检索结果-南通市图书馆

Beta-7 integrin controls enterocyte migration in the small intestine

World Journal of Gastroenterology 2015年第6期21卷 1759-1764页

作者： Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst angela schippers Norbert Wagner Nikolaus Gassler Institute of Pathology RWTH Aachen University Department of Pediatrics RWTH Aachen University Department of Medical Statistics RWTH Aachen University

AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and ***:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before *** total small intestine was isolated,dissected,and used for morphometrical *** U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each *** outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically ***:Integrins containing the beta-7-chain were exclusively expressed on *** the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically ***,the Peyer’s patches of beta-7integrin-deficient mice appeared *** beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the *** difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and *** of small intestinal enterocytes was different between the experimental groups measured by cellmax ***:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer.

关键词： Barrier function Cell migration Inflammatory bowel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fatty acid binding receptors in intestinal physiology and pathophysiology

引用

World Journal of Gastrointestinal Pathophysiology 2010年第5期1卷 147-153页

作者： Elke Kaemmerer Patrick Plum Christina Klaus Ralf Weiskirchen Christian Liedtke Maximilian Adolf angela schippers Norbert Wagner Andrea Reinartz Nikolaus Gassler Department of Pediatrics RWTH Aachen University Institute of Pathology RWTH Aachen University Institute of Clinical Chemistry and Pathobio-chemistry RWTH Aachen University Department of Medicine Ⅲ RWTH AachenUniversity

Free fatty acids are essential dietary components and recognized as important molecules in the maintenance of cellular *** the last decade,the molecular pathways for free fatty acid sensing in the gastrointestinal tract have been further elucidated by molecular identification and functional characterization of fatty acid binding *** sensing molecules belong to the family of G proteincoupled *** the intestine,four important receptors have been described so *** differ in molecular structure,ligand specificity,expression pattern,and functional *** this review,an overview of intestinal fatty acid binding receptors and their role in intestinal physiology and pathophysiology is given.

关键词： G protein Intestine Free fatty acid Receptor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：