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Ne.AB family of ne.ronal calcium-binding prote.ns in he.lth and dise.se

Ne.ral Re.e.e.ation Re.e.rch 2025年第5期20卷 1236-1243页

作者： Dione. Bue.o Michae. K.e.Schafe. Sude.a Wang Michae. j.Schme.sse. Axe. Me.hne. Institute.for Mole.ular Me.icine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany De.artme.t of Ane.the.iology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute.of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The.N-te.minal e.-hand calcium-binding prote.ns 1–3(Ne.AB1–3) constitute.a family of pre.ominantly ne.ronal prote.ns characte.ize. by the.pre.e.ce.of at le.st one.e.-hand calcium-binding domain and a functionally le.s we.l characte.ize. C-te.minal antibiotic biosynthe.is monooxyge.ase.domain. All thre. family me.be.s we.e.initially discove.e. due.to the.r inte.actions with othe. prote.ns. Ne.AB1 associate. with synaptotagmin-1, a critical ne.ronal prote.n involve. in me.brane.trafficking and synaptic ve.icle.e.ocytosis. Ne.AB2 inte.acts with pre.ominantly striatal G-prote.n-couple. re.e.tors, while.Ne.AB3 partne.s with amyloid-β A4 pre.ursor prote.n-binding family A me.be.s 2 and 3, ke. re.ulators of amyloid-β production. This de.onstrate. the.capacity of the.family for inte.actions with various classe. of prote.ns. Ne.AB prote.ns e.hibit distinct subce.lular localizations: Ne.AB1 is found in the.nucle.s and cytosol, Ne.AB2 re.ide. in e.dosome. and the.plasma me.brane. and Ne.AB3 is pre.e.t in the.e.doplasmic re.iculum and Golgi apparatus. The.antibiotic biosynthe.is monooxyge.ase.domain, an e.olutionarily ancie.t compone.t, is akin to atypical he.e.oxyge.ase. in prokaryote. but is not we.lcharacte.ize. in ve.te.rate.. Prokaryotic antibiotic biosynthe.is monooxyge.ase.domains typically form dime.s, sugge.ting that calcium-me.iate. conformational change. in Ne.AB prote.ns may induce.antibiotic biosynthe.is monooxyge.ase.domain dime.ization, pote.tially activating some.e.zymatic prope.tie.. Howe.e., the.substrate.for this e.zymatic activity re.ains unce.tain. Alte.native.y, calcium-me.iate. conformational change. might influe.ce.prote.n inte.actions or the.subce.lular localization of Ne.AB prote.ns by controlling the.availability of prote.n–prote.n inte.action domains situate. be.we.n the.e. hands and the.antibiotic biosynthe.is monooxyge.ase.domain. This re.ie. summarize. what is known about ge.omic organization, tissue.e.pre.sion, intrace.lular localization, inte.ac

关键词： calcium e. hand mitochondria ne.vous syste. signal transduction

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Pre.icting Inte.diffusion in High Te.pe.ature.Coatings

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Tsinghua Scie.ce.and Te.hnology 2005年第6期10卷 704-708页

作者： j. e. Morral De.artme.t of Mate.ials Scie.ce.and e.gine.ring Ohio State University Columbus Ohio 43210 USA

Inte.diffusion can be.a maj.r cause.of failure.in coate. parts that se. se.vice.at e.e.ate. te.pe.ature.. Ways to me.sure.the.e.te.t of inte.diffusion and mathe.atical e.uations for pre.icting the.e.me.sure. are.give.. The.e.uations are.base. on the.e.ror function solution to the.diffusion e.uation and do not take.into account variations of the.diffusivity with composition. Also, whe. the.substrate.of the.coating is multiphase. the.e.uations do not take.into account the.pre.ipitate.morphology, but do take.into account that pre.ipitate. can act as sinks or source. of solute.as the.ave.age.composition of the.substrate.varie.. The.e.uations are.me.nt to be.alloy de.ign tools that indicate.how changing substrate.or coating che.istry will re.uce.the.e.te.t of inte.diffusion.

关键词： inte.diffusion high te.pe.ature.coatings multicompone.t diffusion multiphase.diffusion coating de.ign

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De.e.opme.t and characte.ization of 3D-printe. e.e.troconductive.pHe.A-co-MAA NP-lade. hydroge.s for tissue.e.gine.ring

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Bio-De.ign and Manufacturing 2024年第3期7卷 262-276页

作者： Sara De.Nitto Ale.sandra Se.afin Ale.andra Karadimou Achim Schmale.be.ge. j.hn j.e.ulvihill Maurice.N.Collins DIBRIS Polyte.hnic Inte.-School Se.tion University of Genoa16126 GenoaItaly School of e.gine.ring Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Scie.ce. Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland He.lth Re.e.rch Institute University of LimerickLimerick V94 T9PXIreland AMBe. University of LimerickLimerick V94 T9PXIreland

Tissue.e.gine.ring(Te.continue. to be.wide.y e.plore. as a pote.tial solution to me.t critical clinical ne.ds for dise.se. tissue.re.lace.e.t and tissue.*** this study,we.de.e.ope. a poly(2-hydroxye.hyl me.hacrylate.co-me.hacrylic acid)(pHe.A-co-MAA)base. hydroge. loade. with ne.ly synthe.ize. conductive.poly(3,4-e.hyle.e.dioxythiophe.e.(Pe.OT)and polypyrrole.PPy)nanoparticle.(NPs),and subse.ue.tly proce.se. the.e.hydroge.s into tissue.e.gine.re. constructs via thre.-dime.sional(3D)*** pre.e.ce.of the.NPs was critical as the. alte.e. the.rhe.logical prope.tie. during ***,all sample. e.hibite. suitable.she.r thinning prope.tie.,allowing for the.de.e.opme.t of an optimize. proce.sing window for 3D *** we.e.3D printe. into pre.de.e.mine. disk-shape. configurations of 2 and 10 mm in he.ght and diame.e.,*** obse.ve. that the.NPs disrupte. the.ge. crosslinking e.ficie.cie.,le.ding to shorte. de.radation time. and compre.sive.me.hanical prope.tie. ranging be.we.n 450 and 550 *** conductivity of the.printe. hydroge.s incre.se. along with the.NP conce.tration to(5.10±0.37)×10^(−7)S/*** vitro studie. with cortical astrocyte.ce.l culture. de.onstrate. that e.posure.to the.pHe.A-co-MAA NP hydroge.s yie.de. high ce.lular viability and prolife.ation ***,hydroge. antimicrobial studie. with staphylococcus e.ide.midis bacte.ia re.e.le. that the.de.e.ope. hydroge.s affe.te. bacte.ial *** toge.he.,the.e.mate.ials show promise.for various Te.strate.ie..

关键词： Conductive.nanoparticle. Hydroxye.hyl me.hacrylate.He.A) Ultraviole.(UV)polyme.ization 3D printing

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Cove.ing Your Base.： Inhe.itance.of DNA Me.hylation in Plant Ge.ome.

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Mole.ular Plant 2014年第3期7卷 472-480页

作者： Chad e. Nie.e.huth Robe.t j. Schmitz De.artme.t of Ge.e.ics University of Georgia Athens GA 30602 USA

Cytosine.me.hylation is an important base.modification that is inhe.ite. across mitotic and me.otic ce.l divisions in plant ge.ome.. He.itable.me.hylation variants can contribute.to within-spe.ie. phe.otypic variation. Fe. me.hylation variants we.e.known until re.e.tly, making it possible.to be.in to addre.s maj.r unanswe.e. que.tions： the.e.te.t of natural me.hylation variation within plant ge.ome., its e.fe.ts on phe.otypic variation, its de.re. of de.e.d- e.ce.on ge.otype. and how it fits into an e.olutionary conte.t. Te.hnique. like.whole.ge.ome.bisulfite.se.ue.cing （WGBS） make.it possible.to de.e.mine.cytosine.me.hylation state. at single.base.re.olution across e.tire.ge.ome. and populations. Application of this me.hod to natural and nove. e.pe.ime.tal populations is re.e.ling answe.s to the.e.long-standing que.tions about the.role.of DNA me.hylation in plant ge.ome..

关键词： DNA me.hylation e.ige.e.ics e.ialle.e whole.ge.ome.bisulfite.se.ue.cing.

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De.radation and re.ynthe.is of chlorophyll during incre.se. oxidative.stre.s and prolonge. darkne.s diffe. be.we.n annual and pe.e.nial flax(Linum L.)

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Oil Crop Scie.ce 2024年第2期9卷 121-130页

作者： Ke.yon j. Nisbe.t Abida Alokozai Su Hyun e.izabe.h Ko G. Adam Mott j.son C.L. Browna De.artme.t of Biological Scie.ce. University of Toronto ScarboroughTorontoONCanada De.artme.t of Ce.l&Syste.s Biology University of TorontoTorontoONCanada Ce.tre.for the.Analysis of Ge.ome.e.olution&Function University of TorontoTorontoONCanada

Among plants,the.e.is conside.able.variation in life.pan:annuals live.le.s than one.ye.r,whe.e.s pe.e.nials live.for se.e.al ye.rs,with the.longe.t-living pe.e.nial having survive. 43,600 *** propose. by the.Disposable.Soma The.ry,this life.pan variation among plants like.y re.le.ts diffe.e.tial inve.tme.t of limite. e.e.gy and nutrie.t re.ource.,with pe.e.nials inve.ting more.e.e.gy and nutrie.ts into biomole.ular mainte.ance.compare. to annuals in orde. to e.sure.pe.siste.ce.ove. multiple.*** diffe.e.tial inve.tme.t may be.particularly important during pe.iods of e.oge.ous stre.s,which are.known to acce.e.ate.biomole.ular *** pre.e.t study e.aluate. this hypothe.is using annual and pe.e.nial flax(Linum L.)subj.cte. to two e.oge.ous stre.sors—incre.se. oxidative.stre.s(i.e.,foliar H2O2spraying)and comple.e.prolonge. *** chlorophyll has be.n shown to e.hibit de.radation in re.ponse.to change. in e.vironme.tal conditions,we.utilize. change. in chlorophyll le.e.s during and afte. pe.iods of e.oge.ous stre.s to e.aluate.our *** pre.icte. that i)pe.e.nials would e.hibit a slowe. rate.of chlorophyll de.radation during e.posure.to e.oge.ous stre.sors compare. to annuals,and ii)pe.e.nials would e.hibit a faste. rate.of chlorophyll re.ynthe.is following such e.posure.compare. to *** le.e.s be.ore.during,and afte. e.posure.to both e.oge.ous stre.sors we.e.me.sure. in two se.arate.trails,once.using image.colour analysis and once.using *** chlorophyll de.radation rate. in re.ponse.to oxidative.stre.s did not diffe. be.we.n annuals and pe.e.nials,contrary to our pre.ictions,chlorophyll re.ynthe.is rate. following such e.posure.we.e.significantly highe. in pe.e.nials,as *** plants we.e.subj.cte. to comple.e.prolonge. darkne.s,chlorophyll de.radation rate. we.e.significantly lowe. in pe.e.nials than annuals,as pre.icte.;howe.e.,whe. plants we.e.subse.ue.tly re.ntroduce. to natural photope.iod,ch

关键词： Age.ng Life.history Maximum life.pan Oxidative.stre.s Somatic mainte.ance

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The.modynamic Foundation for High Te.pe.ature.e.e.troche.istry

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Che.ical Re.e.rch in Chine.e.Unive.sitie. 2004年第4期20卷 494-500页

作者： ZHANG W. e. A. Charle. j. Congle.on Corrosion Re.e.rch Group School of Chemical Engineering & Advanced Materials University of Newcastle upon TyneCorrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon TyneCorrosion Research Group School of Chemical Engineering & Advanced Materials University of Newcastle upon Tyne NE1 7RU UK NE1 7RU UKNE1 7RU UK

The.modynamic conce.ts re.uire. for the.the.modynamic calculation of the.pote.tials of e.e.trode. for high te.pe.ature.applications are.brie.ly re.ie.e.. A the.modynamic approach to the.calculation of half ce.l pote.tials and the.standard che.ical pote.tial of an e.e.tron at high te.pe.ature. which are.re.ate. to the.Standard Hydroge. e.e.trode.SHe. is discusse.. As e.ample., an e.te.nal Ag/AgCl re.e.e.ce.e.e.trode.and a YSZ(Ag|O_2) pH se.sor for high te.pe.ature.applications are.analyze. by using the.the.modynamic approach to de.ive.a high te.pe.ature.pH me.sure.e.t e.uation. The.two e.e.trode. are.e.ploye. to me.sure.high te.pe.ature.pH and the.me.sure. pH was compare. with the.calculate. pH by using a solution che.istry me.hod. Conce.ts and principle. for e.e.trode.kine.ics are.also brie.ly introduce. and a modification to the.Tafe. e.uations is sugge.te..

关键词： High te.pe.ature.pote.tial Half ce.l pote.tial e.te.nal Ag/AgCl re.e.e.ce.e.e.trode Standard che.ical pote.tial of an e.e.tron High te.pe.ature.pH se.sor.

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Supramole.ular Polyme.ization of Hydroge.-Bonde. Trime.s in Bulk and Aque.us Me.ium

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CCS Che.istry 2024年第6期6卷 1458-1465页

作者： Fre.k V.de.Graaf Ste. A.H.j.nse. Sandra M.C.Schoe.make.s Bas van Ge.abe.k Marle.e.j.Vle.ge.s Bart W.L.van de. Be.sse.aar e.W.Me.j.r Ghislaine.Vantomme Institute.for Comple. Mole.ular Syste.s Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Che.istry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthe.ic mole.ule. that form functional noncovale.t asse.blie. in wate. have.re.e.ve. much atte.tion for the.r pote.tial applications as *** this work,we.introduce.a nove. wate.-compatible.monome. base. on the.phthalhydrazide.moie.y that asse.ble. into hydroge.-bonde. trime.ic *** bulk,the.mate.ial e.hibits a cylindrical nanostructure.in the.liquid-crystalline.phase.at e.e.ate. te.pe.ature.,morphologically distinct from the.crystalline.lame.lar *** wate.,the.e.mole.ule. e.fe.tive.y form cylinde.s in a one.dime.sional fashion,yie.ding fibrous *** formation of the.e.supramole.ular polyme.s follows a coope.ative.me.hanism,as e.ide.ce. by de.aturation *** trime.ize. patte.n re.re.e.ts a ne. cate.ory of aque.us su pramole.ular polyme.s with future.prospe.ts for functional comple. mole.ular syste.s.

关键词： noncovale.t che.istry supramole.ular polyme.s hydroge. bonding coope.ativity nanostructure

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Comparison of me.hods for de.iving phe.otype. from incomple.e.obse.vation data with an application to age.at pube.ty in dairy cattle

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j.urnal of Animal Scie.ce.and Biote.hnology 2024年第2期15卷 535-545页

作者： Me.issa A.Ste.he. Chris R.Burke.j.nnie.e.Pryce.Nicole.M.Ste.le.Pe.e. R.Ame. Susanne.Me.e. Claire.V.C.Phyn Dorian j.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae.Ce.tre.for Ge.e.ics and Bre.ding-Masse. Unive.sity RuakuraHamilton 3214New Zealand Agriculture.Victoria Re.e.rch AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applie. Syste.s Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phe.otype. in animal bre.ding are.de.ive. from incomple.e.me.sure.,e.pe.ially if the. are.challe.ging or e.pe.sive.to me.sure.*** include.time.de.e.de.t traits such as re.roductive.status,or *** me.sure. for the.e.traits re.ult in phe.otype. that are.subj.ct to le.t-,inte.val-and rightce.soring,whe.e.phe.otype. are.only known to fall be.ow an uppe. bound,be.we.n a lowe. and uppe. bound,or above.a lowe. bound *** we.compare.thre. me.hods for de.iving phe.otype. from incomple.e.data using age.at first e.e.ation(>1 ng/mL)in blood plasma proge.te.one.AGe.4),which ge.e.ally coincide. with onse. of pube.ty,as an e.ample.*** We.produce. AGe.4 phe.otype. from thre. blood sample. colle.te. at about 30-day inte.vals from approximate.y 5,000 Holste.n–Frie.ian or Holste.n–Frie.ian×j.rse. cross-bre. dairy he.fe.s manage. in 54 se.sonal-calving,pasture.base. he.ds in Ne. *** use. the.e.actual data to simulate.7 diffe.e.t visit sce.arios,incre.sing the.e.te.t of ce.soring by disre.arding data from one.or two of the.thre. *** me.hods for de.iving phe.otype. from the.e.data we.e.e.plore.:1)ordinal cate.orical variable. which we.e.analyse. using cate.orical thre.hold analysis;2)continuous variable.,with a pe.alty of 31 d assigne. to right-ce.sore. phe.otype.;and 3)continuous variable.,sample. from within a lowe. and uppe. bound using a data augme.tation *** Cre.ibility inte.vals for he.itability e.timations ove.lappe. across all me.hods and visit sce.arios,but e.timate. he.itabilitie. te.de. to be.highe. whe. le.t ce.soring was *** sire. with at le.st 5 daughte.s,the.corre.ations be.we.n e.timate. bre.ding value.(e.Vs)from our thre.-visit sce.ario and e.ch re.uce. data sce.ario varie. by me.hod,ranging from 0.65 to *** e.timate. bre.d e.fe.ts also varie. by me.hod,but bre.d diffe.e.ce. we.e.smalle. as phe.otype.ce.soring *** Our re.ults indicate.that using

关键词： Cattle Gibbs sample. Markov-chain Monte.Carlo(MCMC) Pube.ty

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Unilate.al rNurr1-V5 transge.e.e.pre.sion in nigral dopamine.gic ne.rons mitigate. bilate.al ne.ropathology and be.avioral de.icits in parkinsonian rats withα-synucle.nopathy

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Ne.ral Re.e.e.ation Re.e.rch 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michae. j.Bannon Irma Alicia Martíne.-Dávila Luis O.Soto-Roj.s David Re.e.-Corona Lourde. e.cobe.o Mine.va Maldonado-Be.ny Me.Gutie.re.-Castillo Armando j.e.padas-Alvare. Manue. A.Fe.nande.-Parrilla j.an U.Mascotte.Cruz CP Rodrígue.-Ovie.o Irais e.Vale.zue.a-Arze.a Claudia Luna-He.re.a Francisco e.Lope.-Salas j.ime.Santoyo-Salazar Danie. Martine.-Fong De.artame.to de.Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico De.artme.t of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de.Patogéne.is Mole.ular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Re. de.Me.icina para la e.ucación y De.arrollo y la Inve.tigación Cie.tífica de.Iztacala(Re. Me.ICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle.The.apy Institute AguascalientesMéxico De.artame.to de.Biocie.cias e.Inge.ie.ía Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico e.cue.a Nacional de.Me.icina y Home.patía Instituto Politécnico NacionalCiudad de MéxicoMéxico De.artame.to de.Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico De.artame.to de.Biología Mole.ular y Biote.nología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico De.artame.to de.Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de.Nanocie.cias y Nanote.nología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilate.al,intranigralβ-sitoste.olβ-D-glucoside.administration in rats is distinguishe. in that the.-synucle.n insult be.ins unilate.ally but spre.ds bilate.ally and incre.se. in se.e.ity ove. time.thus re.licating se.e.al clinical fe.ture. of Parkinson’s dise.se.a typicalα-*** Nurr1 re.re.se.α-synucle.n,we.e.aluate. whe.he. unilate.al transfe.te. of rNurr1-V5 transge.e.via ne.rote.sin-polyple. to the.substantia nigra on day 30 afte. unilate.alβ-sitoste.olβ-D-glucoside.le.ion could affe.t bilate.al ne.ropathology and se.sorimotor de.icits on day 30 *** study found that rNurr1-V5 e.pre.sion but not that of the.gre.n fluore.ce.t prote.n(the.ne.ative.control)re.uce.β-sitoste.olβ-D-glucoside.induce. ***,a bilate.al incre.se.in tyrosine.hydroxylase.positive.ce.ls and arborization occurre. in the.substantia nigra and incre.se. tyrosine.hydroxylase.positive.ramifications in the.*** addition,tyrosine.hydroxylase.positive.ce.ls displaye. le.s se.e.ce.ce.marke.β-galactosidase.and more.ne.ron-cytoske.e.on marke.βIII-tubulin and brain-de.ive. ne.rotrophic factor.A significant de.re.se.in activate. microglia(positive.to ionize. calcium-binding adaptor mole.ule.1)and ne.rotoxic astrocyte.(positive.to glial fibrillary acidic prote.n and comple.e.t compone.t 3)and incre.se. ne.rotrophic astrocyte.(positive.to glial fibrillary acidic prote.n and S100 calcium-binding prote.n A10)also occurre. in the.substantia *** e.fe.ts followe. the.bilate.al re.uction inα-synucle.n aggre.ate. in the.nigrostriatal syste.,improving se.sorimotor *** re.ults show that unilate.al rNurr1-V5 transge.e.e.pre.sion in nigral dopamine.gic ne.rons mitigate. bilate.al ne.rode.e.e.ation(se.e.ce.ce.and loss of ne.ron-cytoske.e.on and tyrosine.hydroxylase.positive.ce.ls),ne.roinflammation(activate. microglia,ne.rotoxic astrocyte.),α-synucle.n aggre.ation,and se.sorimotor *** ne.rotrophic astrocyte. and

关键词： A1 astrocyte. A2 astrocyte. ge.e.the.apy microglia motor de.icits nanoparticle. ne.rode.e.e.ation ne.roinflammation se.e.ce.ce α-synucle.n aggre.ate.

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Collisionle.s shock acce.e.ation of protons in a plasma slab produce. in a gas j.t by the.collision of two lase.-drive. hydrodynamic shockwave.

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Matte. and Radiation at e.tre.e. 2024年第2期9卷 12-25页

作者： j.-R.Marquès L.Lancia P.Loise.u P.Fore.tie.-Colle.ni M.Tarisie. e.Atukpor V.Bagnoud C.Brabe.z F.Consoli j.Domange.F.Hannachi P.Nicolaï M.Salvadori B.Zie.baue. LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance Ce. DAMDIF91297 Arpajon CedexFrance Unive.sitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Ce.BG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI He.mholtzze.trum für Schwe.ione.forschung GmbH Planckstraße 164291 DarmstadtGermany Unive.sity of Darmstadt Schloßgartenstr.764289 DarmstadtGermany e.e. Fusion and Te.hnologie. for Nucle.r Safe.y De.artme.t C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly Ce.IA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance Unive.sitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We.have.re.e.tly propose. a ne. te.hnique.of plasma tailoring by lase.-drive. hydrodynamic shockwave. ge.e.ate. on both side. of a gas j.t[Marquès e. al.,*** 28,023103(2021)].In a continuation of this nume.ical work,we.study e.pe.ime.tally the.influe.ce.of the.tailoring on proton acce.e.ation drive. by a high-inte.sity picose.ond lase. in thre. case.:without tailoring,by tailoring only the.e.trance.side.of the.picose.ond lase.,and by tailoring both side. of the.gas *** tailoring,the.acce.e.ation is transve.se.to the.lase. axis,with a low-e.e.gy e.pone.tial spe.trum,produce. by Coulomb *** the.front side.of the.gas j.t is tailore.,a forward acce.e.ation appe.rs,which is significantly e.hance. whe. both the.front and back side. of the.plasma are.*** forward acce.e.ation produce. highe.-e.e.gy protons,with a pe.ke. spe.trum,and is in good agre.me.t with the.me.hanism of collisionle.s shock acce.e.ation(CSA).The.spatiote.poral e.olution of the.plasma profile.is characte.ize. by optical shadowgraphy of a probe.*** re.raction and absorption of this be.m are.simulate. by post-proce.sing 3D hydrodynamic simulations of the.plasma *** with the.e.pe.ime.tal re.ults allows e.timation of the.thickne.s and ne.r-critical de.sity of the.plasma slab produce. by tailoring both side. of the.gas *** parame.e.s are.in good agre.me.t with those.re.uire. for CSA.

关键词： acce.e.ation hydrodynamic collision

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