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Energy and Power Engineering 2015年第5期7卷 193-202页

作者： Neilton Fidelis da silva angela Oliveira da Costa Rachel Martins Henriques Marcio Giannini Pereira Marcos Aurelio Freitas Vasconcelos Energy Planning Program (PPE) Coordination of Postgraduate Programs in Engineering at the Federal University of Rio de Janeiro (COPPE/UFRJ) Cidade Universit&aacute ria Rio de Janeiro Brazil International Virtual Institute of Global Change—IVIG Centro de Tecnologia Cidade Universit&aacute ria Rio de Janeiro Brazil Federal Institute of Education Science and Technology of Rio Grande do Norte (IFRN) Natal Brazil

The use of Urban Solid Waste (USW) as sources of energy has acquired rising importance in current discussions of alternative energy supplies, in particular in Brazil. This paper brings to these discussions an examination of the concept of solid wastes, including their historic origins and formation, taking their social, economic and cultural characteristics into account, including point view of waste production liturgy. Consequently, a spendthrift society slanted towards the decreasing marginal utility of assets must make efficient use of its USW in order to reduce excessive output. Besides that, this document presents the Brazilian potential of urban solid waste to produce electric power.

关键词： Urban Solid Wastes Renewable Energy Energy Planning Brazil

Remodeling of the cell wall as a drought-tolerance mechanism of a soybean genotype revealed by global gene expression analysis

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aBIOTECH 2021年第1期2卷 14-31页

作者： Flaviane silva Coutinho Juliano Mendonça Rodrigues Lucas Leal Lima Rosilene Oliveira Mesquita Paola Avelar Carpinetti João Paulo Batista Machado Camilo Elber Vital Pedro Marcus Vidigal maria Eduarda Soares Ramos mariana Rocha Maximiano angela Mehta maria Goreti Almeida Oliveira Elizabeth Pacheco Batista Fontes Humberto Josuéde Oliveira Ramos Departamento de Bioquímica e Biologia Molecular Universidade Federal de ViçsaViçsaMinas GeraisBrazil Departamento de Fitotecnia Universidade Federal do CearáFortalezaCearáBrazil Núcleo de Análise de Biomoléculas(NuBioMol) Universidade Federal de ViçsaViçsaMinas GeraisBrazil Instituto de Ciéncias Agrárias Universidade Federal de ViçsaFlorestalMinas GeraisBrazil Embrapa Recursos Genéticos e Biotecnologia BrasíliaDFBrazil Universidade Federal de Juiz de Fora Juiz de ForaMinas GeraisBrazil

Drought stress is major abiotic stress that affects soybean ***,it is widely desirable that soybean becomes more tolerant to *** provide insights into regulatory mechanisms of the stress response,we compared the global gene expression profiles from leaves of two soybean genotypes that display different responses to water-deficit(BR 16 and Embrapa 48,drought-sensitive and droughttolerant,respectively).After the RNA-seq analysis,a total of 5335 down-regulated and 3170 up-regulated genes were identified in the *** the other hand,the number of genes differentially expressed was markedly lower in the Embrapa 48,355 up-regulated and 471 down-regulated ***,induction and expression of protein kinases and transcription factors indicated signaling cascades involved in the drought ***,the results suggest that the metabolism of pectin is differently modulated in response to drought stress and may play a role in the soybean defense mechanism against *** occurs via an increase of the cell wall plasticity and crosslink,which contributed to a higher hydraulic conductance(Kf)and relative water content(RWC%).The drought-tolerance mechanism of the Embrapa 48 genotype involves remodeling of the cell wall and increase of the hydraulic conductance to the maintenance of cell turgor and metabolic processes,resulting in the highest leaf RWC,photosynthetic rate(A),transpiration(E)and carboxylation(A/Ci).Thus,we concluded that the cell wall adjustment under drought is important for a more efficient water use which promoted a more active photosynthetic metabolism,maintaining higher plant growth under drought stress.

关键词： Gene expression RNA-seq Molecular physiology Water-use efficiency

Complex interactomes and post-translational modifications of the regulatory proteins HABP4 and SERBP1 suggest pleiotropic cellular functions

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World Journal of Biological Chemistry 2019年第3期10卷 44-64页

作者： Carolina Colleti Talita Diniz Melo-Hanchuk Flavia Regina Moraes da silva angela Saito Jorg Kobarg Faculty of Pharmaceutical Sciences University of CampinasCampinas 13083-871Brazil Institute of Biology Departament of Biochemistry and Tissue BiologyUniversity of CampinasCampinas 13083-862Brazil Laboratório Nacional de Biociencias CNPEMCampinas 13083-970Brazil

The 57 kda antigen recognized by the Ki-1 antibody,is also known as intracellular hyaluronic acid binding protein 4 and shares 40.7%identity and 67.4%similarity with serpin mRNA binding protein 1,which is also named CGI-55,or plasminogen activator inhibitor type-1-RNA binding protein-1,indicating that they might be paralog proteins,possibly with similar or redundant functions in human *** the identification of their protein interactomes,both regulatory proteins have been functionally implicated in transcriptional regulation,mRNA metabolism,specifically RNA splicing,the regulation of mRNA stability,especially,in the context of the progesterone hormone response,and the DNA damage *** proteins also show a complex pattern of post-translational modifications,involving Ser/Thr phosphorylation,mainly through protein kinase C,arginine methylation and SUMOylation,suggesting that their functions and locations are highly ***,they show a highly dynamic cellular localization pattern with localizations in both the cytoplasm and nucleus as well as punctuated localizations in both granular cytoplasmic protein bodies,upon stress,and nuclear splicing *** reports in the literature show altered expressions of both regulatory proteins in a series of cancers as well as mutations in their genes that may contribute to *** review highlights important aspects of the structure,interactome,post-translational modifications,sub-cellular localization and function of both regulatory proteins and further discusses their possible functions and their potential as tumor markers in different cancer settings.

关键词： Cancer Cell signaling Regulatory protein Protein interactions Post-translational modifications

Analysis of Forging Dies Coated with Tungsten Carbide through HVOF Processing

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Journal of Mechanics Engineering and Automation 2016年第7期6卷 373-378页

作者： Vanessa Moura de Souza angela Selau Marques Jorge Antoenio Huff Alexandre da silva Rocha Luciano Kempski GES (Group of Engineering Surface) Federated University of Rio Grande do Sul Porto Alegre Brazil

In this paper we present a performance evaluation of thermal spraying coated hot forging dies conducted in a production line. The High Velocity Oxy-Fuel process was used for the deposition of a tungsten carbide coating, which is characterized by its optimal adherence and low porosity. A metallurgical characterization of the layer was previously done, in order to obtain reference information to assist in the interpretation of the practical tests results. The coated die allowed an increase in productivity of 37.5%, besides better dimensional stability results through the process and legibility of printed numbers.

关键词： Hot forging coating die surface.

Optimizing Hot Forging Process Parameters of Hollow Parts Using Tubular and Cylindrical Workpiece： Numerical Analysis and Experimental Validation

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Journal of Mechanics Engineering and Automation 2018年第2期8卷 60-70页

作者： angela Selau Marques Luana DeLuccade Costa Rafael Luciano dalcin Alberto Moreira Guerreiro Brito Lirio Schaeffer Alexandre da silva Rocha Faculty of Engineering Metallurgical Department Federal Universityof Rio Grande do Sul (UFRGS) Avenue Bento Goncalves 9500 Porto Alegre CEP 91509-900 Brazil

CAE （computer aided engineering） evaluates the forging process virtually to optimize the industrial production. The numerical and experimental investigations of forging process of a hollow part are important in industrial point of view. This study has been focused on the development of a 3D elastic-plastic FEM （finite element model） of hot forging to evaluate the forming process of hollow parts. The validity of this method was verified through a laboratory experiment using aluminum alloy （AA6351） with medium geometric complexity. The distributions of effective strain, temperature, metal flow and strength were analyzed for two different initial workpieces （tubular and cylindrical）. It was observed that both initial workpieces can be used to produce the final hollow part using the numerical simulation model. The results showed that the numerical analyses predict, filling cavity, calculated strength, work temperature and material flow were in agreement with the experimental results. However, some problems such as air trapping in the die causing incomplete filling could not be predicted and this problem was resolved experimentally by drilling small holes for air release in the dies.

关键词： Hot forging FEM hollow parts AA6351.

Family Organization in the Care of Pediatric Heart Transplant Patients:The Genogram as an Investigative Tool

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Health 2015年第11期7卷 1409-1418页

作者： silvania Braga Ribeiro angela maria Alves e Souza Ana Ruth Macedo Monteiro Kiarelle Lourenco Penaforte Sarah maria de Sousa Feitoza Virna Ribeiro Feitosa Cestari Flávia Paula Magalhaes Monteiro maria Gyslane Vasconcelos Sobral Samila Torquato Araújo Máguida Gomes da silva Mona Lisa Menezes Bruno Islene Victor Barbosa Isabelle Barbosa Pontes Department of Nursing Universidade de FortalezaFortalezaBrazil

This study aimed to describe structure, functionality and development of pediatric heart transplant families, from the understanding of the experienced chronic condition. A descriptive, exploratory study using a qualitative approach was developed in a hospital situated in a city of Northeast Brazil, in 2012. The study was conducted with three families, using the Calgary Family Assessment Model (CFAM). In addition to the genogram, an analysis of the children’s/adolescents’ family members was conducted at the time of interview. Two families were binuclear families and one was mononuclear. From the evaluation, it was possible to determine the care and support network of children and adolescents with heart transplants, as well as some difficulties faced by the investigated families. Nurses are important in this family context since the visualization of the family genogram can generate a change in the nursing care to each family.

关键词： Chronic Disease Heart Transplant Child Family Nursing Assessment

Detection of dengue virus serotype 3 in Cajamarca,Peru:Molecular diagnosis and clinical characteristics

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 456-462页

作者： Miguel Angel Aguilar-Luis Hugo Carrillo-Ng Sungmin Kym Wilmer silva-Caso Eduardo Verne Luis J.del Valle Jorge Bazán-Mayra Victor Zavaleta-Gavidia daniel Cornejo-Pacherres Yordi Tarazona-Castro Ronald Aquino-Ortega angela Cornejo-Tapia Juana del Valle-Mendoza School of Medicine Research and Innovation Center of the Faculty of Health SciencesUniversidad Peruana de Ciencias AplicadasLimaPeru Laboratorio de Biologia Molecular Instituto de Investigación NutricionalLimaPeru Facultad de Medicina Alberto Hurtado Universidad Peruana Cayetano HerediaLimaPeru Division of Infectious Diseases Department of Internal MedicineChungnam National University School of MedicineDaejeonRepublic of Korea Barcelona Research Center for Multiscale Science and Engineering Departament d'Enginyeria QuímicaEEBEUniversitat Politècnica de Catalunya(UPC)BarcelonaSpain Laboratorio Regional de Cajamarca Dirección Regional de Salud de Cajamarca(DIRESA)CajamarcaPeru

Objective:To describe and molecularly characterize an outbreak of dengue virus(DENV)infection in Cajamarca,an Andean region in ***:A total of 359 serum samples from patients with acute febrile illness were assessed for the presence of DENV via RT-PCR,ELISA NS1,Ig M and Ig G in Cajamarca,Peru from January 2017 to June *** evaluation of the different diagnostic tests and their applicability was ***:Dengue virus was detected in 24.7%of samples by ***,serological analysis detected 30.3%positive cases via ELISA NS1 antigen,16.7%via ELISA Ig G and 9.7%via ELISA Ig *** of the cases corresponded to DENV-3(77.5%).The use of RT-PCR performed better in primary infections(Pdary infections(Pdary infections(96.6%).The most frequent symptoms associated with fever were headaches,myalgias,and arthralgias across all ***:We report an important outbreak of dengue infection caused by DENV-3 in Cajamarca,*** findings encourage the use of NS1 antigen and Ig M *** findings demonstrate an increasing expansion of DENV-3 in Peru and highlight the importance of molecular diagnosis and serotype characterization among the clinically defined dengue cases to strengthen the Peruvian epidemiological surveillance.

关键词： Dengue DENV Arbovirus Diagnosis Peru

Tropical Isabella Grape Juices： Bioactive Compounds and Antioxidant Power Depends on Harvest Season

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Journal of Food Science and Engineering 2013年第2期3卷 64-70页

作者： Cinthia Bau Betim Cazarin Luiz Claudio Correa Juliana Kelly da silva angela Giovana Batista Cibele Priscila Busch Furlan Aline Camarao Telles Biasoto Giuliano Elias Pereira Ana Cecilia Poloni Rybka Mairio Roberto Marostica Junior Department of Food and Nutrition University of Campinas Campinas Sao Paulo 13083-862 Brazil Brazilian Agricultural Research Corporation Embrapa Tropical Semi-arid Petrolina Pernambuco 56302-970 Brazil Brazilian Agricultural Research Corporation Embrapa Grape & Wine/Tropical Semi-arid Petrolina Pernambuco 56302-970Brazil

Grapes are important sources of antioxidants compounds and one of the most used varieties to elaborate juices is ＂Isabel＂, or ＂Isabella＂, as it is called in North-America. This study aimed to evaluate the antioxidant activity of Isabella grape juices from the tropical semi-arid climate produced in Brazil on March and September, 2010. Total phenolics and anthocyanins were determined, as well as the antioxidant capacity by DPPH, FRAP and hydrophilic ORAC methods. Test T was used to compare statistical difference at 5% of significance level. As expected, the results showed that the season can play a significant role on phenolics content and antioxidant power. Polyphenols content in juices varied from 82.9 ± 0.92 to 102.2± 1.59 mg GAE 100 mL1- and anthocyanins content ranged from 44.3 ± 2.01 to 129.5 ± 2.82 mg cyanidin-3-glucoside 100 mL-1. Regression analyses showed a high correlation of antioxidant capacity and anthocyanins content. Grapes from Sao Francisco River Valley demonstrated to be a good source of antioxidant for human diet.

关键词： Isabella grape Vitis labrusca grape juice antioxidant activity anthocyanins phenolic content.

Early expression of the <i>tbx</i>22 gene in zebrafish influences positioning of pharyngeal arch cartilages

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American Journal of Molecular Biology 2012年第4期2卷 318-331页

作者： Tammy Lynne silva angela Allard Cox V. P. Boominathan Peter Alan Jezewski Tracie Lee Ferreira Department of Biology University of Massachusetts Dartmouth Dartmouth USA Department of Bioengineering University of Massachusetts Dartmouth Dartmouth USA Department of Periodontology Institute of Oral Health Research University of Alabama at Birmingham Birmingham USA

Mutations in human TBX22 cause X-linked cleft palate with anklyoglossia syndrome. The two zebrafish tbx22 splice isoforms, tbx22-1 and tbx22-2, encode proteins of 444 and 400 amino acids, respectively. Zebrafish tbx22 mRNA expression mirrors mammalian TBX22 expression and is consistent with early patterning of the vertebrate face. In zebrafish, tbx22 mRNA is strongly expressed during early pharyngeal arch development in the ventral mesenchyme, and a later expression domain is found in ectomesenchymal cells underlying the stomodeum, a bilaminar epithelial structure demarcating the early forming mouth. Therefore, tbx22 is hypothesized to be involved in craniofacial development. The objective of this work is to characterize the role of tbx22 during craniofacial development in zebrafish. Tbx22 knockdown revealed that defects in tbx22 signaling cause mild clefting, joint defects and dorsoventral patterning defects in cartilages. Quantitative PCR and in situ analysis revealed that knockdown of tbx22 also causes a dramatic decrease in expression of osr1 and gdf5. Craniofacial patterning is dependent on proper signals from endoderm, mesoderm and ectoderm. The early influence of tbx22 on signals within the ventral mesenchyme impacts the domains of several key pharynx-geal arch signals, thereby helping to regulate proper patterning of the developing jaw.

关键词： Zebrafish Tbx Signaling Pharyngeal Pouch

Expression of Multidrug Resistance ATP-Binding Cassette(ABC)Transporters in Canine Mammary Tumors

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Advances in Breast Cancer Research 2015年第3期4卷 77-85页

作者： Breno S.Salgado Suely Nonogaki Luisa M.Soares angela Akamatsu Cristiano R.N.da silva Thiago P.Anacleto Rodolfo Malagó Rafael M.Rocha Fátima Gartner Noeme S.Rocha Departamento de Patologia Faculdade de Medicina de BotucatuUniversidade Estadual PaulistaCampus de BotucatuBotucatuBrazil Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto(Intitute of Biomedical Sciences Abel Salazar of University of Porto)OportoPortugal Fundacao Antonio Prudente Hospital A.C.CamargoSao PauloBrazil Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e ZootecniaUniversidade Estadual PaulistaUNESP.BotucatuBrazil Hospital Escola de Medicina Veterinária Fundacao de Ensino e Pesquisa de Itajubá—FEPIItajubáBrazil

Mammary neoplasms are the most common tumors in female dogs. They are usually treated using solely surgical mastectomy—which is recognized as unsatisfactory in many cases. Given this, the benefits of chemotherapy in dogs with mammary cancer need to be further explored. Some drugs that can be used for treating canines with mammary tumors may be substrates of uptake and/or efflux transporters such as the ATP-binding cassette (ABC) transporters. Unfortunately, very little is known regarding the pathobiology of such proteins in canine tumors, including mammary cancer. Accordingly, this study was designed to characterize the expression of ABC transporters P-glycoprotein, MRP1, and MRP2 and their relation with clinicopathologic factors in order to allow a better understanding of their influence in canine mammary cancer. P-glycoprotein was expressed in tumors from 55.8% of patients, while MRP1 and MRP2 were expressed in 37.2% and 39.5% of tumors, respectively. P-glycoprotein expression showed to be related with regional lymph node spread (P = 0.0038), as well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245). MRP1 revealed a strong association with a higher histological grade (P date markers for a validation study on therapy outcome.

关键词： MDR1 P-Gp MRP1 MRP2 ABCC2 Mammary Neoplasms Prognosis Dog