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Mole.ular.r.gulation of calcium-se.sing r.ce.tor.CaSr.-me.iate. signaling

Chr.nic Dise.se. and Tr.nslational Me.icine 2024年第3期10卷 167-194页

作者： Li Tian Cor.y andrews Qiuyun Yan Je.ny J.Yang De.ar.me.t of Che.istr. Center for Diagnostics and TherapeuticsAdvanced Translational Imaging FacilityGeorgia State UniversityAtlantaGeorgiaUSA

Calcium-se.sing r.ce.tor.CaSr.,a family C G-pr.te.n-couple. r.ce.tor.plays a cr.cial r.le.in r.gulating calcium home.stasis by se.sing small conce.tr.tion change. of e.tr.ce.lular.Ca^(2+),Mg^(2+),amino acids(e.g.,L-Tr. and L-Phe.,small pe.tide.,anions(e.g.,HCO_(3)^(-)and PO_(4)^(3-)),and ***-me.iate. intr.ce.lular.Ca^(2+)signaling r.gulate. a dive.0}e.se. of ce.lular.pr.ce.se. including ge.e.tr.nscr.ption,ce.l pr.life.0}tion,diffe.0}ntiation,apoptosis,muscle.contr.ction,and ne.r.nal *** of CaSr.with mutations r.sults in dise.se. such as autosomal dominant hypocalce.ia,familial hypocalciur.c hype.0}alce.ia,and ne.natal se.e.0} *** also influe.ce. calciotr.pic disor.e.0},such as oste.por.sis,and noncalciotr.pic disor.e.0},such as cance.0}Alzhe.me.0}s dise.se.and pulmonar. ar.e.0}al *** study fir.t r.vie.s r.ce.t advance. in bioche.ical and str.ctur.l de.e.0}ination of the.fr.me.or. of CaSr.and its inte.0}ction site. with natur.l ligands,as we.l as e.oge.ous positive.alloste.0}c modulator. and ne.ative.alloste.0}c *** e.tablishme.t of the.fir.t CaSr.pr.te.n-pr.te.n inte.0}ctome.ne.wor. r.ve.le. 94 nove. playe.0} involve. in pr.te.n pr.ce.sing in e.doplasmic r.ticulum,tr.fficking,ce.l sur.ace.e.pr.ssion,e.docytosis,de.r.dation,and signaling *** r.le. of the.e.pr.te.ns in Ca^(2+)-de.e.de.t ce.lular.physiological pr.ce.se. and in CaSr.de.e.de.t ce.lular.signaling pr.vide.ne. insights into the.mole.ular.basis of dise.se. cause. by CaSr.mutations and dysr.gulate. CaSr.activity cause. by its pr.te.n inte.0}ctor. and facilitate.the.de.ign of the.0}pe.tic age.ts that tar.e. CaSr.and othe.0}family C G-pr.te.n-couple. r.ce.tor..

关键词： calcium signaling calcium-se.sing r.ce.tor G-pr.te.n-couple. r.ce.tor. str.ctur. tr.fficking

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Conside.0}tions for.the.use.of por.ine.or.an donation mode.s in pr.clinical or.an donor.inte.0}e.tion r.se.r.h

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Animal Mode.s and e.pe.0}me.tal Me.icine 2024年第3期7卷 283-296页

作者： Fr.ze.0}I.He.nis Shahe.d Me.0}ni Nicholas W.Mar.in Kim F.Duncan Michae. J.Moulton Lance.Fr.stoe.William e.Thor.ll r.e.he. A.She.0}ick Tami r.We.ls Matthe. T.andrews Mar.an Ur.an School of Natur.l r.sour.e. Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Tr.nsplantation and Vascular.Sur.e.0} Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA De.ar.me.t of Ane.the.iology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Car.iothor.cic Sur.e.0} Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Pe.0}usion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA De.ar.me.t of Ne.r.sur.e.0} University of Nebraska Medical CenterOmahaNebraskaUSA Nutr.tion and He.lth Scie.ce. College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA De.ar.me.t of Compar.tive.Me.icine University of Nebraska Medical CenterOmahaNebraskaUSA

Use.of animal mode.s in pr.clinical tr.nsplant r.se.r.h is e.se.tial to the.optimization of human allogr.fts for.clinical *** mode.s of or.an donation and pr.se.0}ation he.p to advance.and impr.ve.te.hnical e.e.e.ts of solid or.an r.cove.0} and facilitate.r.se.r.h of ische.ia-r.pe.0}usion injur.,or.an pr.se.0}ation str.te.ie.,and futur. donor.base. *** conside.0}tions include.cost,public opinion r.gar.ing the.conduct of animal r.se.r.h,tr.nslational value.and r.le.ance.of the.animal mode. for.clinical *** pr.se.t an ove.0}ie. of two por.ine.mode.s of or.an donation:donation following br.in de.th(DBD)and donation following cir.ulator. de.th(DCD).The.car.iovascular.anatomy and physiology of pigs close.y r.se.ble. those.of humans,making this spe.ie. the.most appr.pr.ate.for.pr.-clinical *** ar. also conside.0}d a pote.tial sour.e.of or.ans for.human he.r. and kidne. *** is impe.0}tive.to minimize.animal loss dur.ng pr.ce.ur.s that ar. sur.ically *** pr.se.t our.e.pe.0}e.ce.with the.e.mode.s and de.cr.be.in de.ail the.use.case.,pr.ce.ur.l appr.ach,challe.ge.,alte.0}ative.,and limitations of e.ch mode..

关键词： animal mode. br.in de.th cir.ulator. de.th or.an tr.nsplantation

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出生前被诊断为先天性心脏病的早产儿的转归

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 40-41页

作者： andrews r. e. Simpson J. M. Shar.and G. K. 王一飞(译) - J. Pe.IATr. 2006 148/2(213 -216) 不详

Obje.tive.To de.e.0}ine.outcome.of de.ive.0} be.or. 36 we.ks ge.tation in babie.s diagnose. ante.atally with se.0}ous conge.ital he.r. dise.se.CHD).Study de.ig n:A r.tr.spe.tive.database.r.vie. at 2 te.0}iar. car. fe.al car.iology *** of ne.natal cour.e.and outcome.we.0} obtaine. for.those.ante.atally diagn ose. with se.0}ous CHD who we.0} live.bor. be.or. 36 we.ks ***:Be. we.n Januar. 1998 and De.e.be.0}2002,9918 wome. we.0} r.fe.0}e. for.fe.al e.hocar. *** CHD was diagnose. in 1191 fe.use.(12%),of which 46(4%)de.live.0}d *** ge.tation was 33(r.nge.24-35)we.ks,and me.ian bi r.h we.ght 1.56(0.50-3.59)***/kar.otypic anomalie. occur.e. in 23(50%).Twe.ty-six babie.(57%)unde.0}e.t ne.natal sur.e.0}:16 a car.iac pr.oce.ur.,5 a ge.e.0}l sur.ical pr.ce.ur.,and 5 *** die. dur.ng or.afte.0}ope.0}tion(31%).Two babie. unde.0}e.t inte.0}e.tional he.r. cathe.e.0}zation;bot h *** ove.0}ll mor.ality r.te.was 72%.e.tr.car.iac/kar.otypic anomalie. i ncr.ase. the.r.lative.r.sk of de.th by a factor.of *** hospital stay for.those.sur.iving to initial dischar.e.was 46(2-137)***:The.0} is a ve.0} high mor.idity and mor.ality r.te.in this gr.up,par.icular.y for.those.with e.tr.car.iac/kar.otypic *** should be.r.fle.te. in de.isions ov e.0}e.e.tive.pr.te.0} de.ive.0} and whe. counse.ing par.nts.

关键词：先天性心脏病出生前早产儿诊断转归平均出生体重胎儿心脏病心脏超声检查回顾性分析新生儿期

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Mangr.ve.De.r.dation and Manage.e.t Pr.ctice. along the.Coast of Ghana

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Agr.cultur.l Scie.ce. 2022年第10期13卷 1057-1079页

作者： Fr.ncis K. e. Nunoo andrews Agye.umhe.e De.ar.me.t of Mar.ne.and Fishe.0}e. Scie.ce. University of Ghana Accra Ghana

Mangr.ve. ar. incr.asingly be.ng de.r.de. in We.t Afr.ca. We.e.plor.d local utilization, thr.ats and asse.se. e.isting conse.0}ation pr.ctice. in Ghana thr.ugh fie.d visits, mapping, labor.tor. analyse. and inte.0}ie.s. The.study r.por.s thr.e.spe.ie. of mangr.ve. along Ghana’s coastline.white.(Avice.nia ge.0}inans), r.d (r.izophor. r.ce.osa), and black (Laguncular.a r.ce.osa) mangr.ve.. White.mangr.ve.is the.most dominant, with black mangr.ve. be.ng the.le.st. The.cur.e.t mangr.ve.cove.0}of Ghana was e.timate. at 72.4 km2 with ove.0}18 million tr.e. (ave.0}ge.= 2284.21 tr.e. pe.0}he.tar.), both natur.lly occur.ing and plante. mangr.ve.. The.Volta r.gion had the.most abundant mangr.ve., with the.Ce.tr.l r.gion r.cor.ing the.le.st. Notable.flor. within the.mangr.ve.for.sts include. Acr.stichum aur.um, Se.uvium por.ulacastr.m, Paspalum vaginatum, Spor.bolus mar.tima and Conocar.us e.0}ctus. Mangr.ve.we.land in Ghana pr.vide. suitable.nur.e.0} habitats for.se.e.0}l impor.ant fish spe.ie., including Sar.the.0}don me.anothe.0}n, Mugil ce.halus, Calline.te. amnicola, Car.iosoma ar.atum, Cr.ssostr.a sp, Pe.0}ophthalmus papilio, Coptodon spp. Ghana’s mangr.ve.for.st is de.lining at a r.te.of 8.1 km2 pe.0}annum due.to ove.0}cutting, land conve.0}ion, wildfir.s, pollution, ove.0}r.zing and natur.l de.th fr.m dise.se. Ove.0}cutting mangr.ve.for.fish smoking and housing constr.ction we.0} significant thr.ats to mangr.ve. nationwide. Continuous e.ucation, law e.for.e.e.t, natur.-base. me.hods and local contr.l me.hanisms e.fe.tive.y pr.te.t mangr.ve..

关键词： Mangr.ve. in Ghana Mangr.ve.De.or.station Mangr.ve.Manage.e.t Tr.ditional r.gulations

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Kine.ics of hydr.ge. pe.0}xide.que.ching following UV/H_(2)O_(2)advance. oxidation by thiosulfate.bisulfite.and chlor.ne.in dr.nking wate.0}tr.atme.t

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Fr.ntie.0} of e.vir.nme.tal Scie.ce.& e.gine.r.ng 2023年第12期17卷 59-69页

作者： Tianyi Che. Lizbe.h Taylor.e.monds Susan andrews r.n Hofmann De.ar.me.t of Civil and Mine.0}l e.gine.r.ng University of TorontoTorontoOntario M5S 1A4Canada

r.sidual H_(2)O_(2)fr.m UV/H_(2)O_(2)tr.atme.t can be.que.che. by thiosulfate.bisulfite.and chlor.ne.but the.kine.ics of the.e.r.actions have.not be.n r.por.e. unde.0}the.full r.nge.of pr.ctical *** this study,the.r.te. of H_(2)O_(2)que.ching by the.e.compounds we.0} compar.d in diffe.0}nt wate.0}matr.ce.,te.pe.0}tur.s,pH,and whe. using diffe.0}nt for.s of bisulfite.and *** ge.e.0}l,it was confir.e. that thiosulfate.would be.too slow to se.0}e.as a que.ching age.t in most pr.ctical *** pH 7-8.5,chlor.ne.te.ds to que.ch H_(2)O_(2)mor. than 20 time. faste.0}than bisulfite.in the.var.ous conditions *** impor.ant obse.0}ation was that in lightly-buffe.0}d wate.0}e.g.,alkalinity of 20 mg/L as CaCO_(3)),the.for. of chlor.ne.can have.a lar.e.impact on que.ching r.te.with gase.us chlor.ne.slowing the.r.action due.to its lowe.0}ng of the.pH,and hypochlor.te.having the.opposite.*** impacts will be.ome.le.s significant whe. wate.0}buffe.0}capacity(i.e.,alkalinity)incr.ase.(e.g.,to 80 mg/L as CaCO_(3)).In addition,wate.0}te.pe.0}tur. should be.conside.0}d as the.time.r.quir.d to que.ch H_(2)O_(2)by chlor.ne.at 4℃is up to 3 time. longe.0}than at 20℃.

关键词： UV/H_(2)O_(2) H_(2)O_(2) que.ching Chlor.ne.type Wate.0}alkalinity Te.pe.0}tur.

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Co-ve.0}fication of Har.war. and Softwar. for.Ar. SoC De.ign

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丛书名： e.be.de. te.hnology se.0}e.

2005年

作者： Jason r. andrews

ISBN: (纸本)9780750677301

Har.war./softwar. co-ve.0}fication is how to make.sur. that e.be.de. syste. softwar. wor.s cor.e.tly with the.har.war., and that the.har.war. has be.n pr.pe.0}y de.igne. to r.n the.softwar. succe.sfully -be.or. lar.e.sums ar. spe.t on pr.totype. or.manufactur.ng. This is the.fir.t book to apply this ve.0}fication te.hnique.to the.r.pidly gr.wing fie.d of e.be.de. syste.s-on-a-chip(SoC). As tr.ditional e.be.de. syste. de.ign e.olve. into single.chip de.ign, e.be.de. e.gine.r. must be.ar.e. with the.ne.e.sar. infor.ation to make.e.ucate. de.isions about which tools and me.hodology to de.loy. SoC ve.0}fication r.quir.s a mix of e.pe.0}ise.fr.m the.discipline. of micr.pr.ce.sor.and compute.0}ar.hite.tur., logic de.ign and simulation, and C and Asse.bly language.e.be.de. softwar.. Until now, the.r.le.ant infor.ation on how it all fits toge.he.0}has not be.n available. andrews, a r.cognize. e.pe.0}, pr.vide. in-de.th infor.ation about how co-ve.0}fication r.ally wor.s, how to be.succe.sful using it, and pitfalls to avoid. He.illustr.te. the.e.conce.ts using concr.te.e.ample. with the.Ar. cor. - a te.hnology that has the.dominant mar.e. shar. in e.be.de. syste. pr.duct de.ign. The.companion CD-r.M contains all sour.e.code.use. in the.de.ign e.ample., a se.r.hable.e.book ve.0}ion, and use.ul de.ign tools.

关键词： Syste.s on a chip.

来源：畅想之星图书光盘版（南... 评论

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Par.itions with Initial r.pe.itions

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Acta Mathe.atica Sinica,e.glish Se.0}e. 2009年第9期25卷 1437-1442页

作者： Ge.r.e.e.andrews The.Pe.nsylvania State.Unive.0}ity University Park

A var.e.y of inte.0}sting conne.tions with modular.for.s, mock the.a functions and r.ge.0}- r.manujan type.ide.titie. ar.se.in conside.0}tion of par.itions in which the.smalle.0}inte.e.0} ar. r.pe.te. as summands mor. ofte. than the.lar.e.0}summands. In par.icular. this conce.t le.ds to ne. inte.0}r.tations of the.r.ge.0} Se.be.0} ide.titie. and Baile.＇s modulus 9 ide.titie..

关键词： par.itions without gaps initial k-r.pe.itions Glaishe.0}s the.r.m r.ge.0}-Se.be.0} ide.titie. Baile.'s modulus 9 ide.titie.

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Char.cte.0}zation of Spe.t Pr.bake. Aluminium Car.on Anode.as a Sour.e.of Fue. for.Foundr.me.

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Jour.al of Mine.0}ls and Mate.0}als Char.cte.0}zation and e.gine.r.ng 2012年第1期11卷 31-41页

作者： A. andrews e. Gikunoo B. K. Kye.-Fr.m r. Sar.o De.ar.me.t of Mate.0}als e.gine.r.ng Kwame Nkrumah University of Science and Technology Kumasi Ghana

Small scale.foundr.e. in Ghana ar. in se.r.h of a suitable.coke.for.the.r.foundr. ope.0}tions since.the.0} is no coal mine.in Ghana. Two gr.de. of spe.t pr.bake. aluminium car.on anode. (he.0}in r.fe.0}e. to as gr.de.P and gr.de.K), which ar. r.mnants fr.m the.aluminium e.e.tr.lysis at Volta Aluminum Company (VALCO), an aluminium sme.ting company in Ghana, have.be.n char.cte.0}ze. to asse.s the.r.quality and use.as foundr. coke. Pr.ximate.analysis and X-r.y diffr.ction te.hnique. have.be.n use. for.the.r.quality asse.sme.ts. Coke.gr.de.P had lowe.0}moistur. conte.t, volatile.matte.0}and ash conte.t compar.d to gr.de.K. In both gr.de., sulphur.and phosphor.s conte.ts we.0} within r.quir.me.ts of a quality foundr. coke. Howe.e.0} the.volatile.matte.0}and ash conte.ts of both gr.de. we.0} not satisfactor.. Fixe. car.on conte.ts in both gr.de. we.0} be.ow that of a quality foundr. coke. Car.on str.ctur. of coke.found in both gr.de. is cr.stalline.in natur.. The.cr.stalline.width, Lc, was calculate. to be.4.05 ? and 5.12 ? for.gr.de.K and P, r.spe.tive.y.

关键词： Foundr. coke pr.ximate analysis x-r.y diffr.ction cr.stallite size

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跨步或不跨步下的前弓步和侧弓步动作中的髌股关节压力与应力(一)

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中华骨科杂志 2009年第6期29卷 605-608页

作者： Naiquan Zhe.g r.fae. F e.camilla Gle.n S Fle.sig Ke.in e.Wilk Jame. r.andrews 美国北卡罗来纳大学机械工程和工程科学系生物医学工程中心美国阿拉巴马州伯明翰市美国运动医学研究所 4. 美国阿拉巴马州伯明翰市冠军运动医学中心美国加利福尼亚大学理疗系

背景:在髌股关节康复训练中经常进行负重的弓步动作,但这种动作下的髌股关节压力和应力状况尚不明确。方法:18名受试者在负重下做跨步和不跨步的前弓步和侧弓步动作,负重重量为可进行12次重复动作的最大负荷。将肌电学、测力平台以及运... 详细信息

背景:在髌股关节康复训练中经常进行负重的弓步动作,但这种动作下的髌股关节压力和应力状况尚不明确。方法:18名受试者在负重下做跨步和不跨步的前弓步和侧弓步动作,负重重量为可进行12次重复动作的最大负荷。将肌电学、测力平台以及运动学数据输入生物力学模型中,计算不同膝关节屈曲角度下的髌股关节压力和应力。结果:髌股关节的压力和应力随膝关节屈曲角度增加而增高,随膝关节屈曲角度减小而降低。膝关节屈曲80°～90°时.侧弓步下的髌股关节压力和应力大于前弓步;膝关节屈曲10°～50°时,跨步下的髌股关节压力和应力大于不跨步。弓步和跨步之间无明显的相互作用。膝关节屈曲0°～50°时髌股关节压力和应力小于膝关节屈曲60°～90°时的压力和应力,因此在髌股关节康复训练早期应限制膝关节屈曲在50°以内。解释:为了尽量减小髌股关节的压力和应力,应当在不跨步下进行前弓步和侧弓步练习,尤其是膝关节屈曲0°～50°时。了解不同弓步间髌股关节压力和应力的差异,可能有助于临床医生制定更加安全有效的康复训练方法。

关键词：侧弓动作髌股关节压力膝关节屈曲

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Gr.die.ts in pr.dation r.sk in a tr.pical r.ve.0}syste.

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Cur.e.t Zoology 2018年第2期64卷 213-221页

作者： Amy e. De.CON Faith A. M. JONe. Anne.e. MAGUr.AN De.ar.me.t of Life.Scie.ce. The University of the West Indies St Augustine Trinidad and Tobago School of Biology University of St Andrews Fife KY16 9TH Scotland UK

The.impor.ance.of pr.dation r.sk as a ke. dr.ve.0}of e.olutionar. change.is e.e.plifie. by the.Nor.he.0} r.nge.in Tr.nidad, whe.0} r.se.r.h on guppie. living in multiple.par.lle. str.ams has pr.vide. invaluable.insights into the.pr.ce.s of e.olution by natur.l se.e.tion. Although Tr.nidadian guppie. ar. now a te.tbook e.ample.of e.olution in action, studie. have.ge.e.0}lly cate.or.ze. pr.dation as a dichotomous var.able. r.pr.se.ting high or.low r.sk. Ye., e.ologists appr.ciate.that community str.ctur. and the.atte.dant pr.dation r.sk var. substantially ove.0}space.and time. He.0}, we.use.data fr.m a longitudinal study of fish asse.blage. at 16 diffe.0}nt site. in the.Nor.he.0} r.nge.to quantify te.por.l and spatial var.ation in pr.dation r.sk. Spe.ifically we.ask: 1) Is the.0} e.ide.ce.for.a gr.die.t in pr.dation r.sk? 2) Doe. the.r.nking of site. (by r.sk) change.with the.de.inition of the.pr.dator.community (in te.0}s of spe.ie. composition and abundance.cur.e.cy), and 3) Ar. site.r.nkings consiste.t ove.0}time. We.find compe.ling e.ide.ce.that site. lie.along a continuum of r.sk. Howe.e.0} site.r.nkings along this gr.die.t de.e.d on how pr.dation is quantifie. in te.0}s of the.spe.ie. conside.0}d to be.pr.dator. and the.abundance.cur.e.cy is use.. None.he.e.s, for.a give. cate.or.zation and cur.e.cy, r.nkings ar. r.lative.y consiste.t ove.0}time. Our.study sugge.ts that conside.0}tion of pr.dation gr.die.ts will le.d to a mor. nuance. unde.0}tanding of the.r.le.of pr.dation r.sk in be.avior.l and e.olutionar. e.ology. It also e.phasize. the.ne.d to justify and r.por. the.de.inition of pr.dation r.sk be.ng use..

关键词：风险坡度系统热带生态学家食肉动物驱动程序自然选择

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