检索结果-南通市图书馆

Combinatorial therapies for spinal cord inj.ry repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord inj.ries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord inj.ry recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord inj.ry pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord inj.ry pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord inj.ry

Inflammasome links traumatic brain inj.ry, chronic traumatic encephalopathy, and Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela seplovich Yazan Bouchi j.an Pablo de Rivero Vaccari j.nnifer C.Munoz Parej. andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological surgery and the Miami Proj.ct to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse school of Medicine AtlantaGAUSA

Traumatic brain inj.ry, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain inj.ry, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain inj.ry, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain inj.ry, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain inj.ry

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Testing decreasing variabililty of cockroach forewings through time using four Recent species： Blattella germanica, Polyphaga aegyptiaca, shelfordella lateralis and Blaberus craniifer, with implications for the study of fossil cockroach forewings

在线全文

学校读者我要写书评

暂无评论

Insect science 2012年第2期19卷 129-142页

作者： andrew j. Ross Department of Natural sciences National Museums Scotland Edinburgh UK

Vrsansky, （2000） considered there is decreasing variability in the forewings of cockroaches through time, based on a study of fossil and Recent species. This study tests his theory, based on a study of four Recent species of cockroaches： Blattella germanica （Blattellidae）, Polyphaga aegyptiaca （Polyphagidae）, shelfordella lateralis （Blattidae） and Blaberus craniifer （Blaberidae）. The new results, based on the coefficient of variation （CV） of the number of veins, indicate that Recent species can be more variable than fossil species and therefore do not support the theory. The results also show that at least 30 complete wings of the same species are required for a reliable CV value that is compa- rable between species.

关键词： Blaberidae Blattellidae Blattidae cockroach Polyphagidae variation

Invariant Measures and Asymptotic Gaussian Bounds for Normal Forms of stochastic Climate Model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,series B 2011年第3期32卷 343-368页

作者： Yuan YUAN andrew j. MAj.A Department of Mathematics Courant Institute New York University 251 Mercer Street New York NY 10012 USA Department of Mathematics and Center for Atmospheric Ocean Sciences Courant Institute New York University 251 Mercer Street New York NY 10012 USA

The systematic development of reduced low-dimensional stochastic climate models from observations or comprehensive high dimensional climate models is an important topic for atmospheric low-frequency variability,climate sensitivity,and improved extended range ***,techniques from applied mathematics have been utilized to systematically derive normal forms for reduced stochastic climate models for low-frequency *** was shown that dyad and multiplicative triad interactions combine with the climatological linear operator interactions to produce a normal form with both strong nonlinear cubic dissipation and Correlated Additive and Multiplicative(CAM) stochastic *** probability distribution functions(PDFs) of low frequency climate variables exhibit small but significant departure from Gaussianity but have asymptotic tails which decay at most like a ***,rigorous upper bounds with Gaussian decay are proved for the invariant measure of general normal form stochastic *** Gaussian lower bounds are also established under suitable hypotheses.

关键词： Reduced stochastic climate model Invariant measure Fokker-Planck equation Comparison principle Global estimates of probability density function

Challenges in studying geographic atrophy(GA) age-related macular degeneration: the potential of a new mouse model with GA-like features

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第5期15卷 863-864页

作者： j. Arj.na Ratnayaka andrew j. Lotery Clinical and Experimental sciences Faculty of MedicineUniversity of SouthamptonSouthamptonUK Eye Unit University Hospital Southampton NHS Foundation TrustSouthamptonUK

Loss of central vision critical to everyday activities such as reading,face-recognition and driving due to damage in the central retina (the macula) is the leading cause of irreversible blindness amongst adults in the developed *** condition,termed age-related macular degeneration (AMD),is a complex,chronic degenerative disease driven by a combination of genetic and lifestyle risk *** signs of retinal changes in people as young as 30–40 years have been reported,although these individuals appear to be ***,by the age of 65,the disease is present in ~3% of individuals,which increases dramatically to affect 1/3 of individuals by the eighth decade of *** to intermediate AMD is estimated to affect ~150 million individuals globally,with another 10 million individuals suffering from end-stage,sight-threatening *** terminal stages are broadly grouped into dry (geographic atrophy,GA) or wet (choroidal neovascular,CNV) AMD (sarks et al.,1988;Bird et al.,2014),with similar frequencies reported in *** advances in identifying genetic risk factors,including our discoveries in this field,indicate an initial shared pathology before progressing to aforementioned late-stage ***,GA patients have no effective treatment,which may in part be due to the lack of good in vivo models for GA ***,we summarize our new findings that describe an altogether new mouse model with GA-like features which shows progressive outer retinal pathology (Ibbett et al.,2019) that can be used to gain novel insights into GA and potentially as a tool for drug development.

关键词： macula central vision degenerative disease

Deciphering the mechanobiology of microglia in traumatic brain inj.ry with advanced microsystems

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain inj.ry research:Traumatic brain inj.ry(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic inj.ry damage

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA j.mes L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain inj.ry(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Morphology and efficiency enhancements of PTB7-Th:ITIC nonfullerene organic solar cells processed via solvent vapor annealing

在线全文

学校读者我要写书评

暂无评论

j.urnal of Energy Chemistry 2019年第10期28卷 148-156页

作者： Robert s. Gurney Wei Li Yu Yan Dan Liu andrew j. Pearson Tao Wang school of Materials science and Engineering Wuhan University of TechnologyWuhan 430070HubeiChina state Key Laboratory of silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070HubeiChina Cavendish Laboratory University of CambridgeJ. J. Thomson AvenueCambridge CB3 0HEUK

The nanoscale morphology within the photoactive layer of organic solar cells is critical in determining the power conversion efficiency (PCE). Here, we draw attention to the roles of molecular arrangement, and domain size in improving performance, which can be tuned by subj.cting the photovoltaic materials to solvent vapor annealing (sVA). In our PTB7-Th:ITIC devices, the PCE can be improved by exposing the device to solvent vapor for 60 s after solution casting. The solvent vapor prolongs reorganizational time and increases molecular ordering and domain size/phase separation, which are sub-optimal in pristine PTB7-Th:ITIC blend films. This improved morphology results in better charge mobility, reduced recombination, and ultimately an improved PCE from 7.1% to 7.9% when using Cs2 as the annealing solvent. This simple sVA technique can be applied to a range of OPV systems where the molecular ordering is inferior within the as-cast photoactive layer.

关键词： Polymer solar cells Non-fullerene solvent vapor annealing