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Hendra and Nipah Virus Envelope Glycoproteins and Receptor Interactions

第3届新生病毒性疾病控制学术研讨会

作者： andrew c.hickey Jennifer McEachern christopher c.Broder Department of Microbiology Uniformed Services UniversityBethesdaMaryland 20814USA cSIRO Livestock Industries Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Center for Emerging Infectious DiseasesGeelongAustralia.

Hendra virus(HeV) and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic in a variety of vertebrate animals including humans Numerous frugivorous bat sp...

Hendra virus(HeV) and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic in a variety of vertebrate animals including humans Numerous frugivorous bat species(genus

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Hendra and Nipah Virus Envelope Glycoproteins and Receptor I...

Satellite-enabled enviromics to enhance crop improvement

第3届新生病毒性疾病控制学术研讨会

作者： andrew c.hickey Kimberly A.Bishop Dimple Khetawat Yee-Peng chan KathadneN.Bossart, Dimiter S.Dimitrov Dimitar B.Nikolov christopher c.Broder Department of Microbiology Uniformed Services UniversityBethesdaMaryland 20814USA cSIRO Livestock IndustriesAAHLGeelongVictoria 3220Australia Protein Interactions Group CCRNPCCR and BRPSAIC-FrederickInc.NCINIHFrederickMaryland 21702USA Structural Biology Program Memorial Sloan-Kettering Cancer CenterNew YorkNY 10021USA

Nipah virus(NiV) and Hendra virus(HeV) are the type species of the highly pathogenic paramyxovirus genus *** viruses exhibit a broad species tropism associated with significant morbidity and mortality among a variety of

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende Lee hickey cibele H.Amaral Lucas L.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil ThecROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LiDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

The Mechanism of Henipavirus Fusion:Examining the Relationships between the Attachment and Fusion Glycoproteins

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Virologica Sinica 2009年第2期24卷 110-120页

作者： andrew c. hickey christopher c. Broder Department of Microbiology and Immunology Uniformed Services University of the Health Sciences

The henipaviruses,represented by Nipah virus and Hendra virus,are emerging zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia,Southeast Asia,India and Bangladesh. These viruses enter host cells via a class I viral fusion mechanism mediated by their attachment and fusion envelope glycoproteins;efficient membrane fusion requires both these glycoproteins in conjunction with specific virus receptors present on susceptible host cells. The henipavirus attachment glycoprotein interacts with a cellular B class ephrin protein receptor triggering conformational alterations leading to the activation of the viral fusion(F) glycoprotein. The analysis of monoclonal antibody(mAb) reactivity with G has revealed measurable alterations in the antigenic structure of the glycoprotein following its binding interaction with receptor. These observations only appear to occur with full-length native G glycoprotein,which is a tetrameric oligomer,and not with soluble forms of G(sG) ,which are disulfide-linked dimers. Single amino acid mutations in a heptad repeat-like structure within the stalk domain of G can disrupt its association with F and subsequent membrane fusion promotion activity. Notably,these mutants of G also appear to confer a post-receptor bound conformation implicating the stalk domain as an important element in the G glycoprotein's structure and functional relationship with F. Together,these observations suggest fusion is dependent on a specific interaction between the F and G glycoproteins of the henipaviruses. Further,receptor binding induces measurable changes in the G glycoprotein that appear to be greatest in respect to the interactions between the pairs of dimers comprising its native tetrameric structure. These receptor-induced conformational changes may be associated with the G glycoprotein's promotion of the fusion activity of F.

关键词： Hendra virus Nipah virus Henipavirus Paramyxovirus Viral entry

Harnessing genetic variation at regulatory regions to fine-tune traits for climate-resilient crops

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Molecular Plant 2022年第2期15卷 222-224页

作者： Diep R.Ganguly Lee T.hickey Peter A.crisp Australian Research council centre of Excellence in Plant Energy Biology Research School of BiologyThe Australian National UniversityActonCanberraACT 2601Australia cSIRO Synthetic Biology Future Science Platform CanberraACTAustralia Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLD 4072Australia School of Agriculture and Food Sciences The University of QueenslandBrisbaneQLD 4072Australia

climate change is making it more challenging to meet the food demands of a growing global *** food produc-tion relies on continual crop improvements to generate higher and more stable yields,especially with increasingly unpredictable environments and less arable *** improvement of traits that promote climate resilience and resource utilization,for example,greater photosynthetic capacity,increased nitrogen use efficiency,and optimized root and shoot architecture,repre-sents a promising avenue for engineering crops to yield more with less(Evans and Lawson,2020).A key challenge for crop engineering is optimizing performance in specific environments.

关键词： crops traits environments

NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections

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cellular & Molecular Immunology 2019年第11期16卷 868-877页

作者： Elias Abou-Samra Zachary hickey Oscar A.Aguilar Michal Scur Ahmad Bakur Mahmoud Sergey Pyatibrat Megan M.Tu Jeffrey Francispillai Arthur Mortha James R.carlyle Mir Munir A.Rahim andrew P.Makrigiannis Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawa451 Smyth RoadOttawaON K1H 8M5Canada Department of Immunology University of Toronto1 King’s College CircleTorontoON M5S 1A8Canada Sunnybrook Research Institute 2075 Bayview AvenueTorontoON M4N 3M5Canada Department of Microbiology and Immunology Dalhousie University5850 College StreetHalifaxNS B3H 4R2Canada college of Applied Medical Sciences Taibah UniversityMadinah MunawwarahSaudi Arabia Division of Anatomical Pathology Department of Pathology and Laboratory MedicineThe Ottawa HospitalUniversity of Ottawa501 Smyth RoadOttawaON K1H 8L6Canada

Helper-type innate lymphoid cells(ILc)play an important role in intestinal *** of the NKR-P1 gene family are expressed in various innate immune cells,including natural killer(NK)cells,and their cognate clr ligand family members are expressed in various specialized tissues,including the intestinal epithelium,where they may play an important role in mucosalassociated innate immune *** this study,we show that the inhibitory NKR-P1B receptor,but not the Ly49 receptor,is expressed in gut-resident NK cells,ILc,and a subset ofγδT cells in a tissue-specific ***3 cells constitute the predominant cell subset expressing NKR-P1B in the gut lamina *** known NKR-P1B ligand clr-b is broadly expressed in gut-associated cells of hematopoietic *** genetic deletion of NKR-P1B results in a higher frequency and number of ILc3 andγδT cells in the gut lamina ***,the function of gut-resident ILc3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by citrobacter rodentium or Salmonella typhimurium,resulting in increased systemic bacterial dissemination in NKR-P1B-deficient *** findings highlight the role of the NKR-P1B:clr-b recognition system in the modulation of intestinal innate immune cell functions.

关键词： Innate lymphoid cells Natural killer cells Gut-associated immune cells NKR-P1B receptor Innate immunity

Steatotic livers are susceptible to normothermic ischemiareperfusion injury from mitochondrial complex-Ⅰ?dysfunction

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World Journal of Gastroenterology 2016年第19期22卷 4673-4684页

作者： Michael JJ chu Rakesh Premkumar Anthony JR hickey Yannan Jiang Brett Delahunt Anthony RJ Phillips Adam SJR Bartlett Department of Surgery University of Auckland School of Biological Sciences University of Auckland Maurice Wilkins centre for Biodiscovery University of Auckland Department of Statistics University of Auckland Department of Pathology and Molecular Medicine Wellington School of Medicine University of Otago New Zealand Liver Transplant Unit Auckland City Hospital

AIM: To assess the effects of ischemic preconditioning(IPc, 10-min ischemia/10-min reperfusion) on steatotic liver mitochondrial function after normothermic ischemia-reperfusion injury(IRI).METHODS: Sixty male Sprague-Dawley rats were fed8-wk with either control chow or high-fat/high-sucrose diet inducing > 60% mixed steatosis. Three groups(n = 10/group) for each dietary state were tested:(1) the IRI group underwent 60 min partial hepatic ischemia and 4 h reperfusion;(2) the IPc group underwent IPc prior to same standard IRI; and(3) sham underwent t h e s a m e s u r g e r y w i t h o u t I R I o r I P c. H e p a t i c mitochondrial function was analyzed by oxygraphs. Mitochondrial complex-Ⅰ, complex-Ⅱ enzyme activity, serum alanine aminotransferase(ALT), and histological injury were ***: Steatotic-IRI livers had a greater increase in ALT(2476 ± 166 vs 1457 ± 103 IU/L, P cal injury following IRI compared to the lean liver group. Steatotic-IRI demonstrated lower complex-Ⅰ?activity at baseline [78.4 ± 2.5 vs 116.4 ± 6.0 nmol/(*** protein), P c-IRI also demonstrated impaired complex-Ⅰ?function post-IRI compared to the lean liver IRI group. complex-Ⅱ activity was unaffected by hepatic steatosis or IRI. Lean liver mitochondrial function was unchanged following IRI. IPc normalized ALT and histological injury in steatotic livers but had no effect on overall steatotic liver mitochondrial function or individual mitochondrial complex enzyme activities. cONcLUSION: Warm IRI impairs steatotic liver complex-Ⅰ?activity and function. The protective effects of IPc in steatotic livers may not be mediated through mitochondria.

关键词： Mitochondrial respiration Fatty liver Liver ischemia Oxidative phosphorylation Liver injury Hepatic steatosis Ischemic preconditioning

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复发性癌和转移

国外医学(消化系疾病分册) 1984年第1期 28-34页

作者： hickey c 郁宝铭林言箴

复发性癌转移及其外科治疗结肠有二条淋巴引流途径和二条静脉回流通道。主要的淋巴转移是向头侧端的。在大多数结肠癌病组中约有50%的患者已有淋巴结侵犯。直肠癌的转移方式有直接侵润、淋巴转移、血行转移、腹膜转移及术中种植。 Welch... 详细信息

复发性癌转移及其外科治疗结肠有二条淋巴引流途径和二条静脉回流通道。主要的淋巴转移是向头侧端的。在大多数结肠癌病组中约有50%的患者已有淋巴结侵犯。直肠癌的转移方式有直接侵润、淋巴转移、血行转移、腹膜转移及术中种植。 Welch和Donaldson发现,当原发性肿瘤位于乙状结肠和直肠时,身体某一部位作为“唯一的”和“与其他部位同时发生”的转移的复发率分别为:肝脏13%,45%;腹腔7%,23%;盆腔30%,45%;肺4%,32%;骨0%,7%及脑

关键词：顽固性疼痛脊髓丘脑侧束疼痛缓解神经根切断术吗啡阿片麻醉剂肝动脉栓塞脑室内盆腔滴注经皮双侧性输尿管导管直肠癌患者

双向上腔静脉肺动脉吻合术后二氧化碳对氧合作用及体循环、脑、肺血管血流动力学的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 50-51页

作者： Hoskote A. hickey c. 杜媛

We investigated the effects of different cO2 tensions on oxygenation, pulmonary blood flow(Qp), cerebral blood flow, and systemic blood flow(Qs) after the bidirectional superior cavopulmonary anastomosis (BcPA). Hypoxemia refractory to management of a high pulmonary vascular resistance index(PVRI) may complicate recovery from the BcPA. After BcPA, cO2 was added to the inspired gas of mechanically ventilated patients. The Qp, Qs, PVRI, and systemic vascular resistance index(SVRI) were calculated from oxygen consumption, intravascular pressures, and oxygen saturations. cerebral blood flow was estimated by near infrared spectroscopy and transcranial Doppler. In nine patients(median age 7.1, range 2 to 23 months), arterial oxygen tension increased significantly (pcarbon dioxide tensions (PacO2) of 35, 45, and 55 mm Hg, respectively and decreased to 40±8 mm Hg at PacO2 40 mm Hg. At a PacO2 of 55 and 45 compared with 35 mm Hg, Qp, cerebral blood flow, and Qs increased significantly, PVRI, Qp/Qs, and the ratio of Qp to inferior vena caval blood flow were unchanged, but SVRI decreased. We have demonstrated that after the BcPA, systemic oxygenation, Qp, Qs, and cerebral blood flow increased and SVRI decreased at cO2 tensions of 45 and 55 mm Hg compared with 35 mm Hg. We suggest that hypoxemia after the BcPA is ameliorated by a higher PacO2 and that low PacO2 or alkalosis may be detrimental. Hypercarbic management strategies may allow earlier progression to the BcPA, which may contribute to reducing the interval morbidity in patients with a functional single ventricle.

关键词：氧合作用血流动力学肺血管二氧化碳张力功能性单心室循环血流量分光镜检查脑血流量动脉氧张力近红外线