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Supranutrition of microalgal docosahexaenoic acid and calcidiol improved growth performance,tissue lipid profiles,and tibia characteristics of broiler chickens

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1542-1550页

作者： Sahil Kalia andrew d.magnuson Tao Sun Guanchen Liu Woo Kyun Kim Zackary Johnson Xin Gen Lei department of Animal Science Cornell University252 Morrison HallIthacaNY 14850USA department of Poultry Science University of GeorgiaAthensGAUSA Nicholas School of the Environment Duke UniversityBeaufortNCUSA

Background docosahexaenoic acid(dHA)and calcidiol could be enriched in chicken for improving public nutrition and *** remains unclear if supranutritional levels of dHA and calcidiol impair growth performance or metabolism of broiler *** study was to determine singular and combined effects of high levels of supplemental dHA-rich microalgal biomass or oil and calcidiol on growth performance,concentrations of triglycerides,cholesterol,and nonesterfied fatty acids in plasma,liver,breast,and thigh,and biophysical properties of *** In Exp.1,144 day-old Cornish chicks were divided into 4 groups(6 cages/treatment,6 birds/cage),and were fed a corn-soybean meal basal diet(Bd),Bd+10,000 IU calcidiol/kg(Bd+Cal),Bd HA),and Bd+1%dHA-rich Aurantiochytrium(1.2 g dHA/kg;Bd+d+Cal+dHA for 6 *** Exp.2,180 day-old chicks were divided into5 groups,and were fed:Bd,Bd+dHA(0.33%to 0.66%oil,1.5 to 3.0 g dHA/kg),Bd EPA/kg),Bd+dHA+EPA(1.9%to 3.8%eicosapentaenoic acid-rich Nannochloropsis ***18,0.3 to 0.6 g Bd+dHA+calcidiol(6000 to 12,000 IU/kg diet),and+dHA+EPA+Cal for 6 *** Birds fed Bd+Cal diet in Exp.1 and Bd lower(P+dHAdiet in Exp.2 had higher(Pdy weight gain(10%-11%)and gain:feed ratio(7%),and total cholesterol and triglyceride concentrations in plasma(18%-54%),liver(8%-26%),breast(19%-26%),and thigh(10%-19%),respectively,over the *** two diets also improved(Pd(or)bone mineral density(3%-19%)of *** Supranutrition of dietary calcidiol and dHA alone or together did not produce adverse effects,but led to moderate improvements of growth performance,lipid profiles of plasma and muscle,and bone properties of broiler chickens.

关键词： Broiler Calcidiol Growth performance Microalgae Tibia

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Supranutrition of microalgal docosahexaenoic acid and calcidiol improved growth performance, tissue lipid profiles, and tibia characteristics of broiler chickens

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Journal of Animal Science and Biotechnology 2023年第4期

作者： Sahil Kalia andrew d.magnuson Tao Sun Guanchen Liu Woo Kyun Kim Zackary Johnson Xin Gen Lei

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： andrew Gregory Chengyun Tang Fan Fan department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(Ad)and Alzheimer's diseaserelated dementias(AdRd)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,Ad/AdRd has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche andrew Chan Robert Hoepner Patrick Küry department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human dNA.

关键词： endogenous inflammation Human

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Challenges in Understanding Genome-Wide dNA Methylation

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Journal of Computer Science & Technology 2010年第1期25卷 26-34页

作者：张伟奇 andrew d. Smith Cold Spring Harbor Laboratory Cold Spring Harbor Bioinformatics division TNLIST and MOE Key Lab of Bioinformatics Tsinghua University department of Biological Sciences University of Southern California

dNA methylation is a chemical modification of the bases in genomes. This modification, most frequently found at CpG dinucleotides in eukaryotes, has been identified as having multiple critical functions in broad and diverse species of animals and plants, while mysteriously appears to be lacking from several other well-studied species. dNA methylation has well known and important roles in genome stability and defense, its pattern change highly correlates with gene regulation. Much evidence has linked abnormal dNA methylation to human diseases. Most prominently, aberrant dNA methylation is a common feature of cancer genomes. Elucidating the precise functions of dNA methylation therefore has great biomedical significance. Here we provide an update on large-scale experimental technologies for detecting dNA methylation on a genomic scale. We also discuss new prospect and challenges that computational biologist will face when analyzing dNA methylation data.

关键词： dNA methylation epigenome computational epigenomics

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 101-109页

作者： Mariarosaria d'Amato Gennaro Iengo Nicola Massa Chiara Carlomagno department of Oncology Ospedale San Rocco ASL CasertaSessa Aurunca 81037CampaniaItaly department of Clinical Medicine and Surgery University of Naples Federico IINaples 80131CampaniaItaly

BACKGROUNd Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(dPd),encoded by the dPYd *** 7%of the European population is a carrier of dPYd gene polymorphisms associated with reduced dPd enzyme *** To assess the prevalence of dPYd polymorphisms and their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal *** A total of 300 consecutive patients with a diagnosis of gastrointestinal malignancy and treated with a fluoropyrimidine-based regimen were included in the analysis and divided into two cohorts:(1)149 patients who started fluoropyrimidines after dPYd testing;and(2)151 patients treated without dPYd *** the patients in cohort A,15%tested only the dPYd2A polymorphism,19%tested four polymorphisms(dPYd2A,HapB3,c.2846A>T,and dPYd13),and 66%tested five polymorphisms including *** Overall,14.8%of patients were found to be carriers of a dPYd variant,the most common being dPYd6(12.1%).Patients in cohort A reported≥G3 toxicities(P=0.00098),particularly fewer nonhematological toxicities(P=0.0028)compared with cohort B,whereas there was no statistically significant difference between the two cohorts in hematological toxicities(P=0.6944).Significantly fewer chemotherapy dose reductions(P=0.00002)were observed in cohort A compared to cohort B,whereas there was no statistically significant differences in chemotherapy *** Although this study had a limited sample size,it provides additional information on the prevalence of dPYd polymorphisms in the Italian population and highlights the role of pharmacogenetic testing to prevent severe toxicity.

关键词： dihydropyrimidine dehydrogenase dPYd polymorphisms Fluoropyrimidine Caucasian population Gastrointestinal cancers

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Bio-Imitation of Mexican Migration Routes to the USA with Slime Mould on 3d Terrains

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Journal of Bionic Engineering 2013年第2期10卷 242-250页

作者： andrew Adamatzky Genaro J Martinez department of Computer Sciences University of the West of England Bristol BS16 1QY UK Escuela Superior de Computo Instituto Politecnico Nacional Mexico

Plasmodium ofPhysarum polycephalum （P. polycephalum） is a large single cell visible by an unaided eye. It shows sophisticated behavioural traits in foraging for nutrients and developing an optimal transport network of protoplasmic tubes spanning sources of nutrients. When placed in an environment with distributed sources of nutrients the cell computes＇ an optimal graph spanning the nutrients by growing a network of protoplasmic tubes. P. polycephalum imitates development ofman-made transport networks of a country when configuration of nutrients represents major urban areas, We employed this feature of the slime mould to imitate mexican migration to USA. The Mexican migration to USA is the World＇s larger migration system. We bio-physically imitated the migration using slime mould P. poIycephalum. In laboratory experiments with 3d Nylon terrains of USA we imitated development of migratory routes from Mexico-USA border to ten urban areas with high concentration of Mexican migrants. From results of laboratory experiments we extracted topologies of migratory routes, and highlighted a role of elevations in shaping the human movement networks.

关键词： biomimetics bio-inspired computing migration routes slime mould

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