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Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice

Neural Regeneration Research 2024年第1期19卷 220-225页

作者： Yin Yang Zhaoxi Yang Maoxia Lv ang jia Junjun Li Baitao Liao Jing’an Chen Zhengzheng Wu Yi Shi Yang Xia Dezhong Yao Ke Chen Department of Ophthalmology Sichuan Provincial People’s HospitalMedical SchoolUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroInformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit of NeuroInformation Chinese Academy of Medical SciencesChengduSichuan ProvinceChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Health Management Center Sichuan Provincial Key Laboratory for Human Disease Gene StudySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan ProvinceChina School of Electrical Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the ***,it is not yet clear how the primary visual cortex(V1)is altered in *** study used DBA/2J mice as a model for spontaneous secondary *** aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J *** conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band *** morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue ***-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were *** with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial *** r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J *** findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual *** findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse *** study might offer some innovative perspectives regarding the treatment of glaucoma.

关键词： DBA/2J degeneration gamma band oscillations glaucoma primary visual cortex(V1) retina single-unit recording tuning curve

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铸牢中华民族共同体意识视域下社会主义核心价值观入法入规探究

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西安交通大学学报（社会科学版） 2024年第5期44卷 136-144页

作者：陈蒙雷家昂中南民族大学四部委铸牢中华民族共同体意识研究基地湖北武汉430074 中南民族大学法学院湖北武汉430074 中南民族大学中华民族共同体学院湖北武汉430074

社会主义核心价值观是中华民族精神的时代凝练和现实表达,是社会主义法治建设的灵魂,与中华民族共同体意识紧密关联。铸牢中华民族共同体意识视域下,社会主义核心价值观入法入规彰显了传承中华优秀传统法律文化的文化自觉,是推进中华民... 详细信息

社会主义核心价值观是中华民族精神的时代凝练和现实表达,是社会主义法治建设的灵魂,与中华民族共同体意识紧密关联。铸牢中华民族共同体意识视域下,社会主义核心价值观入法入规彰显了传承中华优秀传统法律文化的文化自觉,是推进中华民族共同体建设的必然选择,为建设中华民族共有精神家园提供方向指引;通过树牢法律信仰、型构法律原则和融入法律规则,弘扬国家与民族的整体价值导向、概括指引全社会的价值认同,并具体设定微观的行为模式和制度指示,实现对铸牢中华民族共同体意识之法治实施的指引和推进。新时代新征程,要关注宪法核心价值观条款完善、民族工作基本法律的核心价值观融入等问题,在规律、技术与价值相互交融的视域下促进核心价值观入法入规的路径优化。着力增强核心价值观入法入规的系统性、针对性和精准性,推进入法理念的升华和入法技术的完善,在对各族人民现实生活场景的科学指引与能动改造中推动全社会铸牢中华民族共同体意识。

关键词：社会主义核心价值观价值认同入法入规中华民族共同体德法共治

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《爱国主义教育法》的时代方位、精神内核和实践进路

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中南民族大学学报（人文社会科学版） 2024年第7期44卷 60-68,183页

作者：潘红祥雷家昂中南民族大学四部委铸牢中华民族共同体意识研究基地湖北武汉430074 中南民族大学中华民族共同体学院湖北武汉430074

《爱国主义教育法》分别以强化中华文化认同增进公民的中华民族认同和国家认同,践行社会主义核心价值观推动全社会铸牢中华民族共同体意识,弘扬爱国主义精神以实现中华民族伟大复兴的国家目标为其精神内核,是应对世界百年未有之大变局... 详细信息

《爱国主义教育法》分别以强化中华文化认同增进公民的中华民族认同和国家认同,践行社会主义核心价值观推动全社会铸牢中华民族共同体意识,弘扬爱国主义精神以实现中华民族伟大复兴的国家目标为其精神内核,是应对世界百年未有之大变局的中国方案和实现中华民族伟大复兴的法治保障。推进《爱国主义教育法》的有效实施,应遵循观念、行动和结构的逻辑进路,强化法治宣传,协调多方参与,健全保障体制机制。

关键词：爱国主义中华民族共同体意识国家认同《爱国主义教育法》

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Dot-shaped beamforming analysis of subarray-based sin-FDA

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Frontiers of Information Technology & Electronic Engineering 2019年第10期20卷 1429-1444页

作者： Bo Wang Jun-wei XIE Jing ZHang jia-ang GE Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China Shaanxi Vocational and Technical College of Transport Xi'an 710018China

Phased array (PA) radar is one of the most popular types of radar. In contrast to PA, the frequency diverse array (FDA) is a potential solution to suppress range-related interference because of its time-range-angle-dependent beampattern. However, the range-angle coupling inherent in the FDA transmit beampattern may degrade the output signal-to-interference-plus-noise ratio (SINR). We propose a dot-shaped beamforming method based on the analyzed four subarray-based FDAs and subarray-based planar FDAs using a sinusoidally increasing frequency offset with elements transmitting at multiple frequencies. The numerical results show that the proposed approach outperforms the existing log-FDA with logarithmical frequency offset in transmit energy focus, sidelobe suppression, and array resolution. Comparative simulation results validate the effectiveness of the proposed method.

关键词： Frequency diverse array Subarray-based frequency diverse array Decoupling Dot-shaped beamforming

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皮肌炎合并肺间质病变的代谢组学研究进展

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医学综述 2024年第8期30卷 924-928页

作者：陈秀奎邹晋梅董建玲罗家昂绵阳市中心医院风湿免疫科四川绵阳621000 成都医学院临床医学系成都610500

皮肌炎(DM)是一种特发性炎症性肌病,主要影响皮肤和肌肉,可累及多器官、系统,以肺部受累最为常见,其中以肺间质病变(ILD)最为多见。目前,DM合并ILD(DM-ILD)的发病机制尚未明确,其早期诊治存在困难。代谢组学是一种新的系统生物学方法,... 详细信息

皮肌炎(DM)是一种特发性炎症性肌病,主要影响皮肤和肌肉,可累及多器官、系统,以肺部受累最为常见,其中以肺间质病变(ILD)最为多见。目前,DM合并ILD(DM-ILD)的发病机制尚未明确,其早期诊治存在困难。代谢组学是一种新的系统生物学方法,它可以全面评估代谢物及其在疾病中的生物学意义。近年代谢组学在临床疾病研究中广泛应用,为疾病研究提供了新的途径。未来深入研究DM-ILD代谢组学将为探索DM-ILD发病机制、潜在诊断生物标志物、治疗方案提供新的方向。

关键词：皮肌炎肺间质病变代谢组学

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Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1246-1260页

作者： Zhaoming Lu Yandan Ren Li Yang ang jia Yi Hu Yu Zhao Wuduo Zhao Bin Yu Wen Zhao jianying Zhang Guiqin Hou State Key Laboratory of Esophageal Cancer Prevention&Treatment School of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China Collaborative Innovation Center of Cancer Chemoprevention Zhengzhou 450001China Center of Advanced Analysis&Gene Sequencing Zhengzhou UniversityZhengzhou 450001China Henan Academy of Medical and Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China

Sulforaphane(SFN), a natural anti-tumor compound from cruciferous vegetables, has been reported to induce protective autophagy to cancer cells, which might impair the anti-tumor efficiency of SFN. However, the accurate function and mechanism of SFN inducing autophagy in cancers are still obscure, especially in esophageal squamous cell carcinoma(ESCC), one of malignancies with high incidence in North China. Here, we mainly explored the potential function of autophagy upon SFN treatment in ESCC and molecular mechanism. We demonstrated that SFN could inhibit cell proliferation and induce apoptosis by activating caspase pathway. Moreover, we found activation of NRF2 pathway by SFN was responsible for the induction of autophagy and also a disadvantage element to the anti-tumor effects of SFN on ESCC, indicating that SFN might induce protective autophagy in ESCC. We, therefore,investigated effects of autophagy inhibition on sensitivity of ESCC cells to SFN and found that chloroquine(CQ) could neutralize the activation of SFN on NRF2 and enhance the activation of SFN on caspase pathway, thus improved the anti-tumor efficiency of SFN on ESCC in vitro and in vivo. Our study provides a preclinical rationale for development of SFN and its analogs to the future treatment of ESCC.

关键词： Sulforaphane Autophagy Chloroquine NRF2 Esophageal squamous cell carcinoma

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Research on Green and Low-Carbon Development Path of China's Automotive Industry

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Chinese Journal of Urban and Environmental Studies 2023年第1期11卷 66-82页

作者： ZHAO Dongchang ZHAO Mingnan SUN Xin ZHang Hongjie LIU Huanran WU Jinlong LEI Zhenlu LI jia’ang QIAN Bing LU Linfeng LIN Yu CHang Wei China Automotive Carbon Digital Technology Center Co. Ltd.

China’s automotive industry has been dedicated to a series of carbon-reduction efforts and has strived for comprehensive green and low-carbon transformation in order to achieve carbon peaking and carbon neutrality goals. On the basis of automobiles’ whole life-cycle(WLC) carbon emission accounting, this paper calculates life-cycle carbon emissions per vehicle, proposes green and low-carbon development path for China’s automotive industry, quantifies and analyzes implicated carbon-reduction potential, and puts forth suggestions for high-quality green and lowcarbon development of China’s automotive industry. The first is to establish a sound standard and data management system; the second is to promote research, development and application of lowcarbon materials and low-carbon technologies; the third is to accelerate the pace of fostering a new consumption model in the automotive industry. The research results can further support national policy-making regarding carbon emissions, promote corporations’ research, development and application of low-carbon technologies, encourage green and low-carbon consumption, and lead the automotive industry to achieve WLC neutrality.

关键词： Automobile life-cycle carbon emission low-carbon transformation

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Structural regulation of coal-derived hard carbon anode for sodium-ion batteries via pre-oxidation

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Rare Metals 2024年第6期43卷 2585-2596页

作者： Meng-Yuan Su Kai-Yang Zhang Edison Huixiang ang Xue-Li Zhang Yan-Ning Liu jia-Lin Yang Zhen-Yi Gu Faaz A.Butt Xing-Long Wu Faculty of Chemistry Northeast Normal UniversityChangchun 130024China MOE Key Laboratory for UV Light-Emiting Materials and Technology.Northeast Normal University.Ministry of Education Changchun 130024China Natural Sciences and Science Education National Institute of EducationNanyang Technological UniversitySingapore 637616Singapore Materials Engineering Department NED University of Engineering and TechnologyKarachi 75300Pakistan

Hard carbon(HC)is broadly recognized as an exceptionally prospective candidate for the anodes of sodium-ion batteries(SIBs),but their practical implementation faces substantial limitations linked to precursor factors,such as reduced carbon yield and increased ***,a cost-effective approach is proposed to prepare a coal-derived HC anode with simple pre-oxidation followed by a post-carbonization process which effectively expands the d_(002)layer spacing,generates closed pores and increases defect *** these modifications,the resulting HC anode attains a delicate equilibrium between plateau capacity and sloping capacity,showcasing a remarkable reversible capacity of 306.3 mAh·g^(-1)at 0.03 A·g^(-1).Furthermore,the produ ced HC exhibits fast reaction kinetics and exceptional rate performance,achieving a capacity of 289 mAh·g^(-1)at 0.1 A·g^(-1),equivalent to~94.5%of that at 0.03 A·g^(-1).When implemented in a full cell configuration,the impressive electrochemical performance is evident,with a notable energy density of 410.6 Wh·kg^(-1)(based on cathode mass).In short,we provide a straightforward yet efficient method for regulating coal-derived HC,which is crucial for the widespread use of SIBs anodes.

关键词： Sodium-ion batteries Hard carbon Anode Coal Pre-oxidation

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Extending Structures for Gel'fand-Dorfman Bialgebras

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Acta Mathematica Sinica,English Series 2024年第2期40卷 619-638页

作者： jia jia WEN Yan Yong HONG School of Mathematics Hangzhou Normal UniversityHangzhou 311121P.R.China

Gel'fand-Dorfman bialgebra,which is both a Lie algebra and a Novikov algebra with some compatibility condition,appeared in the study of Hamiltonian pairs in completely integrable *** also emerged in the description of a class special Lie conformal algebras called quadratic Lie conformal *** this paper,we investigate the extending structures problem for Gel'fand-Dorfman bialgebras,which is equivalent to some extending structures problem of quadratic Lie conformal ***,given a Gel'fand-Dorfman bialgebra(A,o,[.,.]),this problem is how to describe and classify all Gel'fand-Dorfman bialgebra structures on a vector space E(A⊂E)such that(A,o,[.,.])is a subalgebra of E up to an isomorphism whose restriction on A is the identity *** by the theories of extending structures for Lie algebras and Novikov algebras,we construct an object gH2(V,A)to answer the extending structures problem by introducing the notion of a unified product for Gel'fand-Dorfman bialgebras,where V is a complement of A in *** particular,we investigate the special case when dim(V)=1 in detail.

关键词： Gel'fand-Dorfman bialgebra Lie conformal algebra Extending structures problem Novikovalgebra

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Facile synthesis of transition metal complexes with five coplanar metal-carbon σ-bonds

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National Science Review 2024年第4期11卷 11-12页

作者： Guocheng jia Department of Chemistry Hong Kong University of Science and Technology

Carbon is one of the most important elements in chemistry, forming a vast number of organic compounds. It can also form a variety of organometallic compounds with a metal–carbon bond. Metal alkyl, carbene and carbyne complexes are classical examples of organometallic compounds. A particularly interesting class of organometallic compounds are all-carbon metallacycles formed by combination of a metal and a hydrocarbon chain serving as a chelating agent with only carbon atoms as the donor atoms. Many interesting monocyclic metallacycles made of a chelating bidentate hydrocarbon chain are known, for example, metallacyclobutadienes, metallacyclopentadienes and metallabenzenes[1].

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