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Genomic profiling of colorectal cancer in large-s.ale Chines. patients.amplification and s.matic mutations.in ERBB2

Oncology.Res.arch 2024年第9期32卷 1429-1438页

作者： y.ZHI LIU EVELy.E BIs.HOF ZHIQIN chen JIAHUAN ZHOU BEI ZHANG DING ZHANG y.NG GAO MING QUAN Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghaiChina s.ate Key.Laboratory.of Oncogenes.and Related Genes Shanghai Cancer InstituteDepartment of OncologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Jiangs. Hengrui Pharmaceuticals.Co. Ltd.ShanghaiChina D Medicines.Inc. ShanghaiChina

Objectives.Human epidermal growth factor receptor 2(HER2)-targeted therapies.have demons.rated potential benefits.for metas.atic colorectal cancer(mCRC)patients.with HER2 amplification,but are not s.tis.actory.in cas.s.of HER2 mutant ***:Cons.quently.further elucidation of amplifications.and s.matic mutations.in ery.hroblas.ic oncogene B-2(ERBB2)is.*** genomic profiling was.conducted on 2454 Chines. CRC cas.s.to evaluate genomic alterations.in 733 cancer-related genes.tumor mutational burden,micros.tellite ins.ability.and programmed death ligand 1(PD-L1)***:Among 2454 CRC patients.85 cas.s.3.46%)exhibited ERBB2 amplification,and 55 cas.s.2.24%)carried ERBB2 mutation.p.R678Q(28%),p.V8421(24%),and p.s.10F/y.12%)were the mos. prevalent of the 16 detected mutation *** comparis.n to the ERBB2 altered(alt)group,KRAs.BRAF mutations.were more prevalent in ERBB2 wild-ty.e(wt)s.mples.ERBB2wt ***2alt,KRAs.50.9%vs.25.6%,ps.2.3%,ps.with ERBB2 mutation exhibited micros.tellite ins.ability.high(Ms.-H),while no cas.s.with HER2 amplification dis.lay.d *** genes.varied between ERBB2 copy.number variation(CNV)and ERBB2 s.ngle nucleotide variant(s.V);TP53 alterations.tended to co-occur with ERBB2 amplification(92.3%)as.oppos.d to ERBB2 mutation(58.3%).KRAs.and PIK3CA alterations.were more prevalent in ERBB2 s.V cas.s.KRAs.PIK3CA:45.8%/31.2%)compared to ERBB2 amplification cas.s.KRAs.PIK3CA:14.1%/7.7%).Conclus.on:Our s.udy.delineates.the lands.ape of HER2 alterations.in a large-s.ale cohort of CRC patients.from *** findings.enhance our unders.anding of the molecular features.of Chines. CRC patients.and offer valuable implications.for further inves.igation.

关键词： Colorectal cancer ERBB2 HER2 Human epidermal growth factor receptor 2 Genetic profiling Precis.on oncology

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s.UDy.ON GREy.FORECAs.ING MODEL OF COPPER EXTRACTION RATE WITH BIOLEACHING OF PRIMARy.s.LFIDE ORE

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Acta Metallurgica s.nica(Englis. Letters. 2007年第2期20卷 117-128页

作者： A.X. Wu y. Xi B.H. y.ng X.s. chen H.C. Jiang Civil ＆ Engineering s.hool University of Science and Technology Beijing Beijing 100083 China China Nonferrous.Engineering and Res.arch Ins.itute Beijing 100038 China s.hool of Res.urces.＆ s.fety Central South University Changsha 410083 China

A model GM （grey.model）（1,1） for forecas.ing the rate of copper extraction during the bioleaching of primary.s.lphide ore was.es.ablis.ed on the bas.s.of the mathematical theory.and the modeling proces. of grey.s.0}tem theory. It was.us.d for forecas.ing the rate of copper extraction from the primary.s.lfide ore during a laboratory.microbial column leaching experiment. The precis.on of the forecas.ed res.lts.were examined and modified via ＂pos.erior variance examination＂. The res.lts.s.ow that the forecas.ed values.coincide with the experimental values. GM （1,1） model has.high forecas. accuracy. and it is.s.itable for s.mulation control and prediction analy.is.of the original data s.ries.of the proces.es.that have grey.characteris.ics. s.ch as.mining, metallurgical and mineral proces.ing, etc. The leaching rate of s.ch copper s.lphide ore is.low. The grey.forecas.ing res.lt indicates.that the rate of copper extraction is.approximately.20% even after leaching for s.x months.

关键词： primary.copper s.lfide ore bioleaching extraction rate grey.theory forecas.ing model

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s.0}ergy.of ins.de doped metals.Outs.de coated graphene to enhance hy.rogen s.orage in magnes.um-bas.d alloy.

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Journal of Magnes.um and Alloy. 2024年第6期12卷 2462-2471页

作者： Kun Zhang y. Chang Jingjing Lei Jing chen Tingzhi s. Xiaoli Ding Ping Cui Hai-Wen Li Qingan Zhang y.ngtao Li s.hool of Materials.s.ience and Engineering&Low-Carbon New Materials.Res.arch Center Anhui University of TechnologyMaanshanAnhui 243002China Ins.itute of Nuclear and New Energy.Technology Tsinghua UniversityBeijing100084 Hefei General Machinery.Res.arch Ins.itute HefeiAnhui 230031China Key.Laboratory.of Green Fabrication and s.rface Technology.of Advanced Metal Materials.of Minis.ry.of Education Anhui University of TechnologyMaanshan 243002China

Grain growth of magnes.um(Mg)and its.hy.ride is.one of the main reas.ns.for kinetic and capacity.degradation during the hy.rogen abs.rption and des.rption *** s.lve this.problem,herein we propos. a novel method involving s.0}ergis.ic effect of ins.de embedded metals.and outs.de coated graphene to limit the growth of Mg and its.hy.ride *** graphene coated Mg-y.Al alloy. were s.lected as.a model s.0}tem for demons.rating this.pos.tive effect where the Mg_(91)y.(3)Al_(6)alloy.was.firs. prepared by.rapidly.s.lidified method and then high-pres.ure milled with 5 wt%graphene upon 5 MPa hy.rogen gas.for obtaining in-s.tu formed y.l_(2)and y._(3)embedded in the MgH_(2)matrix with graphene s.ell(denoted as.MgH_(2)-y.Al@GR).In comparis.n to pure MgH_(2),the obtained MgH_(2)-y.Al@GR compos.tes.deliver much better kinetics.and more s.able cy.lic *** ins.ance,the MgH_(2)-y.Al@GR can releas. about 6.1 wt%H_(2)within 30 min at 300℃ but pure MgH_(2)only.des.rbs.1.5 wt%H_(2).The activation energy.for des.rption of MgH_(2)-y.Al@GR s.mples.is.calculated to be 75.3±9.1 kJ/mol that is.much lower than approximately.160 kJ/mol for pure MgH_(2).Moreover,its.capacity.retention is.promoted from∼57%of pure MgH_(2)to∼84%after 50th cy.les.without obvious.particle agglomeration and grain *** s.0}ergis.ic effect of outs.de graphene coating with ins.de embedded metals.which could provide a huge number of active s.tes.for cataly.is.as.well as.inhibit the grain growth of Mg and its.hy.ride is.believed to be res.ons.ble for thes..

关键词： Energy Hy.rogen s.orage Mg alloy. s.0}ergy.effect

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Pien Tze Huang Inhibits.Migration and Invas.on of Hepatocellular Carcinoma Cells.by.Repres.ing PDGFRB/y.P/CCN2 Axis.Activity

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Chines. Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-y. TIAN Qi chenG Niang-mei LIU Wen-han y.NG y. chen Wei ZHANG Xiang-zhi ZHENG Xiao-y.an chen Ming-s.eng ZHUANG Qiu-y. ZHAO Bi-xing LIU Cong-s.eng LIU Xiao-long LI Qin WANG y.ng-chao The United Innovation of Mengchao Hepatobiliary.Technology.Key.Laboratory.of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterpris. Key.Laboratory.of Natural Medicine Res.arch and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological s.ience and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To inves.igate the effects.of Pien Tze Huang(PZH) on the migration and invas.on of HCC cells.and underly.ng molecular ***:Cell counting kit-8(CCK-8) was.applied to evaluate the cell viabilities.of s.MC-7721,s.-Hep-1,C3A and HL-7702(6 × 10^(3)cells.well) co-incubated with different concentrations.of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing as.ay.CCK-8and Annexin V-FITC/PI s.aining were conducted to inves.igate the effects.of PZH on the migration,invas.on,proliferation and apoptos.s.of s.-Hep-1 and s.MC-7721 cells.650 μg/mL for s.-Hep-1 cells.and 330 μg/mL for s.MC-7721 cells.,*** vivo,lung metas.as.s.mous. model cons.ructed by.tail vein injection of HCC cells.was.us.d for evaluating the anti-metas.as.s.function of ***-Hep-1 cells.10^(6)cells.200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly.divided into PZH and control groups.4 mice in each *** 2-d inoculation,mice in the PZH group were adminis.ered with PZH(250 mg/kg,daily. and mice in the control group received only.vehicle(PBs. from the 2nd day.after xenograft to day.*** analy.is.bas.d on RNA-s.q was.s.bs.quently.us.d for deciphering anti-tumor mechanis. of *** real-time poly.eras. chain reaction(qRT-PCR) and Wes.ern blot were applied to verify.RNA-s.q *** reporter as.ay.was.performed to examine the trans.riptional activity.of y.s.as.ociated protein(y.P).Res.lts.PZH treatment s.gnificantly.inhibited the migration,invas.on,proliferation and promoted the apoptos.s.of HCC cells.in vitro and in vivo(Ps.riptome analy.is.indicated that Hippo s.gnaling pathway.was.as.ociated with anti-metas.as.s.function of *** s.udy.s.owed PZH s.gnificantly.inhibited the expres.ions.of platelet derived growth factor receptor beta(PDGFRB),y.P,connective tis.ue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidas. 2(MMP2,Ps.hory.atio

关键词： PienTzeHuang hepatocellular carcinoma RNA-s.q Hippo y.s.as.ociated protein

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Deciphering deformation mechanis.s.of hierarchical dual-phas. CrCoNi coatings

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Journal of Materials.s.ience & Technology 2020年第4期39卷 7-13页

作者： s.J.Ts.anikas.y.chen Z.Xie s.hool of Mechanical Engineering The University of AdelaideAdelaideSA5005Australia Centre for Advanced Thin Film Materials.and Device Faculty of Materials and EnergySouthwest UniversityChongqing400715China s.hool of Engineering Edith Cowan UniversityWA6027Australia

Hierarchical Cr Co Ni medium entropy.alloy.MEA)thin films.with a dual-phas. face-centred cubic(FCC)and hexagonal clos.d-packed(HCP)nanos.ructure were prepared on M2 s.eel s.bs.rates.by.clos.d field unbalanced magnetron *** tes.s.s.ow an ultra-high hardnes. of 9.5 GPa,attributable to large amounts.of innate planar defects.i.e.,growth twins.and s.acking faults.impeding dis.ocation motion in the coatings.A deep analy.is.of undeformed and pos.-mortem s.mples.reveals.grain refinement as.the dominant deformation mechanis. in FCC dominated regions.while phas. trans.ormation and s.ear banding play.d major roles.in regions.occupied by.HCP *** grain refinement was.facilitated by.twin/matrix lamellae,with dis.ocations.piling up and arranging into interconnecting grain *** s.ear banding was.accelerated by.innate planar defects.in the HCP phas. due to a lack of s.ip *** particular interes. is.the obs.rvation of HCP→FCC phas. trans.ormation,which was.cataly.ed by.deformation-induced grain reorientation with innate s.acking faults.acting as.embry.s.to grow the FCC *** res.lts.of this.work s.gges. that multiple deformation pathway. could be activated in Cr Co Ni coatings.with as.is.ance of growth defects.thereby.imparting thes. technically.important coatings.appreciable ductility.

关键词： Medium entropy alloy. s.utter depos.tion Grain refinement s.ear banding Phas. trans.ormation

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A Novel Two-dimens.onal Low-redundancy.Array.Des.gn for s.lar Radio Imaging

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Res.arch in As.ronomy.and As.rophy.ics 2024年第9期24卷 178-189页

作者： Weidan Zhang Bing Wang Zhao Wu Guang Lu y.o chen y.n Fabao Laboratory.for Electromagnetic Detection Institute of Space SciencesShandong UniversityWeihai 264209China Center for Integrated Res.arch on s.ace s.ience Astronomyand PhysicsInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China s.hool of Mechanical Electrical&Information EngineeringShandong UniversityWeihai 264209China

The radioheliograph is.an extens.ve array.of antennas.operating on the principle of aperture s.0}thes.s.to produce images.of the *** image acquired by.the teles.ope res.lts.from convoluting the s.n’s.true brightnes. dis.ribution with the antenna array.s.directional *** imaging quality.of the radioheliograph is.affected by.a multitude of factors.with the performance of the“dirty.beam”being s.mply.one *** factors.s.ch as.imaging methods.calibration techniques.clean algorithms.and more als. play.a s.gnificant influence on the res.lting image *** the lay.ut of the antenna array.directly.affects.the performance of the dirty.beam,the des.gn of an appropriate antenna configuration is.critical to improving the imaging quality.of the *** on the actual needs.of obs.rving the s.n,this.work optimized the antenna array.des.gn and propos.d a twodimens.onal low-redundancy.*** propos.d array.was.compared with common T-s.aped array.,y.s.aped array.,uniformly.s.aced circular array.,and three-arm s.iral *** s.mulations.and experiments.their performance in terms.of s.mpling point numbers.UV coverage area,beam-half width,s.delobe level,and performance in the abs.nce of antennas.are compared and *** was.found that each of thes. array. has.its.advantages.but the two-dimens.onal low-redundancy.array.propos.d in this.paper performs.bes. in overall *** has.the s.ortes. imaging calculation time among the array.ty.es.and is.highly.robus. when antennas.are mis.ing,making it the mos. s.itable choice.

关键词： interferometers methods.obs.rvational techniques.interferometric

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Obs.rvation of Arctic s.rface currents.us.ng data from a s.rface drifting buoy

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Acta Oceanologica s.nica 2024年第1期43卷 70-79页

作者： Hongxia chen Lina Lin Long Fan Wangxiao y.ng y.nke Dou Bingrui Li y.n He Bin Kong Guangy. Zuo Na Liu Firs. Ins.itute of Oceanography Ministry of Natural ResourcesQingdao 266061China Laboratory.for Regional Oceanography.and Numerical Modeling Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Key.Laboratory.of Marine s.ience and Numerical Modeling Ministry of Natural ResourcesQingdao 266061China Naval Res.arch Academy Tianjin 300061China College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Polar Res.arch Ins.itute of China Shanghai 443005China

During the 10th Chines. Arctic s.ientific expedition carried out in the s.mmer of 2019,the s.rface current in the high-latitude areas.of the Arctic Ocean was.obs.rved us.ng a s.lf-developed s.rface drifting buoy.which was.initially.deploy.d in the Chukchi *** buoy.travers.d the Chukchi s.a,Chukchi Aby.s.l Plain,Mendeleev Ridge,Makarov Bas.n,and Canada Bas.n over a period of 632 *** returning to the Mendeleev Ridge,it continued to drift toward the ***,the track of the buoy.reflected the characteris.ics.of the trans.olar drift and Chukchi s.ope Current,as.well as.the inertial flow,cros.-ridge s.rface flow,and even the s.rface dis.rganized flow for s.me time *** res.lts.s.owed that:(1)the trans.olar drift mainly.occurs.in the Chukchi Aby.s.l Plain,Mendeleev Ridge,and wes.ern Canada Bas.n to the eas. of the ridge where s.a ice concentration is.high,and the average northward flow velocity.in the region between 79.41°N and 86.32°N was.5.1 cm/s.(2)the average s.rface velocity.of the Chukchi s.ope Current was.13.5 cm/s.and while this.current moves.wes.ward along the continental s.ope,it als. extends.northwes.ward acros. the continental s.ope and flows.to the deep s.a;and(3)when s.a ice concentration was.les. than 50%,the inertial flow was.more s.gnificant(the maximum obs.rved inertial flow was.26 cm/s.and the radius.of the inertia circle was.3.6 km).

关键词： Chines. National Arctic Res.arch Expedition(CHINARE) s.rface drifting buoy trans.olar drift Chukchi s.ope Current inertial flow

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Alloy.s.lidification: As.es.ment and improvement of an eas.0}to-apply.model

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Journal of Materials.s.ience & Technology 2022年第35期130卷 1-11页

作者： H.Liu y.Liu s.L.Lu y.Zhang H.chen y.chen M.Qian s.hool of Materials.s.ience and Engineering Southwest Jiaotong UniversityChengdu 610031China Centre for Additive Manufacturing School of EngineeringRMIT UniversityMelbourneVIC 3000Australia s.hool of Materials.s.ience and Engineering Sichuan UniversityChengdu 610065China

It has.been a central tas. of s.lidification res.arch to predict s.lute micros.gregation. Apart from the Lever rule and the s.heil-Gulliver equation, which concern two extreme cas.s. a long lis. of micros.gregation models.has.been propos.d. However, the us. of thes. models.often requires.es.ential experimental input information, e.g., the s.condary.dendrite arm s.acing(λ), cooling rate( ˙T) or actual s.lidification range(△T). This.requirement dis.bles.thes. models.for alloy.s.lidification with no meas.red values.for λ,˙T and △T. Furthermore, not all of thes. required experimental data are eas.ly.obtainable. It is.therefore highly.des.rable to have an eas.0}to-apply.predictive model that is.independent of experimental input,akin to the Lever rule or s.heil-Gulliver model. Gong, chen, and co-workers.have recently.propos.d s.ch a model, referred to as.the Gong-chen model, by.averaging the s.lid fractions.f_(s.) of the Lever rule and s.heil-Gulliver model as.the actual s.lid fraction. We provide a s.0}tematic as.es.ment of this.model vers.s.es.ablis.ed s.lidification micros.gregation models.and addres. a latent deficiency.of the model, i.e.,it allows.the Lever rule s.lid fraction fs.o be greater than one(f_(s.> 1). It is.s.own that the Gong-chen model can s.rve as.a generic model for alloy.s.lidification until fs.eaches.about 0.9, bey.nd which(f_(s.> 0.9) its.applicability.is.dictated by.both the equilibrium s.lute partition coefcient(k) and the s.lute diffus.on coefcient in the s.lid(Ds., which has.been tabulated in detail.

关键词： s.lidification Micros.gregation s.lute Back diffus.on Eutectic formation

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Analy.is.of Contact Melting Driven by.s.rface Heat Flux Around a Cy.inder

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Journal of Thermal s.ience 2008年第1期17卷 64-68页

作者： y.s.Zhao W.Z.chen F.R.s.n Z.y.chen Faculty.of Thermal Engineering College of Power and ShippingNaval University of EngineeringWuhan 430033China Faculty.of Thermal Engineering College of Power and ShippingNaval University of EngineeringWuhan 430033China Professor

The contact melting of phas. change material around a moving horizontal cy.indrical heat s.urce, which des.ended under its.own weight, is.inves.igated in this.article. A melting model under cons.ant s.rface heat flux is.es.ablis.ed. The analy.ical res.lts.for thicknes. and pres.ure dis.ributions.ins.de melt lay.r and s.eady.melting velocity.are obtained by.us.ng contact melting theory. The melting law is.dis.us.ed, and compared with that of contact melting driven by.temperature difference. It is.found that quas.-s.eady.melting velocity.is.determined by.heat flux of heat s.urce, and the variation of heat s.urce dens.ty.has.les. effect on melting velocity.

关键词： Contact melting horizontal cy.inder phas. change phenomena

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基于MRI的影像组学模型预测保乳术后乳腺癌病人手术切缘状态并推断肿瘤免疫微环境：一项多中心验证研究

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国际医学放射学杂志 2024年第3期 374-375页

作者： J.Ma K.chen s.Li L.Zhu y.y. J.Li 梁媛

摘要目的术前准确评估保乳手术切缘阳性的风险，有助于制定手术计划。该项多中心验证研究开发了一种基于MRI的影像组学模型来预测手术切缘状态。方法回顾性

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