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Chinese Optics Letters 2021年第3期19卷 46-52页

作者： Christian R.Petersen Mikkel b.Lotz Christos Markos Getinet Woyessa David Furniss angela b.seddon Rafael J.Taboryski O.bang DTU Fotonik Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark DTU Nanolab Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark NORbLIS DK-2830 VirumDenmark Mid-Infrared Photonics Group University of NottinghamNottingham NG72RDUK NKT Photonics DK-3460 Bi「ke「0dDenmark

Thermal nanoimprinting is a fast and versatile method for transferring the anti-reflective properties of subwavelength nanostructures onto the surface of highly reflective substrates, such as chalcogenide glass optical fiber end faces. In this paper, the technique is explored experimentally on a range of different types of commercial and custom-drawn optical fibers to evaluate the influence of geometric design, core/cladding material, and thermo-mechanical properties. Up to32.4% increased transmission and 88.3% total transmission are demonstrated in the 2–4.3 μm band using a mid-infrared(IR) supercontinuum laser.

关键词： nanoimprint lithography anti-reflection hot imprint chalcogenide glass optical fiber mid-infrared supercontinuum

Multiparametric ultrasound as a new concept of assessment of liver tissue damage

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World Journal of Gastroenterology 2024年第12期30卷 1663-1669页

作者： angela Peltec Ioan Sporea Department of Internal Medicine Discipline of GastroenterologyState University of Medicine and Pharmacy"Nicolae Testemitanu"Chishinev 2019Moldova Department of Gastroenterology and Hepatology "Victor Babes"University of Medicine and PharmacyTimisoara 300736Romania

Liver disease accounts for approximately 2 million deaths per year *** chronic liver diseases(CLDs),whether of toxic,genetic,autoimmune,or infectious origin,undergo typical histological changes in the structure of the *** changes may include the accumulation of extracellular matrix material,fats,triglycerides,or tissue *** methods for diagnosing CLD,such as conventional b-mode ultrasound(US),play a significant role in *** US,when coupled with b-mode US,can be helpful in evaluating the hemodynamics of hepatic vessels and detecting US findings associated with hepatic *** elastography can assess liver stiffness,serving as a surrogate marker for liver *** is important to note that interpreting these values should not rely solely on a histological ***-enhanced US(CEUS)provides valuable information on tissue perfusion and enables excellent differentiation between benign and malignant focal liver *** evaluation,the etiology of liver disease,and the patient current comorbidities all influence the interpretation of liver stiffness *** measurements are most clinically relevant when interpreted as a probability of compensated advanced CLD.b-mode US offers a subjective estimation of fatty infiltration and has limited sensitivity for mild *** controlled attenuation parameter requires a dedicated device,and cutoff values are not clearly ***-titative US parameters for liver fat estimation include the attenuation coefficient,backscatter coefficient,and speed of *** parameters offer the advantage of providing fat quantification alongside b-mode evaluation and other US *** US(MPUS)of the liver introduces a new concept for complete noninvasive *** encourages examiners to utilize the latest features of an US machine,including conventional b-mode,liver stiffness evaluation,fat quantification,dispersion imaging,

关键词： Multiparametric ultrasound Ultrasound-based elastography Liver stiffness Noninvasive diagnostic test for chronic liver disease Liver steatosis assessment Portal hypertension evaluation

A Golden Touch in the Design of Multifunctional Porphyrin Metallacages:Host-Guest Chemistry for Drug-Target Interactions

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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-Prieto Darren Wragg Nicole Heiduk Mihyun Park Nicole Strittmatter Roland A.Fischer angela Casini Guillermo Moreno-Alcántar Chair of Medicinal and bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and MetalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Munich Data Science Institute(MDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms holds great ***,the synthesis of MCgs with increased complexity and functionality is a great challenge since understanding of the interaction of MCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic MCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

Spatiotemporal modeling of mid-infrared photoluminescence from terbium(Ⅲ) ion doped chalcogenide-selenide multimode fibers

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Journal of Rare Earths 2019年第11期37卷 1157-1163页

作者： Slawomir Sujecki Lukasz Sojka Zhuoqi Tang Dinuka Jayasuriya David Furniss Emma barney Trevor benson angela seddon Telecommunications and Teleinformatics Department Wroclaw University of Science and TechnologyWroclawPoland Mid-Infrared Photonics Group George Green Institute for Electromagnetics ResearchFaculty of EngineeringThe University of NottinghamNottinghamUK

A numerical model was developed to study the time dynamics of photo luminescence emitted by Tb^3+doped multimode chalcogenide-selenide glass fibers pumped by laser light at approximately 2μ*** model consists of a set of partial differential equations(PDEs),which describe the temporal and spatial evolution of the photon density and level populations within the *** order to solve numerically the PDEs a method of lines was *** modeling parameters were extracted from measurements and from data available in the *** numerical results obtained support experimental *** particular,the developed model reproduces the discrepancies that are observed between the photoluminescence decay curves obtained from different points along the *** numerical analysis was also used to explain the source of these discrepancies.

关键词： Chalcogenide glass fiber Numerical modeling Photoluminescence Mid-infrared light Rare earths

Time-resolved terahertz spectroscopy of charge carrier dynamics in the chalcogenide glass As_(30)Se_(30)Te_(40)[Invited]

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Photonics Research 2016年第3期4卷 22-28页

作者： Tianwu Wang Elena A.Romanova Nabil Abdel-Moneim David Furniss Anna Loth Zhuoqi Tang angela seddon Trevor benson Andrei Lavrinenko Peter Uhd Jepsen Department of Photonics Engineering (DTU Fotonik) Technical University of Denmark Saratov State University Department of Physics Faculty of Engineering University of Nottingham

broadband(1.6–18 THz) terahertz time-domain spectroscopy(THz-TDS) and time-resolved terahertz spectroscopy(TRTS) were performed on a 54 μm thick chalcogenide glass(As_(30)Se_(30)Te_(40)) sample with a two-color laser-induced air plasma THz system in transmission and reflection modes, respectively. Two absorption bands at 2–3 and 5–8 THz were observed. TRTS reveals an ultrafast relaxation process of the photoinduced carrier response, well described by a rate equation model with a finite concentration of mid-bandgap trap states for self-trapped *** photoinduced conductivity can be well described by the Drude–Smith conductivity model with a carrier scattering time of 12–17 fs, and we observe significant carrier localization effects. A fast refractive index change was observed 100 fs before the conductivity reached its maximum, with 2 orders of magnitude larger amplitude than expected for the optically induced THz Kerr effect, indicating that free carriers are responsible for the transient index change.

关键词： Te Invited Se Time-resolved terahertz spectroscopy of charge carrier dynamics in the chalcogenide glass As

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina bottermann Jana brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

Potential role of metabolomics in diagnosis and surveillance of gastric cancer

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World Journal of Gastroenterology 2014年第36期20卷 12874-12882页

作者： angela W Chan Richdeep S Gill Daniel Schiller Michael b Sawyer Daniel Schiller Division of General Surgery University of Alberta Edmonton Alberta T6G 2B7 Canada Division of Medical Oncology Cross Cancer Institute University of Alberta Edmonton Alberta T6G 1Z2 Canada

Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics’ role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool.

关键词： Gastric cancer Metabolomics Screening biomarkers Surveillance

Development of a sample preparation approach to measure the size of nanoparticle aggregates by electron microscopy

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Particuology 2019年第4期17卷 49-57页

作者： Agnieszka Dudkiewicz angela Lehner Qasim Chaudhry Kristian Molhave Guenter Allmaier Karen Tiede Alistair b.A. boxall Peter Hofmann John Lewis The Food and Environment Research Agency Sand Hutton York Y041 1LZ UK Department of Environment The University of York Heslington York YO10 5DD UK National Centre for Food Manufacturing The University of Lincoln Holbeach PE12 7AG UK Research Group bio- and Polymer Analysis Institute of Chemical Technologies and Analytics TU Wien (Vienna University of Technology) Getreidemarkt 9 A-1060 Vienna Austria University of Chester Parkgate Road Chester CH1 4BJ UK Department of Micro and Nanotechnology Technical University of Denmark DTU Bldg 345b Lyngby 2800 Denmark Research Centre for Global Food Security and Ecosystems University of Hohenheim Wollgrasweg 43 70155 Stuttgart Germany Department of Geoinformatics - Z.GIS University of Salzburg Schillerstr. 30 A-5020 Salzburg Austria

Electron microscopy (EM) is widely used for nanoparticle (NP) sizing. Following an initial assessment of two sample preparation protocols described in the current literature as"unperturbed", we found that neither could accurately measure the size of NPs featuring a broad size distribution, e.g., aggregates. because many real-world NP samples consist of aggregates, this finding was of considerable concern. The data showed that the protocols introduced errors into the measurement by either inducing agglomeration artefacts or providing a skewed size distribution towards small particles (skewing artefact). The focus of this work was to develop and apply a mathematical refinement to correct the skewing artefact. This refinement provided a much improved agreement between EM and a reference methodology, when applied to the measurement of synthetic amorphous silica NPs. Further investigation, highlighted the influence of NP chemistry on the refinement. This study emphasised the urgent need for greater and more detailed consideration regarding the sample preparation of NP aggregates to routinely achieve accurate measurements by EM. This study also provided a novel refinement solution applicable to the size characterisation of silica and c让rate-coated gold NPs featuring broad size distributions. With further research, this approach could be extended to other NP types.

关键词： Nanoparticles Aggregates Measurement Electron microscopy Sample preparation Artefacts

Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma

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World Journal of Gastroenterology 2005年第10期11卷 1521-1528页

作者： Jian-Hua Ma Emilia Patrut Jan Schmidt Hanns-Peter Knaebel Markus W. büchler angela M(a|¨)rten Department of Surgery

AIM: To determine whether IFN-α is the agent that turns a slightly effective treatment (radiochemotherapy) into a potent therapy, we tested IFN-α for its synergistic ***: Eight pancreatic carcinoma cell lines were treated with the single agents and combinations of *** role of IFN-α regarding a) direct inhibitory effects; b)radio and chemosensitizing effects; c) anti-angiogenic properties and d) enhancement of immunogenicity was ***: Our results show that IFN-α has direct inhibitory properties and some synergistic influence as determined by AnnexinV/PI stain and cell count. IFN-α is also able to prevent the increase in proliferation rate and VEGF secretion of CDDP resistant cells. Having taken the results from immunogenicity experiments together, we found cells that can be influenced by IFN-α but were less susceptible against T cells. Furthermore, high expression of MHC molecules, CD118, EGF-R and Fas was predictive for a good ***: In conclusion, IFN-α has direct cytotoxic effects, acts as a radiosensitizer and circumvents tumor cell-regrowth after CDDP treatment. These mechanisms may be responsible for the good clinical outcome of CapRI.

关键词： Interferon-alpha Pancreatic adenocarcinoma Synergistic effects Combination therapy

Helicobacter pylori:a foodborne pathogen?

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World Journal of Gastroenterology 2018年第31期24卷 3472-3487页

作者： Nicoletta C Quaglia angela Dambrosio Department of Emergency and Organ Transplantation Section of Veterinary Clinic and Animal ProductionUniversity of Bari "Aldo Moro"

Helicobacter pylori(H. pylori) is an organism that is widespread in the human population and is sometimes responsible for some of the most common chronic clinical disorders of the upper gastrointestinal tract in humans, such as chronic-active gastritis, duodenal and gastric ulcer disease, low-grade b-cell mucosa associated lymphoid tissue lymphoma of the stomach, and gastric adenocarcinoma, which is the third leading cause of cancer death worldwide. The routes of infection have not yet been firmly established, and different routes of transmission have been suggested, although the most commonly accepted hypothesis is that infection takes place through the faecal-oral route and that contaminated water and foods might play an important role in transmission of the microorganism to humans. Furthermore, several authors have considered H. pylori to be a foodborne pathogen because of some of its microbiological and epidemiological characteristics. H. pylori has been detected in drinking water, seawater, vegetables and foods of animal origin. H. pylori survives in complex foodstuffs such as milk, vegetables and ready-to-eat foods. This review article presents an overview of the present knowledge on the microbiological aspects in terms of phenotypic characteristics and growth requirements of H. pylori, focusing on the potential role that foodstuffs and water may play in the transmission of the pathogen to humans and the methods successfully used for the detection of this microorganism in foodstuffs and water.

关键词： Helicobacter pylori Viable but nonculturable state Foodborne pathogen Food Water Animal reservoirs Culture methods Molecular methods