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Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy

Bioactive Materials 2022年第2期7卷 309-324页

作者： Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren ang gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng Department of Orthopaedics The First Affiliated Hospital of Soochow University188 Shizi StreetSuzhou215006JiangsuChina Institute for Advanced Materials School of Materials Science and EngineeringJiangsu University301 Xuefu RoadZhenjiang212013JiangsuChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055GuangdongChina Department of Orthopaedics The First Affiliated Hospital of USTCUniversity of Science and Technology of China17 Lujiang RoadHefei230001AnhuiChina Department of Oncology The First Affiliated Hospital of USTCUniversity of Science and Technology of China17 Lujiang RoadHefei230001AnhuiChina

Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical ***,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a *** by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido *** peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of *** this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue *** bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone *** a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements.

关键词： Surface biomodification Polyetheretherketone Anti-infectivity and osteo-inductivity Mussel adhesion Bioorthogonal chemistry

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Acquisition of a novel conjugative multidrug-resistant hypervirulent plasmid leads to hypervirulence in clinical carbapenem-resistant Klebsiella pneumoniae strains

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mLife 2023年第3期2卷 317-327页

作者： Gong Li Ling Jia Lei Wan Lijuan Xia ang gao Runshi Yang Ruanyang Sun Minge Wang Juan Du Xinlei Lian Rongmin Zhang Liangxing Fang Xiaoping Liao Yahong Liu Bao-Tao Liu Jian Sun State Key Laboratory for Animal Disease Control and Prevention South China Agricultural UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation South China Agricultural UniversityGuangzhouChina Department of Pathogen Biology and Microbiology Zhejiang University School of MedicineHangzhouChina College of Veterinary Medicine Qingdao Agricultural UniversityQingdaoChina

The co-occurrence of plasmid-mediated multidrug resistance and hypervirulence in epidemic carbapenem-resistant Klebsiella pneumoniae has emerged as a global public health *** this study,an ST23 carbapenem-resistant hyper-virulent ***(CR-HvKP)strain VH1-2 was identified from cucumber in China and harbored a novel hybrid plasmid *** plasmid pVH1-2-VIR carrying both virulence and multidrug-resistance(MDR)genes was likely generated through the recombination of a virulence plasmid and an IncFIIK conjugative MDR plasmid in clinical ST2318622 isolated from a sputum *** plasmid pVH1-2-VIR exhibited the capacity for transfer to the clinical ST11 carbapenem-resistant ***(CRKP)strain via conjugation *** of pVH1-2-VIR plasmid directly converted a CRKP into CR-HvKP strain characterized by hypermucoviscosity,heightened virulence for Galleria mellonella larvae,and increased colonization ability in the mouse *** emergence of such a hybrid plasmid may expedite the spread of CR-HvKP strains,posing a significant risk to human health.

关键词： conjugative virulence plasmid CR-HvKP hybrid plasmid Klebsiella pneumoniae ST23

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光-生物可降解光敏剂/TPS/PBS复合材料的制备及性能研究

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广州化工 2024年第13期52卷 43-46,89页

作者：梁佳慧冯佳利冯晓李燕影刘旭东陈高昂崔子涵周盈盈丁笑晖塔里木大学化学化工学院新疆阿拉尔843300

为研究聚丁二酸丁二醇酯(PBS)基复合材料的光-生物可降解性能,采用溶融热压法制备了光敏剂/TPS/PBS复合材料,研究了在光敏剂存在条件下TPS对复合材料的机械性能、热性能、光降解性能和生物降解性能的影响。实验结果表明,随着TPS含量的增... 详细信息

为研究聚丁二酸丁二醇酯(PBS)基复合材料的光-生物可降解性能,采用溶融热压法制备了光敏剂/TPS/PBS复合材料,研究了在光敏剂存在条件下TPS对复合材料的机械性能、热性能、光降解性能和生物降解性能的影响。实验结果表明,随着TPS含量的增加,降解速率越快,而复合材料的力学性能随之降低,且材料的结晶性能变化不明显。当TPS质量分数为30%且光敏剂质量分数为0.5%时,复合材料既能保持良好的力学性能,又能表现出良好的降解性能。

关键词：聚丁二酸丁二醇酯热塑性淀粉邻苯二甲酸氢铈光-生物可降解复合材料

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Schroth exercises improve health-related quality of life and radiographic parameters in adolescent idiopathic scoliosis patients

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Chinese Medical Journal 2021年第21期134卷 2589-2596页

作者： ang gao Jun-Yu Li Rui Shao Tong-Xuan Wu Yong-Qiang Wang Xiao-Guang Liu Miao Yu Department of Orthopaedics Peking University Third HospitalBeijing 100191China department of Rehabilitation Medicine Peking University Third HospitalBeijing 100191China

Background:Finding an optimal treatment strategy for adolescent idiopathic scoliosis(AIS)patients remains challenging because of its intrinsic *** mild to moderate scoliosis patients with lower skeletal growth potential(Risser 3-5),most clinicians agree with observation treatment;however,the curve progression that occurs during puberty,the adolescent period,and even in adulthood,remains a challenging issue for *** aim of the study is to investigate the efficacy of Schroth exercise in AIS patients with lower skeletal growth potential(Risser 3-5)and moderate scoliosis(Cobb angle 20°-40°).Methods:From 2015 to 2017,data of 64 patients diagnosed with AIS in Peking University Third Hospital were ***-three patients underwent Schroth exercise were classified as Schroth group,and 21 patients underwent observation were classified as observation *** were measured by health-related quality of life(HRQOL)and radiographic *** was assessed using the visual analog scale(VAS)scores for back,Scoliosis Research Society-22(SRS-22)patient *** spinopelvic parameters were obtained from anteroposterior and lateral *** pre-treatment and post-treatment HRQOL and radiographic parameters were tested to validate Schroth exercise *** inter-rater reliability of the radiographic parameters was tested using the interclass correlation coefficient(ICC).The pairedt test was used to examine HRQOL and radiographic *** relevance between C2-C7 sagittal vertical axis(SVA)and thoracic kyphosis was analyzed using Spearman ***:In Schroth group,VAS back score,SRS-22 pain,and SRS-22 self-image domain were significantly improved from pre-treatment 3.0±0.8,3.6±0.5,and 3.5±0.7 to post-treatment 1.6±0.6(t=5.578,P=0.013),4.0±0.3(t=-3.918,P=0.001),and 3.7±0.4(t=-6.468,P<0.001),*** significant improvements of SRS-22 function domain(t=-2.825,P=0.088)and mental health domain(t=-3.17

关键词： Adolescent idiopathic scoliosis Schroth exercises Health-related quality of life Curve progression Cervical alignment

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止口及螺栓对法兰盘结构静力学特性的影响

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东北大学学报（自然科学版） 2022年第10期43卷 1438-1445页

作者：马辉高昂杨天瑞官宏东北大学机械工程与自动化学院辽宁沈阳110819

以含止口配合的螺栓连接法兰盘结构为研究对象,利用ANSYS有限元软件进行数值仿真分析,基于接触算法与实体单元建模方法分析结构受横向载荷时的静力学特性,对比了含止口结构和无止口结构在接触状态和弯曲刚度上的差异.在此基础上,讨论了... 详细信息

以含止口配合的螺栓连接法兰盘结构为研究对象,利用ANSYS有限元软件进行数值仿真分析,基于接触算法与实体单元建模方法分析结构受横向载荷时的静力学特性,对比了含止口结构和无止口结构在接触状态和弯曲刚度上的差异.在此基础上,讨论了不同参数对接触特性和弯曲刚度的影响规律,为后续含止口螺栓连接法兰盘结构的设计提供一定参考.研究结果表明:对接触特性的影响,止口长度的增加有利于降低受压区域面积和接触压力的最大值;对弯曲刚度的影响,螺栓个数对弯曲刚度的影响占主导地位,其次是止口长度和摩擦系数,然后是螺栓预紧力,而止口过盈量对弯曲刚度的影响最小,同时良好的接触状态有利于提高结构弯曲刚度.

关键词：止口螺栓连接接触特性弯曲刚度止口长度过盈量

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Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer(NECTAR):a multi-center phase 2 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1721-1729页

作者： Zhengyang Yang Jiale gao Jianyong Zheng Jiagang Han ang Li Gang Liu Yi Sun Jie Zhang Guangyong Chen Rui Xu Xiao Zhang Yishan Liu Zhigang Bai Wei Deng Wei He Hongwei Yao Zhongtao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityState Key Lab of Digestive HealthNational Clinical Research Center for Digestive DiseasesBeijingChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Air Force Medical UniversityXi'anChina Department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of General Surgery Beijing Xuanwu HospitalCapital Medical UniversityBeijingChina Department of General Surgery Tianjin Medical University General HospitalTianjinChina Department of Anorectal Tianjin People's HospitalTianjinChina Department of Radiology Beijing Friendship Hospital Capital Medical UniversityBeijingChina Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Thoracic Surgery/Institute of Thoracic Oncology West China HospitalSichuan UniversityChengduChina

Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer(LARC)patients with microsatellite stable(MsS)/mismatch repair-proficient(pMMR)tumors is an attractive,but debatable *** phase 2,multicenter,prospective,single-arm study enrolled patients from 6 centers from June 2021 to November *** advanced rectal cancer(LARC,cT_(3-4a)N_(0)M_(0) and cT_(1-4a)N_(1-2)M_(0))patients aged≥18 years with the distance from distal border of tumor to anal verge≤10 cm(identified by Magnetic Resonance Imaging)were qualifed for *** patients received long-course radiotherapy(50 Gy/25 fractions,2 Gy/fraction,5 days/week)and three 21-day cycles capecitabine(850-1000 mg/m2,bid,po,day1-14)and three 21-day cycles tislelizumab(200 mg,***,day8)as *** mesorectal excision(TME)was 6-12 weeks after the end of radiotherapy to achieve radical resection.A total of 50 patients were enrolled in this *** pathological complete response rate was 40.0%[20/50,95%confidence interval(CI):27.61-53.82%],while 15(30.0%,95%CI:19.1-43.75%),9(18.0%,95%CI:9.77-30.8%),2(4.0%,95%CI:1.10-13.46%)patients respectively achieved grade 1,2,and 3 tumor ***-related adverse events(TRAEs)occurred in 28(56.0%)LARC patients,including 26(52.0%)with grade I-II and 2(4.0%)with grade II(1 with grade 3 immune-related colitis and 1 with grade 3 rash).PD-1 blockade plus long-course chemoradiotherapy(CRT)showed promising therapeutic effects according to pathological complete response rate and is well-tolerated in LARC patients.A larger randomized controlled study is desired to further validate the above findings.

关键词： rectal cancer phase

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High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-ang Kang Hua-Ming Li Ya-Ting Chen Meng-Jie Deng Yan Li Yue-Ming Peng Jian-Jun gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

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Origin of the low formation energy of oxygen vacancies in CeO_(2)

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Chinese Physics B 2022年第10期31卷 488-492页

作者：许涵尚彤彤王雪锋高昂谷林 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

Oxygen vacancies play a crucial role in determining the catalytic properties of Ce-based catalysts,especially in oxidation *** design of catalytic activity requires keen insight into oxygen vacancy formation *** this work,we investigate the origin of oxygen vacancies in CeO_(2)from the perspective of electron density via high-energy synchrotron powder x-ray *** refinement results indicate that there is no obvious hybridization between bonded Ce and O atoms in CeO_(2).Subsequent quantitative topological analysis of the experimental total electron density reveals the closed-shell interaction behavior of the Ce-O *** results of first-principles calculation indicate that the oxygen vacancy formation energy of CeO_(2)is the lowest among three commonly used redox *** findings indicate the relatively weak bond strength of the Ce-O bond,which induces a low oxygen vacancy formation energy for CeO_(2)and thus promotes CeO_(2)as a superior catalyst for oxidation *** work provides a new direction for design of functional metal oxides with high oxygen vacancy concentrations.

关键词： CeO_(2) oxygen vacancy synchrotron x-ray diffraction electron-density distribution

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Ultrahigh-performance planar β-Ga2O3 solar-blind Schottky photodiode detectors

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Science China(Technological Sciences) 2021年第1期64卷 59-64页

作者： LIU Zeng ZHI YuSong ZHang ShaoHui LI Shan YAN ZuYong gao ang ZHang ShiYu GUO DaoYou Wang Jun WU ZhenPing LI PeiGang Tang WeiHua Laboratory of Information Functional Materials and Devices School of ScienceBeijing University of Posts and TelecommunicationsBeijing 100876China Division of Interdisciplinary and Comprehensive Research&Platform for Characterization and Test Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Center for Optoelectronics Materials and Devices&Key Laboratory of Optical Field Manipulation of Zhejiang Province Department of PhysicsZhejiang Sci-Tech UniversityHangzhou 310018China China Telecom Huzhou Branch Huzhou 313000China

The low dark current, high responsivity and high specific detectivity could be preferably achieved in detectors based on junctions, owing to the efficient constraint of carriers. Compared with the other junctions, planar Schottky junctions have simple structures and technological demands and are easy integrated. Herein, in this work, we prepared the β-Ga_(2)O_(3) thin film by metalorganic chemical vapor deposition method to construct planar Ti/β-Ga2O3/Ni Schottky photodiode detectors with different onstate resistances. Fortunately, all the devices exhibit state-of-the-art performances, such as responsivity of 175–1372 A W^(-1),specific detectivity of 10^(14) Jones and external quantum efficiency of 85700%–671500%. In addition, the dependences of device performances on the on-state resistances indicate that the higher dark currents, photocurrents and photoresponsivities may well be obtained when on-state resistance is smaller, due to the less external power is used to overcome the impendence and condensance at the Ti/β-Ga_(2)O_(3) and Ni/β-Ga_(2)O_(3) interfaces, but contributing to higher electric current flow both in the dark and under illuminations.

关键词： β-Ga2O3 Schotttky photodiode solar-blind device scale on-state resistance

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深基坑外墙单支模新型模板施工技术

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建筑技术开发 2023年第2期50卷 43-45页

作者：高昂中铁建设集团有限公司北京100131

以3号楼公寓式酒店等两项(利山大厦二期公寓式酒店)工程为实例,针对深基坑外墙单支模外侧模板的选型,提出了一种新型外侧模板体系“槽钢龙骨+木胶板+高强水泥复合板模板”体系。施工过程通过应用该体系,浇筑完成的混凝土观感及实体质量... 详细信息

以3号楼公寓式酒店等两项(利山大厦二期公寓式酒店)工程为实例,针对深基坑外墙单支模外侧模板的选型,提出了一种新型外侧模板体系“槽钢龙骨+木胶板+高强水泥复合板模板”体系。施工过程通过应用该体系,浇筑完成的混凝土观感及实体质量良好,解决了地下室外墙模板支设体系繁杂的问题,解决冬期施工的困难,同时梳理归集而成的施工工艺技术,可供相似工程参考借鉴。

关键词：深基坑外侧模板单侧支模钢龙骨水泥复合板

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