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Endoscopic Staging and Treatment of Early Gastric Cancer

Journal of Cancer Therapy 2013年第1期4卷 92-98页

作者： angel Ferrández Sonia Mostacero angel Lanas Fundación Hospital de Calahorra La Rioja Spain Service of Digestive Diseases Hospital Clínico Lozano Blesa Zaragoza Spain&The Centro de Investigación Biomédica en Red Barcelona Spain Service of Digestive Diseases Hospital Clínico Lozano Blesa Zaragoza Spain&The Centro de Investigación Biomédica en Red Barcelona Spain&Universidad de Zaragoza Zaragoza Spain.

Gastric cancer is the most common cancer worldwide and it is often diagnosed in an advanced stage. In countries where screening endoscopy is performed widely, early detection is possible. In fact, early gastric cancer incidence is increasing during the last years worldwide and screening could be a major factor in such increase. In the past, the standard treatment of gastric cancer was surgical resection;however, the endoscopic treatment has increased due to advances in the instruments available and clinician experience. In fact, endoscopic resection has become one of the greatest advances in EGC treatment. It is the standard treatment in most of the cases because early gastric cancer is associated with a low rate of lymph node metastasis and a high survival rate. Endoscopic Mucosal Resection and more recently Endoscopic Submucosal Dissection are the two main developed procedures. Endoscopic Submucosal Dissection achieves a higher rate of en-bloc resection, complete resection, curative resection and lower local recurrence compared with Endoscopic Mucosal Resection group. The disadvantages associated with Endoscopic Submucosal Dissection, such as higher perforation rates and longer procedure time, will probably improve as the endoscopists experience increases and new endoscopic tools are developed. The aim of this paper is to review the management of EGC with a special focus on endoscopic detection, staging, therapy, surveillance, and prevention.

关键词： Early Gastric Cancer Endoscopic Mucosa Resection Endoscopic Submucosal Dissection Endoscopic

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The Geomagnetic Field

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Journal of High Energy Physics, Gravitation and Cosmology 2016年第1期2卷 33-40页

作者： angel Fierros Palacios Instituto de Investigaciones Eléctricas División de Energías Alternas Mexico City México

In this paper a solution to the problem of the self-generated magnetic field of the Earth is pro-posed. The solution is based on the existence of a steady-state current distribution localized in some region inside the convective zone of the planet, constituted by the fluid Outer Core. The magnitude of the self-generated magnetic field is obtained and it is shown to be a dipolar field.

关键词： The Geomagnetic Field

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Vascular endothelial growth factor：an essential neurotrophic factor for motoneurons？

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Neural Regeneration Research 2018年第7期13卷 1181-1182页

作者： Paula M.Calvo angel M.Pastor Rosa R.de la Cruz Departamento de Fisiologia Facultad de Biologia Universidad de Sevilla Sevilla Spain

Vascular endothelial growth factor（VEGF）,an angiogenic factor with neuroprotective effects：The VEGF was initially characterized by its vasculogenic and angiogenic activities and its capacity to promote vascular permeability（Yancopoulos et al.,2000）.VEGF is also known as VEGF-A and is the prototype member of a related group of five trophic factors,VEGF-B,VEGF-C,VEGF-D and placental growth factor（Pl GF;Lange et al.,2016）.

关键词： VEGFR Vascular endothelial growth factor:an essential neurotrophic factor for motoneurons

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The Last Pterosaurs: First Record from the Uppermost Maastrichtian of the Tremp Syncline (Northern Spain)

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1198-1227页

作者： DALLA VECCHIA Fabio M. RIERA Violeta OMS Josep Oriol DINARS-TURELL Jaume GAETE Rodrigo GALOBART angel Institut Català de Paleontologia "M. Crusafont" (ICP) Grup de Recerca del Mesozoic Escola Industrial 23E-08201 SabadellSpain Universitat Autònoma de Barcelona Departament de GeologiaCerdanyola del VallèsBarcelonaE-08193Spain Istituto Nazionale di Geofisica e Vulcanologia Laboratorio di PaleomagnetismoVia di Vigna Murata 605I-00143 RomaItaly Museu de la Conca Dellà C/del Museu 4E-25650 IsonaSpain

Pterosaur bones are for the first time reported from the Tremp Syncline （Spain） and the southern Pyrenees. They come from the Torrebilles-2 site （Isona, Lleida Province） in the upper Maastrichtian part of the Tremp Formation, which falls within the C29r magnetochron. Fragmentary long bones are referred to the Pterosauria based on their cortical thinness, micro-architecture, and histological features. They belong to very large to possibly giant individuals. The most complete specimen is possibly a partial right femur. The review of the Maastrichtian pterosaur record shows that only a few specimens can be referred to the C29r （which contains the K/Pg boundary）. The identification of fragmentary remains could improve our knowledge about the abundance and distribution of these flying sauropsids just before the end-Cretaceous mass extinction.

关键词： Pterosauria bone morphology histology latest Maastrichtian European Archipelago,Ibero-Armorican Island Tremp Syncline.

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Toughening of Immiscible rPS/SAN Blends by SEBS Elastomers: Properties and Morphology

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Journal of Materials Science and Chemical Engineering 2022年第3期10卷 42-62页

作者： Khaled Bedjaoui Rodrigo Navarro Rachida Krache Juan Lopez Valentin Rebeca Herrero Calderon Alberto Fernandez Torres angel Marcos Fernandez Laboratory Multiphas Polymeric Materials (LMPMP) Faculty of Technology University Ferhat Abbas Setif-1 Setif Algerie Instituto de Ciencia y Tecnologia de Polimeros (CSIC) Department of Fisica de Polimeros Elastomeros y Aplicaciones Energeticas Madrid Spain

In this research, an attempt was made to improve compatibility in a polymer blend composed of incompatible constituents, namely, recycled polystyrene (rPS) and polystyrene-co-acrylonitrile (SAN), through the addition of a compatibilizer. The compatibilizing agent, styrene-ethylenebutadiene-styrene block copolymer (SEBS), was added to the polymer blend in ratios of 5 and 10 wt%. For this purpose, blends of rPS and SAN at different ratios, without and with varying concentrations of compatibilizer, were prepared by melt blending using a co-rotating twin-screwextruder. Mechanical properties including tensile and impact strength, rheological properties (RPA), thermal behaviour (DSC) and morphological characteristics (SEM) were evaluated. According to the results obtained by complex viscosity, the blends behave as a pseudoplastic fluid. The results showed that the addition of SEBS increased the Izod impact strength and the elongation at break and decreased the tensile strength and tensile modulus. rPS/SAN blend modified with SEBS had better mechanical properties than the rPS/SAN alloy. SEM photographs revealed that the SEBS was not only distributed in the SAN phase but also distributed in rPS phase in rPS/SAN/SEBS blend. Furthermore, DSC analysis for blends of rPS/SAN gave a good indication of the improvement on miscibility for most compositions. SEM micrographs of tensile fracture surfaces indicated that the formation of the co-continuous phase and the improvement of interface adhesion are the most important reasons for the excellent tensile properties of the rPS/SAN/SEBS blends. Within the range of analysed compositions, the morphologies investigated by SEM are typical of immiscible blends.

关键词： Recycled Polystyrene SAN Toughening Polymer Blends Rheology

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Common microscopic origin of the phase transitions in Ta_(2)NiS_(5) and the excitonic insulator candidate Ta_(2)NiSe_(5)

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npj Computational Materials 2021年第1期7卷 1919-1932页

作者： Lukas Windgätter Malte Rösner Giacomo Mazza Hannes Hübener Antoine Georges Andrew J.Millis Simone Latini angel Rubio Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGemany Radboud University Institute for Molecules and MaterialsHeijendaalseweg 1356525 AJ NijmegenNetherlands Department of Quantum Matter Physics University of GenevaQuai Ernest-Ansermet 241211 GenevaSwitzerland College de France 11 place Marcelin Berthelot75005 ParisFrance Center for Computational Quantum Physics Flatiron InstituteNew YorkNY 10010USA.CPHTCNRSEcole PolytechniqueIP Paris91128 PalaiseauFrance Department of Physics Columbia UniversityNew YorkNY 10027USA.Nano-Bio Spectroscopy Group Departamento de Fisica de Materiales Universidad del Pais Vasco20018 San SebastianSpain

The structural phase transition in Ta-NiSes has been envisioned as driven by the formation of an excitonic insulating ***,the role of structural and electronic instabilities on crystal symmetry breaking has yet to be ***,the phase transition in its complementary material Ta_(2)NiS_(5)does not show any experimental hints of an excitonic insulating *** present a microscopic investigation of the electronic and phononic effects involved in the structural phase transition in Ta_(2)NiSe_(5)and Ta-Niss using extensive first-principles *** both materials the crystal symmetries are broken by phonon instabilities,which in tum lead to changes in the electronic bandstructure also observed in the experiment.A total energy landscape analysis shows no tendency towards a purely electronic instability and we find that a sizeable lattice distortion is needed to open a *** conclude that an excitonic instability is not needed to explain the phase transition in both Ta_(2)NiSe_(5)and Ta_(2)NiS_(5).

关键词： phase structural transitions

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Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin

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Journal of Environmental Sciences 2013年第7期25卷 1408-1418页

作者： Gabriela V. Aguirre-Martínez Sara Buratti Elena Fabbri angel T. DelValls M. Laura Martín-Díaz Unitwin/Unesco/WiCoP Physical Chemistry Department University of Cdiz Faculty of Marine and Environmental SciencesPolígono Río San Pedro s/n 11510 Puerto Real Cdiz Spain Andalusian Center for Marine Science and Technology (CACYTMAR) Campus Universitariode Puerto Real11510 Puerto Real Cdiz Spain University of Bologna Interdepartment Centre for Research in Environmental Sciences (CIRSA)via S. Alberto 16348123 Ravenna Italy

Although pharmaceuticals have beendetected in the environment only in the range from ng/L to μg/L, it has beendemonstrated that they can adversely affect the health status of aquatic organisms. Lysosomal membrane stability （LMS） has previously been applied as an indicator of cellularwell-being todetermine health status in bivalve mussels. The objective of this study is to evaluate LMS in Ruditapes philippinarum haemolymph using the neutral red retention assay （NRRA）. Clamswere exposed in laboratory conditions to caffeine （0.1, 5, 15, 50 μg/L）, ibuprofen （0.1, 5, 10, 50 μg/L）, carbamazepine and novobiocin （both at 0.1, 1, 10, 50 μg/L） for35days. Results show adose-dependent effect of the pharmaceuticals. The neutral red retention time measured at the end of the bioassaywas significantly reduced by 50% after exposure to environmental concentrations （p 〈 0.05）（caffeine = 15 μg/L; ibuprofen = 10 μg/L; carbamazepine = 1 μg/L and novobiocin = 1 μg/L）, compared to controls. Clams exposed to these pharmaceuticalswere considered to present adiminished health status （retention time 〈45 min）, significantlyworse than controls （96 min）（p 〈 0.05）. The predicted no environmental effect concentration （PNEC） results showed that these pharmaceuticals are very toxic at the environmental concentrations tested. Measurement of the alteration of LMS has been found to be a sensitive technique that enables evaluation of the health status of clams after exposure to pharmaceuticals under laboratory conditions, thus representing a robust Tier-1 screening biomarker.

关键词： neutral red pharmaceuticals bioassay haemolymph bivalves health status Manila clam

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What Determined Your Social Hierarchy in High School in America and China?Effects of Different Ability in High School Society

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留学 2018年第21期 88-89页

作者： angel Zhang 美国Summit Country Day School 11年级

写这篇论文的原因跟我自身的经历有关.在美高,成绩在学校社交圈中可能没有那么重要,但这并不意味着成绩不重要.相对地,跟社交能力相关的因素反而占比大一些.在国内,性格和社交能力固然重要,但学习能力占比要更大一些.在现在,来自学校社... 详细信息

写这篇论文的原因跟我自身的经历有关.在美高,成绩在学校社交圈中可能没有那么重要,但这并不意味着成绩不重要.相对地,跟社交能力相关的因素反而占比大一些.在国内,性格和社交能力固然重要,但学习能力占比要更大一些.在现在,来自学校社交圈的压力已经成了伴随着学生的长久压力之一,而且处理不当可能会带来较严重的结果.写这篇论文是想分析影响ranking of social intercourse的因素,并给大家们一些可参考的信息,社交其实并没有那么可怕.

关键词：学术论文作品展示记者社交能力社交圈学习能力学校成绩

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Managing extremely distal periprosthetic femoral supracondylar fractures of total knee replacements-a new PHILOS-ophy

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World Journal of Orthopedics 2017年第10期8卷 809-813页

作者： Kevin J Donnelly Adam Tucker angel Ruiz Neville W Thompson Department of Trauma and Orthopaedic Surgery Altnagelvin Hospital

We report two cases where a proximal humeral locking plate was used for the fixation of an extremely distal, type Ⅲ peri-prosthetic femoral fractures in relation to a total knee replacement(TKR). In each case there was concern regarding the fixation that could be achieved using the available anatomic distal femoral plates due to the size and bone quality of distal fragment. The design of the Proximal Humeral Internal Locking System(PHILOS) allows nine 3.5-mm locking screws to be placed over a small area in multiple directions. This allowed a greater number of fixation points to be achieved in the distal fragment. Clinical and radiological short-term follow-up(6-12 mo) has been satisfactory in both cases with no complications. We suggest the use of this implant for extremely distal femoral fractures arising in relation to the femoral component of a TKR.

关键词： Distal Femoral Periprosthetic Fracture PHILOS Open reduction and internal fixation

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Senning operation for correction of the transposition of the great arteries, results, long-term outcome and quality of life

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World Journal of Cardiovascular Diseases 2012年第3期2卷 213-219页

作者： Miguel angel Maluf Disciplina de Cirurgia Cardiovascular Universidade Federal de Sao PauloSao PauloBrazil

Objective: Long-term results after the Senning operation for transposition of the great arteries are little known. Sinus node dysfunction and systemic ventricular dysfunction are crucial in patient survival. We evaluated the results, long term outcome and quality of life in a group of 39 patients. Methods: The study was a retrospective analysis, of 39 (39/40 = 97.5%) surgical surviving patients, submitted to Senning operation, with a mean follow-up time of 14.7 +/– 3.1 years. Electrocardiogram, echocardiogram, and chest radiograph series were performed every 6 months. Thirty six patients of this series underwent Holter study and ergometric test, to evaluate the physical capacity. Three patients living overseas were excluded. Results: There was only one late death (1/39) (late mortality = 2.5%): a 16 year-old patient had a no cardiac death. The actuarial survival was 95.0% (38/40) (simple or with little VSD, TGA). The probability of staying in sinus rhythm, in 39 surviving patients was 77.1% (30) or normal right ventricular function was 76.5% (29), 10 to 20 years after operation. The incidence of sinus node and right ventricular dysfunction increased gradually over time. No re-operations and pacemaker implantation, was performed. Functional class: I = 30 (85.7%) cases and functional class II = 5 (14.3%) cases. Conclusions: Patients with simple TGA submitted to Senning procedure in our experience, presented during late follow-up: 1—Low incidence of right ventricular dysfunction and active arrhythmias;2—Low mortality and no sudden death recorded;3—Good quality of life and 4—Satisfactory surgical results (free of re-operation or definitive pacemaker implantation).

关键词： Congenital Heart Disease Surgery Treatment Outcome

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