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航空变频交流真空灭弧室的设计研究

真空电子技术 2024年第2期 90-101页

作者：夏尚文武建文佟子昂茶岩吴生修梅有柱王小军北京航空航天大学自动化科学与电气工程学院北京100191 贵州天义电器有限责任公司贵州遵义563002 昆山国力电子科技股份有限公司江苏昆山215334 陕西斯瑞新材料股份有限公司陕西西安710077

随着航空电气负载的增长,传统恒压恒频电源已难以满足需求,变频电源正成为现代飞机电气系统的发展方向。变频条件下真空灭弧技术面临三方面的挑战:一是开断难度的增加,二是通流能力下降,三是小体积、轻量化的设计限制。通过两个关键技术... 详细信息

随着航空电气负载的增长,传统恒压恒频电源已难以满足需求,变频电源正成为现代飞机电气系统的发展方向。变频条件下真空灭弧技术面临三方面的挑战:一是开断难度的增加,二是通流能力下降,三是小体积、轻量化的设计限制。通过两个关键技术:小体积下的开断能力提升技术,轻量化结构下的通流能力设计方法,提出适应航空变频条件的变频灭弧室设计方案。分析变频条件下影响电流开断能力的触头因素,设计灭弧室小体积触头结构。提出一体式外置主屏蔽罩结构方案,为增加触头直径提升开断能力提供保障。提出趋肤效应下的导体结构轻量化方法,采用外置屏蔽罩增加散热能力,研制出了航空变频交流真空灭弧室。基于设计的三相接触器样机搭建了符合航空变频条件的实验环境,对灭弧室的开断能力、绝缘性能与温升情况进行了实验研究。结果表明:设计的灭弧室能够在360~800 Hz频率范围内有效开断过载电流1.68 kA,样机成功开断50次三相过载电流1.1 kA。开断前后三相主回路接触压降稳定,最高仅为83.49 mV,所有接触压降均低于设计值100 mV。整机重量仅为975 g,满足设计要求的同时具备更高开断能力。研究为航空变频电源系统的发展提供了实验数据支持,对推进航空电器领域真空开断技术应用具有重要意义。

关键词：航空变频电源真空灭弧室航空交流接触器中频开断特性

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai o.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyag.ov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.g.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.g.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang g.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.g.o Y.N.g.o P.S.ge C.Q.geng L.S.geng A.gilman L.gong T.gong B.gou W.gradl J.L.gu A.guevara L.C.gui A.Q.g.o F.K.g.o J.C.g.o J.g.o Y.P.g.o Z.H.g.o A.guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.g.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua g.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li g.Li g.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang g.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu g.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.g.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.olsen Q.ouyang P.Pakhlov g.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of g.osciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China goethe University Frankfurt D-60325 Frankfurt am MainGermany guangxi Normal University Guilin 541004China guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 geV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm reg.on high luminosity STCF detector conceptual design

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X射线冷核星系团研究进展

天文学进展 2014年第1期32卷 71-94页

作者：刘昂余恒北京师范大学天文系北京市100875

冷核是指在一部分X射线星系团中出现的低温高亮的核状结构。冷核星系团在X射线表面亮度轮廓、温度轮廓、中心冷却时间、质量沉积率、熵轮廓等多个方面具有与非冷核星系团截然不同的观测特征。星系团冷核的发现距今已有40年,人们对冷核... 详细信息

冷核是指在一部分X射线星系团中出现的低温高亮的核状结构。冷核星系团在X射线表面亮度轮廓、温度轮廓、中心冷却时间、质量沉积率、熵轮廓等多个方面具有与非冷核星系团截然不同的观测特征。星系团冷核的发现距今已有40年,人们对冷核的认识经历了由冷流模型到稳定冷核模型的转变。但是直到今天,冷核的产生机制和维持条件仍未完全弄清。研究冷核对于理解活动星系核产能机制、星系际元素增丰过程、星系团的形成与演化、大尺度结构形成等众多领域具有非常重要的意义。

关键词：星系团星系团内物质 X射线冷流冷核

SA inhibits complex Ⅲ activity to generate reactive oxygen species and thereby induces gA overproduction in ganoderma lucidum

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SA inhibits complex Ⅲ activity to generate reactive oxygen ...

TLR4 signaling promotes a CoX-2/PgE2/STAT3 positive feedback loop in hepatocellular carcinoma(HCC) cells

中国菌物学会2018年学术年会

作者： Rui Liu ang Ren Liang Shi Jing Zhu Mingwen Zhao Key Laboratory of Agricultural Environmental Microbiology Ministry of AgricultureMicrobiology DepartmentCollege of Life SciencesNanjing Agricultural University

ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids（gAs）. Salicylic acid（SA） was previously reported to induce the biosynthesis of gA in g. lucidum. In this study, we found that SA induces gA biosynthesis by increasing RoS production, and further research found that NADPH oxidase-silenced strains exhibited a partial reduction in the response to SA, resulting in the induction of increased RoS production. Furthermore, the localization of RoS shows that mitochondria are sources of RoS production in response to SA treatment. An additional analysis focused on the relationship between SA-induced RoS production and mitochondrial functions, and the results showed that inhibitors of mitochondrial complexes I and II exert approximately 40–50% superimposed inhibitory effects on the respiration rate and H2o2 content when co-administered with SA. However, no obvious superimposed inhibition effects were observed in the sample co-treated with mitochondrial complex III inhibitor and SA, implying that the inhibitor of mitochondrial complex III and SA might act on the same site in mitochondria. Additional experiments revealed that complex III activity was decreased 51%, 62% and 75% after treatment with 100, 200, and 400?μM SA, respectively. our results highlight the finding that SA inhibits mitochondrial complex III activity to increase RoS generation. In addition, inhibition of mitochondrial complex III caused RoS accumulation, which plays an essential role in SA-mediated gA biosynthesis in g. lucidum. This conclusion was also demonstrated in complex III-silenced strains. To the best of our knowledge, this study provides the first demonstration that SA inhibits complex III activity to increase the RoS levels and thereby regulate secondary metabolite biosynthesis.

关键词： Salicylic acid Reactive oxygen species Mitochondrial complex Ⅲ ganoderic acids

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TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback...

Nitric oxide involved in regulating HS induced gA biosynthesis via inhibition of aconitase in ganoderma lucidum

第十届全国免疫学学术大会

作者： Jian Zhang ang Lin guan Wang Zhao Huajun Han Qiuju Institute of Immunopharmaceutical Sciences School of Pharmaceutical Sciences Shandong University

Backg.ound Hepatocellular carcinoma(HCC) is the fifth most common cancer worldwide and ranks second among all the primary cancer-related mortalities. The high recurrence and poor prog.osis of HCC accentuate the need to clarify the pathogenesis and develop new therapeutic approaches. Toll-like receptors(TLRs), expressed by a great variety of immune cells, have also been found in many tumor tissues and cell lines. Evidences showed that intestinal microecological disorder would affect HCC progression, during which TLR4 signaling pathway might play an important role. AIM To investigate the underlying mechanism of TLR4 signaling pathway in HCC development. Methods Human hepatoma cell lines Hep g2 and H7402 as well as TLR4-/- mice were used in this study. Cell prolifera-tion was analyzed by WST-1 assay. Real-time quantitative PCR, Western blot, Immunohistochemistry and ELISA methods were used to analyze the expression levels of molecules associated with TLR4 signaling. Results In this study, we found a CoX-2/PgE2/STAT3 positive feedback loop exists in HCC cells, which could be provoked by TLR4 activation. Consistently, TLR4, CoX-2 and p-STAT3 were highly expressed in primary HCC tumor tissues compared to adjacent non-tumor sites, and positively correlated with each other. Further investigation demonstrated this loop played a dominant role in TLR4-induced HCC cell proliferation and multidrug resistance(MDR) of HCC to chemotherapeutics in vitro. Importantly, by using a primary HCC model, we observed CoX-2/PgE2/STAT3 loop was significantly blocked in TLR4-/- mice compared to wild type mice, and there was no obvious tumorgenesis sign in TLR4-/- mice. Moreover, specific silence or inhibition of TLR4 could increase the sensitivity of HCC to chemotherapeutics in vitro. Conclusion These findings clarified one critical mechanism of TLR4 signaling pathway involved in HCC progress, which may provide new sights for HCC clinical treatment and development of novel liver-targeted anti-t

关键词： TLR4 HCC Proliferation Multidrug Resistance STAT3

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Nitric oxide involved in regulating HS induced GA biosynthes...

多彩菌物美丽中国——中国菌物学会2019年学术年会

作者： Rui Liu ang Ren Liang Shi Jing Zhu Mingwen Zhao Key Laboratory of Agricultural Environmental Microbiology Ministry of AgricultureMicrobiology Department College of Life Sciences Nanjing Agricultural University

ganoderma lucidum（g. lucidum） is one of the best-known medicinal basidiomycetes in the world,because it containing a wide range of immuno-modulatory and bioactive compounds. ganoderic acid（gA） is one of the major secondary metabolites in g. lucidum, a basidiomycete with high commercial value. Previous studies have shown that heat stress（HS） increases gA biosynthesis via induced reactive oxygen species（RoS）accumulation in g. lucidum[1] and No relieves HS-induced gA accumulation in g. lucidum[2]. To determine the mechanism that No relieves HS-induced gA accumulation in g. lucidum, the effect of No on the RoS content was examined under heat treatment. The results showed that No decreased the production of MitRoS under heat treatment. Further research found that No reduced the MitRoS content through inhibit the aconitase activity. In the aconitase silenced strains（Aconi）, treatment with No donor（SNP） showed no obviously effect on the mitRoS and gA content relative to the untreated sample. Combined with the prior results, these findings indicate that No inhibits aconitase activity to reduced mitRoS content and thereby relieved HS-induced gA overproduction in ganoderma *** S-nitrosylation, the incorporation of a nitroso g.oup to a Cys thiol, has been established as a significant route through which No transmits its g.obal cellular influence. To study the mechanism of the inhibition of the aconitase activity in g. lucidum, the aconitase proteins S-Nitrosylation was ***-switch technology（BST） and mass spectrometric analysis revealed that Acon was S-nitrosylated at amino acid residues, Cys 594. The substitution of Cys 594 with non-nitrosylatable Ser with site-directed mutagenesis causes the abolishes its responsiveness to the No-reducted enzymatic activity. These findings demonstrate that No inhibited the activity of aconitase through S-nitrosylation at Cys 594 thereby relieved HS-induced gA biosynthesis in ganoderma lucidum..

关键词： Nitric oxide Heat stress ganoderic Acid Aconitase S-Nitrosylation

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一类轻量级最优S盒的构造方法

山东大学学报（理学版） 2018年第7期53卷 85-94页

作者：李昂关杰解放军信息工程大学密码工程学院河南郑州450001

S盒是对称密码算法中主要的非线性部件,其密码性质的好坏将直接影响到密码算法的整体安全性。给出了一类4比特最优S盒的构造方法,证明了此类最优S盒属于同一仿射等价类g1,统计给出其差分、线性和代数次数等密码学性质,计算出此类S盒的... 详细信息

S盒是对称密码算法中主要的非线性部件,其密码性质的好坏将直接影响到密码算法的整体安全性。给出了一类4比特最优S盒的构造方法,证明了此类最优S盒属于同一仿射等价类g1,统计给出其差分、线性和代数次数等密码学性质,计算出此类S盒的硬件实现平均等效门数为25.6。在此基础上,通过带轮密钥的3轮MISTY结构和Feistel结构构造了一类8比特S盒,给出了结构最优性的定义,并给出8比特S盒达到结构最优性的一个充分条件。

关键词：最优S盒仿射等价 MISTY结构 Feistel结构结构最优性

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协同烟羽治理烟气余热利用系统的节能分析

能源工程 2024年第4期44卷 65-68页

作者：许一凡蔡昂宁旭隰刚张晓辉李准梁秀进李存文河北华电石家庄鹿华热电有限公司河北石家庄050200 华电电力科学研究院有限公司浙江杭州310030

为控制烟囱冒白烟现象的发生,某330MW机组配备有冷凝-再热烟羽治理系统,系统包含烟气冷却器、烟气加热器和烟气冷凝器,成为纯环保设备。根据投运后系统运行特点和烟羽治理效果需求,为实现节能降耗,系统进行了协同余热利用改造。改造内... 详细信息

为控制烟囱冒白烟现象的发生,某330MW机组配备有冷凝-再热烟羽治理系统,系统包含烟气冷却器、烟气加热器和烟气冷凝器,成为纯环保设备。根据投运后系统运行特点和烟羽治理效果需求,为实现节能降耗,系统进行了协同余热利用改造。改造内容包括:(1)新增板式换热器A,用于非供暖期烟气冷却器出口热媒水和低加系统凝结水换热;(2)新增板式换热器B,用于供暖期烟气冷却器出口热媒水与供暖回水换热;(3)新增板式换热器C,用于供暖期冷凝器出口循环冷却水与供暖水补水换热。板式换热器A可排挤低加系统抽汽,板式换热器B和C可减少供暖抽汽耗量。性能试验结果显示,协同烟羽治理余热利用系统在非供暖期可降低机组发电煤耗1.09g/(kW·h),供暖期可降低机组发电煤耗2.30g/(kW·h),节能效益显著。

关键词：烟羽治理冷凝-再热协同余热利用节能降耗

生物制剂益赛普联合甲氨蝶呤治疗难治性类风湿关节炎的疗效观察

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重庆医学 2013年第26期42卷 3100-3101,3104页

作者：汪珊安徽省合肥市第一人民医院风湿科 230061

目的探讨生物制剂益赛普联合甲氨蝶呤治疗难治性类风湿关节炎的临床疗效。方法将2010年1月至2012年1月该院收治的30例难治性类风湿关节炎患者分为两组，各15例，对照组患者采用甲氨蝶呤口服（每周15mg）治疗；联合治疗组患者采用生物制... 详细信息

目的探讨生物制剂益赛普联合甲氨蝶呤治疗难治性类风湿关节炎的临床疗效。方法将2010年1月至2012年1月该院收治的30例难治性类风湿关节炎患者分为两组，各15例，对照组患者采用甲氨蝶呤口服（每周15mg）治疗；联合治疗组患者采用生物制剂益赛普（每次12．5～25．0mg，每周2次）皮下注射联合甲氨蝶呤（每周15mg）进行治疗，3个月为1个疗程。结果两组的治疗效果、差异无统计学意义。联合治疗组的ACR20有效率为73．3％，ACR50有效率为46．7％，ACR70有效率为26．7％，显著高于对照组，差异有统计学意义（P〈0．01）。对照组有4例患者出现胃肠道不适。结论生物制剂益赛普和甲氨蝶呤联合治疗难治性类风湿关节炎具有较好的临床疗效。

关键词：关节炎,类风湿益赛普甲氨蝶呤