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Applied Mathematics and Mechanics(English Edition) 2008年第5期29卷 653-663页

作者：焦建军陈兰荪 Juan J.Nieto Torres angela School of Mathematics and Statistics Guizhou College of Finance and Economics Department of Applied Mathematics Dalian University of Technology Department of Mathematical Analysis Faculty of MathematicsUniversity of Santiago de Compostela15782 Santiago de Compostela Spain Department of Psychiatry Radiology and Public Health Faculty of Medicine University of Santiago de CompostelaSpain

We investigate a stage-structured delayed predator-prey model with impulsive stocking on prey and continuous harvesting on predator. According to the fact of biological resource management, we improve the assumption of a predator-prey model with stage structure for predator population that each individual predator has the same ability to capture prey. It is assumed that the immature and mature individuals of the predator population are divided by a fixed age, and immature predator population does not have the ability to attach prey. Sufficient conditions are obtained, which guarantee the global attractivity of predator-extinction periodic solution and the permanence of the system. Our results show that the behavior of impulsive stocking on prey plays an important role for the permanence of the system, and provide tactical basis for the biological resource management. Numerical analysis is presented to illuminate the dynamics of the system.

关键词： stage-structured, impulsive stocking continuous harvesting global attractivity permanence

Experimental assessment of regenerative properties of platelet rich plasma on the human skin-a review

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Plastic and Aesthetic Research 2022年第1期9卷 387-393页

作者： Marco Mario Tresoldi angela Faga Giovanni Nicoletti Unit of Plastic and Reconstructive Surgery Department of Clinical SurgicalDiagnostic and Pediatric SciencesUniversity of PaviaPavia 27100Italy Department of Surgery Istituti Clinici Scientifici MaugeriPavia 27100Italy Department of Clinical Surgical Diagnostic and Pediatric Sciences and Department of Public Health and Experimental and Forensic MedicineAdvanced Technologies for Regenerative Medicine and Inductive Surgery Research CenterUniversity of PaviaPavia 27100Italy Plastic Surgery Unit Azienda Socio-Sanitaria Territoriale di PaviaPavia 27100Italy

Several studies demonstrated the favorable effects of platelet rich plasma(PRP)on the skin and promoted its wide use in clinical *** growth factors stored in platelet alfa-granules allow for the tissue regeneration and the main fields of application of PRP in current clinical practice are the cartilage and musculoskeletal defects,osteoarthritis and other bone disorders,chronic and difficult to heal wounds,and aesthetic *** relevant number of different PRP preparation protocols may explain the inconsistency of the different clinical outcomes reported in the *** the technological advances in PRP preparation,the objective assessment of the clinical efficacy of PRP from the literature reports still is difficult due to the low homogeneity of the samples in terms of both inclusion criteria and ***,it might be useful to establish standardized and reproducible experimental models to confirm and objectively measure the effectiveness of the available clinical *** experimental investigations have been carried out to objectively assess the effectiveness of PRP and platelet gel on several *** far as the skin is concerned,the studies carried out to date are limited to fibroblasts in in-vitro culture models or to collagen,vascular supply,epithelium,and hair follicle in in-vivo *** skin,however,is a very complex organ,where different cell lines coexist and feature complex mutual interaction.A model that combines the advantages of both in-vitro and in-vivo cultures is the ex-vivo *** demonstration of the platelet derived growth factors effects through the ex-vivo human full-thickness skin culture model is a keystone to support the evidence of the PRP effectiveness,as it represents an objective,fast,reproducible,and ethical investigational method.

关键词： Platelet rich plasma PRP ex-vivo regeneration culture techniques skin

Impact of new treatment options for hepatitis c virus infection in liver transplantation

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World Journal of Gastroenterology 2015年第38期21卷 10760-10775页

作者： Elda Righi angela Londero Alessia Carnelutti Umberto Baccarani Matteo Bassetti Infectious Diseases Division Santa Maria della Misericordia University Hospital Liver Transplant Unit Santa Maria della Misericordia University Hospital

Liver transplant candidates and recipients with hepatitis C virus(HCV)-related liver disease greatly benefit from an effective antiviral therapy. The achievement of a sustained virological response before transplantation can prevent the recurrence of post-transplant HCV disease that occurs universally and correlates with enhanced progression to graft cirrhosis. Previous standard-of-care regimens(e.g.,pegylated-interferon plus ribavirin with or without first generation protease inhibitors,boceprevir and telaprevir) displayed suboptimal results and poor tolerance in liver transplant recipients. A new class of potent direct-acting antiviral agents(DAA) characterized by all-oral regimens with minimal side effects has been approved and included in the recent guidelines for the treatment of liver transplant recipients with recurrent HCV disease. Association of sofosbuvir with ribavirin and/or ledipasvir is recommended in liver transplant recipients and patients with decompensated cirrhosis. Other regimens include simeprevir,daclatasvir,and combination of other DAA. Possible interactions should be monitored,especially in coinfected human immunodeficiency virus/HCV patients receiving antiretrovirals.

关键词： Hepatitis C virus Direct antiviral agents Liver tr

Nodal Solutions of the Brezis-Nirenberg Problem in Dimension 6

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Analysis in Theory and Applications 2022年第1期38卷 1-25页

作者： angela Pistoia Giusi Vaira 无 Dipartimento di Scienze di Base e Applicate per Vlngegneria Sapienza Universita di RomaVia Scarpa 1600161 RomaItaly Dipartimento di Matematica Universita degli studi di Bari“Aldo Moro”via Edoardo Orabona 470125 BariItaly

We show that the classical Brezis-Nirenberg problem-△μ=μ|μ|+λμinΩ,μ=0 on■Ω,when O is a bounded domain in R^(6)has a sign-changing solution which blows-up at a point in n asλapproaches a suitable valueλ_(0)>0.

关键词： Sign-changing solutions blow-up phenomenon Ljapunov-Schmidt reduction Transversality theorem

Novel therapy for non-cirrhotic hyperammonemia due to a spontaneous splenorenal shunt

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World Journal of Gastroenterology 2014年第25期20卷 8288-8291页

作者： Shari S Rogal angela Hu Rupal Bi Obaid Shaikh Division of Gastroenterology Hepatology and Nutrition University of Pittsburgh Medical Center Pittsburgh PA 15213 United States University of Pittsburgh School of Medicine Pitts-burgh PA 15213 United States Department of Radiology Veterans Affairs Pitts-burgh Healthcare System Pittsburgh PA 15240 United States Division of Gastroenterology Veterans Affairs Pittsburgh Healthcare System Pittsburgh PA 15240 United States

Spontaneous splenorenal shunts in the absence of cirrhosis have rarely been reported as a cause hyperammonemia with encephalopathy. Several closure techniques of such lesions have been described. Here we report a case of a patient with no history of liver disease who developed significant confusion. After an extensive workup, he was found to have hyperammonemia and encephalopathy due to formation of a spontaneous splenorenal shunt. There was no evidence of cirrhosis on biopsy or imaging and no portal hypertension when directly measured. The shunt was 18 mm and too large for embolization so the segment of the splenic vein between the portal vein and the shunt was occluded using an Amplatzer plug. Thus, the superior mesenteric flow was directed entirely to the liver. After interventional radiology closure of the shunt using this technique there was complete resolution of *** case represents the first report of a successful closure of splenorenal shunt via percutaneous embolization of the splenic vein with an amplatzer plug using a common femoral vein approach.

关键词： Splenorenal shunt Gastric bypass Hyperammonemia Encephalopathy

Pre-school childcare in England, 1939-2010

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Pre-school childcare in England, 1939-2010

Governing the gold rush into emerging markets: a case study of Indonesia’s regulatory responses to the expansion of Chinese-backed online P2P lending

作者： (1981-)Davis angela

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Financial Innovation 2020年第1期6卷 842-865页

作者： angela Tritto Yujia He Victoria Amanda Junaedi Institute for Emerging Market Studies The Hong Kong University of Science and TechnologyLo Ka Chung BuildingClear Water BayKowloonHong Kong SARChina Patterson School of Diplomacy and International Commerce University of KentuckyLexingtonKY 40506USA Business School The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina

Peer-to-peer(P2P)lending has the potential to boost financial inclusion in emerging *** paper contributes to the literature on fintech governance in emerging Asian *** examines the case of the Indonesian government’s approach in regulating the P2P lending sector using both primary interviews and secondary firmlevel *** by regulation tightening in China and regulatory gaps in Indonesia,Chinese investments became the largest in this sector contributing,however,to growing risks from illegal business *** Indonesian government responded by creating new regulations and institutions,mitigating risks without stifling the potential for financial *** conclude a proactive approach towards monitoring and regulating emerging high-tech industries should be sought by strengthening links with industry and civil society,and through international cooperation for policy and knowledge sharing.

关键词： Fintech P2P Internet finance Governance Emerging market

Potential role of metabolomics in diagnosis and surveillance of gastric cancer

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World Journal of Gastroenterology 2014年第36期20卷 12874-12882页

作者： angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer Daniel Schiller Division of General Surgery University of Alberta Edmonton Alberta T6G 2B7 Canada Division of Medical Oncology Cross Cancer Institute University of Alberta Edmonton Alberta T6G 1Z2 Canada

Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics’ role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool.

关键词： Gastric cancer Metabolomics Screening Biomarkers Surveillance

Cardiopulmonary Comorbidity, Radiomics and Machine Learning, and Therapeutic Regimens for a Cerebral fMRI Predictor Study in Psychotic Disorders

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Neuroscience Bulletin 2019年第5期35卷 955-957页

作者： Xiao-Hui Wang angela Yu Xia Zhu Hong Yin Long-Biao Cui Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China Department of Medicine Eastern Health Box Hill VIC 3128 Australia Department of Military Psychology School of Medical Psychology Fourth Military Medical University Xi’an 710032 China Department of Radiology Xijing Hospital Fourth Military Medical University Xi’an 710032 China Department of Clinical Psychology School of Medical Psychology Fourth Military Medical University Xi’an 710032 China

Recently, two researches by Doucet et al. and Collin et al. used functional neuroimaging as a tool to improve the management of schizophrenia and other psychotic disorders [1, 2]. We would like to highlight several issues in relation to cardiopulmonary comorbidity, radiomics and machine learning, and therapeutic regimens, along with their clinical implications.

关键词： Cardiopulmonary Comorbidity Radiomics Machine Learning Psychotic Disorders

Snow damages on trees of an uneven age in mixed broadleaf forests:effects of topographical conditions and tree characteristics

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Journal of Forestry Research 2019年第4期30卷 1383-1394页

作者： Farzam Tavankar angela Lo Monaco Mehrdad Nikooy Rachele Venanzi Amireslam Bonyad Rodolfo Picchio Department of Forestry Khalkhal BranchIslamic Azad UniversityKhalkhalIran Department of Agriculture and Forest Sciences(DAFNE) Tuscia UniversityVia S.Camillo de Lellis01100 ViterboItaly Department of Forestry Faculty of Natural ResourcesUniversity of GuilanSomehsaraIran

Snow damage on natural stands is an important problem concerning mountainous forest *** the present research,the frequency and intensity of heavy snow damage on natural stands and the relationship of damages with characteristics of trees,stand and topography were studied in mountainous forests of northern Iran.A systematic sampling design was applied to the study area(140 ha),with 122 circular *** grid dimension was100 m and each plot area was 1000 m^*** four types of snow damage to trees include:crown damage(8.6%),stem breakage(5.4%),uprooting(3.2%),and bending(1.4%).The frequency of crown damage grew with an increase inthe diameter at breast height(DBH),while the frequency of stem breakage,uprooting and bending decreased with an increase the *** frequency of crown damage,stem breakage,and total damages was related to tree species(p<0.01).Not all tree species were equally susceptible to snow *** amount of damage grew with increasing elevation and slope angle and decreased with increasing soil *** trees(DBH<25 cm)were more susceptible to snow damage than other *** damage decreased by as the trees in the stand became more mixed in *** susceptibility of trees to snow damage increased by height and slenderness *** adequate silvicultural operation,snow damage can be reduced to a minimum level in these natural forests.

关键词： Mixed forest Slenderness coefficient Snow damage Stem breakage Uprooting