combining the whole old-growth forest mass,(i.e.,using tree allometric relationships,deadwood factor conversions,root-to-shoot ratios,litterfall and soil samplings) by the respective organic carbon *** results show the considerable capacity of these forest ecosystems in storing CO_(2)in biomass and soil,with carbon pool values ranging from 532.2to 596.5 Mg C *** trees and 0-20 cm topsoil had larger carbon pool,contributing 53.0 and 22.1%,*** most cases,organic carbon concentration was higher(more than 60%) than the average carbon conversion rate of 50%,especially in living trees,deadwood,and woody *** study contributes further scientific evidence of the capacity of old-growth forests in storing CO_(2)in their different compartments,with special evidence on tree biomass,litterfall and mineral soil,thereby highlighting the key role of old-growth forests within the challenge of climate change mitigation.

关键词： Ecosystem carbon pool Organic carbon concentration Ecosystem compartment Climate change mitigation Carbon forestry

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Chronic liver failure-consortium acute-on-chronic liver failure and acute decompensation scores predict mortality in Brazilian cirrhotic patients

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World Journal of Gastroenterology 2017年第28期23卷 5237-5245页

作者： Rafael Veiga Picon Franciele Sabadin Bertol Cristiane Valle Tovo angelo Zambam de Mattos Gastroenterology and Hepatology Unit Nossa Senhora da Conceicao Hospital Gastro-enterology and Hepatology Unit Federal University of Health Sciences of Porto Alegre Gastroenterology and Hepatology Unit Pontifical Catholic University of Rio Grande do Sul

To validate prognostic scores for acute decompensation of cirrhosis and acute-on-chronic liver failure in Brazilian *** is a prospective cohort study designed to assess the prognostic performance of the chronic liver failure-consortium (CLIF-C) acute decompensation score (CLIF-C AD) and CLIF-C acute-on-chronic liver failure score (CLIF-C ACLF), regarding 28-d and 90-d mortality, as well as to compare them to other prognostic models, such as Model for End-Stage Liver Disease (MELD), MELD Sodium (MELD-Na), Child-Pugh (CP) score, and the CLIF-C Organ Failure score (CLIF-C OF). All participants were adults with acute decompensation of cirrhosis admitted to the Emergency Department of a tertiary hospital in southern Brazil. Prognostic performances were evaluated by means of the receiver operating characteristic (ROC) curves, area under the curves (AUC) and 95%*** hundred and thirteen cirrhotic patients were included. At admission, 18 patients had acute-on-chronic liver failure (ACLF) and 95 individuals had acute decompensation (AD) without ACLF, of which 24 eventually developed ACLF during the course of hospitalization (AD evolving to ACLF group). The AD group had significantly lower 28-d (9.0%) and 90-d (18.3%) mortality as compared to the AD evolving to ACLF group and to the ACLF group (both P < 0.001). On the other hand, 28-d and 90-d mortalities were not significantly different between AD evolving to ACLF group and ACLF group (P = 0.542 and P = 0.708, respectively). Among patients with ACLF, at 28 d from the diagnosis, CLIF-C ACLF was the only score able to predict mortality significantly better than the reference line, with an AUC (95%CI) of 0.71 (95%CI: 0.54-0.88, P = 0.021). Among patients with AD, all prognostic scores performed significantly better than the reference line regarding 28-d mortality, presenting with similar AUCs: CLIF-C AD score 0.75 (95%CI: 0.63-0.88), CP score 0.72 (95%CI: 0.59-0.85), MELD score 0.75 (95%CI: 0.61-0.90),

关键词： Cirrhosis Acute-on-chronic liver failure Mortality Prediction Prognosis Acute decompensation of cirrhosis

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Sarcopenia in heart failure： mechanisms and therapeutic strategies

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Journal of Geriatric Cardiology 2016年第7期13卷 615-624页

作者： Agnese Collamati Emanuele Marzetti Riccardo Calvani Matteo Tosato Emanuela D'angelo Alex N Sisto Francesco Landi Center for Geriatric Medicine (CEMI) Institute of Internal Medicine and Geriatrics Catholic University of the Sacred Heart Rome Italy

Chronic heart failure （CHF） is a highly prevalent condition among the elderly and is associated with considerable morbidity, institution-alization and mortality. In its advanced stages, CHF is often accompanied by the loss of muscle mass and strength. Sarcopenia is a geriatric syndrome that has been actively studied in recent years due to its association with a wide range of adverse health outcomes. The goal of this review is to discuss the relationship between CHF and sarcopenia, with a focus on shared pathophysiological pathways and treatments. Mal- nutrition, systemic inflammation, endocrine imbalances, and oxidative stress appear to connect sarcopenia and CHF. At the muscular level, alterations of the ubiquitin proteasome system, myostatin signaling, and apoptosis have been described in both sarcopenia and CHF and could play a role in the loss of muscle mass and function. Possible therapeutic strategies to impede the progression of muscle wasting in CHF patients include protein and vitamin D supplementation, structured physical exercise, and the administration of angiotensin-converting enzyme inhibitors and β-blockers. Hormonal supplementation with growth hormone, testosterone, and ghrelin is also discussed as a potential treatment.

关键词： Ghrelin Muscle loss Protein supplementation Vitamin D

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Organizational behavior : key concepts, skills & best practices / angelo Kinicki, Robert Kreitner.

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2003年

作者： angelo Kinicki Robert Kreitner.

来源：畅想之星图书光盘版（南... 评论

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Biomarkers of Aging: An Overview

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Biomedical and Environmental Sciences 1991年第Z1期 130-133页

作者： angelo TURTURRO,RONALD W.HART National Center for Toxicological Research Jefferson National Center for Toxicological Research Jefferson Akansas 72079 Akansas 72079

INTRODUCTION Although aging has often been thought of as some intrinsic, immutable process, an alternative is to approach aging as a toxic endpoint resulting from a combination of endogenous and exogenous damage. Aging is then defined as consisting of a combination of functional declines observed in every organism system, occurring at different ages for different systems (Shock, 1985). One measure of this decline is death, and mortality is often used as a surrogate for aging. The sources of endogenous

关键词： Biomarkers of Aging An Overview

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